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41. 发明授权

US07462450B2 Chemical arrays 失效
标题翻译：化学阵列
公开(公告)号：US07462450B2
公开(公告)日：2008-12-09
申请号：US11030562
申请日：2005-01-05
申请人： Steven M. Lefkowitz , Michel G. M. Perbost , Roy H. Kanemoto , Carol T. Schembri
发明人： Steven M. Lefkowitz , Michel G. M. Perbost , Roy H. Kanemoto , Carol T. Schembri
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00274 , B01J2219/00378 , B01J2219/00497 , B01J2219/00518 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/00009 , G01N2035/00158
摘要： Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a reagent station with a continuous volume of reagent which chemically reacts with precursors or the web. The flexible elongated web is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web to receive a biopolymer array.
摘要翻译：方法，装置和计算机程序产品以形成聚合物阵列，每个聚合物阵列具有在柔性细长网的表面上的特征图案，其包括。在一种方法中，将聚合物或其前体单元在施用站施加到表面。多个特征被覆盖在具有与前体或网络化学反应的连续体积的试剂的试剂站。柔性细长腹板沿长度方向驱动穿过施用台。可以根据需要重复该顺序以形成沿着网的阵列。还提供了制备柔性细长网的表面以接收生物聚合物阵列的方法。

42. 发明授权

US07364896B2 Test strips including flexible array substrates and method of hybridization 有权
标题翻译：测试条包括柔性阵列底物和杂交方法
公开(公告)号：US07364896B2
公开(公告)日：2008-04-29
申请号：US10286117
申请日：2002-10-31
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： C12M1/34 , G01N15/06 , C07H21/02 , A61K38/00 , C07K1/00
CPC分类号： B01L9/54 , B01J19/0046 , B01L3/5027 , B01L3/505 , B01L3/5085 , B01L7/00 , B01L2300/0636 , G01N35/00009 , G01N2035/00158
摘要： Individual and aggregate test strip arrays having a backing strip supporting a flexible array substrate which supports an addressable collection of probes are taught. Hybridization cells for use with the individual test strip arrays are also disclosed, and in particular embodiments the hybridization cells closely fit a portion or all of the individual test strip arrays. Array hybridization systems that include test strip arrays and hybridization cells are disclosed with methods for performing a hybridization assay on a sample solution.
摘要翻译：教导了具有支撑支撑可寻址的探针集合的柔性阵列基板的背衬条的单个和聚集测试条阵列。还公开了用于单个测试条阵列的杂交细胞，并且在特定实施方案中，杂交细胞与单个测试条阵列的一部分或全部紧密配合。公开了包括测试条阵列和杂交细胞的阵列杂交系统，用于对样品溶液进行杂交测定。

43. 发明授权

US07247499B2 Method for conducting binding reactions on a solid surface within an enclosed chamber 有权
标题翻译：在封闭室内的固体表面上进行结合反应的方法
公开(公告)号：US07247499B2
公开(公告)日：2007-07-24
申请号：US11041129
申请日：2005-01-21
申请人： Carol T. Schembri , Leslie B. Overman , Charles Z. Hotz
发明人： Carol T. Schembri , Leslie B. Overman , Charles Z. Hotz
IPC分类号： G01N33/566 , C12Q1/68 , C12M1/34 , C07K1/00 , C07H21/02
CPC分类号： C07H21/00 , B01F9/002 , B01F13/005 , B01F13/0054 , B01F13/0059 , C07B2200/11 , C12Q1/6876 , G01N33/54393 , Y10T436/143333
摘要： The invention provides an apparatus and method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber. The invention may be used in conducting hybridization reactions, as of biopolymers such as DNA, RNA, oligonucleotides, peptides, polypeptides, proteins, antibodies, and the like. In another aspect, the invention provides an improved method for mixing a thin film of solution, as in a hybridization chamber. The invention further provides a kit for carrying out the methods of the invention.
摘要翻译：本发明提供了用于在封闭室内的固体表面上进行化学或生化反应的装置和方法。本发明可用于进行杂交反应，如生物聚合物如DNA，RNA，寡核苷酸，肽，多肽，蛋白质，抗体等。另一方面，本发明提供了一种混合溶液薄膜的改进方法，如在杂交室中。本发明还提供了一种用于实施本发明方法的试剂盒。

