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41. 发明授权

US08041783B2 Method for distribution of configuration settings for medical devices 有权
标题翻译：分配医疗设备配置设置的方法
公开(公告)号：US08041783B2
公开(公告)日：2011-10-18
申请号：US11408916
申请日：2006-04-20
申请人： Norbert Rahn , Gudrun Zahlmann , Markus Schmidt , Ali-Nejat Bengi , Horst Schreiner
发明人： Norbert Rahn , Gudrun Zahlmann , Markus Schmidt , Ali-Nejat Bengi , Horst Schreiner
IPC分类号： G06F15/177
CPC分类号： G06Q50/22 , G06F19/00 , G16H10/20 , G16H40/40
摘要： A method is provided for configuring medical devices such as medical devices used in a clinical trial. Based on the needs of the clinical trial, a definition of a configuration of the medical devices to be used in the clinical trial is generated and the configuration data is transformed into a profile. The profile is distributed to sites at which the clinical trial will be conducted and the profile is applied to the medical devices at the sites to configure the medical devices. The medical devices are thereby capable of producing data that is comparable as between the sites used in the clinical trial.
摘要翻译：提供了一种用于配置诸如在临床试验中使用的医疗装置的医疗装置的方法。根据临床试验的需要，生成临床试验中使用的医疗装置的结构的定义，将配置数据变换为简档。该配置文件分发到将进行临床试验的站点，并将配置文件应用于现场的医疗设备以配置医疗设备。因此，医疗装置能够产生与在临床试验中使用的部位之间可比较的数据。

42. 发明授权

US07715604B2 System and method for automatically registering three dimensional cardiac images with electro-anatomical cardiac mapping data 有权
标题翻译：用于自动记录三维心脏图像与电解剖心脏图像数据的系统和方法
公开(公告)号：US07715604B2
公开(公告)日：2010-05-11
申请号：US11330633
申请日：2006-01-12
申请人： Yiyong Sun , Fred S. Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
发明人： Yiyong Sun , Fred S. Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
IPC分类号： G06K9/00 , G06K9/32 , A61B5/05
CPC分类号： A61B5/0035 , A61B5/042 , A61B5/055 , A61B6/03 , G06T7/33 , G06T2207/30048
摘要： A system and method for automatically registering a three dimensional (3D) pre-operative image of an anatomical structure with intra-operative electrophysiological (EP) points of a 3D electro-anatomical (EA) image map of the anatomical structure is disclosed. The pre-operative image is displayed in a first supporting view. The intra-operative EA image map is displayed in a second supporting view. An alignment of the pre-operative image with the intra-operative map is performed by identifying at least one corresponding point on each image. The view of the pre-operative image is integrated with the EA map based on the alignment.
摘要翻译：公开了一种用于自动登记解剖结构的三维（3D）术前图像的解剖结构的3D电解剖（EA）图像的手术电生理（EP）点的系统和方法。术前图像显示在第一支持视图中。术中EA图像映射显示在第二支持视图中。通过识别每个图像上的至少一个对应点来执行术前图像与手术前图像的对准。基于对齐，将术前图像的视图与EA图集成。

43. 发明申请

US20090252287A1 Operating method for a swiveling polyplanar imaging system for time-resolved imaging of an object being examined 有权
标题翻译：用于正在检查的物体的时间分辨成像的旋转多面成像系统的操作方法
公开(公告)号：US20090252287A1
公开(公告)日：2009-10-08
申请号：US12383422
申请日：2009-03-24
申请人： Jan Boese , Norbert Rahn
发明人： Jan Boese , Norbert Rahn
IPC分类号： H05G1/60 , G06T15/00 , G06T17/00
CPC分类号： A61B6/02 , A61B6/4441 , A61B6/481 , A61B6/503 , A61B6/504
摘要： An operating method for a polyplanar imaging system for time-resolved imaging of an object is provided. First and second data records are recorded at a fan angle β from different angular positions by a first and second imaging planes arranged at an offset angle γ relative to each other and swiveled through an angle of at least φ=180°+β. A third data record is created by selecting projection images from the first data record beginning from a starting angle α and from the second data record so that the third data record covers an angular range of at least φ. Three-dimensional images are reconstructed based on the third data record. The starting angle α is varied for continuously creating the third data record until α has attained its final value. The contrast of projection images in the third data record or of three-dimensional images is evaluated.
摘要翻译：提供了一种用于物体的时间分辨成像的多平面成像系统的操作方法。第一和第二数据记录以相对于彼此以偏移角γ布置并且旋转至少φ180°+β的角度的第一和第二成像平面从不同角度位置以扇形角度β记录。通过从起始角α和第二数据记录开始从第一数据记录中选择投影图像，使得第三数据记录覆盖至少phi的角度范围来创建第三数据记录。基于第三数据记录重建三维图像。变化的起始角度α用于连续创建第三数据记录，直到α达到其最终值。评估第三数据记录或三维图像中的投影图像的对比度。

