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41. 发明专利

ES2310057B1 METODO DE ANALISIS MOLECULAR Y TRATAMIENTO EN DEMENCIA DE CUERPOS DE LEWY. 未知
公开(公告)号：ES2310057B1
公开(公告)日：2009-11-17
申请号：ES200401764
申请日：2004-07-19
申请人： ORYZON GENOMICS SA
发明人： BARRACHINA CASTILLO MARTA , MAES TAMARA , BUESA ARJOL CARLOS , FERRER ABIZANDA ISIDRO
IPC分类号： G01N33/573 , A61P25/08 , C12Q1/34

42. 发明专利

MY190849A METHODS OF TREATING MULTIPLE SCLEROSIS 未知
公开(公告)号：MY190849A
公开(公告)日：2022-05-12
申请号：MYPI2017001810
申请日：2017-06-09
申请人： ORYZON GENOMICS SA
发明人： MAES TAMARA , MASCARO CRUSAT CRISTINA , ROTLLANT POZO DAVID
IPC分类号： A61K31/42
摘要： Provided herein are methods for treating multiple sclerosis using (-) 5-((((trans)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine, or a pharmaceutically acceptable salt or solvate thereof. [No Suitable Figure]

43. 发明专利

RU2766259C2 КОМБИНАЦИИ ИНГИБИТОРОВ LSD1 ДЛЯ ЛЕЧЕНИЯ ГЕМАТОЛОГИЧЕСКИХ ЗЛОКАЧЕСТВЕННЫХ ЗАБОЛЕВАНИЙ 未知
公开(公告)号：RU2766259C2
公开(公告)日：2022-02-10
申请号：RU2018136153
申请日：2017-03-13
申请人： ORYZON GENOMICS SA
发明人： SISERI FILIPPO , LUNARDI SERENA , MAES TAMARA , MASKARO KRUSAT KRISTINA , TIRAPU FERNANDES DE LA KUESTA INIGO
IPC分类号： A61K31/135 , A61K31/00 , A61P35/00
摘要： Группаизобретенийотноситсяк областилечениягиперпролиферативныхнарушений, преждевсегогематологическихзлокачественныхзаболеваний. Заявленакомбинациядлялечениягиперпролиферативногонарушения, содержащаясоединениеформулы (I):илиегофармацевтическиприемлемуюсольи терапевтическийагент, выбранныйизтретиноина, цитарабина, пинометостата, вориностата, риколиностата, энтиностата, децитабина, азацитидина, квизартиниба, нутлина-3A, дасатиниба, JQ1 иихфармацевтическиприемлемыхсолей. Заявленыфармацевтическаякомпозицияи набордлялечениягиперпролиферативногонарушения, содержащиеуказаннуюкомбинацию, атакжеспособлечениягематологическихзлокачественныхзаболеванийи применениекомбинациидляприготовлениялекарственногосредства. Изобретенияобеспечиваютсинергетическийтерапевтическийэффект. 7 н. и 23 з.п. ф-лы, 22 ил., 4 табл., 2 пр.

44. 发明专利

SG11202000077RA METHODS OF TREATING BEHAVIOR ALTERATIONS 未知
公开(公告)号：SG11202000077RA
公开(公告)日：2020-02-27
申请号：SG11202000077R
申请日：2018-08-03
申请人： ORYZON GENOMICS SA
发明人： MAES TAMARA , ROTTLANT POZO DAVID , GRIÑÁN FERRE CHRISTIAN , PALLÀS LLIBERIA MERCÈ , NADAL ALEMANY ROSER , ARMARIO GARCÍA ANTONIO
IPC分类号： A61K31/44 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau omit omoioninim Imo oimIE (43) International Publication Date 07 February 2019 (07.02.2019) (10) International Publication Number WO 2019/025588 Al WIPO I PCT (51) International Patent Classification: A61K 31/44 (2006.01) A61P 25/28 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/30 (2006.01) A61P 25/16 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 17382544.9 03 August 2017 (03.08.2017) 17382545.6 03 August 2017 (03.08.2017) 18382299.8 30 April 2018 (30.04.2018) Published: — with international search report (Art. 21(3)) PCT/EP2018/071120 03 August 2018 (03.08.2018) English English EP EP EP (71) Applicant: ORYZON GENOMICS, S.A. [ES/ES]; Car- rera de San Jeronimo 15, 2a planta, 28014 Madrid (ES). = (72) Inventors: MAES, Tamara; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). ROTTLANT POZO, David; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). GRISAN FERRE, Christian; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). PALLAS LLIBERIA, Meree; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). NADAL ALEMANY, Roser; Oryzon Ge- nomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). ARMARIO GARCIA, Antonio; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). (74) Agent: OSWIN RIDDERBUSCH, VOSSIUS & PART- NER; Patentanwalte Rechtsanwalte mbB, SiebertstraBe 3, 81675 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 O \" (57) : Provided herein are methods for treating behavior alterations using KDM1A inhibitors, particularly 5-((((1R,2S)- 2-(4- 0 (benzyloxy)phenyi)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine. (54) Title: METHODS OF TREATING BEHAVIOR ALTERATIONS

