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41. 发明专利

UA112285C2 СПОЛУКИ ТА КОМПОЗИЦІЯ ЯК ІНГІБІТОРИ ПРОТЕЇНКІНАЗИ 未知
公开(公告)号：UA112285C2
公开(公告)日：2016-08-25
申请号：UAA201203042
申请日：2010-08-27
申请人： IRM LLC , NOVARTIS AG
发明人： HUANG SHENLIN , JIN XIANMING , LIU ZUOSHENG , POON DANIEL , TELLEW JOHN , WAN YONGQIN , WANG XING , XIE YONGPING
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07D403/04
摘要： Данийвинахідзабезпечуєновийклассполук, фармацевтичнікомпозиції, щомістятьтакісполуки, тавикористаннятакихсполукдлялікуванняабопрофілактикихворобаборозладів, пов'язанихз аномальноюабодерегульованоюактивністюкінази, зокремахворобаборозладів, якізалучаютьаномальнуактиваціюВ-Raf.

42. 发明专利

CA2771775C COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2771775C
公开(公告)日：2015-01-20
申请号：CA2771775
申请日：2010-08-27
申请人： IRM LLC , NOVARTIS AG
发明人： HUANG SHENLIN , JIN XIANMING , LIU ZUOSHENG , POON DANIEL , TELLEW JOHN E , WAN YONGQIN , WANG XING , XIE YONGPING
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00 , C07D401/14
摘要： The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

43. 发明专利

SMT201400133B 未知
公开(公告)号：SMT201400133B
公开(公告)日：2014-11-10
申请号：SM201400133
申请日：2014-09-12
申请人： NOVARTIS AG
发明人： POON DANIEL , WAN YONGQIN , HUANG SHENLIN , LIU ZUOSHENG , WANG XING , XIE YONGPING , TELLEW JOHN , JIN XIANMING
摘要： The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

44. 发明专利

ES2492499T3 Compuestos y composiciones que son inhibidores de la proteína quinasa 未知
公开(公告)号：ES2492499T3
公开(公告)日：2014-09-09
申请号：ES10748211
申请日：2010-08-27
申请人： IRM LLC , NOVARTIS AG
发明人： HUANG SHENLIN , JIN XIANMING , LIU ZUOSHENG , POON DANIEL , TELLEW JOHN , WAN YONGQIN , WANG XING , XIE YONGPING
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07D403/04
摘要： Un compuesto seleccionado entre: N-[(2S)-1-({4-[3-(3-cloro-5-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)propan- 2-il]carbamato de metilo; N-[(2S)-1-[(4-{3-[3-cloro-5-(propano-1-sulfonamido)fenil]-1-(propan-2-il)-1H-pirazol-4-il}pirimidin-2-il)amino]pro pan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(3-cloro-2-metanosulfonamidopiridin-4-il)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)pr opan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(3-fluoro-2-metanosulfonamidopiridin-4-il)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)pr opan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(2-cloro-3-etanosulfonamido-4,5-difluorofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amin o)propan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(2,4-difluoro-3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)pro pan-2-il]carbamato de metilo; N-[(2S)-1-({4-[1-(propan-2-il)-3-(2,4,5-trifluoro-3-metanosulfonamidofenil)-1H-pirazol-4-il]pirimi-din-2-il} amino)propan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)propan-2-il]carb amato de metilo; N-[(2S)-1-[(4-{3-[2,4-difluoro-3-(propano-1-sulfonamido)fenil]-1-(propan-2-il)-1H-pirazol-4-il}pirimidin-2-il)amino ]propan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(3-cyclopropanosulfonamido-2,5-difluorofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amin o)propan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(5-cloro-3-cyclopropanosulfonamido-2-fluorofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}a mino)propan-2-il]carbamato de metilo; N-[(2S)-1-[(4-{3-[5-cloro-2-fluoro-3-(propano-1-sulfonamido)fenil]-1-(propan-2-il)-1H-pirazol-4-il}pirimidin-2-il)a mino]propan-2-il]carbamato de metilo; N-[(2S)-1-[(4-{3-[2,6-difluoro-3-(propano-1-sulfonamido)fenil]-1-(propan-2-il)-1H-pirazol-4-il}pirimidin-2-il)amino ]propan-2-il]carbamato de metilo; N-[(2S)-1-{[4-(3-{2-fluoro-3-[(3,3,3-trifluoropropano)sulfonamido]fenil}-1-(propan-2-il)-1H-pirazol-4-il)pirimidin-2 -il]amino}propan-2-il]carbamato de metilo; N-[(2S)-1-[(4-{3-[2-fluoro-3-(propano-1-sulfonamido)fenil]-1-(propan-2-il)-1H-pirazol-4-il}pirimidin-2-il)amino]pr opan-2-il]carbamato de metilo; y N-[(2S)-1-({4-[3-(2-fluoro-3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)propan- 2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(5-cloro-2-fluoro-3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino) propan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(2,5-difluoro-3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)pro pan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(5-cloro-2-fluoro-3-metanosulfonamidofenil)-1-etil-1H-pirazol-4-il]pirimidin-2-il}amino)propan-2 -il]carbamato de metilo; N-[(2S)-1-({4-[3-(2-fluoro-3-metanosulfonamido-5-metilfenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino) propan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(2-cloro-3-metanosulfonamido-5-metilfenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino) propan-2-il]carbamato de metilo; N-[(2S)-1-({4-[3-(2-cloro-5-fluoro-3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino) propan-2-il]carbamato de metilo; N-[(2R)-1-({4-[3-(5-cloro-2-fluoro-3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino) propan-2-il]carbamato de metilo; y N-[(2S)-1-({4-[3-(2,5-dicloro-3-metanosulfonamidofenil)-1-(propan-2-il)-1H-pirazol-4-il]pirimidin-2-il}amino)prop an-2-il]carbamato de metilo.

