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41. 发明授权

US6033869A Polynucleotide encoding a novel human cytokine/steroid receptor 失效
标题翻译：编码新型人细胞因子/类固醇受体的多核苷酸
公开(公告)号：US6033869A
公开(公告)日：2000-03-07
申请号：US822264
申请日：1997-03-20
申请人： Surya K. Goli , Jennifer L. Hillman , Lynn E. Murry
发明人： Surya K. Goli , Jennifer L. Hillman , Lynn E. Murry
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P5/00 , A61P13/00 , A61P15/00 , A61P25/00 , A61P43/00 , C07K14/705 , C07K14/715 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/63
CPC分类号： C07K14/72 , C07K14/715 , A61K38/00
摘要： The present invention provides a human cytokine/steroid receptor protein (CYSTAR) and polynucleotides which identify and encode CYSTAR. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of CYSTAR, as well as diagnostic assays.
摘要翻译：本发明提供了人细胞因子/类固醇受体蛋白（CYSTAR）和识别和编码CYSTAR的多核苷酸。本发明还提供表达载体，宿主细胞，抗体和拮抗剂。本发明还提供了用于预防和治疗与CYSTAR表达相关的疾病的方法以及诊断测定法。

42. 发明授权

US5955312A DNA encoding a novel microtubule-associated protein 失效
标题翻译：编码新型微管相关蛋白的DNA
公开(公告)号：US5955312A
公开(公告)日：1999-09-21
申请号：US805117
申请日：1997-02-24
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12P21/06 , C07H21/00 , C07H21/04 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human microtubule-associated protein (hLC3) and the polynucleotides which identify and encode hLC3. The invention also provides genetically engineered expression vectors, host cells, and a method for producing hLC3. The invention also provides hLC3 as well as agonists, antibodies, and antagonists of hLC3, and the use thereof for the prevention and treatment of diseases associated with the expression of hLC3. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding hLC3 for the treatment of diseases associated with the expression of hLC3. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding hLC3.
摘要翻译：本发明提供了人微管相关蛋白（hLC3）和识别和编码hLC3的多核苷酸。本发明还提供基因工程表达载体，宿主细胞和生产hLC3的方法。本发明还提供hLC3以及hLC3的激动剂，抗体和拮抗剂，以及其用于预防和治疗与hLC3表达有关的疾病的用途。另外，本发明提供了将反义分子用于编码hLC3的多核苷酸用于治疗与hLC3表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合hLC3的抗体的诊断测定法。

43. 发明授权

US5871970A Calcium-binding protein 失效
标题翻译：钙结合蛋白
公开(公告)号：US5871970A
公开(公告)日：1999-02-16
申请号：US828242
申请日：1997-03-31
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A01N43/38 , A61K38/00 , C07K1/00 , C07K14/00 , C07K14/47 , C07K16/00 , C07K17/00 , C12N5/06 , C12N5/16 , C12N15/12 , C12P21/04 , C12P21/08 , C12N15/63 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/4728 , A61K38/00
摘要： The present invention provides a human calcium-binding protein (HCBP) and polynucleotides which identify and encode HCBP. The invention also provides expression vectors and host cells, agonists, antibodies, and antagonists. In addition, the invention provides methods for producing HCBP and for treating or preventing disorders associated with the expression of HCBP.
摘要翻译：本发明提供了人钙结合蛋白（HCBP）和鉴定和编码HCBP的多核苷酸。本发明还提供表达载体和宿主细胞，激动剂，抗体和拮抗剂。此外，本发明提供了生产HCBP并用于治疗或预防与HCBP表达相关的病症的方法。

44. 发明授权

US5863764A DNA encoding a human membrane protein 失效
标题翻译：编码人膜蛋白的DNA
公开(公告)号：US5863764A
公开(公告)日：1999-01-26
申请号：US791924
申请日：1997-01-31
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C07K14/435 , C12N15/64 , G01N33/58
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a human membrane protein (NHMP1) and polynucleotides which identify and encode NHMP1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHMP1 and a method for producing NHMP1. The invention also provides for agonists, antibodies, or antagonists specifically binding NHMP1, and their use, in the prevention and treatment of diseases associated with expression of NHMP1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHMP1 for the treatment of diseases associated with the expression of NHMP1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHMP1.
摘要翻译：本发明提供了人膜蛋白（NHMP1）和识别和编码NHMP1的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码NHMP1的核酸序列的宿主细胞和生产NHMP1的方法。本发明还提供特异性结合NHMP1的激动剂，抗体或拮抗剂及其在预防和治疗与NHMP1表达有关的疾病中的用途。此外，本发明提供了反义分子用于编码NHMP1的多核苷酸用于治疗与NHMP1表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHMP1的抗体的诊断测定法。

