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41. 发明专利

AU2005266803A1 Inhibitors of VEGF receptor and HGF receptor signaling 未知
公开(公告)号：AU2005266803A1
公开(公告)日：2006-02-02
申请号：AU2005266803
申请日：2005-07-28
申请人： METHYLGENE INC
发明人： ZHAN LIJIE , RAEPPEL FRANCK , BERSTEIN NAOMY , GRANGER MARIE-CLAUDE , WILLIAM STEPHEN , SAAVEDRA OSCAR MARIO , VAISBURG ARKADII
IPC分类号： C07D495/04 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P35/00 , C07D487/04 , C07D491/04 , C07D498/04 , C07D513/04
摘要： The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

42. 发明专利

ES2635131T3 Inhibidores de la actividad de la proteína tirosina cinasa 未知
公开(公告)号：ES2635131T3
公开(公告)日：2017-10-02
申请号：ES08800252
申请日：2008-08-28
申请人： METHYLGENE INC
发明人： CLARIDGE STEPHEN WILLIAM , ISAKOVIC LJUBOMIR , MANNION MICHAEL , RAEPPEL STÉPHANE , SAAVEDRA OSCAR MARIO , GAUDETTE FRÉDÉRIC , ZHAN LIJIE , ZHOU NANCY Z , RAEPPEL FRANCK , DEZIEL ROBERT , VAISBURG ARKADII , UNO TETSUYUKI
IPC分类号： C07D495/04 , A61K31/00 , A61K31/4365 , A61P9/00 , A61P27/02 , A61P35/00
摘要： Un compuesto de Fórmula (I) **(Ver fórmula)** : y sales farmacéuticamente aceptables del mismo, y mezclas racémicas y escalémicas, diastereómeros y enantiómeros del mismo, en la que D se selecciona entre el grupo que consiste en: (1) un sistema anular heteroaromático de 6 miembros, furanilo, tetrahidropiridilo, tienilo, o pirazolilo, cada uno de los cuales está sustituido con 1 o 2 grupos R38 independientemente seleccionados, en los que cada R38 se selecciona independientemente entre el grupo que consiste en halo, - C(O)NR36R39, -C(O)O-(CH2)nNR36R39, -(CH 2)jNR39(CH2)iS(O)j(alquilo C1-C6), - (CH2)jNR39(CH2)R36, -C(O)(CH2)jNR39(CH2)nR36, -(CH2)nP(>=O)(alquilo C1-C6)2, - (CH2)jNR39CH2(CH2)nP(>=O)(alquilo C1-C6)2, NR13C(X1)NR13-arilP(>=O)(alquilo C1-C6)2, NR13C(X1)NR13-heteroarilP( >=O)(alquilo C1-C6)2, -(CH2)jNR39(CH2)i[O(CH2)i]x(CH2)jR99, - (CH2)jNR39(CH2)iSO(0-2)(CH2)i[O(CH2)i]j(CH2)j R99, y -(CH2)jNR39(CH2)jR100, en los que cada j es un número entero que varía independientemente de 0 a 4, n es un número entero que varía de 0 a 6, x es un número entero que varía de 1-6, cada uno de i es un número entero que varía independientemente de 1 a 3, y los restos -(CH2)i- y - (CH2)n- de los grupos R38 anteriores incluyen opcionalmente un doble o triple enlace carbono-carbono donde n es un número entero entre 2 y 6; R36 se selecciona entre el grupo que consiste en H, -OH, alquilo C1-C6, cicloalquilo C3-C10, -(CH2)n(arilo C6-C10), -(CH2)n(heterociclilo de 5-10 miembros) y -(CH2)nA4R37, en los que cada n es un número que varía independientemente de 0 a 6, A4 se selecciona entre el grupo que consiste en O, S, SO, y SO2; y (2) imidazolilo sustituido con alquilo C1-C6 y -(CH2)jNR39(CH2)nR36, en la que j es un número entero de 0 a 4, n es un número entero de 0 a 6, y R36 es -(CH2)n3OR37 en la que n3 es un número entero que varía de 0 a 6, en la que R37 es alquilo C1-C6, y R39 es H; M es **(Ver fórmula)** Z es -O-;

43. 发明专利

DK2183254T3 HÆMMERE AF PROTEINTYROSINKINASEAKTIVITET 未知
公开(公告)号：DK2183254T3
公开(公告)日：2017-09-11
申请号：DK08800252
申请日：2008-08-28
申请人： METHYLGENE INC
发明人： CLARIDGE STEPHEN WILLIAM , ISAKOVIC LJUBOMIR , MANNION MICHAEL , RAEPPEL STÉPHANE , SAAVEDRA OSCAR MARIO , GAUDETTE FRÉDÉRIC , ZHAN LIJIE , ZHOU NANCY Z , RAEPPEL FRANCK , DEZIEL ROBERT , VAISBURG ARKADII , UNO TETSUYUKI
IPC分类号： C07D495/04 , A61K31/00 , A61K31/4365 , A61P9/00 , A61P27/02 , A61P35/00

44. 发明专利

AU2011241420B2 Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders 未知
公开(公告)号：AU2011241420B2
公开(公告)日：2015-04-16
申请号：AU2011241420
申请日：2011-04-08
申请人： METHYLGENE INC
发明人： RAEPPEL STEPHANE , ZHAN LIJIE , CLARIDGE STEPHEN WILLIAM , RAEPPEL FRANCK , GAUDETTE FREDERIC , VAISBURG ARKADII
IPC分类号： C07D495/04 , A61K31/4365 , A61K31/444 , A61K31/496 , A61K31/5377 , A61P27/02
摘要： Disclosed are compounds, and compositions of same, that are protein tyrosine kinase inhibitors. The compounds find use in the treatment of ophthalmic diseases, disorders and conditions. Said compounds are of the formulae (I), (II) or (III). Wherein R = (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) or (XII).

