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41. 发明授权

US08198068B2 Method for stonewashing fabrics using cellulase 有权
标题翻译：使用纤维素酶染色织物的方法
公开(公告)号：US08198068B2
公开(公告)日：2012-06-12
申请号：US12811533
申请日：2009-02-19
申请人： Guifang Wu , Sarah Teter , Paul Harris , Weijian Lai
发明人： Guifang Wu , Sarah Teter , Paul Harris , Weijian Lai
IPC分类号： D06M16/00 , C09B67/00 , C12N9/62
CPC分类号： C12N9/2437 , C12Y302/01004 , D06B11/0096 , D06P5/15 , D06P5/158
摘要： A method of forming localized variation of color density in the surface of a dyed cellulosic fabric with reducing back staining, with a composition comprising a cellulose having the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having at least 75% sequence identity with SEQ ID NO: 2 is provided. A method for biopolishing a cellulose-containing fabric by using the new endoglucanase is also provided.
摘要翻译：一种在具有减少反向染色的染色纤维素织物的表面中形成颜色密度的局部变化的方法，其中组合物包含具有SEQ ID NO：2的氨基酸序列的纤维素或具有至少75％序列的氨基酸序列提供了与SEQ ID NO：2的同一性。还提供了通过使用新的内切葡聚糖酶来生物抛光含纤维素的织物的方法。

42. 发明授权

US08148155B2 Methods for increasing homologous recombination of a nucleic acid sequence 有权
标题翻译：增加核酸序列同源重组的方法
公开(公告)号：US08148155B2
公开(公告)日：2012-04-03
申请号：US10420035
申请日：2003-04-21
申请人： Paul Harris , Howard Brody
发明人： Paul Harris , Howard Brody
IPC分类号： C12N15/00 , C12N1/15 , C12N15/64 , C12N15/80
CPC分类号： C12P21/00 , C12N15/80 , C12N15/902
摘要： The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous fungal host cells a first nucleic acid sequence encoding a recombination protein and a second nucleic acid sequence comprising one or more regions which are homologous with the genome of the filamentous fungal host cell, wherein (i) the recombination protein promotes the recombination of the one or more regions with the corresponding homologous region in the host's genome to incorporate the second nucleic acid sequence by homologous recombination, and (ii) the number of host cells comprising the incorporated second nucleic acid sequence in the population is increased at least 20% compared to the same population without the first nucleic acid sequence; (b) and isolating from the population a filamentous fungal cell comprising the incorporated second nucleic acid sequence.
摘要翻译：本发明涉及用于增加引入宿主细胞的核酸序列的同源重组的方法，其包括：（a）向丝状真菌宿主细胞群体中引入编码重组蛋白和第二核酸序列的第一核酸序列包括与丝状真菌宿主细胞的基因组同源的一个或多个区域，其中（i）重组蛋白促进一个或多个区域与宿主基因组中的相应同源区域的重组，以掺入第二核酸序列通过同源重组，和（ii）与没有第一核酸序列的相同群体相比，包含所述群体中掺入的第二核酸序列的宿主细胞的数量增加至少20％; （b）并从群体中分离包含掺入的第二核酸序列的丝状真菌细胞。

43. 发明授权

US08097772B2 Polypeptides having beta-glucosidase activity and polynucleotides encoding same 有权
公开(公告)号：US08097772B2
公开(公告)日：2012-01-17
申请号：US11997625
申请日：2006-08-04
申请人： Kristian Krogh , Paul Harris
发明人： Kristian Krogh , Paul Harris
IPC分类号： C12N15/31 , C12N15/82 , C12N15/10 , C12N15/52 , A01H5/00
CPC分类号： C12N9/2477 , C12N9/2437
摘要： The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

