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    • 43. 发明申请
    • Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
    • 制备4-四唑基-4-苯基哌啶化合物的方法
    • US20070072909A1
    • 2007-03-29
    • US11495221
    • 2006-07-28
    • Kevin BrownTimothy DoyleJohn Whitehead
    • Kevin BrownTimothy DoyleJohn Whitehead
    • A61K31/454A61K31/165A61K31/41C07D403/02
    • C07D211/64C07D257/04C07D307/22C07D401/04
    • Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar1 is —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Z1 and Z2 are each independently a —(C1-C4 alkyl) group; R1 is —(CH2)nC(O)N(R3)(R4) where R3 and R4 are each independently H or —(C1-C4 alkyl); R2 is halogen, —C1-C3 alkyl, —O—(C1-C3 alkyl), —NH(C1-C3 alkyl) or —N(C1-C3 alkyl)2; n is an integer ranging from 1 to 4; m is an integer ranging from 0 to 4; and, in certain embodiments, the phenyl moiety attached to the 4-position of the piperidine ring of a compound according to Formula I can be optionally substituted with one or more R2 groups.
    • 公开了可用于制备根据式I的4-四唑基-4-苯基哌啶化合物的方法,组合物和中间体,其中Ar 1是-C 3 -C 3 - 苯基,萘基,蒽基,菲基或 - (5-7元)杂芳基,各自是未取代的或被一个或多个R 2 O 2基团取代; Ar 2是苯基,萘基,蒽基,菲基或 - (5-7-元)杂芳基,各自是未取代的或被一个或多个R 2 O 2基团取代; Z 1和Z 2各自独立地为 - (C 1 -C 4 -C 4烷基)基团; R 1是(CH 2)n C(O)N(R 3)(R 0) 其中R 3和R 4各自独立地为H或 - (C 1 -C 4)烷基, 烷基); R 2是卤素,-C 1 -C 3烷基,-O-(C 1 -C 3 - (C 1 -C 3烷基)或-NH(C 1 -C 3烷基)或-N(C 1 -C 3烷基) 3 烷基)2。 n为1〜4的整数; m为0〜4的整数; 并且在某些实施方案中,与式I化合物的哌啶环的4-位连接的苯基部分可任选被一个或多个R 2 O 2基团取代。
    • 45. 发明授权
    • Method and apparatus for reducing DC offsets in a communication system
    • 用于减少通信系统中的直流偏移的方法和装置
    • US07072427B2
    • 2006-07-04
    • US10289377
    • 2002-11-07
    • Gregory S. RawlinsKevin BrownMichael W. RawlinsDavid F. Sorrells
    • Gregory S. RawlinsKevin BrownMichael W. RawlinsDavid F. Sorrells
    • H04B1/10
    • H03G3/20H04B1/30
    • Methods and apparatuses for reducing DC offsets in a communication system are described. In a first aspect, a feedback loop circuit reduces DC offset in a wireless local area network (WLAN) receiver channel. The frequency response of the feedback loop circuit can be variable. In a second aspect, a circuit provides gain control in a WLAN receiver channel. The stored DC offset is subtracted from the receiver channel. First and second automatic gain control (AGC) amplifiers are coupled in respective portions of the receiver channel. In a third aspect, a feedback loop circuit reduces DC offset in a WLAN receiver channel. The feedback loop circuit includes a storage element that samples and stores receiver channel DC offset. The loop is opened, and the DC offset stored in the storage element is subtracted from the receiver channel. Circuits for monitoring DC offset, and for providing control signals for controlling the frequency response of the DC offset reducing circuits are also provided.
    • 描述用于减少通信系统中的DC偏移的方法和装置。 在第一方面,反馈回路电路减少无线局域网(WLAN)接收机信道中的DC偏移。 反馈回路电路的频率响应是可变的。 在第二方面,电路在WLAN接收机信道中提供增益控制。 从接收机通道中减去存储的直流偏移。 第一和第二自动增益控制(AGC)放大器耦合在接收机通道的相应部分中。 在第三方面,反馈回路电路减少WLAN接收机信道中的DC偏移。 反馈回路电路包括采样和存储接收机通道DC偏移的存储元件。 打开该循环,并从接收器通道中减去存储在存储元件中的DC偏移。 还提供了用于监控DC偏移的电路,以及用于提供用于控制DC偏移减小电路的频率响应的控制信号。
    • 46. 发明申请
    • System and method for helical cone-beam computed tomography with exact reconstruction
    • 具有精确重建的螺旋锥束计算机断层扫描系统和方法
    • US20060140335A1
    • 2006-06-29
    • US10545265
    • 2004-02-09
    • Dominic HeuscherFrederic NooKevin BrownJed Pack
    • Dominic HeuscherFrederic NooKevin BrownJed Pack
    • H05G1/60A61B6/00G01N23/00G21K1/12
    • G06T11/006A61B6/027G06T2211/416G06T2211/421
    • A helical conebeam computed tomography imaging system includes an x-ray source (12) that produces an x ray conebeam, and an x-ray detector array (16) that detects the x ray conebeam after passing through an examination region (14). The x-ray detector array (16) generates projection data in a detector coordinate system defined with reference to the detector array (16). A derivative processor (60) computes a derivative of the projection data with respect to a helix angle of the helical trajectory at fixed projection direction to generate differentiated projection data. A convolution processor (64) convolves the differentiated projection data with a kernel function to produce filtered projection data. The convolving is performed in the detector coordinate system. A backprojector (42, 82) backprojects the filtered projection data to obtain an image representation.
