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41. 发明授权

US06524813B1 Polynucleotide encoding spo0J1 of Staphylococcus aureus 失效
标题翻译：编码金黄色葡萄球菌spo0J1的多核苷酸
公开(公告)号：US06524813B1
公开(公告)日：2003-02-25
申请号：US09040796
申请日：1998-03-18
申请人： Martin Karl Russel Burnham , Andrew Fosberry , John Hodgson , Deborah Jaworski , Elizabeth Lawlor , Martin Rosenberg , Lisa Kathleen Shilling , Min Wang , Judith Ward
发明人： Martin Karl Russel Burnham , Andrew Fosberry , John Hodgson , Deborah Jaworski , Elizabeth Lawlor , Martin Rosenberg , Lisa Kathleen Shilling , Min Wang , Judith Ward
IPC分类号： C12N1531
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： The invention provides spo0J1 polypeptides and polynucleotides encoding spo0J1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo0J1 polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了spo0J1多肽和编码spo0J1多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用spo0J1多肽筛选抗菌化合物的方法。

42. 发明授权

US06346608B1 MecB 失效
公开(公告)号：US06346608B1
公开(公告)日：2002-02-12
申请号：US09621855
申请日：2000-07-24
申请人： Martin Karl Russel Burnham , Andrew Fosberry , John Hodgson , Deborah Jaworski , Elizabeth Lawlor , Martin Rosenberg , Lisa Kathleen Shilling , Min Wang , Judith Ward
发明人： Martin Karl Russel Burnham , Andrew Fosberry , John Hodgson , Deborah Jaworski , Elizabeth Lawlor , Martin Rosenberg , Lisa Kathleen Shilling , Min Wang , Judith Ward
IPC分类号： C07K100
CPC分类号： C12N9/14 , A61K38/00 , A61K48/00 , Y10S530/82 , Y10S530/825
摘要： The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mecB polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了mecB多肽和编码mecB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用mecB多肽筛选抗菌化合物的方法。

43. 发明授权

US6124119A mecB 失效
公开(公告)号：US6124119A
公开(公告)日：2000-09-26
申请号：US40843
申请日：1998-03-18
申请人： Deborah Jaworski , Elizabeth Lawlor , Martin Rosenberg , Lisa Kathleen Shilling , Min Wang , Judith Ward , Martin Karl Russel Burnham , Andrew Fosberry , John Hodgson
发明人： Deborah Jaworski , Elizabeth Lawlor , Martin Rosenberg , Lisa Kathleen Shilling , Min Wang , Judith Ward , Martin Karl Russel Burnham , Andrew Fosberry , John Hodgson
IPC分类号： G01N33/50 , A61K31/00 , A61K35/76 , A61K38/00 , A61K38/45 , A61K38/46 , A61K39/085 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P9/00 , A61P11/00 , A61P13/00 , A61P13/02 , A61P13/12 , A61P17/00 , A61P19/00 , A61P19/02 , A61P27/00 , A61P27/02 , A61P31/00 , A61P31/04 , C07K14/195 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N9/16 , C12N15/00 , C12N15/09 , C12N15/55 , C12Q1/42 , C12Q1/68 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/569 , G01N33/68 , C12P21/06 , C07H21/04 , C12N1/20 , C12N5/00
CPC分类号： C12N9/14 , A61K38/00 , A61K48/00 , Y10S530/82 , Y10S530/825
摘要： The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mecB polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了mecB多肽和编码mecB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用mecB多肽筛选抗菌化合物的方法。

