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42. 发明申请

WO0240656A3 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, AND 84234, NOVEL HUMAN GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR, GLYCOSYLTRANSFERASE, DEAD TYPE HELICASE, CENTAURIN, DEHYDROGENASE/REDUCTASE, AND METAL TRANSPORTER FAMILY MEMBERS AND USES THEREOF 审中-公开
标题翻译： 47476,67210,49875,464242,33201,83378,84233,64708,85041和84234，新型人类核酸分解刺激剂，糖苷衍生物，死亡型真皮激素，半乳糖，脱氢酶/还原酶和金属转运蛋白家族成员及其用途
公开(公告)号：WO0240656A3
公开(公告)日：2004-02-26
申请号：PCT/US0145291
申请日：2001-11-14
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E , CURTIS RORY A J , GLUCKSMANN MARIA ALEXANDRA
发明人： MEYERS RACHEL E , CURTIS RORY A J , GLUCKSMANN MARIA ALEXANDRA
IPC分类号： A61K38/00 , C07K14/47 , C12N9/02 , C12N9/10 , C12N9/90 , C12N15/12 , C07K16/18 , G01N33/50
CPC分类号： C12N9/0004 , A61K38/00 , C07K14/4702 , C12N9/1048 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules, designated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234 nucleic acid molecules, which encode novel Guanine Nucleotide Dissociation Stimulator, Glycosyltransferase, DEAD type helicase, Centaurin, Dehydrogenase/Reductase, and Metal Transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 nucleic acid molecules, host cells nt which the expression vectors have been introduced, and nonhuman transgenic animals in which a 474476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 gene has been introduced or disrupted. The invention still further provides isolated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 proteins, fusion proteins, antigenic peptides and anti-47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为47476,67210,49875,4842,33201,83378,84233,64708,85041和84234核酸分子，其编码新的鸟嘌呤核苷酸解离刺激因子，糖基转移酶，DEAD型解旋酶，半胱氨酸脱氢酶，脱氢酶 /还原酶和金属转运蛋白家族成员。本发明还提供反义核酸分子，含有47476,67210,49875,46842,33201,83378,84233,64708,85041或84234核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人类已经引入或破坏了474476,67210,498075,4842,33201,83378,84233,64708,85041或84234基因的转基因动物。本发明还进一步提供分离的47476,67210,49875,4842,33201,83378,84233,64708,85041或84234蛋白，融合蛋白，抗原肽和抗-47476,67210,49875,4642,33201,83378,84233， 64708,85041或84234抗体。还提供了利用本发明组合物的诊断方法。

43. 发明申请

WO0208273A3 47508, A NOVEL HUMAN HISTONE DEACETYLASE FAMILY MEMBER AND USES THEREOF 审中-公开
标题翻译： 47508，一种新的人类组织脱乙酰酶家族成员及其用途
公开(公告)号：WO0208273A3
公开(公告)日：2003-04-24
申请号：PCT/US0123153
申请日：2001-07-23
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E
发明人： MEYERS RACHEL E
IPC分类号： A61K38/00 , C12N9/16 , C12N15/55 , C07K16/40 , C12Q1/68 , G01N33/50 , G01N33/577
CPC分类号： C12N9/16 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 47508 nucleic acid molecules, which encode novel human histone deacetylase members. The invention also provides antisense nucleic molecules, recombinant expression vectors containing 47508 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47508 gene has been introduced or disrupted. The invention still further provides isolated 47508 proteins, fusion proteins, antigenic peptides and anti-47508 antibodies. Diagnostic methods utilizing compositions of the invention are aslo provided.
摘要翻译：本发明提供编码新的人组蛋白脱乙酰酶成员的分离的核酸分子，命名为47508核酸分子。本发明还提供了反义核酸分子，含有47508个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了47508基因的非人类转基因动物。本发明还进一步提供分离的47508蛋白，融合蛋白，抗原肽和抗-47508抗体。使用本发明组合物的诊断方法。

