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41. 发明授权

US09138553B2 Ventilation interface for sleep apnea therapy 有权
公开(公告)号：US09138553B2
公开(公告)日：2015-09-22
申请号：US13494323
申请日：2012-06-12
申请人： Thomas Wood
发明人： Thomas Wood
IPC分类号： A61M16/06 , A61M16/20
CPC分类号： A61M16/0666 , A61M16/06 , A61M16/0616 , A61M16/0694 , A61M16/0816 , A61M16/0833 , A61M16/20 , A61M16/201 , A61M2206/20
摘要： The ventilation interface for sleep apnea therapy interfaces a ventilation device to the patient's airways. The ventilation interface includes a pair of nasal inserts made from flexible, resilient silicone which are oval shaped in cross-section and slightly tapered from a base proximal the ventilation supply to the distal tip end. A bead flange is disposed about the exterior of each insert at the distal end of the insert. A bleed port for release of exhaled air is defined through a conical vent projecting normally to the path of the incoming air flow, and continues through a nipple extending to the exterior of the air conduit. In one embodiment, a pair of nasal inserts are integral with a nasal cannula body, with bleed ports axially aligned with each insert. In another embodiment, each insert is independently connected to a separate, thin-walled, flexible supply line.

42. 发明授权

US09089463B1 Patient head support for receiving medical treatment in the prone position 有权
标题翻译：病人头部支撑在俯卧位接受治疗
公开(公告)号：US09089463B1
公开(公告)日：2015-07-28
申请号：US14337343
申请日：2014-07-22
申请人： Thomas Wood
发明人： Thomas Wood
IPC分类号： A61G7/07 , A61M16/06 , A61M16/00 , A61M16/08
CPC分类号： A61G7/072 , A61G13/121 , A61G13/1215 , A61G13/1285 , A61G13/1295 , A61G2200/325 , A61M16/06 , A61M16/0683 , A61M16/0875 , A61M2016/0661
摘要： A patient head support for treatment in the prone position. A patient head support apparatus which facilitates management of the respiratory function of a patient residing in a prone position. The apparatus includes a support base and a deformable resilient insert placed within it. The insert has a depression for receiving the patient's face either with or without a facial mask. The apparatus is provided with a passageway for delivery of gaseous inhalant to the patient and a coupling means at the external port to facilitate connection of the tubing to an external supply of an inhalant gas, allowing patients to be sedated rather than anesthetized for treatment.
摘要翻译：患者头部支撑在俯卧位治疗。一种患者头部支撑装置，其便于管理位于俯卧位的患者的呼吸功能。该装置包括支撑基座和放置在其内的可变形弹性插入件。插入物具有用于接收患者面部的凹陷部，其具有或不具有面罩。该装置设置有用于将气体吸入剂输送到患者的通道和在外部端口处的联接装置，以便于将管道连接到外部吸入剂气体供给装置，允许患者镇静而不是被麻醉以进行治疗。

43. 发明授权

US07955596B2 B. anthracis prevention and treatment: mutant B. anthracis lacking luxs activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production 有权
标题翻译： B.炭疽预防和治疗：突变体B.炭疽菌缺乏勒克斯活性和呋喃酮抑制生长，AI-2群体感应和毒素生产
公开(公告)号：US07955596B2
公开(公告)日：2011-06-07
申请号：US12044135
申请日：2008-03-07
申请人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
发明人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
IPC分类号： A01N63/00 , A61K39/00 , A61K39/02 , C12N1/12 , C12N15/74 , C12N15/75
CPC分类号： C07K14/32
摘要： The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B. anthracis infection, or enhance an immune response to B. anthracis infection, by administering a vaccine comprising a B. anthracis cell in which the luxS gene is mutated.
摘要翻译：本发明涉及炭疽芽孢杆菌具有编码功能性LuxS多肽的luxS基因的发现，并且炭疽杆菌合成功能性的AI-2群体感应分子。本发明提供了与野生型炭疽芽孢杆菌相比，不产生功能性AI-2分子并具有生长缺陷的缺乏luxS基因功能的突变体B.炭疽杆菌。本发明还涉及通过抑制炭疽芽孢杆菌LuxS多肽的活性或通过将炭疽杆菌暴露于呋喃酮而抑制炭疽芽孢杆菌生长或预防或治疗炭疽杆菌感染的方法。特别地，本发明涉及使用呋喃酮（一种抑制AI-2介导的群体感应的化合物）来抑制炭疽芽孢杆菌的生长，抑制炭疽杆菌毒素生产，特别是保护性抗原的产生，并防止或治疗炭疽杆菌感染。本发明还提供了通过施用包含luxS基因突变的炭疽杆菌细胞的疫苗来预防炭疽杆菌感染或增强对炭疽杆菌感染的免疫应答的方法。

