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41. 发明授权

US6101405A Method and device for positioning a living body 失效
标题翻译：用于定位生物体的方法和装置
公开(公告)号：US6101405A
公开(公告)日：2000-08-08
申请号：US128479
申请日：1998-08-04
申请人： Nobuyoshi Yasuda , Naoki Yanai
发明人： Nobuyoshi Yasuda , Naoki Yanai
IPC分类号： A61B10/00 , A61B5/117 , A61B5/145 , A61B5/1455 , A61B5/00
CPC分类号： G06K9/00006 , A61B5/1172 , G06K9/00919
摘要： A method of and a device for positioning an area of a living body to be measured relative to a detecting probe during a biodata measurement with the use of a biodata measuring apparatus designed to irradiate with light the area of the living body by means of the detecting probe then held in contact with the area of the living body, then to detect light transmitted through and/or reflected from the area of the living body, and finally to measure a predetermined biodata within the living body on the basis of a spectrum of the transmitted and/or reflected light. A plurality of local fixing units are utilized for fixing a plurality of predetermined portions of the living body, respectively. The portions of the living body are fixed respectively by the local fixing units during the biodata measurement to thereby fix the area to be measured relative to the positioning device.
摘要翻译：一种在生物量测量期间使用生物数据测量装置来定位待测量的生物体的区域的方法和装置，所述生物数据测量装置被设计成通过检测来照射生物体的区域然后将探针与生物体的区域接触，然后检测通过活体区域传播和/或反射的光，最后根据生物体的光谱测量生物体内的预定生物数据发射和/或反射光。多个局部固定单元分别用于固定生物体的多个预定部分。在生物量测量期间，生物体的部分分别由局部固定单元固定，从而固定相对于定位装置测量的区域。

42. 发明授权

US6080854A Process for synthesizing carbapenem intermediates 失效
标题翻译：合成碳青霉烯中间体的方法
公开(公告)号：US6080854A
公开(公告)日：2000-06-27
申请号：US129206
申请日：1998-07-27
申请人： John Y. Chung , Nobuyoshi Yasuda , Johnnie L. Leazer, Jr.
发明人： John Y. Chung , Nobuyoshi Yasuda , Johnnie L. Leazer, Jr.
IPC分类号： C07D205/08
CPC分类号： C07D205/08 , Y02P20/55
摘要： A process of synthesizing a compound of formula I is described: ##STR1## wherein P and P' independently represent H or a protecting group, R.sub.1 represents H or C.sub.1-4 alkyl, and Hal represents a halogen characterized by reacting a compound of formula 2: ##STR2## with R.sub.2 OH, wherein R.sub.2 is C.sub.1-4 alkyl, C.sub.6-10 aryl or C.sub.5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: ##STR3## and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula 1.
摘要翻译：描述了合成式I化合物的方法：其中P和P'独立地表示H或保护基，R 1表示H或C 1-4烷基，Hal表示卤素，其特征在于使式2化合物与R2OH反应其中R 2是C 1-4烷基，C 6-10芳基或C 5-10杂芳基，在酸催化剂或碳二亚胺试剂存在下制备式3化合物：和式3化合物在碱存在下和卤代烷基化剂以制备式1化合物。

43. 发明授权

US6078828A Pressure regulating device and method of regulating pressure applied to living body during biodata measurement 有权
标题翻译：压力调节装置及生物量测量过程中调节压力的方法
公开(公告)号：US6078828A
公开(公告)日：2000-06-20
申请号：US129427
申请日：1998-08-05
申请人： Nobuyoshi Yasuda , Naoki Yanai
发明人： Nobuyoshi Yasuda , Naoki Yanai
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/6843 , A61B5/0059
摘要： A method of and an apparatus for regulating a pressure applied to an area of a living body during a biodata measurement with the use of a biodata measuring apparatus. The apparatus is designed to irradiate with light the area of the living body by means of a detecting probe then held in contact with the area of the living body, then to detect light transmitted through and/or reflected from the area of the living body, and finally to measure a predetermined biodata within the living body on the basis of a spectrum of the transmitted and/or reflected light. The method and the apparatus include pressing, during the biodata measurement, the area of the living body with a predetermined pressure through a soft pressure medium to thereby regulate the pressure applied to the area of the living body to a value equal to the predetermined pressure.
摘要翻译：一种利用生物数据测量装置在生物量测量期间调节施加到生物体区域的压力的方法和装置。该装置被设计成借助于与生物体的区域保持接触的检测探头用光照射生物体的区域，然后检测从生物体的区域透过和/或反射的光，并且最终根据透射光和/或反射光的光谱来测量活体内的预定生物数据。该方法和装置包括在生物量测量期间通过软压力介质以预定的压力压制生物体的面积，从而将施加到生物体的区域的压力调节至等于预定压力的值。