44. 发明申请

WO0238773A3 A HUMAN PHOSPHOLIPASE C AND USES THEREOF 审中-公开
标题翻译：人类磷脂酶C及其用途
公开(公告)号：WO0238773A3
公开(公告)日：2003-03-27
申请号：PCT/US0125252
申请日：2001-08-10
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
发明人： MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
IPC分类号： A61K48/00 , C12N9/16 , C12N15/54 , C12Q1/68 , A61K38/43 , C07K16/40 , C12N9/12 , C12N9/20 , C12N15/11 , G01N33/50
CPC分类号： C12Y301/04003 , A01K2217/05 , A01K2217/075 , A61K48/00 , A61K2039/505 , C07K2319/00 , C12N9/16 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The invention provides isolated nucleic acids molecules, designated 32544 nucleic acid molecules, which encode novel phospholipase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32544 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32544 gene has been introduced or disrupted. The invention still further provides isolated 32544 proteins, fusion proteins, antigenic peptides and anti-32544 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的磷脂酶家族成员的分离的核酸分子，命名为32544核酸分子。本发明还提供反义核酸分子，含有32544个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及32544基因导入或破坏的非人类转基因动物。本发明还进一步提供分离的32544蛋白，融合蛋白，抗原肽和抗32544抗体。还提供了利用本发明组合物的诊断方法。

45. 发明申请

WO0200863A3 32140, A NOVEL HUMAN ALDEHYDE DEHYDROGENASE AND USES THEREFOR 审中-公开
标题翻译： 32140，一种新的人类脱氢脱氢酶及其用途
公开(公告)号：WO0200863A3
公开(公告)日：2003-02-13
申请号：PCT/US0120479
申请日：2001-06-27
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E , COOK WILLIAM JAMES
发明人： MEYERS RACHEL E , COOK WILLIAM JAMES
IPC分类号： C12N9/02 , C12N15/53 , A61K38/43 , C07K16/40 , C12Q1/68 , G01N33/68
CPC分类号： C12N9/0008 , A01K2217/05 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 32140 nucleic acid molecules, which encode novel aldehyde dehydrogenase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32140 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32140 gene has been introduced or disrupted. The invention still further provides isolated 32140 proteins, fusion proteins, antigenic peptides and anti-32140 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的醛脱氢酶家族成员的分离的核酸分子，命名为32140核酸分子。本发明还提供了反义核酸分子，含有32140个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞以及其中32140基因被引入或破坏的非人类转基因动物。本发明还进一步提供了分离的32140蛋白，融合蛋白，抗原肽和抗32140抗体。还提供了利用本发明组合物的诊断方法。

46. 发明申请

WO0179489A8 39228, A NOVEL HUMAN ALCOHOL DEHYDROGENASE AND USES THEREFOR 审中-公开
标题翻译： 39228，一种新的人类酒精脱氢酶及其用途
公开(公告)号：WO0179489A8
公开(公告)日：2003-01-09
申请号：PCT/US0112591
申请日：2001-04-18
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E , RUDOLPH-OWEN LAURA A
发明人： MEYERS RACHEL E , RUDOLPH-OWEN LAURA A
IPC分类号： A61K38/00 , C12N9/04 , C12N15/53 , C12N15/11 , C07K16/40 , C12N15/62 , C12Q1/68 , G01N33/573 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C12N9/0006 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated Adhr-1 nucleic acid molecules, which encode a novel family of alcohol dehydrogenase (Adh) proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing Ahdr-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an Adhr-1 gene has been introduced or disrupted. The invention still further provides isolated Ahdr-1 proteins, fusion proteins, antigenic peptides, and anti-Adhr-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了编码新型醇脱氢酶（Adh）蛋白家族的分离的核酸分子，命名为Adhr-1核酸分子。本发明还提供反义核酸分子，含有Ahdr-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已经引入或破坏了Adhr-1基因的非人类转基因动物。本发明还进一步提供了分离的Ahdr-1蛋白，融合蛋白，抗原肽和抗-Adhr-1抗体。还提供了利用本发明组合物的诊断方法。

47. 发明申请

WO0220800A3 16658, 14223, and 16002, NOVEL HUMAN KINASES AND USES THEREFOR 审中-公开
标题翻译： 16658,14223和16002，新的人类动物及其用途
公开(公告)号：WO0220800A3
公开(公告)日：2002-12-27
申请号：PCT/US0124601
申请日：2001-08-03
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
发明人： MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
IPC分类号： C12N9/12 , C12N15/54 , C07K16/40 , C12N5/10 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/12
摘要： The invention provides isolated nucleic acids molecules, designated 16658, 14223, and 16002 nucleic acid molecules, which encode novel kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16658, 14223, and 16002 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16658, 14223, and 16002 gene has been introduced or disrupted. The invention still further provides isolated 16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, -14223, and -16002 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新型激酶家族成员的分离的核酸分子，命名为16658,14223和16002核酸分子。本发明还提供了反义核酸分子，含有16658,14223和16002核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及其中已经存在16658,14223和16002基因的非人类转基因动物引入或中断本发明还进一步提供分离的16658,14223和16002蛋白，融合蛋白，抗原肽和抗-16658,14223和16002蛋白，融合蛋白，抗原肽和抗-16658,1423和-16002抗体。还提供了利用本发明组合物的诊断方法。