45. 发明授权

US5861495A Human zinc binding proteins 失效
标题翻译：人锌结合蛋白
公开(公告)号：US5861495A
公开(公告)日：1999-01-19
申请号：US786606
申请日：1997-01-21
申请人： Jennifer L. Hillman , Janice Au-Young , Roger Coleman , Surya K. Goli
发明人： Jennifer L. Hillman , Janice Au-Young , Roger Coleman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07H21/02 , C07H21/04
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides three zinc binding proteins (designated individually as ZB-1, ZB-2, and ZB-3, and collectively as ZB) and polynucleotides which identify and encode ZB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding ZB and a method for producing ZB. The invention also provides for use of ZB and agonists, antibodies, or antagonists specifically binding ZB, in the prevention and treatment of diseases associated with expression of ZB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding ZB for the treatment of diseases associated with the expression of ZB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding ZB.
摘要翻译：本发明提供三种锌结合蛋白（分别命名为ZB-1，ZB-2和ZB-3，统称为ZB）和识别和编码ZB的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码ZB的核酸序列和生产ZB的方法。本发明还提供使用ZB和特异性结合ZB的激动剂，抗体或拮抗剂在预防和治疗与ZB表达相关的疾病中的用途。另外，本发明提供反义分子用于编码ZB的多核苷酸用于治疗与ZB表达有关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合ZB的抗体的诊断测定法。

46. 发明授权

US5843668A Human SQM1 protein homolog 失效
公开(公告)号：US5843668A
公开(公告)日：1998-12-01
申请号：US757036
申请日：1996-11-26
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K39/395 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/705 , A61K2039/51 , A61K38/00 , Y10T436/143333
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human SQM2. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human SQM2. The invention also provides for the use of purified SQM2 and its agonists in the production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. Additionally, the invention provides for the use of SQM2 antagonists and inhibitors, including antisense molecules to SQM2 polynucleotides (i.e., gene sequences) in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding SQM2 and anti-human SQM2 antibodies which specifically bind to SQM2.

47. 发明授权

US5831049A Human thioredoxin 失效
标题翻译：人硫氧还蛋白
公开(公告)号：US5831049A
公开(公告)日：1998-11-03
申请号：US775978
申请日：1997-01-03
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/02 , C07H21/02 , C07H21/04
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides a human thioredoxin (TRDX) and polynucleotides which identify and encode TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX and a method for producing TRDX. The invention also provides for agonists, antibodies, or antagonists specifically binding TRDX, and their use, in the prevention and treatment of diseases associated with expression of TRDX. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TRDX for the treatment of diseases associated with the expression of TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX in the production of recombinant proteins. The invention also provides for the use of purified TRDX in the production of recombinant proteins. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TRDX.
摘要翻译：本发明提供鉴定和编码TRDX的人硫氧还蛋白（TRDX）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码TRDX的核酸序列和生产TRDX的方法。本发明还提供了特异性结合TRDX的激动剂，抗体或拮抗剂及其在预防和治疗与TRDX表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码TRDX的多核苷酸用于治疗与TRDX表达相关的疾病的用途。本发明还提供了在重组蛋白的产生中包含编码TRDX的核酸序列的基因工程表达载体和宿主细胞。本发明还提供了纯化的TRDX在重组蛋白的生产中的应用。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TRDX的抗体的诊断测定法。

48. 发明授权

US5792648A Human macrophage antigen 失效
公开(公告)号：US5792648A
公开(公告)日：1998-08-11
申请号：US690095
申请日：1996-07-31
申请人： Jennifer L. Hillman , Janice Au-Young , Surya K. Goli
发明人： Jennifer L. Hillman , Janice Au-Young , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C07H21/04 , C12N15/63
CPC分类号： C07K14/7056 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human macrophage antigen (TMAH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding TMAH. The invention also provides for the use of substantially purified TMAH and its agonists, antibodies, antagonists or inhibitors in pharmaceutical compositions for treatment of diseases associated with expression of TMAH. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the genomic sequence or transcripts encoding TMAH and anti-TMAH antibodies which specifically bind to TMAH.

49. 发明授权

US5763248A CDNA encoding a human ATP synthase Fo subunit (ASYSD) 失效
标题翻译： CDNA编码人类ATP合成酶Fo亚基（ASYSD）
公开(公告)号：US5763248A
公开(公告)日：1998-06-09
申请号：US948195
申请日：1997-10-09
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/14 , C12N15/00 , C12N15/63 , C12N15/85 , C07H71/04
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYSD and for treating disorders associated with expression of ASYSD.
摘要翻译：本发明提供了人ATP合成酶d亚基（ASYSD）和编码ASYSD的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了用于产生ASYSD和用于治疗与ASYSD表达相关的疾病的方法。

50. 发明授权

US5763220A Human apoptosis-related calcium-binding protein 失效
公开(公告)号：US5763220A
公开(公告)日：1998-06-09
申请号：US766605
申请日：1996-12-12
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61P1/00 , A61P1/16 , A61P9/10 , A61P13/12 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/14 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , C12P21/02 , C12N1/00 , C12N15/63
CPC分类号： C07K14/4747 , C07K14/4702 , A61K38/00
摘要： The present invention provides a human apoptosis-related calcium-binding protein (HARC) and polynucleotides which identify and encode HARC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HARC and a method for producing HARC. The invention also provides for agonists, antibodies, or antagonists specifically binding HARC, and their use, in the prevention and treatment of diseases associated with expression of HARC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HARC for the treatment of diseases associated with the expression of HARC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HARC.

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