专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明专利

SG177182A1 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS 未知
公开(公告)号：SG177182A1
公开(公告)日：2012-01-30
申请号：SG2011089851
申请日：2006-04-10
申请人： NOVARTIS AG
发明人： ALLGEIER HANS , AUBERSON YVES , CARCACHE DAVID , FLOERSHEIM PHILIPP , GUIBOURDENCHE CHRISTEL , FROESTL WOLFGANG , KALLEN JOERG , KOLLER MANUEL , MATTES HENRI , NOZULAK JOACHIM , ORAIN DAVID , RENAUD JOHANNE
IPC分类号： C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07D207/32 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/96 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R 1 and R 2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.

42. 发明专利

MY142474A 1H-QUINAZOLINE-2,4-DIONES 未知
公开(公告)号：MY142474A
公开(公告)日：2010-11-30
申请号：MYPI20061558
申请日：2006-04-06
申请人： NOVARTIS AG
发明人： ALLGEIER HANS , NOZULAK JOACHIM , ORAIN DAVID , RENAUD JOHANNE , AUBERSON YVES , CARCACHE DAVID , FLOERSHEIM PHILIPP , GUIBORDENCHE CHRISTEL , FROESTEL WOLFGANG , KALLEN J XD RG , KOLLER MANUEL , MATTES HENRI
IPC分类号： A61K31/517 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07D207/32 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/96 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： THE PRESENT RELATES TO 1H-QUINAZOLINE -2.4-DIONES OF FORMULA (1) 0 H 0 R 'IN'- // N S 0 R N 0 H WHEREIN RI AND R2 ARE AS DEFINED IN THE SPECIFICATION, THEIR PREPARATION, THEIR USE AS PHARMACEUTICALS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. FURTHER, INTERMEDIATES FOR THE MANUFACTURE OF COMPOUNDS OF FLORMULA (1) ARE AND COMBINATIONS COMPRISING COMPOUNDS OF FORMULA (1) ARE DISCLOSED.

43. 发明专利

PE13662009A1 1H-QUINAZOLIN-2,4-DIONAS 未知
公开(公告)号：PE13662009A1
公开(公告)日：2009-09-21
申请号：PE0008102009
申请日：2006-04-07
申请人： NOVARTIS AG
发明人： ALLGEIER HANS , AUBERSON YVES , CARCACHE DAVID , FLOERSHEIM PHILIPP , GUIBOURDENCHE CHRISTEL , FROESTL WOLFGANG , KALLEN JORG , KOLLER MANUEL , MATTES HENRI , NOZULAK JOACHIM , ORAIN DAVID , RENAUD JOHANNE
IPC分类号： A61K31/517 , A61P25/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07D207/32 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/00 , C07D239/26 , C07D239/96 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： SE REFIERE A COMPUESTOS DERIVADOS DE 1H-QUINAZOLIN-2,4-DIONAS DE FORMULA (I) DONDE R1 ES CF3, CHF2, CH2F, CH3CHF-, ENTRE OTROS; R2 ES ALQUILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, NITRO, CN, OH, ENTRE OTROS SUSTITUYENTES, FENILO OPCIONALMENTE SUSTITUIDO CON CN, OH, FORMILO, ENTRE OTROS SUSTITUYENTES, HETEROCICLILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH, AMINO, CN, ENTRE OTROS SUSTITUYENTES, HETEROCICLILALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(6-ACETIL-2,4-DIOXO-7-TRIFLUORO-METIL-1,4-DIHIDRO-2H-QUINAZOLIN-3-IL)-METAN-SULFONAMIDA, N-[6-(1-HIDROXI-ETIL)-2,4-DIOXO-7-TRIFLUORO-METIL-1,4-DIHIDRO-2H-QUINAZOLIN-3-IL]-METAN-SULFONAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE AMPA COMPETITIVOS SIENDO UTILES EN EL TRATAMIENTO DE EPILEPSIA, PSICOSIS, ESCLEROSIS MULTIPLE, ENFERMEDAD DE PARKINSON

44. 发明专利

PT934326E ACIDOS AMINOALCANOFOSFONICOS SUBSTITUIDOS 未知
公开(公告)号：PT934326E
公开(公告)日：2006-08-31
申请号：PT97946755
申请日：1997-10-22
申请人： NOVARTIS AG
发明人： ACKLIN PIERRE , ALLGEIER HANS , AUBERSON YVES , OFNER SILVIO , JACOB VEENSTRA SIEM
IPC分类号： A61K31/675 , A61P9/00 , A61P25/00 , A61P25/08 , A61P43/00 , C07F9/6509 , C07F9/00