44. 发明申请

US20110296558A1 Polypeptides having expansin Activity and Polynucleotides Encoding Same 失效
标题翻译：具有扩展蛋白活性的多肽和编码相同的多核苷酸
公开(公告)号：US20110296558A1
公开(公告)日：2011-12-01
申请号：US13144863
申请日：2010-01-29
申请人： Alfredo Lopez de Leon , Michael Rey , Paul Harris
发明人： Alfredo Lopez de Leon , Michael Rey , Paul Harris
IPC分类号： A01H5/00 , C07H21/00 , C12P1/00 , C12N15/63 , C12N5/10 , C07H21/02 , C07K14/37 , C12P21/02
CPC分类号： C12P7/10 , C12N9/2437 , C12P19/14 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having expansin activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有扩展蛋白活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

45. 发明授权

US07960160B2 Polypeptides having xylanase activity from Aspergillus fumigatus 有权
标题翻译：具有来自烟曲霉的木聚糖酶活性的多肽
公开(公告)号：US07960160B2
公开(公告)日：2011-06-14
申请号：US11054191
申请日：2005-02-09
申请人： Debbie Yaver , Paul Harris , Suzanne Otani , Janine Lin , Haiyan Ge
发明人： Debbie Yaver , Paul Harris , Suzanne Otani , Janine Lin , Haiyan Ge
IPC分类号： C12N9/24 , C12N15/56
CPC分类号： C12N9/2482 , C12N9/248 , C12Y302/01008
摘要： The present invention relates to an isolated polypeptide having xylanase activity from Aspergillus fumigatus with a molecular weight of approximately 50 kDa by SDS-PAGE and homologous polypeptides thereof comprising an amino acid sequence having at least 95% identity with amino adds 20 to 397 of SEQ ID NO: 6; encoded by a polynucleotide comprising a nucleotide sequence having at least 95% identity with nucleotides 107 to 1415 of SEQ ID NO: 5: or encoded by a polynucleotide that hybridizes under high stringency conditions with (i) nucleotides 107 to 1415 of SEQ ID NO: 5, (ii) the cDNA sequence of (i), or (iii) a full-length complementary strand of (i) or (ii). The present invention also relates to a method for producing such polypeptides having xylanase activity comprising: (a) cultivating a wild-type Aspergillus fumigatus cell under conditions conducive for production of the polypeptide; and (b) recovering the polypeptide.
摘要翻译：本发明涉及通过SDS-PAGE分析重量为约50kDa的烟曲霉具有木聚糖酶活性的分离多肽，并且其同源多肽包含与氨基具有至少95％同一性的氨基酸序列，添加SEQ ID NO：20至397 NO：6; 由包含与SEQ ID NO：5的核苷酸107至1415具有至少95％同一性的核苷酸序列的多核苷酸编码，或由在高严格条件下与（i）SEQ ID NO：5的核苷酸107至1415杂交的多核苷酸编码。 5，（ii）（i）或（iii）（i）或（ii）的全长互补链的cDNA序列。本发明还涉及生产具有木聚糖酶活性的多肽的方法，其包括：（a）在有利于产生多肽的条件下培养野生型烟曲霉细胞; 和（b）回收多肽。

46. 发明申请

US20110131686A1 Polypeptides having beta-glucosidase activity and polynucleotides encoding same 失效
标题翻译：具有β-葡糖苷酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US20110131686A1
公开(公告)日：2011-06-02
申请号：US12918461
申请日：2009-03-06
申请人： Kristian Krogh , Paul Harris
发明人： Kristian Krogh , Paul Harris
IPC分类号： C12N9/42 , C07H21/00 , C12N15/63 , C12N1/00 , C12N5/10 , C12N15/00 , A01H5/00 , C07H21/02 , C12P19/00 , C12P1/00
CPC分类号： C12P19/02 , C12N9/2445 , C12Y302/01021
摘要： The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有β-葡糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