44. 发明授权

US5698741A Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-b enzoxazin-2-one 失效
标题翻译：（ - ）6-氯-4-环丙基 - 乙炔基-4-三氟甲基-1,4-二氢-2H-3,1-苯并恶嗪-2-酮的不对称合成
公开(公告)号：US5698741A
公开(公告)日：1997-12-16
申请号：US680940
申请日：1996-07-15
申请人： Andrew S. Thompson , Edward G. Corley , Edward J. J. Grabowski , Nobuyoshi Yasuda
发明人： Andrew S. Thompson , Edward G. Corley , Edward J. J. Grabowski , Nobuyoshi Yasuda
IPC分类号： C07B53/00 , C07C213/00 , C07C215/68 , C07C215/70 , C07C217/58 , C07D265/18 , C07C211/00 , C07C51/16
CPC分类号： C07D265/18 , C07C213/00 , C07C215/70 , C07C217/58 , Y02P20/55
摘要： An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.
摘要翻译：公开了改进的高效HIV逆转录抑制剂的合成，涉及在手性氨基醇存在下产生手性产物的乙酰化物和三氟甲基酮。

45. 发明授权

US4554269A Kasugamycin derivatives, pharmaceutical compositions and method of use 失效
标题翻译：春日霉素衍生物，药物组合物和使用方法
公开(公告)号：US4554269A
公开(公告)日：1985-11-19
申请号：US573377
申请日：1984-01-24
申请人： Takao Takaya , Nobuyoshi Yasuda , Hideo Tsutsumi , Keiji Matsuda
发明人： Takao Takaya , Nobuyoshi Yasuda , Hideo Tsutsumi , Keiji Matsuda
IPC分类号： C07H15/207 , A61K31/71 , C07H15/20
CPC分类号： C07H15/207
摘要： This invention relates to new aminoglycoside derivatives and pharmaceutically acceptable salts thereof. More particularly it relates to new aminoglycoside derivatives and pharmaceutically acceptable salts thereof which have anti-viral activity, and immuno-stimulating activity and pharmaceutical compositions comprising the same. In addition, this invention also relates to methods of preparing the aminoglycoside derivatives and salts thereof.
摘要翻译：本发明涉及新的氨基糖苷衍生物及其药学上可接受的盐。更具体地说，本发明涉及具有抗病毒活性的新的氨基糖苷衍生物及其药学上可接受的盐以及免疫刺激活性以及包含其的药物组合物。此外，本发明还涉及制备氨基糖苷衍生物及其盐的方法。

46. 发明申请

US20090131664A1 Method for Producing 4(3H)-Quinazolinone Derivative 审中-公开
标题翻译：生产4（3H） - 喹唑啉酮衍生物的方法
公开(公告)号：US20090131664A1
公开(公告)日：2009-05-21
申请号：US11922479
申请日：2006-07-04
申请人： Atsushi Akao , Takehiko Iida , Takahiro Itoh , Toshiaki Mase , Kimihiko Sato , Naotaka Sawada , Chie Kadowaki , Takayuki Tsuritani , Nobuyoshi Yasuda
发明人： Atsushi Akao , Takehiko Iida , Takahiro Itoh , Toshiaki Mase , Kimihiko Sato , Naotaka Sawada , Chie Kadowaki , Takayuki Tsuritani , Nobuyoshi Yasuda
IPC分类号： C07D401/02
CPC分类号： C07D239/74
摘要： This invention is related to a method for producing 3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone comprising a step for reacting 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazin-4-one with 4-[3-(1-pyrrolidinyl)propoxy]aniline or an acid-addition salt thereof, or 4-(1-cyclobutyl-4-piperidinoy9oxyaniline or acid addition salt thereof in the presence of an acid catalyst.
摘要翻译：本发明涉及一种制备3- {4- [3-（1-吡咯烷基）丙氧基]苯基} -5-三氟甲基-4（3H） - 喹唑啉酮的方法，该方法包括使2-甲基-5-三氟甲基 - 4H-3,1-苯并恶嗪-4-酮与4- [3-（1-吡咯烷基）丙氧基]苯胺或其酸加成盐或4-（1-环丁基-4-哌啶基）苯氧基苯胺或其酸加成盐在酸催化剂的存在。

