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41. 发明专利

DE10157290A1 未知
公开(公告)号：DE10157290A1
公开(公告)日：2003-06-05
申请号：DE10157290
申请日：2001-11-22
申请人： MAX PLANCK GESELLSCHAFT
发明人： HUBER ROBERT , SONDERMANN PETER , JACOB UWE
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P37/00
摘要： The invention relates to pharmaceutical compositions containing one of the receptors FcyR llb or FcyR III in a recombinant-produced, soluble form, and to the use of the same for the treatment of diseases or conditions which are caused by exuberant immunoreactions and the pathologically increased formation of antibodies, especially auto-antibodies. Said pharmaceutical compositions are especially useful in the fields of multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis.

42. 发明专利

DE19960225A1 未知
公开(公告)号：DE19960225A1
公开(公告)日：2001-07-26
申请号：DE19960225
申请日：1999-12-14
申请人： MAX PLANCK GESELLSCHAFT , PROTEROS BIOSTRUCTURES GMBH
发明人： STROBL STEFAN , FERNANDEZ-CATALAN CARLOS , BODE WOLFRAM , HUBER ROBERT , SUZUKI KOICHI
IPC分类号： A61K9/64 , C12N9/64 , C12N15/55 , C12N15/57 , C12N9/50 , A61K38/48

43. 发明专利

AU6281100A Novel diketopiperazines 未知
公开(公告)号：AU6281100A
公开(公告)日：2001-03-05
申请号：AU6281100
申请日：2000-08-08
申请人： MAX PLANCK GESELLSCHAFT , BYK GULDEN LOMBERG CHEM FAB
发明人： SCHASCHKE NORBERT , MORODER LUIS , HUBER ROBERT , BODE WOLFRAM , SOMMERHOFF CHRISTIAN
IPC分类号： A61K38/00 , A61P11/00 , C07K5/02 , C07K5/12 , C07D241/08 , A61K31/495 , C07D401/12 , C07D487/14

44. 发明专利

DE19937721A1 未知
公开(公告)号：DE19937721A1
公开(公告)日：2001-02-15
申请号：DE19937721
申请日：1999-08-10
申请人： MAX PLANCK GESELLSCHAFT , BYK GULDEN LOMBERG CHEM FAB
发明人： SCHASCHKE NORBERT , MORODER LUIS , HUBER ROBERT , BODE WOLFRAM , SOMMERHOFF CHRISTIAN
IPC分类号： A61K38/00 , A61P11/00 , C07K5/02 , C07K5/12 , C07K7/02 , A61K38/07 , C07K7/06
摘要： This invention relates to compounds of formula (I) wherein M, A1, A2, A3, A4, B1, B2, B3, B4, Y1 and Y2 have the meanings cited in the description. Said compounds are novel, effective tryptase-inhibitors.

47. 发明专利

DE60222115T2 未知
公开(公告)号：DE60222115T2
公开(公告)日：2008-05-21
申请号：DE60222115
申请日：2002-05-13
申请人： BACHER ADELBERT , MAX PLANCK GESELLSCHAFT
发明人： BACHER ADELBERT , HECHT STEFAN , HUBER ROBERT , KAISER JOHANNES , ROHDICH FELIX , STEINBACHER STEFAN
IPC分类号： C12N9/88 , G06F17/50 , G06F19/00
摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.

48. 发明专利

AT371729T 未知
公开(公告)号：AT371729T
公开(公告)日：2007-09-15
申请号：AT02748701
申请日：2002-05-13
申请人： BACHER ADELBERT , MAX PLANCK GESELLSCHAFT
发明人： BACHER ADELBERT , HECHT STEFAN , HUBER ROBERT , KAISER JOHANNES , ROHDICH FELIX , STEINBACHER STEFAN
IPC分类号： C12N9/88 , G06F17/50 , G06F19/00
摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.

49. 发明专利

CO5590936A2 COMPUESTO FARMACEUTICO QUE CONTIENE SFCYR IIB O SFCYR III 未知
公开(公告)号：CO5590936A2
公开(公告)日：2005-12-30
申请号：CO04057552
申请日：2004-06-18
申请人： MAX PLANCK GESELLSCHAFT
发明人： HUBER ROBERT , SONDERMANN PETER , UWE JACOB
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P37/00
摘要： 1.- Compuesto farmacéutico en forma de una solución acuosa, caracterizado porque comprende FcyR IIb y FcyR III producidos en forma recombinante, de sistemas de expresión eucariónticos o especialmente procariónticos en una cantidad de 40 hasta 4000 mg, preferiblemente 100 hasta 1000 mg y una concentración de hasta 50 mg/ml y eventualmente otros excipientes y sustancias auxiliares farmacéuticamente aceptables.2.- Compuesto farmacéutico según la reivindicación 1, caracterizada porque se encuentra en forma de solución inyectable.3.- Compuesto farmacéutico según la reivindicación 1 o 2, caracterizado porque contiene FcyR IIb según SEQ ID NO. 1, o en los terminales N y/o C una forma prolongada de la proteína nativa con secuencias adecuadas preferiblemente según SEQ ID NO. 3.4.- Compuesto farmacéutico según una de las reivindicaciones 1 o 2, caracterizado porque contiene FcyR III, según SEQ ID NO. 2 o en los terminales N y/o C una forma prolongada de la proteína nativa con secuencias adecuadas, preferiblemente según SEQ ID NO. 45.- Empleo de un compuesto farmacéutico según una de las reivindicaciones 1 a 4 para combatir enfermedades o estados originados por reacciones inmunológicas y formación patológica aumentada de anticuerpos, especialmente de autoanticuerpos.6.- Empleo según la reivindicación 5, caracterizado porque la enfermedad es esclerosis múltiple, lupus eritematoso sistémico, artritis reumatoide o una enfermedad que está acompañada por un número aumentado de células NK.

50. 发明专利

DE10308594A1 New monoclinical crystal of 2C-methyl-D-erythritol-4-phosphate synthase, useful in rational design of specific inhibitors, potentially useful as antimalarial, antibiotic and herbicidal agents 未知
公开(公告)号：DE10308594A1
公开(公告)日：2004-08-26
申请号：DE10308594
申请日：2003-02-27
申请人： BACHER ADELBERT , MAX PLANCK GESELLSCHAFT
发明人： BACHER ADELBERT , EISENREICH WOLFGANG , HECHT STEFAN , KAISER JOHANNES , ROHDICH FELIX , HUBER ROBERT , STEINBACHER STEFAN , GERHARDT STEFAN
IPC分类号： C12N9/04 , C12N9/00 , C12Q1/00
摘要： A monoclinic crystal (A) that contains the protein 2C-methyl-D-erythritol-4-phosphate synthase (I) is new. Independent claims are also included for: (1) a data-storage device that contains the atomic coordinates of the three-dimensional structure of (I) as a complex (C) with an inhibitor (II) of (I) and optionally also a divalent metal ion; (2) method for growing a crystal that contains (I) and optionally metal ions; (3) several methods for identifying potential inhibitors (X) of (I); and (4) (X) identified by the methods of (3). ACTIVITY : Protozoacide; Antibacterial; Herbicide. No biological data given. MECHANISM OF ACTION : Inhibition of 2C-methyl-D-erythritol-4-phosphate synthase.

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