45. 发明专利

BRPI0816064A2 Inibidores da atividade de proteína tirosina cinase. 未知
公开(公告)号：BRPI0816064A2
公开(公告)日：2015-03-31
申请号：BRPI0816064
申请日：2008-08-28
申请人： METHYLGENE INC
发明人： CLARIDGE STEPHEN WILLIAM , ISAKOVIC LJUBOMIR , MANNION MICHAEL , RAEPPEL STÉPHANE , SAAVEDRA OSCAR MARIO , GAUDETTE FRÉDÉRIC , ZHAN LIJIE , ZHOU NANCY Z , RAEPPEL FRANCK , DEZIEL ROBERT , VAISBURG ARKADII , UNO TETSUYUKI
IPC分类号： C07D495/04 , A61K31/00 , A61K31/4365 , A61P9/00 , A61P27/02 , A61P35/00

46. 发明专利

CA2608726C INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING 未知
公开(公告)号：CA2608726C
公开(公告)日：2013-07-09
申请号：CA2608726
申请日：2006-05-19
申请人： METHYLGENE INC
发明人： SAAVEDRA OSCAR MARIO , CLARIDGE STEPHEN WILLIAM , ZHAN LIJIE , RAEPPEL FRANCK , VAISBURG ARKADII , RAEPPEL STEPHANE , DEZIEL ROBERT , MANNION MICHAEL , ZHOU NANCY Z , ISAKOVIC LJUBOMIR
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00 , C07D487/04
摘要： The invention relates to the inhibition of vascular endothelial growth factor (VEGF) receptor signaling and hepatocyte growth factor (HGF) receptor signaling The invention provides compound A and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. Formula (A).

47. 发明专利

SG184882A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY 未知
公开(公告)号：SG184882A1
公开(公告)日：2012-11-29
申请号：SG2012076725
申请日：2011-04-08
申请人： METHYLGENE INC
发明人： RAEPPEL STEPHANE , RAEPPEL FRANCK , CLARIDGE STEPHEN WILLIAM , ZHAN LIJIE , GAUDETTE FREDERIC , MANNION MICHAEL , SATO NORIFUMI , YUKI YOHEI , KISHIDA MASASHI , VAISBURG ARKADII
摘要： Compounds that inhibit protein tyrosine kinase activity are disclosed, preferably of Formulae (II) and (III). In particular, said compounds inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides said compounds, compositions thereof and methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions.

48. 发明专利

AU2011241422A1 Inhibitors of protein tyrosine kinase activity 未知
公开(公告)号：AU2011241422A1
公开(公告)日：2012-11-01
申请号：AU2011241422
申请日：2011-04-08
申请人： METHYLGENE INC
发明人： RAEPPEL STEPHANE , RAEPPEL FRANCK , CLARIDGE STEPHEN WILLIAM , ZHAN LIJIE , GAUDETTE FREDERIC , MANNION MICHAEL , SATO NORIFUMI , YUKI YOHEI , KISHIDA MASASHI , VAISBURG ARKADII
IPC分类号： C07D495/04 , A61K31/444 , A61P27/02 , A61P35/00
摘要： Compounds that inhibit protein tyrosine kinase activity are disclosed, preferably of Formulae (II) and (III). In particular, said compounds inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides said compounds, compositions thereof and methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions.

49. 发明专利

CA2796054A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY AND USE THEREOF TO TREAT OPHTHALMIC DISORDERS 未知
公开(公告)号：CA2796054A1
公开(公告)日：2011-10-20
申请号：CA2796054
申请日：2011-04-08
申请人： METHYLGENE INC
发明人： CLARIDGE STEPHEN WILLIAM , GAUDETTE FREDERIC , RAEPPEL FRANCK , RAEPPEL STEPHANE , VAISBURG ARKADII , ZHAN LIJIE
IPC分类号： C07D495/04 , A61K31/4365 , A61K31/444 , A61K31/496 , A61K31/5377 , A61P27/02
摘要： Disclosed are compounds, and compositions of same, that are protein tyrosine kinase inhibitors. The compounds find use in the treatment of ophthalmic diseases, disorders and conditions. Said compounds are of the formulae (I), (II) or (III). Wherein R = (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) or (XII).

50. 发明专利

CA2796008A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY 未知
公开(公告)号：CA2796008A1
公开(公告)日：2011-10-20
申请号：CA2796008
申请日：2011-04-08
申请人： METHYLGENE INC
发明人： RAEPPEL STEPHANE , RAEPPEL FRANCK , CLARIDGE STEPHEN WILLIAM , ZHAN LIJIE , GAUDETTE FREDERIC , MANNION MICHAEL , SATO NORIFUMI , YUKI YOHEI , KISHIDA MASASHI , VAISBURG ARKADII
IPC分类号： C07D495/04 , A61K31/444 , A61P27/02 , A61P35/00
摘要： Compounds that inhibit protein tyrosine kinase activity are disclosed, preferably of Formulae (II) and (III). In particular, said compounds inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides said compounds, compositions thereof and methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions.

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