45. 发明专利

NZ598924A COMPOUNDS COMPRISING PYRIMIDYL AND PYRAZOLYL MOIETIES AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：NZ598924A
公开(公告)日：2013-07-26
申请号：NZ59892410
申请日：2010-08-27
申请人： IRM LLC , NOVARTIS AG
发明人： HUANG SHENLIN , JIN XIANMING , LIU ZUOSHENG , POON DANIEL , TELLEW JOHN E
IPC分类号： A61K31/506 , C07D401/14 , A61P35/00 , C07D403/04
摘要： Disclosed are compounds of Formula (Ia), salts thereof and methods for their preparation. Specific examples of compounds of Formula (Ia) include: methyl N-[(2S)-1-({ 4-[3-(3-chloro-5-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl} amino)propan-2-yl] carbamate, methyl N-[(2S)-1-{ [4-(3-{ 2-fluoro-3-[(3,3,3-trifluoropropane)sulfonamido]phenyl} -1-(propan-2-yl)-1H-pyrazol-4-yl)pyrimidin-2-yl]amino} propan-2-yl] carbamate, N-[5-chloro-3-(4-{ 2-[(2-cyanoethyl)amino]pyrimidin-4-yl} -1-(propan-2-yl)-1H-pyrazol-3-yl)-2-fluorophenyl]methanesulfonamide, and methyl N-[(2S)-I-( { 4-[3-(S-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl} amino)propan-2-yl]carbamate. Compounds of formula Ia are useful for treating diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases of disorders that inveolve abnormal activation of B-Raf. Examples of diseases include lung carcinoma, pancreatic carcinoma, bladder carcinoma, colon carcinoma, and myeloid disorders, prostate cancer, thyroid cancer, melanoma, adenomas and carcinomas of the ovary, eye, liver, biliary tract, and nervous system.

46. 发明专利

MX2013005535A COMPUESTO DE 3- (AMINO-ARIL) -PIRIDINA. 未知
公开(公告)号：MX2013005535A
公开(公告)日：2013-07-03
申请号：MX2013005535
申请日：2011-11-17
申请人： NOVARTIS AG
发明人： SENDZIK MARTIN , BARSANTI PAUL A , PFISTER KEITH B , SUTTON JAMES , ANTONIOS-MCCREA WILLIAM R , HU CHENG , PAN YUE , WAN LIFENG , JIN XIANMING , MARTIN ERIC J
IPC分类号： C07D213/74 , A61K31/44 , A61P35/00
摘要： La presente invención proporciona un compuesto de la fórmula (I): (Ver Formula) y las sales farmacéuticamente aceptables, enantiómeros, estereoisómeros, rotámeros, tautómeros, diaestereómeros, o racematos del mismo. También se proporcionan composiciones farmacéuticas que contienen estos compuestos, y métodos para el tratamiento de una enfermedad o condición mediada por CDK9 utilizando estos compuestos y composiciones.

47. 发明专利

ZA201202020B COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：ZA201202020B
公开(公告)日：2012-12-27
申请号：ZA201202020
申请日：2012-03-19
申请人： IRM LLC , NOVARTIS AG
发明人： HUANG SHENLIN , JIN XIANMING , LIU ZUOSHENG , POON DANIEL , TELLEW JOHN , WAN YONGQIN , WANG XING , XIE YONGPING
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

48. 发明专利

AU2010286569A1 Compounds and compositions as protein kinase inhibitors 未知
公开(公告)号：AU2010286569A1
公开(公告)日：2012-04-12
申请号：AU2010286569
申请日：2010-08-27
申请人： NOVARTIS AG , IRM LLC
发明人： HUANG SHENLIN , JIN XIANMING , LIU ZUOSHENG , POON DANIEL , TELLEW JOHN E , WAN YONGQIN , WANG XING , XIE YONGPING
摘要： The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

49. 发明专利

CA2771563A1 BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES 未知
公开(公告)号：CA2771563A1
公开(公告)日：2011-03-10
申请号：CA2771563
申请日：2010-09-02
申请人： NOVARTIS AG
发明人： BARSANTI PAUL A , HU CHENG , JIN XIANMING , NG SIMON C , PFISTER KEITH B , SENDZIK MARTIN , SUTTON JAMES
IPC分类号： C07D401/04 , A61K31/444 , A61P35/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor.

50. 发明专利

CA2771775A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2771775A1
公开(公告)日：2011-03-03
申请号：CA2771775
申请日：2010-08-27
申请人： IRM LLC , NOVARTIS AG
发明人： HUANG SHENLIN , JIN XIANMING , LIU ZUOSHENG , POON DANIEL , TELLEW JOHN E , WAN YONGQIN , WANG XING , XIE YONGPING
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

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