47. 发明申请

US20100263092A1 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same 有权
公开(公告)号：US20100263092A1
公开(公告)日：2010-10-14
申请号：US12823036
申请日：2010-06-24
申请人： Nikolaj Spodsberg , Paul Harris , Randall Kramer
发明人： Nikolaj Spodsberg , Paul Harris , Randall Kramer
IPC分类号： A01H5/00 , C12N15/63 , C12P21/02 , C12N5/07 , C07K1/14 , C07H21/04 , C12N9/00 , C12N5/10
CPC分类号： C12N9/2434
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

48. 发明申请

US20100143971A1 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
标题翻译：具有纤维增强活性的多肽和编码其的多核苷酸
公开(公告)号：US20100143971A1
公开(公告)日：2010-06-10
申请号：US12631101
申请日：2009-12-04
申请人： Nikolaj Spodsberg , Paul Harris , Randall Kramer
发明人： Nikolaj Spodsberg , Paul Harris , Randall Kramer
IPC分类号： C12P21/02 , C07H21/04 , A01H5/00 , C12N5/04 , C07H21/02 , C12N15/80 , C12P19/04
CPC分类号： C12N9/2434
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维素分解增强活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

49. 发明申请

US20100108458A1 Releasable Drive Arrangement 有权
标题翻译：可拆卸驱动装置
公开(公告)号：US20100108458A1
公开(公告)日：2010-05-06
申请号：US12612231
申请日：2009-11-04
申请人： Paul Harris , Raymond Richard Bomford , Darren Christopher Howard
发明人： Paul Harris , Raymond Richard Bomford , Darren Christopher Howard
IPC分类号： F16D13/22
CPC分类号： F16D11/14 , F16D23/12
摘要： A drive arrangement comprising a drive shaft, a clutch arrangement operable, upon axial movement of the drive shaft occurring, to interrupt drive to the drive shaft, an axially movable interrupt shaft, a gear arrangement whereby the interrupt shaft is driven for rotation by the drive shaft at a speed slower than the rotary speed of the drive shaft, disconnect means operable to cause axial movement of the interrupt shaft, and transmission means for transmitting axial movement of the interrupt shaft to the drive shaft.
摘要翻译：一种驱动装置，包括驱动轴，离合器装置，可在所述驱动轴的轴向运动时操作，以中断对驱动轴的驱动，可轴向移动的中断轴，齿轮装置，由此中断轴被驱动以驱动轴以比驱动轴的旋转速度慢的速度，可操作以引起中断轴的轴向移动的断开装置，以及用于将中断轴向轴向运动传递到驱动轴的传动装置。

50. 发明申请

US20090178844A1 Tabletop Cable Management 失效
标题翻译：桌面电缆管理
公开(公告)号：US20090178844A1
公开(公告)日：2009-07-16
申请号：US12236335
申请日：2008-09-23
申请人： Mike Derocher , Stephen DeSaulles , Amos Marchant , Paul Harris
发明人： Mike Derocher , Stephen DeSaulles , Amos Marchant , Paul Harris
IPC分类号： H02B1/015
CPC分类号： A47B97/00
摘要： A cable manager for a tabletop includes raceway and a holder. The tabletop includes a support surface and an edge surface. The raceway is for a cable having an end with a plug. The raceway is configured to be positioned lengthwise along at least a portion of a length of the edge surface. The raceway provides a slot along and through which the cable can, with respect to the support surface, be moved laterally and extended and retracted. The holder is configured to be positioned on the support surface and to retain the plug in a stationary position at a first location adjacent to the support surface. The plug is removable from the holder to be repositioned to a desired one of a plurality of second locations adjacent to the support surface.
摘要翻译：桌面电缆管理器包括滚道和支架。桌面包括支撑表面和边缘表面。滚道用于带有插头的电缆。轨道被配置为沿着边缘表面的长度的至少一部分纵向定位。轨道提供了一个槽，通过该狭槽，电缆可相对于支撑表面横向移动并延伸和缩回。保持器被配置为定位在支撑表面上并且在与支撑表面相邻的第一位置处将插头保持在静止位置。插头可从保持器移除以重新定位到与支撑表面相邻的多个第二位置中的期望的一个。

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