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    • 41. 发明授权
    • Method of resolving optical isomers of amino acid derivative
    • 拆分氨基酸衍生物的光学异构体的方法
    • US07199264B2
    • 2007-04-03
    • US10415559
    • 2001-10-25
    • Shin WatanabeMizue Kawahara
    • Shin WatanabeMizue Kawahara
    • C07B55/00
    • C07C269/08C07B2200/07C07C231/20C07C319/28C07D207/16C07C233/83C07C271/22C07C323/58C07C323/59
    • Provided is a separating method for an optical isomer mixture comprising the steps of mixing an amino acid derivative such as N-(tert-butoxycarbonyl)-DL-alanine in which optical isomers of a D type and an L type are present in a mixture with a hydrophilic compound such as β-cyclodextrin having a different affinity to two kinds of the optical isomers described above and then bringing the resulting aqueous solution or aqueous suspension into contact with a hydrophobic substance such as a solid matter subjected on a surface thereof to hydrophobic treatment on the condition that the pH is 3.5 or lower or under the coexistence of ions including an atomic group having hydrophobicity which can be a counter ion for the amino acid derivative described above such as a triethylammonium ion to thereby separate the D type amino acid derivative from the L type amino acid derivative present in the above aqueous solution or aqueous suspension.
    • 本发明提供了一种旋光异构体混合物的分离方法,包括将混合物中存在D型和L型光学异构体的氨基酸衍生物如N-(叔丁氧羰基)-DL-丙氨酸混合物混合物 对上述两种旋光异构体具有不同亲和性的亲水性化合物如β-环糊精,然后将所得水溶液或水悬浮液与其表面经受的固体物质等疏水性物质接触,进行疏水处理 在pH为3.5以下或者含有具有疏水性的原子团的离子共存的情况下,其可以是上述氨基酸衍生物的反离子,例如三乙基铵离子,从而将D型氨基酸衍生物从 存在于上述水溶液或水性悬浮液中的L型氨基酸衍生物。