44. 发明授权

US06841663B2 Chemical arrays 有权
标题翻译：化学阵列
公开(公告)号：US06841663B2
公开(公告)日：2005-01-11
申请号：US10032608
申请日：2001-10-18
申请人： Steven M. Lefkowitz , Michel G. M. Perbost , Roy H. Kanemoto , Carol T. Schembri
发明人： Steven M. Lefkowitz , Michel G. M. Perbost , Roy H. Kanemoto , Carol T. Schembri
IPC分类号： B01J19/00 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/00 , C07H21/00 , C07H21/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00274 , B01J2219/00378 , B01J2219/00497 , B01J2219/00518 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/00009 , G01N2035/00158
摘要： Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a reagent station with a continuous volume of reagent which chemically reacts with precursors or the web. The flexible elongated web is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web to receive a biopolymer array.
摘要翻译：方法，装置和计算机程序产品以形成聚合物阵列，每个聚合物阵列具有在柔性细长网的表面上的特征图案，其包括。在一种方法中，将聚合物或其前体单元在施用站施加到表面。多个特征被覆盖在具有与前体或网络化学反应的连续体积的试剂的试剂站。柔性细长腹板沿长度方向驱动穿过施用台。可以根据需要重复该顺序以形成沿着网的阵列。还提供了制备柔性细长网的表面以接收生物聚合物阵列的方法。

45. 发明授权

US06261523B1 Adjustable volume sealed chemical-solution-confinement vessel 失效
标题翻译：可调节体积密封的化学溶液 - 限制容器
公开(公告)号：US06261523B1
公开(公告)日：2001-07-17
申请号：US09299976
申请日：1999-04-27
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： B01L300
CPC分类号： B01L3/508 , B01L2200/0689 , B01L2300/041 , B01L2300/0809 , G01N21/0303 , G02B21/34
摘要： An adjustable-volume, sealed chemical-solution-confinement vessel for enclosing the inner bottom surface of the chemical-solution-confinement vessel within a sealed chamber. The chemical-solution-confinement vessel comprises a well-shaped base into which a complementarily-shaped lid is inserted. The lid can be inserted to a first position, in order to create a small volume sealed chamber above the inner bottom surface of the chemical-solution-confinement vessel, and can be retracted to a second position in order to create a larger volume sealed chamber above the inner bottom surface of the chemical-solution-confinement vessel. The lid may contain a port or aperture for introducing a fluid or material into the sealed chamber.
摘要翻译：一个可调节体积的密封化学溶液限制容器，用于将化学溶液 - 限制容器的内底表面封闭在密封室内。化学溶液限制容器包括一个形状良好的基座，插入有互补形状的盖子。盖可以插入到第一位置，以便在化学溶液限制容器的内底表面上方形成小体积的密封腔，并且可以缩回到第二位置，以便产生更大容积的密封室在化学溶液 - 限制容器的内底表面之上。盖可以包含用于将流体或材料引入密封室的端口或孔。

46. 发明授权

US5693233A Methods of transporting fluids within an analytical rotor 失效
标题翻译：在分析转子内输送流体的方法
公开(公告)号：US5693233A
公开(公告)日：1997-12-02
申请号：US566982
申请日：1995-12-04
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： G01N21/07 , G01N33/49 , B01D21/26 , B04B11/00 , B04B11/06
CPC分类号： G01N21/07 , G01N33/491 , Y10T436/111666
摘要： The present invention provides an analytical rotor which holds a fluid in a chamber, typically to allow mixing with a reagent, and transfers the fluid to a receiving chamber in the rotor. The rotor comprises a holding chamber having an single exit duct and a receiving chamber connected to the holding chamber through the exit duct. The exit duct prevents flow at a first rotational speed and allows flow at a second, higher rotational speed. The exit duct may include a capillary passage in which capillary forces prevent flow until the rotational speed is increased. Alternatively, the exit duct may include a siphon.
摘要翻译：本发明提供了一种分析转子，其将流体保持在室中，通常允许与试剂混合，并将流体转移到转子中的接收室。转子包括具有单个出口管道和通过出口管连接到保持室的接收室的保持室。出口管道防止在第一转速下的流动，并允许在第二较高转速下流动。出口管道可以包括毛细通道，毛细管力在其中阻止流动，直到旋转速度增加。或者，出口管可以包括虹吸管。