45. 发明专利

PL189637B1 NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES 未知
公开(公告)号：PL189637B1
公开(公告)日：2005-09-30
申请号：PL32499296
申请日：1996-08-19
申请人： NOVARTIS AG
发明人： ACKLIN PIERRE , ALLGEIER HANS , AUBERSON YVES , BIOLLAZ MICHEL , MORETTI ROBERT , OFNER SILVIO , VEENSTRA SIEM JACOB
IPC分类号： A61K20060101 , A61K31/00 , A61K31/495 , A61K31/498 , A61K31/502 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K31/662 , A61P25/28 , A61P43/00 , C07D20060101 , C07D241/44 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D491/113 , C07F9/6509
摘要： PCT No. PCT/EP96/03644 Sec. 371 Date Feb. 27, 1998 Sec. 102(e) Date Feb. 27, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08155 PCT Pub. Date Mar. 6, 19972,3-Dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives of formula (I), wherein one of the radicals R1, and R2 is a group R5 and the other is a group of formula -CH(R6)-alk-R7 (Ia), -alk-CH(R6-R7 (Ib), -alk-N(R8)-X-R7 (Ic), -alk-N+(R8)(R9)-X-R7A- (Id), -alk-O-X-R7 (Ie) or -alk-S-X-R7 (If), R3, R4 and R5 are each independently of the others hydrogen, lower alkyl, halogen, trifluoromethyl, cyano or nitro, R6 is unsubstituted or lower alkylated and/or lower alkanoylated amino, R7 is hydrogen; an aliphatic, cycloaliphatic or heterocycloaliphatic radical; cyano; acyl derived from carbonic acid or from a semiester or semiamide of carbonic acid, from sulfuric acid or from an aliphatic or aromatic sulfonic acid or from phosphoric acid or from a phosphonic acid ester; amino that is unsubtituted or aliphatically or araliphatically substituted and/or substituted by aliphatic, araliphatic or aromatic acyl; or an aromatic or heteroaromatic radical, R8 is hydrogen; an aliphatic or araliphatic radical; or acyl derived from an aliphatic or araliphatic carboxylic acid or from an aliphatic or araliphatic semiester of carbonic acid, or R7 and R8, together with X and the nitrogen atom bonding R8 and X, form an unsubstitued or substituted mono- or di-azaxycloalkyl, azoxacycloalkyl, azathiacycloalkyl or optionally oxidised thiacycloalkyl radical bonded via a nitrogen atom, or an unsubstituted or substituted, optionally partially hxdrogenated aryl or heteroaryl radical, R9 is an aliphatic or araliphatic radical, or R7, R8 and R9 together with X and the nitrogen atom bonding R8, R9 and X, form an unsubstituted or substituted quaternary heteroaryl radical bonded via the quaternary nitrogen atom, with A- being the anion of a protonic acid, alk is lower alkylene, and X (unless, together with R7 and R8 and the nitrogen atom bonding R8 and X or together with the nitrogen atom bonding R8, R9 and X, it forms part of one of the mentioned ring systems) is a divalent aliphatic, cycloaliphatic or araliphatic radical or a direct bond, and the pharmaceutically acceptable salts thereof can be used in the preparation of a medicament for the treatment of pathological conditions that are responsive to blocking of AMPA, kainate and/or glycine binding sites of the NMDA receptor.

46. 发明专利

DE69631774T2 未知
公开(公告)号：DE69631774T2
公开(公告)日：2005-01-13
申请号：DE69631774
申请日：1996-08-19
申请人： NOVARTIS AG
发明人： ACKLIN PIERRE , ALLGEIER HANS , AUBERSON YVES , BIOLLAZ MICHEL , MORETTI ROBERT , OFNER SILVIO , VEENSTRA JACOB
IPC分类号： A61K20060101 , A61K31/00 , A61K31/495 , A61K31/498 , A61K31/502 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K31/662 , A61P25/28 , A61P43/00 , C07D20060101 , C07D241/44 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D491/113 , C07F9/6509
摘要： PCT No. PCT/EP96/03644 Sec. 371 Date Feb. 27, 1998 Sec. 102(e) Date Feb. 27, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08155 PCT Pub. Date Mar. 6, 19972,3-Dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives of formula (I), wherein one of the radicals R1, and R2 is a group R5 and the other is a group of formula -CH(R6)-alk-R7 (Ia), -alk-CH(R6-R7 (Ib), -alk-N(R8)-X-R7 (Ic), -alk-N+(R8)(R9)-X-R7A- (Id), -alk-O-X-R7 (Ie) or -alk-S-X-R7 (If), R3, R4 and R5 are each independently of the others hydrogen, lower alkyl, halogen, trifluoromethyl, cyano or nitro, R6 is unsubstituted or lower alkylated and/or lower alkanoylated amino, R7 is hydrogen; an aliphatic, cycloaliphatic or heterocycloaliphatic radical; cyano; acyl derived from carbonic acid or from a semiester or semiamide of carbonic acid, from sulfuric acid or from an aliphatic or aromatic sulfonic acid or from phosphoric acid or from a phosphonic acid ester; amino that is unsubtituted or aliphatically or araliphatically substituted and/or substituted by aliphatic, araliphatic or aromatic acyl; or an aromatic or heteroaromatic radical, R8 is hydrogen; an aliphatic or araliphatic radical; or acyl derived from an aliphatic or araliphatic carboxylic acid or from an aliphatic or araliphatic semiester of carbonic acid, or R7 and R8, together with X and the nitrogen atom bonding R8 and X, form an unsubstitued or substituted mono- or di-azaxycloalkyl, azoxacycloalkyl, azathiacycloalkyl or optionally oxidised thiacycloalkyl radical bonded via a nitrogen atom, or an unsubstituted or substituted, optionally partially hxdrogenated aryl or heteroaryl radical, R9 is an aliphatic or araliphatic radical, or R7, R8 and R9 together with X and the nitrogen atom bonding R8, R9 and X, form an unsubstituted or substituted quaternary heteroaryl radical bonded via the quaternary nitrogen atom, with A- being the anion of a protonic acid, alk is lower alkylene, and X (unless, together with R7 and R8 and the nitrogen atom bonding R8 and X or together with the nitrogen atom bonding R8, R9 and X, it forms part of one of the mentioned ring systems) is a divalent aliphatic, cycloaliphatic or araliphatic radical or a direct bond, and the pharmaceutically acceptable salts thereof can be used in the preparation of a medicament for the treatment of pathological conditions that are responsive to blocking of AMPA, kainate and/or glycine binding sites of the NMDA receptor.

