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41. 发明专利

CA3006231A1 ASSAY MODULES HAVING ASSAY REAGENTS AND METHODS OF MAKING AND USING SAME 未知
公开(公告)号：CA3006231A1
公开(公告)日：2007-07-05
申请号：CA3006231
申请日：2006-12-21
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： GLEZER ELI N , DEBAD JEFF D , JEFFREY-COKER BANDELE , KUMAR SUDEEP M , SIGAL GEORGE , SPIELES GISBERT , TSIONKSY MICHAEL , WARNOCK MICHAEL
IPC分类号： G01N35/00 , C12M1/00 , C12Q1/00 , G01N33/48 , G01N33/543
摘要： We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

42. 发明专利

CA2941139A1 ASSAY CARTRIDGES AND METHODS OF USING THE SAME 未知
公开(公告)号：CA2941139A1
公开(公告)日：2004-07-22
申请号：CA2941139
申请日：2003-12-23
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： GLEZER ELI N , LELAND JONATHAN K , BILLADEAU MARK A , LEGINUS JOSEPH M , JEFFREY-COKER BANDELE , DEBAD JEFF D , PHALNIKAR KOUSTUBH A , JAMBUNATHAN SRIRAM
IPC分类号： G01N27/00 , B01L3/00 , B01L9/00 , B01L99/00 , C12Q1/00 , C40B40/10 , G01N1/00 , G01N21/69 , G01N21/76 , G01N27/02 , G01N27/416 , G01N33/483 , G01N33/52 , G01N33/543
摘要： An assay cartridge comprises: an extraction reagent chamber for holding an extraction reagent; a sample chamber adapted to receive an applicator stick, said sample chamber connected to said extraction reagent chamber by an extraction reagent conduit, said sample chamber having a sample introduction port with a sealable closure; and a first detection chamber connected to said sample chamber by a first sample conduit.

43. 发明专利

AU2022204742A1 ASSAY APPARATUSES, CONSUMABLES AND METHODS 未知
公开(公告)号：AU2022204742A1
公开(公告)日：2022-07-21
申请号：AU2022204742
申请日：2022-07-01
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： CHAMBERLIN IAN , CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOCHAR MANISH , KOVACS SANDOR , LE DT , LEIMKUEHLER AARON , PINCKNEY GREG , ROTH KRISTIAN , SIGAL GEORGE , YIN FEI
IPC分类号： G01N35/02 , G01N1/28 , G01N21/00 , G01N33/48
摘要： We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.

44. 发明专利

ES2913283T3 Cartuchos de ensayo 未知
公开(公告)号：ES2913283T3
公开(公告)日：2022-06-01
申请号：ES19000097
申请日：2010-12-03
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： ANDERSON NICHOLAS , DEBAD JEFFERY , GLEZER ELI N , KUMAR SUDEEP , LAWRENCE NOEL , PAGE KENNETH , SIGAL GEORGE , WEST SHARON
IPC分类号： G01N21/03 , B01L3/00 , B01L7/00 , B01L9/00 , G01F23/02 , G01F23/284 , G01F23/292 , G01N21/05 , G01N21/69 , G01N21/76
摘要： Un cartucho de ensayo (3700) para analizar una muestra recogida con una varilla aplicadora (3030) que comprende un eje (3072) y un cabezal de recogida de muestra (3071), dicho cartucho (3700) que comprende una cámara de muestras (3720) que tiene una cavidad alargada que tiene una primera región y una segunda región, en donde la cámara de muestras (3720) comprende un puerto de introducción de muestras, en donde la primera región está próxima al puerto de introducción de muestras y la segunda región está distal al puerto de introducción de muestras, en donde dichas primera y segunda regiones se orientan en un ángulo con respecto entre sí y dicho ángulo se selecciona para doblar dicho eje (3072) tras la inserción de dicha varilla aplicadora (3030) en dicha cámara de muestras (3720) y promover la rotura de dicho eje (3072), y en donde cámara de muestras (3720) comprende una característica de retención del cabezal de muestra ubicada en una transición entre la primera región y la segunda región, en donde dicha característica de retención del cabezal de muestra es una plataforma (3721b), en donde dicha plataforma (3721b) es una discontinuidad escalonada en una superficie interna de dicha cámara de muestras (3720), en donde la cámara de muestras (3720) es curva, y en donde un radio de curvatura de la cámara de muestras (3720) en la primera región es menor que un radio de curvatura de la cámara de muestras (3720) en la segunda región, y la plataforma (3721b) se ubica en una superficie curva exterior de las superficies curvas que definen la cámara de muestras (3720), de manera que cuando el eje (3072) rompe la cámara de muestras (3720), se libera tensión y un extremo de un fragmento unido al cabezal de recogida (3071) se empuja contra la superficie curva exterior y se bloquea en su lugar por la plataforma (3721b).