47. 发明授权

US5173193A Centrifugal rotor having flow partition 失效
标题翻译：离心转子具有流动分隔
公开(公告)号：US5173193A
公开(公告)日：1992-12-22
申请号：US678823
申请日：1991-04-01
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： G01N21/07 , G01N35/00
CPC分类号： G01N21/07 , G01N2035/00237 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a centrifugal rotor which measures and delivers a predetermined volume of fluid to a receiving chamber in the rotor. The rotor comprises a bulk fluid chamber containing a bulk amount of fluid and a metering chamber which has a predetermined volume. The bulk fluid flowing into the metering chamber fills the chamber and excess fluid flows out into an overflow chamber. Thus, a predetermined volume is obtained. This volume is delivered to the receiving chamber through an exit duct which prevents flow at the rotational speed required to fill the metering chamber but allows flow at a second, higher rotational speed. The exit duct is typically a capillary in which capillary forces prevent flow until the rotational speed is increased.
摘要翻译：本发明提供了一种离心转子，其测量并将预定体积的流体输送到转子中的接收室。转子包括容纳大量流体的容积流体室和具有预定体积的计量室。流入计量室的大量流体填充室，过量的流体流入溢流室。因此，获得预定的体积。该体积通过出口管道输送到接收室，该出口管道以满足计量室所需的旋转速度流动，但允许以第二较高转速流动。出口管通常是毛细管，其中毛细管力防止流动，直到旋转速度增加。

48. 发明授权

US09945789B2 Multiple analyte detection systems and methods of detecting multiple analytes 有权
公开(公告)号：US09945789B2
公开(公告)日：2018-04-17
申请号：US11653568
申请日：2007-01-16
申请人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
发明人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
IPC分类号： G01N21/25 , G01N21/78 , G01N21/84 , G01N21/17
CPC分类号： G01N21/78 , G01N21/253 , G01N21/8483
摘要： A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.

49. 发明授权

US07422911B2 Composite flexible array substrate having flexible support 失效
标题翻译：具有柔性支撑的复合柔性阵列基板
公开(公告)号：US07422911B2
公开(公告)日：2008-09-09
申请号：US10285759
申请日：2002-10-31
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： G01N33/53
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00518 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00662 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L3/505 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887 , B01L2300/168 , C40B40/06 , C40B40/10 , C40B50/14 , C40B70/00 , Y10S436/809 , Y10S977/902
摘要： Flexible array substrates having a flexible support, a flexible base, a reflective layer, and a transparent layer, in that order, are taught. Methods of forming the flexible array substrates, devices incorporating flexible array substrates, and arrays having probes arranged on a surface of the flexible array substrate are also taught.
摘要翻译：教导了具有柔性支撑件，柔性基座，反射层和透明层的柔性阵列基板。还教导了形成柔性阵列基板的方法，结合柔性阵列基板的装置和布置在柔性阵列基板的表面上的探针的阵列。

50. 发明授权

US06887715B2 Methods and compositions for producing biopolymeric arrays 失效
标题翻译：用于生产生物聚合物阵列的方法和组合物
公开(公告)号：US06887715B2
公开(公告)日：2005-05-03
申请号：US09997564
申请日：2001-11-28
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , G01N33/543 , C12M3/00
CPC分类号： B01J19/0046 , B01J2219/00274 , B01J2219/00497 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C07B2200/11 , C07H21/00 , C40B40/00 , Y10T436/143333
摘要： Methods and compositions are provided for producing arrays of polymeric binding agents. In the subject methods, the individual polymers of the array are synthesized using solid phase synthesis techniques on the surface of a substrate. A critical feature of the invention is that one or more locations on the substrate surface are spatially and temporally protected by a protective bubble during the synthesis protocol, where the protective bubble may be produced using any convenient bubble producing means. The bubble producing means may be a component of either a substrate or a structure separate from the substrate. Also provided are the arrays produced by the subject methods, kits for use in practicing the subject methods, and methods of using the arrays in analyte detection assays, including hybridization assays, such as gene discovery, differential gene expression and gene sequencing assays.
摘要翻译：提供了用于生产聚合物粘合剂阵列的方法和组合物。在本发明的方法中，使用固相合成技术在基材表面上合成阵列的单个聚合物。本发明的关键特征是在合成方案期间，衬底表面上的一个或多个位置在空间和时间上被保护气泡保护，其中使用任何便利的气泡产生装置可以产生保护气泡。气泡产生装置可以是衬底或与衬底分离的结构的部件。还提供了通过主题方法产生的阵列，用于实践主题方法的试剂盒以及在分析物检测测定中使用阵列的方法，包括杂交测定，例如基因发现，差异基因表达和基因测序测定。

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