    • 螺旋锥束计算机断层摄影成像系统包括产生x射线锥束的X射线源(12)和在通过检查区域(14)之后检测x射线锥束的x射线检测器阵列(16)。 X射线检测器阵列(16)在参考检测器阵列(16)定义的检测器坐标系中产生投影数据。 衍生处理器(60)计算相对于在固定投影方向的螺旋轨迹的螺旋角的投影数据的导数,以产生微分投影数据。 卷积处理器(64)将差分投影数据与内核函数进行卷积,以产生经滤波的投影数据。 在检测器坐标系中进行卷积。 背投影机(42,82)反向投影经过滤的投影数据以获得图像表示。
    • 47. 发明申请
    • Programmable load forming system, components thereof, and methods of use
    • 可编程负载成形系统,其组件和使用方法
    • US20060106487A1
    • 2006-05-18
    • US11239665
    • 2005-09-28
    • Robert AllenKevin BrownAndrew HoltLynn Vershum
    • Robert AllenKevin BrownAndrew HoltLynn Vershum
    • G06F7/00
    • B65G61/00G05B2219/40006Y10T83/2037Y10T83/204Y10T83/2057
    • Programmable load forming systems, components thereof, and methods of use are disclosed. In one aspect, a programmable load forming system is programmed to perform the method of downloading a calculated path from the computer to the robot controller, moving one or more bundles along the calculated path to position the one or more bundles in a predetermined stacking position of a stacking pattern using the robot, and determining if the robot has completed moving along the calculated path. The calculated path is defined, in part, by the stacking pattern and other parameters such as, for example, bundle geometry, bundle levelness, bundle compressibility, among other parameters. In another aspect, the system is programmed to perform a method of sensing the top of a bundle and controllably placing a bundle. Additional aspects are directed to systems and methods of safely operating the robot and an inventive hopper design for holding bottom/tie sheets.
    • 公开了可编程负载成形系统,其组件和使用方法。 一方面,可编程负载形成系统被编程为执行将计算的路径从计算机下载到机器人控制器的方法,沿着所计算的路径移动一个或多个束,以将一个或多个束定位在预定的堆叠位置 使用机器人的堆叠图案,以及确定机器人是否已经完成沿着所计算的路径移动。 计算出的路径部分地由层叠图案和其他参数(例如,束几何,束平坦度,束可压缩性等)被定义。 在另一方面,系统被编程为执行感测束的顶部并且可控地放置束的方法。 另外的方面涉及安全操作机器人的系统和方法以及用于保持底部/连接片的创新的料斗设计。
    • 48. 发明申请
    • Karabiner
    • 卡拉宾纳
    • US20050246875A1
    • 2005-11-10
    • US11111470
    • 2005-04-21
    • Kevin Brown
    • Kevin Brown
    • F16B45/02
    • F16B45/02Y10T24/45277Y10T24/45366Y10T24/45372Y10T24/45414
    • A karabiner including a generally C-shaped body having opposed free ends with a gap therebetween and a gate for closing the gap through constraint. The gate is formed of a wire member located on one free end of the body and includes a shaped free end. The other free end of the body is configured to receive the shaped free end of the gate, and includes a shape that corresponds substantially with the shape of the shaped end of the gate. In one embodiment, the loop is oriented substantially transversely to the plane of the karabiner body, and in another embodiment, the second free end of the body includes a recessed seat. A locking means on the gate or karabiner body is also disclosed.
    • 一种具有大体上C形的主体,其具有相对的自由端,其间具有间隙,并且通过约束来封闭间隙。 门由位于主体的一个自由端上的线构件形成,并且包括成形的自由端。 本体的另一个自由端被配置为接收门的成形自由端,并且包括基本上与门的成形端的形状对应的形状。 在一个实施例中,环路基本上横向于karabiner主体的平面定向,并且在另一个实施例中,主体的第二自由端包括凹座。 还公开了一种在闸门或运动员身体上的锁定装置。