47. 发明专利

DE69913548T2 未知
公开(公告)号：DE69913548T2
公开(公告)日：2004-09-23
申请号：DE69913548
申请日：1999-09-30
申请人： NOVARTIS AG , SIBIA NEUROSCIENCES INC
发明人： ALLGEIER HANS , COSFORD DAVID , FLOR JOSEF , GASPARINI FABRIZIO , GENTSCH CONRAD , HESS D , JOHNSON CARL , KUHN RAINER , TRICKLEBANK MARK , URBAN LASZLO , VARNEY ANDREW , VELI ELEBI GOENUEL , WALKER KATHARINE
IPC分类号： C07D213/06 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K45/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P29/00 , A61P43/00 , C07D213/16 , C07D213/26 , C07D213/65
摘要： The invention provides the use of selective mGluR5 antagonists for the treatment of pain and anxiety, and the use of mGluR antagonists for the treatment of pain, whereby analgesic effect is achieved by interaction of said antagonists primarily or predominantly at peripheral mGluR receptors.

48. 发明专利

NZ502210A Pyridine derivatives 未知
公开(公告)号：NZ502210A
公开(公告)日：2002-07-26
申请号：NZ50221098
申请日：1998-07-09
申请人： NOVARTIS AG , SIBIA NEUROSCIENCES INC
发明人： HECKENDORN ROLAND , JOHNSON EDWIN CARL , KUHN RAINER , VARNEY MARK ANDREW , VELICELEBI GONUL , GASPARINI FABRIZIO , ALLGEIER HANS , AUBERSON YVES , BIOLLAZ MICHEL , COSFORD NICHOLAS DAVID
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61P9/10 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/50 , C07D213/52 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/89 , C07D215/12 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/06 , C07D413/06 , C07F7/08 , C07D213/00
摘要： Compounds of formula (I), pharmaceutical compositions containing compounds of formula (I), and the use of these compounds of for modulating the activity of mGluRs and for treating mGluR5 mediated diseases, including epilepsy and ischemias.

49. 发明专利

AU738973B2 Pyridine derivatives 未知
公开(公告)号：AU738973B2
公开(公告)日：2001-10-04
申请号：AU8974398
申请日：1998-07-09
申请人： NOVARTIS AG , SIBIA NEUROSCIENCES INC
发明人： ALLGEIER HANS , AUBERSON YVES , BIOLLAZ MICHEL , COSFORD NICHOLAS DAVID , GASPARINI FABRIZIO , HECKENDORN ROLAND , JOHNSON EDWIN CARL , KUHN RAINER , VARNEY MARK ANDREW , VELICELEBI GONUL
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61P9/10 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/50 , C07D213/52 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/89 , C07D215/12 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/06 , C07D413/06 , C07F7/08 , C07D213/00
摘要： A compound of formula IwhereinX represents an optionally halo-substituted (C2-4)alkynylene group bonded via vicinal unsaturated carbon atoms.

50. 发明专利

NO20011440A 未知
公开(公告)号：NO20011440A
公开(公告)日：2001-05-15
申请号：NO20011440
申请日：2001-03-21
申请人： NOVARTIS AG , SIBIA NEUROSCIENCES INC
发明人： ALLGEIER HANS , COSFORD NICHOLAS DAVID , FLOR PETER JOSEF
IPC分类号： C07D213/06 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K45/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P29/00 , A61P43/00 , C07D213/16 , C07D213/26 , C07D213/65 , A61K
CPC分类号： A61K31/44

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式