45. 发明专利

SG10201911989SA BIOMARKERS ASSOCIATED WITH LSD1 INHIBITORS AND USES THEREOF 未知
公开(公告)号：SG10201911989SA
公开(公告)日：2020-02-27
申请号：SG10201911989S
申请日：2016-06-10
申请人： ORYZON GENOMICS SA
发明人： MAES TAMARA , MASCARÓ CRUSAT CRISTINA , ROTLLANT POZO DAVID
摘要： The invention relates to biomarkers associated with LSD1 inhibitors and uses thereof to assess target engagement and to follow patient response to treatment. The invention further relates to novel therapeutic uses for LSD1 inhibitors based on said biomarkers.

46. 发明专利

ES2732669T3 Tratamiento de la esclerosis múltiple 未知
公开(公告)号：ES2732669T3
公开(公告)日：2019-11-25
申请号：ES17735004
申请日：2017-06-09
申请人： ORYZON GENOMICS SA
发明人： MAES TAMARA , MASCARO CRUSAT CRISTINA , ROTLLANT POZO DAVID
IPC分类号： A61K31/42
摘要： Un compuesto, que es (-) 5-((((trans)-2-(4-(benciloxi)fenil)ciclopropil)amino)metil)-1,3,4-oxadiazol-2-amina o una sal o solvato farmacéuticamente aceptable del mismo, para uso en el tratamiento de la esclerosis múltiple.

47. 发明专利

RS58951B1 LEČENJE MULTIPLE SKLEROZE 未知
公开(公告)号：RS58951B1
公开(公告)日：2019-08-30
申请号：RSP20190786
申请日：2017-06-09
申请人： ORYZON GENOMICS SA
发明人： MAES TAMARA , MASCARÓ CRUSAT CRISTINA , ROTLLANT POZO DAVID
IPC分类号： A61K31/42

48. 发明专利

SG11201807972YA COMBINATIONS OF LSD1 INHIBITORS FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES 未知
公开(公告)号：SG11201807972YA
公开(公告)日：2018-10-30
申请号：SG11201807972Y
申请日：2017-03-13
申请人： ORYZON GENOMICS SA
发明人： CICERI FILIPPO , LUNARDI SERENA , MAES TAMARA , MASCARO CRUSAT CRISTINA , TIRAPU FERNANDEZ DE LA CUESTA INIGO
IPC分类号： A61K31/12 , A61K31/135 , A61K31/19 , A61K31/282 , A61K31/337 , A61K31/4045 , A61K31/4745 , A61K31/475 , A61K31/495 , A61K31/519 , A61K31/555 , A61K31/704 , A61K31/7068 , A61P35/00
摘要： pharmaceutical compositions comprising them, and their use as medicaments, particularly for the treatment of hematological malignancies.

49. 发明专利

CA2574224A1 MOLECULAR DIAGNOSTIC METHOD AND TREATMENT IN DEMENTIA WITH LEWY BODIES 未知
公开(公告)号：CA2574224A1
公开(公告)日：2006-01-26
申请号：CA2574224
申请日：2005-07-18
申请人： ORYZON GENOMICS SA
发明人： FERRER ABIZANDA ISIDRO , BARRACHINA CASTILLO MARTA , BUESA ARJOL CARLOS , MAES TAMARA
IPC分类号： G01N33/68 , C07K14/47
摘要： The invention describes methods of molecular diagnosis of a concrete form of α-synucleinopathy, the dementia with Lewy bodies (DLB), associated to the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) or the alteration of its ubiquityl-ligase activity. It also refers to the use of compounds that permit the modification of the UCH-L1 levels or of the enzymatic activity of UCH-L1. This invention has application in the diagnosis and treatment of patients suffering from DLB.

50. 发明专利

CA2988220C METHODS OF TREATING MULTIPLE SCLEROSIS 未知
公开(公告)号：CA2988220C
公开(公告)日：2021-03-02
申请号：CA2988220
申请日：2017-06-09
申请人： ORYZON GENOMICS SA
发明人： MAES TAMARA , MASCARO CRUSAT CRISTINA , ROTLLANT POZO DAVID
IPC分类号： A61K31/4245 , A61P21/00 , A61P25/28
摘要： The present disclosure provides a new medicament for treating for multiple sclerosis. More particularly, provided herein is the use of (-) 5-((((trans)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine, or a pharmaceutically acceptable salt or solvate thereof for treating multiple sclerosis in a patient.

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