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41. 发明专利

CZ20033457A3 Pharmaceutical composition comprising medicaments of low solubility and/or medicaments sensitive to acid and neutralized acid polymers 未知
公开(公告)号：CZ20033457A3
公开(公告)日：2004-09-15
申请号：CZ20033457
申请日：2002-05-08
申请人： PFIZER PROD INC
发明人： CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , KETNER RODNEY JAMES , SHANKER RAVI MYSORE , WEST JAMES BLAIR
IPC分类号： C07D215/46 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/405 , A61K31/4706 , A61K31/496 , A61K31/498 , A61K47/32 , A61K47/38 , A61P3/06 , A61P43/00
摘要： Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed.

42. 发明专利

AU2003283688A1 CONTROLLED-RELEASE OF AN ACTIVE SUBSTANCE INTO A HIGH FAT ENVIRONMENT 未知
公开(公告)号：AU2003283688A1
公开(公告)日：2004-06-30
申请号：AU2003283688
申请日：2003-11-28
申请人： PFIZER PROD INC
发明人： OKSANEN CYNTHIA ANN , WEST JAMES BLAIR , CHIDLAW MARK BRIAN , FRIESEN DWAYNE THOMAS , HERBIG SCOTT MAX , NIGHTINGALE JAMES ALAN SCHRIVE
IPC分类号： A61K9/00 , A61K9/20 , A61K9/28 , A61K9/36 , A61K31/137 , A61K31/4985 , A61K31/495 , A61K31/00 , A61K31/135
摘要： A controlled release delivery composition which can be administered to a high fat use environment such as the human gastrointestinal tract following a high fat meal. The delivery composition is embodied as a core surrounded by an asymmetric polymeric membrane. In a preferred embodiment, the asymmetric polymeric membrane is cellulose acetate.

43. 发明专利

NZ501250A Solubilized sertraline compositions 未知
公开(公告)号：NZ501250A
公开(公告)日：2003-05-30
申请号：NZ50125098
申请日：1998-06-15
申请人： PFIZER PROD INC
发明人： FRIESEN DWAYNE THOMAS , HERBIG SCOTT MAX , SHANKER RAVI MYSORE , WEST JAMES BLAIR
IPC分类号： A61K9/20 , A61K31/135 , A61K47/00
摘要： Compositions comprising sertraline or a pharmaceutically acceptable salt thereof, and a solubilising agent. The solubilising agent is present in an amount sufficient to produce a concentration of dissolved sertraline in a use environment containing chloride ions which is 1.5 times higher than the concentration effected by a comparative composition of matter identical thereto but for the inclusion of said solubilising agent.

44. 发明专利

ZA985708B Solubilized sertraline compositions. 未知
公开(公告)号：ZA985708B
公开(公告)日：2000-01-10
申请号：ZA985708
申请日：1998-06-30
申请人： PFIZER PROD INC
发明人： FRIESEN DWAYNE THOMAS , HERBIG SCOTT MAX , SHANKER RAVI MYSORE , WEST JAMES BLAIR
IPC分类号： A61K47/02 , A61K9/00 , A61K9/20 , A61K31/136 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K , C07B
摘要： Compositions of matter comprising sertraline and a solubilizing agent which increases the solubility of sertraline in aqueous chloride ion-containing use environments.

45. 发明专利

AU2004216676B2 Azithromycin dosage forms with reduced side effects 未知
公开(公告)号：AU2004216676B2
公开(公告)日：2011-06-16
申请号：AU2004216676
申请日：2004-05-14
申请人： PFIZER PROD INC
发明人： MCCRAY SCOTT BALDWIN , FRIESEN DWAYNE THOMAS , HAGEN TIMOTHY ARTHUR , LO JULIAN BELKNAP , APPEL LEAH ELIZABETH , WEST JAMES BLAIR , HERBIG SCOTT MAX , CREW MARSHALL DAVID , LYON DAVID KEITH , THOMBRE AVINASH GOVIND
IPC分类号： C07H17/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K31/7052 , A61K38/00 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04
摘要： An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule. Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Also disclosed is a method for reducing gastrointestinal side effects, associated with administering azithromycin to a mammal, comprising contiguously administering azithromycin and an effective amount of alkalizing agent to said mammal wherein the frequency of gastrointestinal side effects is lower than that experienced by administering an equal dose of azithromycin without said alkalizing agent. Further disclosed is a method of treating a bacterial or protozoal infection in a mammal in need thereof comprising contiguously administering to said mammal a single dose of an oral dosage form wherein said oral dosage form comprises azithromycin and an effective amount of an alkalizing agent. Additionally disclosed are azithromycin multiparticulates comprising azithromycin, a surfactant; and a pharmaceutically acceptable carrier.