47. 发明授权

US07074930B2 Amine salts of an integrin receptor antagonist 失效
标题翻译：整合素受体拮抗剂的胺盐
公开(公告)号：US07074930B2
公开(公告)日：2006-07-11
申请号：US10494760
申请日：2002-11-01
申请人： Kenneth M. Wells , Nobuyoshi Yasuda , Yaling Wang
发明人： Kenneth M. Wells , Nobuyoshi Yasuda , Yaling Wang
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07C215/10 , C07D471/04
摘要： Amine salts of 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)-propyl]imidazolidin-1-yl}-3-(6-methoxy-pyridin-3-yl)propionic acid are potent antagonists of the integrin αvβ3 receptor and are useful for the prevention and/or treatment of osteoporosis and vascular restenosis, as well as conditions associated with excessive angiogenesis, such as macular degeneration, diabetic retinopathy, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth. The invention also relates to a process for the preparation of the novel salts as well as pharmaceutical compositions containing the salts and methods of using the salts.
摘要翻译： 3- {2-氧代-3- [3-（5,6,7,8-四氢[1,8]萘啶-2-基） - 丙基]咪唑烷-1-基} -3-（6 - 甲氧基 - 吡啶-3-基）丙酸是整联蛋白α2受体的有效拮抗剂，可用于预防和/或治疗骨质疏松症和血管再狭窄，以及与过度血管生成相关的病症，如黄斑变性，糖尿病视网膜病变，动脉粥样硬化，炎性关节炎，癌症和转移性肿瘤生长。本发明还涉及制备新型盐的方法以及含有盐的药物组合物和使用该盐的方法。

48. 发明授权

US06346617B1 Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof 失效
标题翻译：结晶2-羟甲基碳青霉烯中间体化合物及其合成方法
公开(公告)号：US06346617B1
公开(公告)日：2002-02-12
申请号：US09334397
申请日：1999-06-16
申请人： John Y. Chung , Nobuyoshi Yasuda , Johnnie L. Leazer, Jr. , Mark S. Jensen , Kenneth M. Wells , Chunhua Yang
发明人： John Y. Chung , Nobuyoshi Yasuda , Johnnie L. Leazer, Jr. , Mark S. Jensen , Kenneth M. Wells , Chunhua Yang
IPC分类号： C07D47714
CPC分类号： C07D477/14 , C07D477/02 , Y02P20/55
摘要： A process for preparation of a compound of formula I: wherein: R1 represents CH3 or H; and P represents a protecting group; comprising reacting a compound of formula IV: wherein R1 and P and are defined above and R4 represents triflate or SO2F; in the presence of a catalyst and (R3)3SnCH2OP″, wherein each R3 represents C1-4 lower alkyl, and P″ represents H or a protecting group, to yield the compound of formula I.
摘要翻译：制备式I化合物的方法：其中：R 1表示CH 3或H; 并且P表示保护基团;包括使式IV化合物：其中R 1和P和上述定义，R 4表示三氟甲磺酸酯或SO 2 F;在催化剂和（R3）3SnCH2OP“的存在下，其中每个R 3表示C1- 4低级烷基，P“表示H或保护基，得到式I化合物。

49. 发明授权

US06235898B1 Process for the synthesis of carbapenem intermediated and compounds produced 失效
标题翻译：合成碳青霉烯中和化合物的方法
公开(公告)号：US06235898B1
公开(公告)日：2001-05-22
申请号：US09511958
申请日：2000-02-23
申请人： Mark S. Jensen , Chunhua Yang , Nobuyoshi Yasuda
发明人： Mark S. Jensen , Chunhua Yang , Nobuyoshi Yasuda
IPC分类号： C07D47706
CPC分类号： C07D477/14 , C07F7/2208
摘要： A process of synthesizing a carbapenem compound of formula 6: is disclosed using a compound of formula 4′: The intermediate compounds that are described herein are also included in the present invention.
摘要翻译：公开了使用式4'化合物合成式6的碳青霉烯化合物的方法：本文所述的中间体化合物也包括在本发明中。

50. 发明授权

US6048978A Process for the synthesis of carbapenem intermediates, and compounds produced 失效
标题翻译：合成碳青霉烯中间体的方法和所生产的化合物
公开(公告)号：US6048978A
公开(公告)日：2000-04-11
申请号：US159158
申请日：1998-09-23
申请人： Mark S. Jensen , Chunhua Yang , Nobuyoshi Yasuda
发明人： Mark S. Jensen , Chunhua Yang , Nobuyoshi Yasuda
IPC分类号： C07D477/14 , C07F7/22 , C07D267/22 , C07D487/00
CPC分类号： C07D477/14 , C07F7/2212
摘要： A process of synthesizing a carbapenem compound of formula 6: ##STR1## is disclosed using a compound of formula 4': ##STR2## The intermediate compounds that are described herein are also included in the present invention.
摘要翻译：公开了使用式4'化合物合成式6的碳青霉烯化合物的方法：本文所述的中间体化合物也包括在本发明中。

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