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41. 发明申请

US20130053918A1 LEFT-VENTRICULAR PACING SITE SELECTION GUIDED BY ELECTROGRAM MORPHOLOGY ANALYSIS 审中-公开
标题翻译：电子形态分析指导的左心室选择选择
公开(公告)号：US20130053918A1
公开(公告)日：2013-02-28
申请号：US13598815
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device system and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A control unit is operatively coupled with a plurality of electrodes for controlling the delivery of the pacing pulses, and a sensing module senses a cardiac signal generated in response to the delivered pacing pulses. A processor is configured to deliver a first pacing pulse at a first timing interval to a first pacing site, determine the cardiac signal sensed in response to the delivered first pacing pulse and determine a first morphology corresponding to the determined sensed cardiac signal, compare the first morphology to a threshold morphology and adjust the first timing interval to a second timing interval different from the first timing interval in response to the comparing, and determine the optimal pacing site in response to the adjusting.
摘要翻译：医疗器械系统和相关方法对候选起搏电极部位进行分类，以将起搏脉冲输送到患者的心脏。控制单元与多个电极可操作地耦合，用于控制起搏脉冲的传送，并且感测模块感测响应于所输送的起搏脉冲而产生的心脏信号。处理器被配置为以第一定时间隔将第一起搏脉冲传送到第一起搏位置，确定响应于所传送的第一起搏脉冲而感测的心脏信号，并且确定对应于所确定的感测到的心脏信号的第一形态，比较第一起搏脉冲形态到阈值形态，并且响应于比较将第一定时间隔调整到与第一定时间隔不同的第二定时间隔，并且响应于调整确定最佳起搏位置。

42. 发明申请

US20130030492A1 METHOD FOR DISCRIMINATING ANODAL AND CATHODAL CAPTURE 有权
标题翻译：用于分析阳极和阴极捕获的方法
公开(公告)号：US20130030492A1
公开(公告)日：2013-01-31
申请号：US13192713
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译：可植入装置和相关方法在电刺激期间检测阳极捕获。使用第一阴极和第一阳极传送第一起搏脉冲。使用第一阴极和第二阳极传送第二起搏脉冲。测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。

43. 发明申请

US20130030491A1 METHOD FOR DISCRIMINATING ANODAL AND CATHODAL CAPTURE 有权
标题翻译：用于分析阳极和阴极捕获的方法
公开(公告)号：US20130030491A1
公开(公告)日：2013-01-31
申请号：US13192697
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade W. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade W. Demmer
IPC分类号： A61N1/362
CPC分类号： A61N1/3712
摘要： An implantable device and associated method discriminate between cathodal and anodal capture during electrical stimulation. A control response to a pacing pulse delivered using a candidate cathode electrode and a universal anode and responses to bipolar pacing pulses delivered using candidate bipoles including the candidate cathode are measured. Responsive to the control response meeting a threshold response, the control response is classified as normal and each of the responses for the candidate bipoles are compared to the control response. The responses for the candidate bipoles are each classified based on the comparison.
摘要翻译：可植入装置和相关方法在电刺激期间区分阴极和阳极捕获。测量使用候选阴极电极和通用阳极传送的起搏脉冲的控制响应以及使用包括候选阴极的候选双极传送的双极起搏脉冲的响应。响应于满足阈值响应的控制响应，将控制响应分类为正常，并将候选双极的每个响应与控制响应进行比较。根据比较对候选双极的响应进行分类。

44. 发明授权

US08145307B2 Method and apparatus for enhancing treatable arrhythmia detection specificity by using accumulated patient activity 有权
标题翻译：通过使用积累的患者活动来增强可治疗心律失常检测特异性的方法和装置
公开(公告)号：US08145307B2
公开(公告)日：2012-03-27
申请号：US12869180
申请日：2010-08-26
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
IPC分类号： A61N1/365
CPC分类号： A61B5/1118 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61N1/36542 , A61N1/3962
摘要： A method and apparatus for detecting a cardiac event in a medical device determine an activity level count from an activity sensor signal for each of a number of time segments, store an activity level count for each of the time segments in a histogram, and accumulate the stored activity level counts to determine a percentage of time segments having an activity level count above a given activity level count.
摘要翻译：用于检测医疗装置中的心脏事件的方法和装置根据多个时间段中的每一个的活动传感器信号确定活动水平计数，将每个时间段的活动水平计数存储在直方图中，并且累积存储的活动级别计数以确定具有高于给定活动级别计数的活动级别计数的时间段的百分比。

45. 发明申请

US20110270333A1 METHOD OF DUAL EGM SENSING AND HEART RATE ESTIMATION IN IMPLANTED CARDIAC DEVICES 有权
标题翻译：方法在双眼球感知和心率估计在植入心脏器械
公开(公告)号：US20110270333A1
公开(公告)日：2011-11-03
申请号：US13080807
申请日：2011-04-06
申请人： Robert W. Stadler , Carissa Lynn Bellardine Black
发明人： Robert W. Stadler , Carissa Lynn Bellardine Black
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61B5/04525 , A61B5/02438 , A61B5/0464 , A61B5/686 , A61B5/7203 , A61N1/3622 , A61N1/3962
摘要： A method and apparatus for monitoring a patient's heart rate sense first cardiac events in a heart chamber using a first cardiac electrode pair and sense second cardiac events in the heart chamber using a second cardiac electrode pair. The method includes estimating a first heart rate using the first cardiac events, comparing the first heart rate to a heart rate threshold and estimating a second heart rate using the second cardiac events in response to the first heart rate exceeding the heart rate threshold.
摘要翻译：用于监测患者心率的方法和装置使用第一心脏电极对感测心室中的第一心脏事件，并使用第二心电极对感测心室中的第二心脏事件。该方法包括使用第一心脏事件估计第一心率，将第一心率与心率阈值进行比较，并且响应于超过心率阈值的第一心率估计使用第二心脏事件的第二心率。

