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    • 47. 发明申请
    • USE OF HADES AS TUMOR SUPPRESSOR TARGET
    • 用作肿瘤抑制剂目标
    • US20130157959A1
    • 2013-06-20
    • US13641910
    • 2011-04-21
    • Sungkwan AnJin Hyuk JungJae Ho LeeSeunghee Bae
    • Sungkwan AnJin Hyuk JungJae Ho LeeSeunghee Bae
    • A61K38/17
    • A61K38/17A61K38/53C07K16/18
    • The present invention relates to a new use of Hades as a tumor suppressor target, more particularly to a composition for suppressing tumor comprising an expression or action inhibitor of Hades protein having an amino acid sequence of SEQ ID NO: 2 as an effective ingredient. The present inventors have found that the overexpressed Hades protein interacts with p53 to inhibit the exonuclear mechanism of p53 and the knowdown of Hades induces increase in the expression of p53, demonstrating that Hades is a negative regulator to p53. Therefore, it would be understood that the inhibition of Hades overexpressed in tumor cells contributes to tumor-supressive effects of p53. The drug candidates capable of modulating the expression of the Hades protein, inhibiting the actions of the Hades protein or inhibiting interecation between Hades and p53 are considered a promising anticancer drug.
    • 本发明涉及Hades作为肿瘤抑制靶的新用途,更具体地,涉及具有SEQ ID NO:2的氨基酸序列的Hades蛋白的表达或抑制剂作为有效成分的抑制肿瘤的组合物。 本发明人已经发现,过表达的Hades蛋白与p53相互作用以抑制p53的外核机制,并且Hades的知识诱导p53表达增加,表明Hades是p53的负调节因子。 因此,应当理解,在肿瘤细胞中过表达的Hades的抑制有助于p53的肿瘤抑制作用。 能够调节Hades蛋白表达,抑制Hades蛋白的作用或抑制Hades和p53之间的相互作用的候选药物被认为是有希望的抗癌药物。
    • 48. 发明申请
    • APPARATUS FOR CODE OBFUSCATION AND METHOD THEREOF
    • 用于代码障碍的装置及其方法
    • US20150095656A1
    • 2015-04-02
    • US14360306
    • 2013-09-30
    • Jeong Hyun YiJin Hyuk Jung
    • Jeong Hyun YiJin Hyuk Jung
    • G06F21/14
    • G06F21/14G06F21/125G06F2221/0748
    • Disclosed is an apparatus for code obfuscation includes: an input unit that receives execution codes for android applications; a code analyzer that separates the input execution codes into sensitive codes that needs to be protected from application forgery attack and general codes except for the sensitive codes by analyzing the input execution codes; a dalvik to C code converter that creates native codes by converting the sensitive codes into a C code; an obfuscator that obfuscates the native codes and the general codes; a self code protector that encrypts the obfuscated native codes by adding a tamper-detection code to the obfuscated native codes and then creates self-modified native codes by adding a loading routine; and a code combiner that combines the self-modified native codes with the obfuscated general codes.
    • 公开了一种用于代码混淆的装置,包括:输入单元,其接收Android应用的执行代码; 代码分析器,通过分析输入执行代码,将输入执行代码分离成敏感代码,需要保护免受应用程序伪造攻击和通用代码;敏感代码除外; 通过将敏感代码转换为C代码来创建本地代码的dalvik到C代码转换器; 一个混淆本地代码和一般代码的混淆器; 一个自编码保护器,通过向模糊的本机代码添加篡改检测码,然后通过添加加载例程来创建自修改的本地代码来加密混淆的本机代码; 以及将自修改的本地代码与模糊的一般代码组合的代码组合器。