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41. 发明公开

EP3381045A1 IMPROVED ION MIRROR AND ION-OPTICAL LENS FOR IMAGING 审中-实审
公开(公告)号：EP3381045A1
公开(公告)日：2018-10-03
申请号：EP16869126.9
申请日：2016-11-21
申请人： Micromass UK Limited , Leco Corporation
发明人： HOYES, John Brian , VERENCHIKOV, Anatoly , YAVOR, Mikhail , RICHARDSON, Keith
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/063 , H01J49/067 , H01J49/068 , H01J49/08
摘要： An ion mirror is disclosed comprising an ion entrance electrode section (62) at the ion entrance to the ion mirror, an energy focussing electrode section (66) for reflecting ions back along a longitudinal axis towards said ion entrance, and a spatial focussing electrode section (64) arranged between the ion entrance electrode section (62) and the energy focussing electrode section (66) for spatially focussing the ions. One or more DC voltage supply is provided to apply a DC potential to the ion entrance electrode section (62) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the energy focussing electrode section (66). The ion mirror further comprises: (i) at least one first transition electrode (68) arranged between said ion entrance electrode section (62) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one first transition electrode that is intermediate the DC potential applied to the ion entrance electrode section (62) and the DC potential applied to the spatial focussing electrode section (64); and (ii) at least one second transition electrode (69) arranged between said energy focussing electrode section (66) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one second transition electrode (69) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the ion entrance electrode section (62).

42. 发明公开

EP3082151A1 MASS DETERMINATION USING ION MOBILITY MEASUREMENTS 有权
标题翻译： MASSENBESTIMMUNG MITIONENMOBILITÄTSMESSUNGEN
公开(公告)号：EP3082151A1
公开(公告)日：2016-10-19
申请号：EP16165255.7
申请日：2016-04-14
申请人： Micromass UK Limited
发明人： RICHARDSON, Keith , HOYES, John Brian
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： G01N27/622 , H01J49/004
摘要： A method of mass spectrometry is disclosed comprising: providing an algorithm or relationship that relates the ion mobilities of an analyte ion through three gases of different polarizability to the mass of the analyte ion; measuring the ion mobilities of an analyte ion through first, second and third different drift gases; and using the measured ion mobilities and said algorithm or relationship to determine the mass of the analyte ion. Embodiments of the invention enable the mass of an analyte to be determined without having to know the specific properties of the analyte ion.
摘要翻译：公开了一种质谱方法，其包括：提供将分析物离子的离子迁移率通过三种不同极化性的气体与分析物离子的质量相关联的算法或关系; 测量分析物离子通过第一，第二和第三不同漂移气体的离子迁移率; 并使用测量的离子迁移率和所述算法或关系来确定分析物离子的质量。本发明的实施方案能够确定分析物的质量，而不必知道分析物离子的特定性质。

43. 发明公开

EP3007203A1 MULTIPLE CHANNEL DETECTION FOR TIME OF FLIGHT MASS SPECTROMETER 有权
标题翻译： MEHRKANALIGE ERKENNUNGFÜREIN FLUGZEITMASSENSPEKTROMETER
公开(公告)号：EP3007203A1
公开(公告)日：2016-04-13
申请号：EP15191158.3
申请日：2012-09-28
申请人： Micromass UK Limited
发明人： HOYES, John Brian , GILBERT, Anthony James , SUYAMA, Motohiro
IPC分类号： H01J49/40 , H01J49/02
CPC分类号： H01J49/025 , H01J49/0031 , H01J49/40
摘要： An ion detector for a Time of Flight mass spectrometer is disclosed comprising a single Microchannel Plate 1 which is arranged to receive ions 2 and output electrons 3. The electrons 3 are directed onto a scintillator 9 and onto an array of photodiodes 4 which detects photons 11 generated from the electrons 3. The output from each photodiode 4 is connected to a separate Time to Digital Converter provided on an ASIC 5.
摘要翻译：公开了一种用于飞行时间质谱仪的离子检测器，其包括单个微通道板1，其被布置成接收离子2并输出电子3.电子3被引导到闪烁体9上并且被发射到检测光子11的光电二极管阵列4上从电子3产生。来自每个光电二极管4的输出连接到ASIC5上提供的单独的时间到数字转换器。

44. 发明公开

EP2989454A1 IMPROVED ION MOBILITY SPECTROMETER 有权
标题翻译：改进的离子迁移谱仪
公开(公告)号：EP2989454A1
公开(公告)日：2016-03-02
申请号：EP14718718.1
申请日：2014-04-17
申请人： Micromass UK Limited
发明人： GILES, Kevin , GREEN, Martin Raymond , HOYES, John Brian , PRINGLE, Steven Derek , WILDGOOSE, Jason Lee
IPC分类号： G01N27/62
摘要： A method of analysing ions by ion mobility separation is disclosed. The method comprises controlling the amount of charge within an ion trap (3) and then pulsing the ions from the ion trap (3) into an ion mobility separator (5). This enables the charge injected into the ion mobility separator (5) to be controlled and hence prevents space-charge interactions between the ions from distorting the ion mobility peaks detected by the detector (7).