44. 发明授权

US07669114B2 Software architecture and system for performing validated clinical studies of pharmaceutical related products 有权
标题翻译：用于执行药物相关产品验证临床研究的软件架构和系统
公开(公告)号：US07669114B2
公开(公告)日：2010-02-23
申请号：US11123720
申请日：2005-05-06
申请人： Thomas Wood
发明人： Thomas Wood
IPC分类号： G06F17/00 , H04N7/16 , H04L9/00
CPC分类号： G06F17/21 , G06F19/00 , G06Q50/24 , G16H10/20
摘要： Software, and a master system with hardware and connections, for validated drug clinical studies includes: creating data collection documents with unique identifiers; having operators complete security identification verification before proceeding; having secured operators fill out and sign specified data collection documents; creating permanent records of the preceding; tracking by unique identifiers in a local system; uploading to a central system; independently reviewing filled out signed data collection documents to accept or require clarifications; keeping permanent read only records of all originally filled out and signed documents; making document clarification requests; reviewing each response; assigning new unique identifier links to each version of every revision; iteratively repeating the above until the documents are clean, and storing and tracking every version of every document in the central system; providing a monitor query and document entry history of all changes to all documents to create a secured audit trail.
摘要翻译：软件和具有硬件和连接的主系统用于经过验证的药物临床研究，包括：创建具有唯一标识符的数据收集文档; 操作员完成安全识别验证; 确保操作人员填写并签署指定的数据收集文件; 创建上述的永久记录; 在本地系统中跟踪唯一标识符; 上传到中央系统; 独立审查填写签字数据收集文件以接受或要求澄清; 保留所有原始填写和签名文件的永久性只读记录; 提出文件澄清要求; 回顾每一个回应; 为每个版本的每个版本分配新的唯一标识符链接; 反复重复上述操作，直到文件清洁，并存储和跟踪中央系统中每个文档的每个版本; 提供对所有文档的所有更改的监视器查询和文档输入历史记录，以创建安全的审计跟踪。

45. 发明申请

US20090011210A1 Lightweight glass fiber reinforced thermoplastic material 审中-公开
标题翻译：轻质玻璃纤维增强热塑性材料
公开(公告)号：US20090011210A1
公开(公告)日：2009-01-08
申请号：US12070372
申请日：2008-02-15
申请人： Xiao Gao , Thomas Arnold Ebeling , Brian Hynes , Scott Davis , Thomas Wood , Josephus Theorodus Petrus Dictus , Thomas Arnold Ebeling
发明人： Xiao Gao , Thomas Arnold Ebeling , Brian Hynes , Scott Davis , Thomas Wood , Josephus Theorodus Petrus Dictus , Thomas Arnold Ebeling
IPC分类号： B32B5/00 , B32B37/00 , B32B38/00
CPC分类号： B32B37/206 , B29C70/504 , B29K2101/12 , B29K2105/0845 , B29K2105/128 , B29K2995/0077 , B32B17/04 , B32B27/12 , B32B37/185 , B32B2260/021 , B32B2260/046 , B32B2262/101 , B32B2305/08 , B32B2307/54 , B32B2307/546 , B32B2307/72 , B32B2309/105 , B32B2315/085 , B32B2398/20 , B32B2553/00 , B32B2605/003 , C08J5/043 , Y10T156/10
摘要： A glass fiber reinforced thermoplastic sheet material is provided in which certain properties, or combinations of properties, are improved relative to similar comparative sheet materials. The sheet material generally comprises a glass mat or glass fabric fiber reinforced thermoplastic resin in which the thermoplastic resin at least partially impregnates the glass mat or fabric. The thermoplastic sheet material contains about 15 wt. % to about 65 wt. % of the glass mat or fabric based on the weight of the thermoplastic sheet material and has a thickness in the range of about 0.4 mm to about 3.0 mm. By including glass mat or fabric and maintaining the sheet thickness in the aforementioned range, the present invention thermoplastic sheet material exhibits improved flexural and/or tensile strength and modulus properties at reduced basis weight compared to a comparative thermoplastic sheet materials. A method of providing the glass fiber reinforced thermoplastic sheet material having an improved combination of flexural strength and modulus and/or tensile strength and modulus properties is also described, in which a first layer of a first thermoplastic resin, a second layer of a second thermoplastic resin, and a layer of glass mat or glass fabric are provided; the first thermoplastic resin layer, the second thermoplastic resin layer and the glass mat or glass fabric layer are arranged such that the glass mat or glass fabric layer is interposed between the first and second thermoplastic resin layers; and heat and pressure are applied to substantially melt and compress the first thermoplastic resin and/or the second thermoplastic resin and to at least partially impregnate the glass mat or glass fabric layer with the molten first thermoplastic resin and/or the molten second thermoplastic resin.
摘要翻译：提供了一种玻璃纤维增强的热塑性片材材料，其中相对于类似的比较片材材料，某些特性或性能的组合得到改善。片材通常包括玻璃毡或玻璃纤维增强热塑性树脂，其中热塑性树脂至少部分地浸渍玻璃毡或织物。热塑性片材含有约15wt。％至约65wt。基于热塑性片材的重量的玻璃毡或织物的百分比，其厚度在约0.4mm至约3.0mm的范围内。通过包括玻璃毡或织物并将片材厚度保持在上述范围内，与对比的热塑性片材相比，本发明的热塑性片材具有降低的基重的抗弯强度和/或拉伸强度和模量特性。还描述了提供具有改进的弯曲强度和/或拉伸强度和模量特性的组合的玻璃纤维增强热塑性片材的方法，其中第一热塑性树脂第一层，第二热塑性树脂的第二层树脂和一层玻璃垫或玻璃织物; 第一热塑性树脂层，第二热塑性树脂层和玻璃毡或玻璃织物层被布置成使得玻璃毡或玻璃织物层插入在第一和第二热塑性树脂层之间; 并且施加热和压力以基本上熔化和压缩第一热塑性树脂和/或第二热塑性树脂并且至少部分地用熔融的第一热塑性树脂和/或熔融的第二热塑性树脂浸渍玻璃毡或玻璃织物层。