44. 发明授权

US07596406B2 Device for recording electrophysiological signals and for displaying the signals or signal information elements which are derived therefrom 失效
标题翻译：用于记录电生理信号并显示从其导出的信号或信号信息元素的装置
公开(公告)号：US07596406B2
公开(公告)日：2009-09-29
申请号：US11347549
申请日：2006-02-03
申请人： Jan Boese , Martin Kleen , Norbert Rahn
发明人： Jan Boese , Martin Kleen , Norbert Rahn
IPC分类号： A61B5/44
CPC分类号： A61B5/044 , A61B5/0422
摘要： Device for recording electrophysiological signals and for displaying the signals or signal information elements which are derived therefrom, comprising a catheter which includes a plurality of electrodes arranged in a distributed manner for signal recording and a rendition device for displaying the signals or the individual signal information elements which relate to the respective electrodes and are derived from the signals, wherein the signals or the signal information elements can be displayed in a display which is modeled on the geometric arrangement of the electrodes at the catheter or on the geometric arrangement of the electrodes during the signal recording.
摘要翻译：用于记录电生理信号并用于显示由其导出的信号或信号信息元素的装置，包括导管，该导管包括以分布式布置用于信号记录的多个电极，以及用于显示信号或各个信号信息元素的再现装置其涉及各个电极并且从信号导出，其中信号或信号信息元素可以显示在显示器中，该显示器被建模在导管处的电极的几何排列上或在电极的几何排列期间信号记录。

45. 发明申请

US20080119901A1 Method and system for patient-specific production of a cardiac electrode 有权
标题翻译：用于患者特异性生产心脏电极的方法和系统
公开(公告)号：US20080119901A1
公开(公告)日：2008-05-22
申请号：US11600976
申请日：2006-11-17
申请人： Norbert Rahn , Jan Boese
发明人： Norbert Rahn , Jan Boese
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N2001/0585
摘要： In a method and system for patient-specific production of a cardiac electrode, such as for use in a biventricular pacing system, a 3D representation of the coronary sinus vessel tree is segmented to indicate the interior surface thereof an a representative line from an opening of the coronary sinus vessel tree to an implantation site for the electrode, and a computerized model of the electrode is generated. A computerized virtual implantation of the electrode through the 3D representation of the coronary sinus vessel tree is implemented using the model and the internal surface and the representative line. From the virtual implantation, a determination is made as to whether an electrode conforming to the model can be guided to and implanted at the implantation site in a medically acceptable manner. If so, an actual electrode conforming to the model is then produced. If not, the model generation and the virtual implantation are iteratively modified until a satisfactory implantation result is achieved according to the virtual implantation.
摘要翻译：在用于患者特异性生产心脏电极的方法和系统中，例如用于双心室起搏系统中，冠状窦血管树的3D表示被分割以指示其内表面与来自开口的代表性线将冠状窦血管树移植到电极的植入部位，生成电极的电脑模型。通过冠状窦血管树的3D表示，通过模型和内表面和代表线来实现电极的电脑虚拟植入。从虚拟植入中，确定符合模型的电极是否可以以医学上可接受的方式被引导到植入部位并植入。如果是这样，则产生符合该模型的实际电极。如果不是，则模型生成和虚拟植入被迭代地修改，直到根据虚拟植入实现令人满意的植入结果。