45. 发明专利

AU2019264678B2 IMPROVED ASSAY METHODS 未知
公开(公告)号：AU2019264678B2
公开(公告)日：2022-03-24
申请号：AU2019264678
申请日：2019-11-15
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： AGHVANYAN ANAHIT , GLEZER ELI N , KENTEN JOHN , SIGAL GEORGE , STENGELIN MARTIN
IPC分类号： G01N33/53 , G01N33/532 , G01N33/58
摘要： The present invention is directed to methods for improving assay specificity and performance in binding assays.

46. 发明专利

CA3081228C ASSAY BUFFER, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME 未知
公开(公告)号：CA3081228C
公开(公告)日：2022-02-15
申请号：CA3081228
申请日：2002-09-10
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： MARTIN MARK , SIGAL GEORGE , TSIONSKY MICHAEL , GLEZER ELI N , ALTUNATA SELEN , LELAND JONATHAN K , BILLADEAU MARK A , LEYTNER SVETLANA , HELMS LARRY
IPC分类号： G01N33/52 , G01N33/53 , C12Q1/42 , C12Q1/48 , G01N21/76 , G01N33/531 , G01N33/543 , G01N33/58 , G01N33/68
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. The present invention relates to a kit comprising, in one or more containers, an aqueous reagent composition, the aqueous reagent composition comprising: (a) tripropylamine (TPA) at a concentration between 10 mM and 1000 mM; and (b) an electrolyte solution comprising a pH buffer selected from the group consisting of a tris(hydroxymethyl)aminomethane buffer and a glycylglycine buffer at a concentration of the pH buffer of between 50 mM and 1200 mM, wherein the reagent composition has a pH between 6.5 and 8.5.

47. 发明专利

AU2021277634A1 ASSAY APPARATUSES, CONSUMABLES AND METHODS 未知
公开(公告)号：AU2021277634A1
公开(公告)日：2021-12-23
申请号：AU2021277634
申请日：2021-11-30
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： CHAMBERLIN IAN , CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOCHAR MANISH , KOVACS SANDOR , LE DT , LEIMKUEHLER AARON , PINCKNEY GREG , ROTH KRISTIAN , SIGAL GEORGE , YIN FEI
IPC分类号： G01N35/02 , G01N1/28 , G01N21/00 , G01N33/48
摘要： We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.

48. 发明专利

AU2014249190C1 Improved methods for conducting multiplexed assays 未知
公开(公告)号：AU2014249190C1
公开(公告)日：2021-11-18
申请号：AU2014249190
申请日：2014-03-11
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： GLEZER ELI N , KUMAR SUDEEP , OBEROI PANKAJ , SIGAL GEORGE , TSIONSKY MICHAEL
IPC分类号： G01N33/53 , C12N15/11 , C12Q1/68 , G01N33/483
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

49. 发明专利

AU2019283996B2 Assay Apparatuses, Methods and Reagents 未知
公开(公告)号：AU2019283996B2
公开(公告)日：2021-10-14
申请号：AU2019283996
申请日：2019-12-20
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： CHAMBERLIN IAN , CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE JEFFREY-COKER , KOCHAR MANISH , KOVACS SANDOR , LE D T , LEIMKUEHLER AARON , SIGAL GEORGE , TABAKIN LEO , WILLOUGHBY JON
IPC分类号： G01N21/75 , C40B60/12 , G01J1/20 , G01N21/76 , G01N27/26 , G02B7/36
摘要： Apparatuses, systems, method, reagents and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format. A method is provided for focusing an optical sensor to a spaced apart platform comprising the steps of: providing at least a higher, middle and lower patterns surface, wherein the middle patterned surface and the platform are aligned to each other and wherein a first distance between the higher and middle patterned surfaces and a second distance between the middle surface and lower patterned surface are substantially equal; obtaining a first difference in contract values between the higher and middle patterned surfaces with the optical sensor; obtaining a second difference in contrast values between the middle and lower patterned surfaces with the optical sensor; and comparing the first and second differences in contrast values.

50. 发明专利

CA2941139C ASSAY CARTRIDGES AND METHODS OF USING THE SAME 未知
公开(公告)号：CA2941139C
公开(公告)日：2021-07-20
申请号：CA2941139
申请日：2003-12-23
申请人： MESO SCALE TECHNOLOGIES LLC
发明人： GLEZER ELI N , LELAND JONATHAN K , BILLADEAU MARK A , LEGINUS JOSEPH M , JEFFREY-COKER BANDELE , DEBAD JEFF D , PHALNIKAR KOUSTUBH A , JAMBUNATHAN SRIRAM
IPC分类号： G01N27/00 , B01L3/00 , B01L9/00 , B01L99/00 , C12Q1/00 , C40B40/10 , G01N1/00 , G01N21/69 , G01N21/76 , G01N27/02 , G01N27/416 , G01N33/483 , G01N33/52 , G01N33/543
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

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