48. 发明申请

WO0173060A9 18221, DUAL SPECIFICITY PHOSPHATASE AND USES THEREOF 审中-公开
标题翻译： 18221，双特异性磷酸酶及其用途
公开(公告)号：WO0173060A9
公开(公告)日：2002-12-19
申请号：PCT/US0109603
申请日：2001-03-22
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E
发明人： MEYERS RACHEL E
IPC分类号： A61K38/00 , C12N9/16 , C12N15/55 , A61K31/7088 , A61K39/395 , C07K16/40 , C12N5/10 , C12Q1/42 , C12Q1/68 , G01N33/68
CPC分类号： C12N9/16 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 18221 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18221 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18221 gene has been introduced or disrupted. The invention still further provides isolated 18221 proteins, fusion proteins, antigenic peptides and anti-18221 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods of modulating the differentiation and proliferation of hematopoietic cells (e.g., erythroid cells) utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing hematopoietic disorders are disclosed.
摘要翻译：本发明提供了分离的核酸分子，命名为18221核酸分子，其编码新的双特异性磷酸酶家族成员。本发明还提供了反义核酸分子，含有18221个核酸分子的重组表达载体，导入了表达载体的宿主细胞和导入或破坏了18221基因的非人转基因动物。本发明还提供了分离的18221蛋白，融合蛋白，抗原肽和抗18221抗体。还提供了利用本发明组合物的诊断方法。本发明还提供了利用本发明的组合物调节造血细胞（例如类红细胞）的分化和增殖的方法。因此，公开了治疗，预防和/或诊断造血疾病的方法。

49. 发明申请

WO0220800A9 16658, 14223, and 16002, NOVEL HUMAN KINASES AND USES THEREFOR 审中-公开
标题翻译： 16658，14223和16002，新的人类激酶和用途
公开(公告)号：WO0220800A9
公开(公告)日：2002-10-17
申请号：PCT/US0124601
申请日：2001-08-03
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
发明人： MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
IPC分类号： C12N9/12 , C12N15/54 , C07K16/40 , C12N5/10 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/12
摘要： The invention provides isolated nucleic acids molecules, designated 16658, 14223, and 16002 nucleic acid molecules, which encode novel kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16658, 14223, and 16002 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16658, 14223, and 16002 gene has been introduced or disrupted. The invention still further provides isolated 16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, -14223, and -16002 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的核酸分子，命名为16658,14223和16002核酸分子，其编码新的激酶家族成员。本发明还提供了反义核酸分子，含有16658,14223和16002核酸分子的重组表达载体，导入了表达载体的宿主细胞和其中已经存在16658,14223和16002基因的非人转基因动物介绍或中断。本发明还提供了分离的16658,14223和16002蛋白，融合蛋白，抗原肽和抗16658,14223和16002蛋白，融合蛋白，抗原肽和抗16658,14223和-16002抗体。还提供了利用本发明组合物的诊断方法。

50. 发明申请

WO0164905A3 2504, 15977, AND 14760, NOVEL PROTEIN KINASE FAMILY MEMBERS AND USES THEREFOR 审中-公开
标题翻译： 2504，15977，AND 14760，新型蛋白激酶家族成员及其用途
公开(公告)号：WO0164905A3
公开(公告)日：2002-08-08
申请号：PCT/US0106525
申请日：2001-02-28
申请人： MILLENNIUM PHARM INC , OLANDT PETER J , KAPELLER-LIBERMANN ROSANA , MEYERS RACHEL E
发明人： OLANDT PETER J , KAPELLER-LIBERMANN ROSANA , MEYERS RACHEL E
IPC分类号： A61K38/00 , C07K16/40 , C12N9/12 , C12N15/54 , C12N5/10 , C12N15/62 , C12Q1/48 , C12Q1/68
CPC分类号： C12N9/1205 , A61K38/00 , A61K2039/505 , C07K16/40
摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, or 14760 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, or 14760 nucleic molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, or 14760 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, or 14760 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, or 14760 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为2504,15977或14760核酸分子，其编码新的蛋白激酶家族成员。本发明还提供反义核酸分子，含有2504,15977或14760核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入了2504,15977或14760基因的非人类转基因动物或中断。本发明还进一步提供分离的2504,15977或14760蛋白，融合蛋白，抗原肽和抗2504,15977或14760抗体。还提供了利用本发明组合物的诊断方法。

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