46. 发明申请

US20080064974A1 Method and medical imaging system for acquisition of image data 有权
标题翻译：用于获取图像数据的方法和医学成像系统
公开(公告)号：US20080064974A1
公开(公告)日：2008-03-13
申请号：US11900834
申请日：2007-09-13
申请人： Jan Boese , Andreas Meyer , Norbert Rahn
发明人： Jan Boese , Andreas Meyer , Norbert Rahn
IPC分类号： A61B5/0402
CPC分类号： A61B6/541 , A61B5/0402 , A61B6/4441
摘要： The invention relates to a method and a medical imaging system for acquisition of image data of the heart using a medical imaging procedure during an intervention on the heart, while the heart is stimulated by a pacing signal from an external heart pacemaker, the acquisition and/or reconstruction of the image data being controlled, in particular triggered, by the pacing signal.
摘要翻译：本发明涉及一种用于在心脏介入期间使用医学成像程序获取心脏的图像数据的方法和医学成像系统，同时心脏由来自外部心脏起搏器的起搏信号刺激，采集和/ 或通过起搏信号来重构被特别触发的图像数据。

47. 发明申请

US20080038197A1 Method and apparatus for representing myocardial tissues in different states of damage 有权
标题翻译：用于表示不同损伤状态的心肌组织的方法和装置
公开(公告)号：US20080038197A1
公开(公告)日：2008-02-14
申请号：US11890400
申请日：2007-08-06
申请人： Matthias John , Stefan Lautenschlager , Norbert Rahn
发明人： Matthias John , Stefan Lautenschlager , Norbert Rahn
IPC分类号： A61K49/00 , A61B5/05
CPC分类号： A61B6/504 , A61B5/0275 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/507
摘要： The invention relates to a method for differentially representing myocardial tissue in different states of damage, comprising the following steps: administering a myocardium-suitable contrast agent to a patient under examination; entering at least one patient-specific parameter affecting the speed of uptake by and elimination from the myocardium of said contrast agent; calculating a point in time after administration of the contrast agent at which a difference between a contrast agent content in necrotic myocardial tissue and a contrast agent content in non-necrotic myocardial tissue attains a maximum value, on the basis of the at least one patient-specific parameter, and carrying out, at the point in time calculated, a late-phase CT scan for accentuation of necrotic myocardial tissue compared to non-necrotic myocardial tissue. The invention likewise relates to apparatus, in particular for carrying out the method. A clean copy of the abstract that incorporates the above amendments is provided herewith on a separate page.
摘要翻译：本发明涉及用于差异代表不同损伤状态的心肌组织的方法，包括以下步骤：向被检查的患者施用适合心肌的造影剂; 输入至少一个影响所述造影剂的心肌的摄取速度和消除速度的患者特异性参数; 计算施用造影剂之后的时间点，其中所述造影剂中的坏死心肌组织中的造影剂含量与非坏死性心肌组织中的造影剂含量之间的差异达到最大值，基于至少一个患者 - 具体参数，并且在计算的时间点进行与非坏死心肌组织相比的坏死心肌组织的晚期CT扫描。本发明同样涉及装置，特别是用于实施该方法。包含上述修订的摘要的干净的副本将提供在单独的页面上。

48. 发明申请

US20070287902A1 Method and Device for Visually Assisting an Electrophysiological Use of a Catheter in the Heart 有权
标题翻译：视力辅助心脏导管电生理使用的方法和装置
公开(公告)号：US20070287902A1
公开(公告)日：2007-12-13
申请号：US10569957
申请日：2004-08-24
申请人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
发明人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
IPC分类号： A61B18/14
CPC分类号： A61B6/032 , A61B5/055 , A61B5/7285 , A61B6/541 , A61B8/14 , A61B8/543 , A61B18/1492 , A61B2018/00375 , A61B2018/00839 , G01R33/5608
摘要： The invention relates to a device and to a method for visual assistance during the electrophysiological use of a catheter in the heart, enabling electroanatomic 3D mapping data relating to an area of the heart to be treated to be visualised during the use of the catheter. Before the catheter is used, 3D image data of a body region containing the area to be treated is detected by means of a method for tomographic 3D imaging. The area to be treated or significant parts thereof are extracted from said 3D image data, in order to obtain selected 3D image data. The electroanatomic 3D mapping data and the selected 3D image data obtained are then classed in terms of position and dimension, and are adjacently visualised, for example, during the catheter ablation. The inventive method and associated device enable the orientation of the operator to be improved during the use of a catheter in the heart.
摘要翻译：本发明涉及一种用于在心脏中电生理使用导管期间的视觉辅助的装置和方法，使得在使用导管期间能够使待处理的心脏区域的电解剖3D图映射数据被可视化。在使用导管之前，通过用于断层3D成像的方法来检测包含待处理区域的身体区域的3D图像数据。从所述3D图像数据中提取要处理的区域或其重要部分，以便获得所选择的3D图像数据。然后根据位置和尺寸对所获得的电解剖3D图像数据和所选择的3D图像数据进行分类，并且例如在导管消融期间相邻地可视化。本发明的方法和相关装置使得在使用心脏中的导管时能够改善操作者的取向。

