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41. 发明授权

US06287763B1 Screening methods for compounds useful in the regulation of body weight 失效
标题翻译：用于调节体重的化合物的筛选方法
公开(公告)号：US06287763B1
公开(公告)日：2001-09-11
申请号：US08870511
申请日：1997-06-06
申请人： Frank Lee , Dennis Huszar , Wei Gu
发明人： Frank Lee , Dennis Huszar , Wei Gu
IPC分类号： C12Q168
CPC分类号： G01N33/5091 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K49/00 , A61K2039/505 , C07K14/723 , C07K2319/00 , C12N2799/021 , C12Q1/6897 , G01N33/5008 , G01N33/502 , G01N33/5023 , G01N33/5041 , G01N33/5088 , G01N33/74 , G01N2500/00
摘要： The present invention relates to drug screening assays, and diagnostic and therapeutic methods for the treatment of body weight disorders, such as obesity, anorexia and cachexia, utilizing the melanocortin 4-receptor (MC4-R) as the target for intervention. The invention also relates to compounds that modulate the activity or expression of the MC4-R, and the use of such compounds in the treatment of body weight disorders.
摘要翻译：本发明涉及药物筛选试验，以及利用黑皮质素4-受体（MC4-R）作为干预对象的治疗体重疾病如肥胖，厌食和恶病质的诊断和治疗方法。本发明还涉及调节MC4-R的活性或表达的化合物，以及这些化合物在治疗体重紊乱中的用途。

42. 发明授权

US5951973A Use of interleukin-4 (IL-4) to treat rheumatoid arthritis 失效
标题翻译：使用白介素-4（IL-4）治疗类风湿关节炎
公开(公告)号：US5951973A
公开(公告)日：1999-09-14
申请号：US466543
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , A61K38/20
CPC分类号： C12N15/70 , C07K14/5406 , C07K16/247 , C12N15/66 , A61K38/00 , C07K2319/02 , Y10S514/825 , Y10S514/885
摘要： A method of treating rheumatoid arthritis comprising administering human Interleukin-4 (IL-4) to an individual afflicted with the disease. The IL-4 is administered with a pharmaceutically acceptable carrier in a dose ranging from 1 .mu.g to 100 mg.
摘要翻译：一种治疗类风湿性关节炎的方法，包括给患有该疾病的个体施用人白细胞介素-4（IL-4）。 IL-4以1μg至100mg的剂量施用药学上可接受的载体。

43. 发明授权

US5908609A Screening methods for compounds useful in the regulation of body weight 失效
公开(公告)号：US5908609A
公开(公告)日：1999-06-01
申请号：US662560
申请日：1996-06-10
申请人： Frank Lee , Dennis Huszar , Wei Gu
发明人： Frank Lee , Dennis Huszar , Wei Gu
IPC分类号： A61K38/00 , A61K38/17 , A61K48/00 , C07K14/72 , C12Q1/68 , G01N33/50 , G01N33/74 , A61K49/00 , A61K38/22 , C12Q1/02
CPC分类号： G01N33/5091 , A61K49/00 , C07K14/723 , C12Q1/6897 , G01N33/5008 , G01N33/502 , G01N33/5088 , G01N33/74 , A01K2217/05 , A01K2217/075 , A61K2039/505 , A61K48/00 , C07K2319/00 , C12N2799/021 , G01N2500/00
摘要： The present invention relates to drug screening assays, and diagnostic and therapeutic methods for the treatment of body weight disorders, such as obesity, anorexia and cachexia, utilizing the melanocortin 4-receptor (MC4-R) as the target for intervention. The invention also relates to compounds that modulate the activity or expression of the MC4-R, and the use of such compounds in the treatment of body weight disorders.

44. 发明授权

US5807996A Fused polypeptides comprising interleukin-4 polypeptide fragments 失效
标题翻译：包含白细胞介素-4多肽片段的融合多肽
公开(公告)号：US5807996A
公开(公告)日：1998-09-15
申请号：US468735
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N1/21 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , C07K14/00
CPC分类号： C07K14/5406 , C07K16/247 , C12N15/66 , C12N15/70 , C12N15/86 , A61K38/00 , C07K2319/00 , C07K2319/02 , C12N2710/16243
摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
摘要翻译：提供了表达B细胞生长因子活性和T细胞生长因子活性的哺乳动物蛋白质和其突变蛋白，称为白细胞介素-4（IL-4s）。本发明的化合物包括天然人和鼠IL-4，其突变蛋白和与公开的cDNA有效同源的核酸，和/或能编码哺乳动物IL-4及其突变蛋白的核酸。

45. 发明授权

US4083794A Detergent composition 失效
标题翻译：洗涤剂组成
公开(公告)号：US4083794A
公开(公告)日：1978-04-11
申请号：US690803
申请日：1976-05-27
申请人： Frank Lee , Charles Fearnley , Glenda Helen Fordham
发明人： Frank Lee , Charles Fearnley , Glenda Helen Fordham
IPC分类号： C11D3/37 , C11D9/22 , C11D7/56 , C11D7/38
CPC分类号： C11D9/225 , C11D3/3761 , C11D3/3769
摘要： A soap or synthetic detergent composition is provided which comprises an anionic and/or non-ionic surfactant and(a) from 0.1 to 2.5% by weight of a compound consisting essentially of hydrolyzed polymaleic anhydride with a molecular weight of 300 to 5000 or of a water-soluble salt of such hydrolyzed polymaleic anhydride, or(b) from 0.1 to 2.5% by weight of a hydrolyzed copolymer with a molecular weight of 300 to 1000 from 2.5 to 100, preferably 2.5 to 30 moles of maleic anhydride with 1 mole of monoethylenically unsaturated monomer or mixture of monomer.Also a method of washing textiles, preferably cellulosics, with an aqueous bath containing 0.5 to 20 g/l of said soap or synthetic detergent composition is provided.The deposit of scale on working parts of the washing machine employed and of residual calcium and magnesium salts onto textiles is reduced or inhibited by using said soap or synthetic detergent composition.
摘要翻译：提供了一种皂或合成洗涤剂组合物，其包含阴离子和/或非离子表面活性剂和（A）0.1至2.5％按重量含水量聚乙烯异氰酸酯的化合物的重量计，分子量为300至5000或A 这种水解聚异氰酸酯的水溶性盐，或（B）以2.5至100的分子量为300至1000的水解共聚物的重量为0.1至2.5％，优选2.5至30摩尔的马来酸酐与1摩尔单体不饱和单体或单体混合物。

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