46. 发明申请

US20110270110A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 有权
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：US20110270110A1
公开(公告)日：2011-11-03
申请号：US12768944
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler
发明人： Xusheng Zhang , Robert W. Stadler
IPC分类号： A61B5/0464 , A61B5/0452
CPC分类号： A61N1/3622 , A61B5/0464 , A61B5/686 , A61B5/7203 , A61N1/3962
摘要： A medical device and associated method for monitoring a patient's heart rhythm sensing a cardiac signal determine whether a cardiac signal is noise corrupted by obtaining cardiac signal pulses and generating a pulse amplitude threshold in response to the plurality of signal pulses. The number of signal sample points exceeding the pulse amplitude threshold in each of the of signal pulses is computed. The cardiac signal is determined to be noise corrupted or non-corrupted in response to the computed number of signal sample points.
摘要翻译：用于监测感测心脏信号的患者心律的医疗装置和相关方法通过获得心脏信号脉冲并响应于多个信号脉冲产生脉冲幅度阈值来确定心脏信号是否被噪声破坏。计算每个信号脉冲中超过脉冲振幅阈值的信号采样点数。响应于所计算的信号采样点数，心脏信号被确定为噪声损坏或未被破坏。

47. 发明申请

US20110270104A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 有权
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：US20110270104A1
公开(公告)日：2011-11-03
申请号：US12768892
申请日：2010-04-28
申请人： Robert W. Stadler , Xusheng Zhang
发明人： Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/0402
CPC分类号： A61B5/0464 , A61B5/0245 , A61B5/7203 , A61N1/3622
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a cardiac evidence counter is greater than a predetermined detection threshold, determining whether to advance from a current state to a next state in response to the evidence counter being greater than the predetermined detection threshold, determining whether advancing from a previous state to the current state occurred while in one of a low variability mode and a high variability mode during the previous state, and determining whether to advance from the current state to a previous state in response to determining whether advancing from a previous state to the current state occurred while operating in one of a low variability mode and a high variability mode during the previous state.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括确定心脏证据计数器是否大于预定检测阈值;响应于证据计数器大于预定检测阈值来确定是否从当前状态提前到下一状态在先前状态下，确定是否从先前状态进入到当前状态，同时以低可变性模式和高可变性模式之一发生，并且响应于是否前进而确定是否从当前状态前进到先前状态在先前状态期间以低变异性模式和高可变性模式之一操作时发生从先前状态到当前状态。

48. 发明授权

US07894894B2 Method and apparatus for detecting arrhythmias in a subcutaneous medical device 有权
标题翻译：用于检测皮下医疗装置中的心律失常的方法和装置
公开(公告)号：US07894894B2
公开(公告)日：2011-02-22
申请号：US11687108
申请日：2007-03-16
申请人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
发明人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
IPC分类号： A61N1/39
CPC分类号： A61N1/3621 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/3956
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes, the plurality of electrodes forming a first sensing vector and a second sensing vector different from the first sensing vector, determining a characteristic associated with cardiac signals sensed along the first sensing vector during a predetermined sensing window, determining the characteristic associated with cardiac signals sensed along the second sensing vector during the predetermined sensing window, comparing the determined characteristic associated with cardiac signals sensed along the first sensing vector and the determined characteristic associated with cardiac signals sensed along the second sensing vector, and delivering a therapy in response to the comparing.
摘要翻译：一种用于检测医疗装置中的心脏事件的方法和装置，包括感测来自多个电极的心脏信号，所述多个电极形成与第一感测向量不同的第一感测向量和第二感测向量，确定与在预定感测窗口期间沿着第一感测矢量感测的心脏信号，在预定感测窗口期间确定与沿着第二感测向量感测的心脏信号相关联的特征，比较与沿着第一感测矢量感测的心脏信号相关联的确定的特征，与沿着第二感测矢量感测的心脏信号相关联的特征，以及响应于比较递送治疗。

49. 发明授权

US07774049B2 Method and apparatus for determining oversensing in a medical device 有权
标题翻译：用于确定医疗装置中的过敏的方法和装置
公开(公告)号：US07774049B2
公开(公告)日：2010-08-10
申请号：US11742616
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61B5/0452
CPC分类号： A61N1/3704 , A61N1/3925
摘要： A method and apparatus for determining oversensing of cardiac signals that includes a housing containing electronic circuitry, an electrode coupled to the electronic circuitry to sense cardiac signals, and a processor, positioned within the housing, to determine an oversensing characteristic associated with the cardiac signals sensed over a predetermined sensing window, and to identify oversensing in response to the determined oversensing characteristic.
摘要翻译：一种用于确定心脏信号过度感测的方法和装置，其包括包含电子电路的壳体，耦合到电子电路以感测心脏信号的电极以及位于壳体内的处理器，以确定与感测到的心脏信号相关联的过度感应特性在预定的感测窗口上，并且响应于所确定的过敏特性来识别过敏。

50. 发明授权

US07742812B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07742812B2
公开(公告)日：2010-06-22
申请号：US11380830
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/39
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, determining rates of change of the sensed cardiac signals, and determining a range of the sensed cardiac signals. The sensed cardiac signals are detected as being associated with the cardiac event in response to the determined rates of change and the determined range.
摘要翻译：一种检测心脏事件的方法，其包括感测来自多个电极的心脏信号，确定所感测的心脏信号的变化速率，以及确定感测的心脏信号的范围。根据所确定的变化速率和所确定的范围，将所感测到的心脏信号检测为与心脏事件相关联。

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