44. 发明授权

US5681713A Expression of heterologous proteins in Drosophila cells 失效
标题翻译：异源蛋白在果蝇细胞中的表达
公开(公告)号：US5681713A
公开(公告)日：1997-10-28
申请号：US98016
申请日：1993-07-27
申请人： Hanne Ranch Johansen , Ariane Adrienne Van Der Straten-Ponthoz , Martin Rosenberg
发明人： Hanne Ranch Johansen , Ariane Adrienne Van Der Straten-Ponthoz , Martin Rosenberg
IPC分类号： A61K39/00 , C07K14/16 , C07K16/10 , C12N9/72 , C12N15/85 , C12N15/10 , C12N15/65 , C12N15/79 , C12N15/90
CPC分类号： C07K14/005 , C07K16/1063 , C12N15/85 , C12N9/6459 , C12Y304/21069 , A61K39/00 , C12N2740/16122 , C12N2800/90 , C12N2830/002 , C12N2830/75 , C12N2830/80
摘要： The present invention provides a novel method for expression of high levels of heterologous proteins in Drosophila cells.
摘要翻译：本发明提供了一种在果蝇细胞中表达高水平异源蛋白质的新方法。

45. 发明授权

US6046025A Expression of heterologous proteins in drosophila cells 失效
标题翻译：异源蛋白在果蝇细胞中的表达
公开(公告)号：US6046025A
公开(公告)日：2000-04-04
申请号：US433293
申请日：1995-05-03
申请人： Hanne Ranch Johansen , Ariane Adrienne Van Der Straten-Ponthoz , Martin Rosenberg
发明人： Hanne Ranch Johansen , Ariane Adrienne Van Der Straten-Ponthoz , Martin Rosenberg
IPC分类号： A61K39/00 , C07K14/16 , C07K16/10 , C12N9/72 , C12N15/85 , C12N15/10 , C12N5/10 , C12N15/64 , C12N15/67
CPC分类号： C07K14/005 , C07K16/1063 , C12N15/85 , C12N9/6459 , C12Y304/21069 , A61K39/00 , C12N2740/16122 , C12N2800/90 , C12N2830/002 , C12N2830/75 , C12N2830/80
摘要： The present invention provides a novel method for expression of high levels of heterologous proteins in Drosophila cells.
摘要翻译：本发明提供了一种在果蝇细胞中表达高水平异源蛋白质的新方法。

46. 发明授权

US5705359A Expression of heterologous proteins in drosophila cells 失效
标题翻译：异源蛋白在果蝇细胞中的表达
公开(公告)号：US5705359A
公开(公告)日：1998-01-06
申请号：US434095
申请日：1995-05-03
申请人： Hanne Ranch Johansen , Ariane Adrienne Van Der Straten-Ponthoz , Martin Rosenberg
发明人： Hanne Ranch Johansen , Ariane Adrienne Van Der Straten-Ponthoz , Martin Rosenberg
IPC分类号： A61K39/00 , C07K14/16 , C07K16/10 , C12N9/72 , C12N15/85 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/06
CPC分类号： C07K14/005 , C07K16/1063 , C12N15/85 , C12N9/6459 , C12Y304/21069 , A61K39/00 , C12N2740/16122 , C12N2800/90 , C12N2830/002 , C12N2830/75 , C12N2830/80
摘要： The present invention provides a method for the expression of heterologous genes, under the control of a Drosophila metollothionein promoter, inserted at high copy number into Drosophila melanogaster cells.
摘要翻译：本发明提供了一种在以高拷贝数插入果蝇黑素瘤细胞中的在果蝇控制的异源基因表达的方法。

