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41. 发明授权

US09508537B2 Photo-dissociation of proteins and peptides in a mass spectrometer 有权
标题翻译：蛋白质和肽在质谱仪中的光解离
公开(公告)号：US09508537B2
公开(公告)日：2016-11-29
申请号：US14130440
申请日：2012-07-06
申请人： Jeffery Mark Brown , Kevin Giles , Daniel James Kenny , Paul Murray , Keith Richardson
发明人： Jeffery Mark Brown , Kevin Giles , Daniel James Kenny , Paul Murray , Keith Richardson
IPC分类号： H01J49/06 , H01J49/42 , H01J49/00 , H01J49/10 , H01J49/26 , H01J49/40
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analyzed using a Time of Flight mass analyzer.
摘要翻译：公开了一种质谱方法，其包括将来自激光器的第一光子引导到位于2D或线性离子导向器或离子阱内的离子上。扫描第一光子的频率，并检测由离子发射的第一光子和/或第二光子。然后使用飞行时间质量分析仪对离子进行质量分析。

42. 发明授权

US09190256B2 MALDI imaging and ion source 有权
标题翻译： MALDI成像和离子源
公开(公告)号：US09190256B2
公开(公告)日：2015-11-17
申请号：US14130453
申请日：2012-07-06
申请人： Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/26 , H01J49/16 , H01J49/00 , H01J49/04 , H01J49/06
CPC分类号： H01J49/062 , H01J49/0004 , H01J49/0463 , H01J49/065 , H01J49/164 , H01J49/26
摘要： An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.
摘要翻译：公开了一种用于质谱仪的离子源，其包括将激光束聚焦到目标衬底的上表面上的透镜和反射镜装置。镜头具有有效的焦距＆nlE; 300 mm。激光束以一定角度被引导到靶基底上; 相对于与靶基板的垂直度，其中＆amp; nlE; 3°。一个或多个离子导向器接收从目标衬底释放的离子，并沿基本上绕过透镜和反射镜的离子路径向上透射离子。

43. 发明申请

US20150090873A1 Method of Single Point Internal Lock-Mobility Correction 有权
标题翻译：单点内锁移动校正方法
公开(公告)号：US20150090873A1
公开(公告)日：2015-04-02
申请号：US14123532
申请日：2012-06-01
申请人： Jeffery Mark Brown , Kevin Giles
发明人： Jeffery Mark Brown , Kevin Giles
IPC分类号： H01J49/00 , H01J49/26 , G01N27/62
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/26
摘要： A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions.
摘要翻译：公开了一种质谱法，其包括使离子通过离子迁移谱仪并获得第一离子迁移率漂移时间数据。将校准功能应用于第一离子迁移率漂移时间数据以确定离子的物理化学性质（例如CCS）。然后获取第二离子迁移率漂移时间数据，并且将校准功能应用于第二离子迁移率漂移时间数据，以确定一种或多种已知或参考离子的物理化学性质。

44. 发明申请

US20140224974A1 Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer 有权
标题翻译：蛋白质和肽在质谱仪中的光解离
公开(公告)号：US20140224974A1
公开(公告)日：2014-08-14
申请号：US14130428
申请日：2012-07-06
申请人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
发明人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.
摘要翻译：公开了一种自动重复执行多个操作循环的质谱法，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将第一离子暴露于第一光离解装置以形成多个第二离子并质量分析第二离子; 和（iii）将第一离子暴露于第一光解离装置以形成多个第二离子，使第二离子碎裂以形成多个第三离子并大量分析第三离子。

45. 发明授权

US08624179B2 Method of charge reduction of electron transfer dissociation product ions 有权
标题翻译：电子转移离解产物离子的电荷还原方法
公开(公告)号：US08624179B2
公开(公告)日：2014-01-07
申请号：US12995778
申请日：2009-06-05
申请人： Weibin Chen , Asish B. Chakraborty , John Charles Gebler , Jeffery Mark Brown
发明人： Weibin Chen , Asish B. Chakraborty , John Charles Gebler , Jeffery Mark Brown
IPC分类号： B01D59/44
CPC分类号： H01J49/0095 , H01J49/0072 , H01J49/062 , H01J49/165 , H01J49/26 , H01J49/36
摘要： A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
摘要翻译：公开了一种质谱仪，其中通过使碎片离子与诸如八氢嘧啶并氮杂吖庚因的中性超碱原料气体反应，母体离子的电子转移离解断裂产生的高电荷碎片离子在质子转移反应池35内在电荷状态下降低。

46. 发明授权

US07863557B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07863557B2
公开(公告)日：2011-01-04
申请号：US12282394
申请日：2007-03-14
申请人： Jeffery Mark Brown
发明人： Jeffery Mark Brown
IPC分类号： H01J49/42 , H01J49/22
CPC分类号： H01J49/408
摘要： A multi-turn Time of Plight mass analyzer is disclosed comprising a first electric sector (5) and a second electric sector (8). The second electric sector (8) is arranged orthogonal to the first electric sector (5). Ions may make multiple loops or circuits of the mass analyzer before being detected and mass analyzed enabling a high resolution mass analyzer to be provided. According to another embodiment the mass analyzer may have an open-loop geometry wherein the first electric sector is elongated and further electric sectors are arranged in a staggered manner along the length of the first electric sector. The first and second electric sectors (5,8) may be sub-divided into a plurality of electric sector segments.
摘要翻译：公开了一种多回合时间质量分析器，其包括第一电扇区（5）和第二电扇区（8）。第二电扇区（8）布置成与第一电扇区（5）正交。在检测到质子分析仪之前，离子可能会产生多个回路或质量分析器，并进行质量分析，以提供高分辨率质量分析仪。根据另一个实施例，质量分析器可以具有开环几何形状，其中第一电气部分是细长的，并且进一步的电扇区沿着第一电气部分的长度以交错的方式布置。第一和第二电扇区（5,8）可以被细分成多个电扇区段。

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