49. 发明申请

US20070238964A1 Method for providing information of a locally resolved reconstruction quality of a target volume in a three-dimensional reconstruction volume presentation 有权
标题翻译：用于在三维重建体积呈现中提供目标体积的局部分辨的重建质量的信息的方法
公开(公告)号：US20070238964A1
公开(公告)日：2007-10-11
申请号：US11725377
申请日：2007-03-19
申请人： Matthias John , Norbert Rahn
发明人： Matthias John , Norbert Rahn
IPC分类号： A61B5/05
CPC分类号： A61B6/032 , A61B8/12 , A61B8/5238 , G06T11/008
摘要： The invention relates to a method and a device for locally-resolved visualization of the reconstruction quality, especially of the coverage of a target volume to be recorded as an image and reproduced in a three-dimensional reconstruction volume presentation, especially in the human body, by two-dimensional and/or three-dimensional images covering subareas of the volume recorded by a recording device arranged inside the target volume, with which the three-dimensional reconstruction volume presentation is created, with the subareas of the target volume covered by the individual images being determined and a visual locally-resolved presentation of the reconstruction quality, especially of the coverage, being created and output as a function of the subarea coverage.
摘要翻译：本发明涉及一种用于本地解析的重建质量可视化的方法和装置，特别是要被记录为图像并在三维重建体积呈现中特别是在人体中再现的目标体积的覆盖范围，通过覆盖由配置在目标体积内的记录装置记录的体积的二维和/或三维图像，三维重建体积呈现被创建，其中目标体积的子区域由个体覆盖图像被确定，并且重建质量，特别是覆盖范围的视觉局部解决呈现被创建并作为子区域覆盖的函数而被输出。

50. 发明申请

US20070083108A1 Method for visually supporting an invasive examination or therapy of the heart with the aid of an invasive instrument 有权
标题翻译：借助于侵入性仪器视觉上支持侵入性检查或治疗心脏的方法
公开(公告)号：US20070083108A1
公开(公告)日：2007-04-12
申请号：US11524611
申请日：2006-09-21
申请人： Jan Boese , Norbert Rahn
发明人： Jan Boese , Norbert Rahn
IPC分类号： G01N23/04 , A61B5/05
CPC分类号： A61B6/12 , A61B5/7285 , A61B6/541 , A61B8/543 , A61B34/20 , A61B90/36 , A61B2017/00243 , A61B2090/376
摘要： To visually support a catheter ablation in the heart, three-dimensional image data have been used prior to the intervention. During ablation, the position of the catheter is pinpointed by an orientation system. The orientation system acquires electroanatomical 3D mapping data. the two-dimensional image data is assigned to the 3D mapping data in the correct position and dimensions which is a time-consuming step. The invention makes provision for the orientation system being in a fixed location relative to the X-ray system so that a positionally and dimensionally correct alignment of the X-ray image data set with the 3D mapping data is no longer required. An image or surface based 3D-3D alignment of the three-dimensional data acquired prior to the intervention with the three-dimensional X-ray image data is considerably less time-consuming than alignment thereof with the 3D mapping data and is more reliable because more structures is recognized in the three-dimensional X-ray image data.
摘要翻译：为了可视地支持心脏中的导管消融，在干预之前已经使用三维图像数据。在消融期间，导管的位置由定位系统精确定位。取向系统获取电解剖3D绘图数据。将二维图像数据分配给三维映射数据，该数据是正确的位置和尺寸，这是耗时的步骤。本发明提供了相对于X射线系统的定位系统在固定位置的设置，使得不再需要X射线图像数据集与3D映射数据的位置和尺寸校正对准。在三维X射线图像数据的干预之前获取的三维数据的图像或基于表面的3D-3D对准与3D映射数据的对准相比，耗时更少，并且更可靠，因为更多在三维X射线图像数据中识别结构。

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