47. 发明授权

US4925799A Plasmid cloning vector pAS1 失效
标题翻译：质粒克隆载体pAS1
公开(公告)号：US4925799A
公开(公告)日：1990-05-15
申请号：US819406
申请日：1986-01-16
申请人： Martin Rosenberg
发明人： Martin Rosenberg
IPC分类号： C12N15/73
CPC分类号： C12N15/73
摘要： A plasmid cloning vector containing both transcriptional and translational regulatory sequences derived from the bacteriophage lambda genome was constructed to achieve high level expression of prokaryotic and eukaryotic genes. The system utilizes a plasmid vehicle carrying the strong, regulatable lambda promoter, P.sub.L, and host lysogens into which this vector can be stabily transformed. The lysogen synthesizes sufficient repressor (cI) to control P.sub.L expression and thereby stabilize plasmids which carry such a highly efficient promoter. Use of a temperature sensitive repressor permits simple, rapid induction of P.sub.L transcripts at any given time. Efficient transcription of essentially any coding sequence is assured by providing the phage lambda antitermination factor, N, and a site on the transcription unit for its utilization (Nut site). This pAS1 plasmic closely resembles the earlier constructed pKC30cII, also a regulatory protein which activates promoters for lysogenic development.
摘要翻译：构建含有衍生自噬菌体λ基因组的转录和翻译调控序列的质粒克隆载体，以实现原核和真核基因的高水平表达。该系统使用携带强的可调节的λ启动子，PL和宿主溶菌体的质粒载体，其中该载体可以稳定地转化到其中。溶菌酶合成足够的阻遏物（cI）以控制PL表达，从而稳定携带这种高效启动子的质粒。使用温度敏感的阻遏物允许在任何给定时间内简单，快速地诱导PL成誊本。通过提供噬菌体λ抗突变因子N和转录单位上用于其利用的位点（Nut位点）来确保基本上任何编码序列的有效转录。该pAS1等位基因非常类似于早期构建的pKC30cII，也是一种调节蛋白，其激活用于溶原性发育的启动子。

48. 发明授权

US4637980A Externalization of products of bacteria 失效
标题翻译：细菌产品外化
公开(公告)号：US4637980A
公开(公告)日：1987-01-20
申请号：US521517
申请日：1983-08-09
申请人： Jeffrey I. Auerbach , Martin Rosenberg
发明人： Jeffrey I. Auerbach , Martin Rosenberg
IPC分类号： C12N1/21 , A61K9/50 , A61K35/12 , A61K35/74 , C12N1/06 , C12N1/20 , C12N9/36 , C12N15/00 , C12N15/09 , C12N15/67 , C12N15/73 , C12P1/04 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , C07H15/12 , C12N1/00
CPC分类号： C12N9/2462 , A61K9/5068 , C12N1/06 , C12N15/67 , C12N15/73
摘要： A bacterial product is made by transforming a temperature sensitive lysogen with a DNA molecule which codes, directly or indirectly, for the product, culturing the transformant under permissive conditions and externalizing the product by raising the temperature to induce phage encoded functions.
摘要翻译：通过用直接或间接编码产物的DNA分子转化温度敏感的溶菌素制备细菌产物，在允许的条件下培养转化体并通过升高温度使产物外化以诱导噬菌体编码的功能。

49. 发明申请

US20080076709A1 Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US20080076709A1
公开(公告)日：2008-03-27
申请号：US11698250
申请日：2007-01-25
申请人： Michael Black , Martin Burnham , Jason Fedon , John Hodgson , David Knowles , Michael Lonetto , Richard Nicholas , Leslie Palmer , Julie Pratt , Raymond Reichard , Martin Rosenberg , Christopher Traini , Judith Ward , Richard Warren
发明人： Michael Black , Martin Burnham , Jason Fedon , John Hodgson , David Knowles , Michael Lonetto , Richard Nicholas , Leslie Palmer , Julie Pratt , Raymond Reichard , Martin Rosenberg , Christopher Traini , Judith Ward , Richard Warren
IPC分类号： A61K38/16 , A61P31/00 , C07K14/00
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译：本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。

50. 发明申请

US20060258573A1 Peptide anti-tumor agent 有权
标题翻译：肽抗肿瘤剂
公开(公告)号：US20060258573A1
公开(公告)日：2006-11-16
申请号：US11264684
申请日：2005-10-31
申请人： Martin Rosenberg
发明人： Martin Rosenberg
IPC分类号： A61K38/12 , A61K38/10
CPC分类号： C07K7/06 , A61K38/00 , C07K7/64
摘要： Disclosed herein are isolated, purified peptides, biologically active fragments and analogs of the peptides having anti-tumor activity in mammals, pharmaceutical formulations comprising the peptides, fragments and analogs and methods of treating mammals suffering from tumors using such materials.
摘要翻译：本文公开了分离的，纯化的肽，在哺乳动物中具有抗肿瘤活性的肽的生物活性片段和类似物，包含肽，片段和类似物的药物制剂以及使用这种材料治疗患有肿瘤的哺乳动物的方法。

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