45. 发明公开

EP2850647A2 ORTHOGONAL ACCELERATION COAXIAL CYLINDER TIME OF FLIGHT MASS ANALYSER 有权
标题翻译： KOAXIALZYLINDER-FLUGZEITMASSENANALYSATOR DER ORTHOGONALEN BESCHLEUNIGUNG
公开(公告)号：EP2850647A2
公开(公告)日：2015-03-25
申请号：EP13724351.5
申请日：2013-05-16
申请人： Micromass UK Limited
发明人： HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/40
摘要： A Time of Flight mass analyzer is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. An ion detector is disposed within the annular ion guide. Ions are orthogonally accelerated in a first axial direction from the first annular ion guide section into the second annular ion guide section. An axial DC potential is maintained along at least a portion of the second annular ion guide section so that the ions are reflected in a second axial direction which is substantially opposed to the first axial direction. The ions undergo multiple axial passes through the second annular ion guide section before being detected by the ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括具有纵向轴线的环形离子引导件，并且包括第一环形离子引导部分和第二环形离子引导部分。离子被引入到第一环形离子引导部分中，使得离子在第一环形离子引导部分内围绕纵向轴线形成基本上稳定的圆周轨道。离子检测器设置在环形离子导向器内。离子在从第一环形离子引导部分到第二环形离子引导部分的第一轴向方向上正交加速。沿着第二环形离子引导部分的至少一部分保持轴向DC电位，使得离子在基本上与第一轴向方向相对的第二轴向反射。在被离子检测器检测到之前，离子经过多个轴向通过第二环形离子引导部分。

46. 发明公开

EP2686870A1 ELECTROSTATIC GIMBAL FOR CORRECTION OF ERRORS IN TIME OF FLIGHT MASS SPECTROMETERS 有权转让
标题翻译： ELEKTROSTATISCHE KARDANISCHE FEHLERKORREKTUR BEI TOF-MASSENSPEKTROMETERN
公开(公告)号：EP2686870A1
公开(公告)日：2014-01-22
申请号：EP12715713.9
申请日：2012-03-13
申请人： Micromass UK Limited
发明人： HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： Electrostatic means for correcting misalignments of optics within a time of flight mass spectrometer A Time of Flight mass analyser is disclosed comprising one or more electrostatic devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括布置并适于校正离子等时平面中的倾斜的一个或多个装置，并且在离子检测器中调整离子的等时平面以与检测平面平行。

47. 发明授权

EP0970504B1 TIME OF FLIGHT MASS SPECTROMETER AND DUAL GAIN DETECTOR THEREFOR 有权
标题翻译：飞行质谱仪和双倍的增益探测器THEREFOR
公开(公告)号：EP0970504B1
公开(公告)日：2004-11-17
申请号：EP99902664.4
申请日：1999-01-25
申请人： Micromass UK Limited
发明人： BATEMAN, Robert Harold , GILBERT, Anthony James , MERREN, Thomas Oliver , HOYES, John Brian , COTTRELL, Jonathan Charles
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/40
摘要： An ion detector (27) for use in a time-of-flight mass spectrometer (1) is disclosed. The ion detector (27), which has an extended dynamic range, comprises at least one microchannel plate electron multiplier (42, 32) together with first and second collection electrodes (36, 38; 39). The second collection electrode (36, 38) is arranged such that in receives more electrons per ion entering the ion detector (27) than the first collection electrode (39). In one embodiment the collection electrodes (36, 38; 39) are formed in an array consisting of a larger plate-like collection electrode (36, 38) and a smaller plate-like collection electrode (39). In an alternative embodiment a second microchannel plate electron multiplier is arranged between the first collection electrode (46) and the second collection electrode (47). In this embodiment the first collection electrode consists either of a grid electrode (42) or more preferably of a wire electrode, and the second collection electrode consists of a plate-like electrode (43).

48. 发明授权

EP3289602B1 MULTI-REFLECTING TOF MASS SPECTROMETER 有权
公开(公告)号：EP3289602B1
公开(公告)日：2020-07-29
申请号：EP16720534.3
申请日：2016-04-29
申请人： Micromass UK Limited , Leco Corporation
发明人： HOYES, John Brian , RICHARDSON, Keith , VERENCHIKOV, Anatoly , YAVOR, Mikhail
IPC分类号： H01J49/40 , H01J49/06

49. 发明授权

EP2850648B1 ORTHOGONAL ACCELERATION COAXIAL CYLINDER TIME OF FLIGHT MASS ANALYSER 有权
公开(公告)号：EP2850648B1
公开(公告)日：2020-03-18
申请号：EP13724352.3
申请日：2013-05-16
申请人： Micromass UK Limited
发明人： HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/40
摘要： A Time of Flight mass analyzer is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. An ion detector is disposed within the annular ion guide. Ions are orthogonally accelerated in a first axial direction from the first annular ion guide section into the second annular ion guide section. An axial DC potential is maintained along at least a portion of the second annular ion guide section so that the ions are reflected in a second axial direction which is substantially opposed to the first axial direction. The ions undergo multiple axial passes through the second annular ion guide section before being detected by the ion detector.

50. 发明公开

EP3378090A1 IMAGING MASS SPECTROMETER 审中-实审
公开(公告)号：EP3378090A1
公开(公告)日：2018-09-26
申请号：EP16866997.6
申请日：2016-11-16
申请人： Micromass UK Limited , Leco Corporation
发明人： HOYES, John Brian , VERENCHIKOV, Anatoly , YAVOR, Mikhail , RICHARDSON, Keith , WILDGOOSE, Jason
IPC分类号： H01J49/40
CPC分类号： H01J49/405 , H01J49/0004 , H01J49/062 , H01J49/067 , H01J49/10 , H01J49/406
摘要： A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.

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