47. 发明专利

DK1537859T3 未知
公开(公告)号：DK1537859T3
公开(公告)日：2008-11-17
申请号：DK04252643
申请日：2004-05-06
申请人： PFIZER PROD INC
发明人： APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , HAGEN TIMOTHY ARTHUR , HERBIG SCOTT MAX , LO JULIAN BELKNAP , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , THOMBRE AVINASH GOVIND , WEST JAMES BLAIR
IPC分类号： A61K9/16 , C07H17/00 , A61K9/00 , A61K9/20 , A61K31/7052 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04
摘要： An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule. Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Also disclosed is a method for reducing gastrointestinal side effects, associated with administering azithromycin to a mammal, comprising contiguously administering azithromycin and an effective amount of alkalizing agent to said mammal wherein the frequency of gastrointestinal side effects is lower than that experienced by administering an equal dose of azithromycin without said alkalizing agent. Further disclosed is a method of treating a bacterial or protozoal infection in a mammal in need thereof comprising contiguously administering to said mammal a single dose of an oral dosage form wherein said oral dosage form comprises azithromycin and an effective amount of an alkalizing agent. Additionally disclosed are azithromycin multiparticulates comprising azithromycin, a surfactant; and a pharmaceutically acceptable carrier.

48. 发明专利

GEP20074056B AZITHROMYCIN DOSAGE FORMS WITH REDUCED SIDE EFFECTS 未知
公开(公告)号：GEP20074056B
公开(公告)日：2007-03-12
申请号：GEAU2004008414
申请日：2004-05-14
申请人： PFIZER PROD INC
发明人： HAGEN TIMOTHY ARTHUR , HERBIG SCOTT MAX , LO JULIAN BELKNAP , THOMBRE AVINASH GOVIND , APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , WEST JAMES BLAIR
IPC分类号： A61K9/16 , C07H17/00 , A61K9/00 , A61K9/20 , A61K31/7052 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04
摘要： An oral dosage form comprises alkalizing agent and an azithromycin multiparticulate compri¬sing azithromycin and glyceryl monobehenate, glyceryl dibehenate, glyceryl tribehenate and a po¬loxamer.

50. 发明专利

OA12858A Azithromycin dosage forms with reduced side effects. 未知
公开(公告)号：OA12858A
公开(公告)日：2006-09-15
申请号：OA1200400253
申请日：2004-05-14
申请人： PFIZER PROD INC
发明人： APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , HAGEN TIMOTHY ARTHUR , HERBIG SCOTT MAX , LO JULIAN BELKNAP , LYON DAVID KEIT , MCCRAY SCOTT BALDWIN , THOMBRE AVINASH GOVIND , WEST JAMES BLAIR
IPC分类号： A61K31/7048 , C07H17/00 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/7052 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04
摘要： An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule. Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Also disclosed is a method for reducing gastrointestinal side effects, associated with administering azithromycin to a mammal, comprising contiguously administering azithromycin and an effective amount of alkalizing agent to said mammal wherein the frequency of gastrointestinal side effects is lower than that experienced by administering an equal dose of azithromycin without said alkalizing agent. Further disclosed is a method of treating a bacterial or protozoal infection in a mammal in need thereof comprising contiguously administering to said mammal a single dose of an oral dosage form wherein said oral dosage form comprises azithromycin and an effective amount of an alkalizing agent. Additionally disclosed are azithromycin multiparticulates comprising azithromycin, a surfactant; and a pharmaceutically acceptable carrier.

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