46. 发明授权

US07365184B2 B. anthracis prevention and treatment: mutant B. anthracis lacking luxS activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production 失效
标题翻译： B.炭疽预防和治疗：突变体B.蒽醌缺乏luxS活性和呋喃酮抑制生长，AI-2群体感应和毒素生产
公开(公告)号：US07365184B2
公开(公告)日：2008-04-29
申请号：US10823396
申请日：2004-04-12
申请人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
发明人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
IPC分类号： C07H21/04 , C12N15/00 , C12N21/02 , C12P21/04 , C12P21/06
CPC分类号： C07K14/32
摘要： The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B. anthracis infection, or enhance an immune response to B. anthracis infection, by administering a vaccine comprising a B. anthracis cell in which the luxS gene is mutated.
摘要翻译：本发明涉及炭疽芽孢杆菌具有编码功能性LuxS多肽的luxS基因的发现，并且炭疽杆菌合成功能性的AI-2群体感应分子。本发明提供了与野生型炭疽芽孢杆菌相比，不产生功能性AI-2分子并具有生长缺陷的缺乏luxS基因功能的突变体B.炭疽杆菌。本发明还涉及通过抑制炭疽芽孢杆菌LuxS多肽的活性或通过将炭疽杆菌暴露于呋喃酮而抑制炭疽芽孢杆菌生长或预防或治疗炭疽杆菌感染的方法。特别地，本发明涉及使用呋喃酮（一种抑制AI-2介导的群体感应的化合物）来抑制炭疽芽孢杆菌的生长，抑制炭疽杆菌毒素生产，特别是保护性抗原的产生，并防止或治疗炭疽杆菌感染。本发明还提供了通过施用包含luxS基因突变的炭疽杆菌细胞的疫苗来预防炭疽杆菌感染或增强对炭疽杆菌感染的免疫应答的方法。

47. 发明申请

US20070277733A1 APPARATUS FOR APPLYING A PROTECTIVE LAYER TO A PIPE JOINT 审中-公开
标题翻译：将保护层应用于管接头的装置
公开(公告)号：US20070277733A1
公开(公告)日：2007-12-06
申请号：US11756661
申请日：2007-06-01
申请人： Thomas Wood , Mario Perez
发明人： Thomas Wood , Mario Perez
IPC分类号： B05C13/02 , B05C1/08
CPC分类号： B29C63/06 , F16L58/181
摘要： An apparatus and method for applying a protective material to the girth weld of pipe. The apparatus is particularly suited for protecting a pipe that, except for the ends adjacent to the weld, is protected by layer of a semi-interpenetrating polymer network of epoxy and polyolefin resins. Using the apparatus and method, the protective material is firmly bonded to both the exposed steel end and the pre-existing protective layer.
摘要翻译：一种将保护材料施加到管道环形焊缝的装置和方法。该设备特别适用于保护管道，除了邻近焊缝的端部之外，环氧树脂和聚烯烃树脂的半互穿聚合物网络层被保护。使用该设备和方法，保护材料牢固地结合到暴露的钢端和预先存在的保护层。

48. 发明申请

US20070248875A1 OXYGEN-REDUCING CATALYST LAYER 有权
标题翻译：氧化还原催化剂层
公开(公告)号：US20070248875A1
公开(公告)日：2007-10-25
申请号：US11379523
申请日：2006-04-20
申请人： Dennis O'Brien , Alison Schmoeckel , George Vernstrom , Radoslav Atanasoski , Thomas Wood , Ruizhi Yang , E. Easton , Jeffrey Dahn , David O'Neill
发明人： Dennis O'Brien , Alison Schmoeckel , George Vernstrom , Radoslav Atanasoski , Thomas Wood , Ruizhi Yang , E. Easton , Jeffrey Dahn , David O'Neill
IPC分类号： H01M4/96 , H01M4/90
CPC分类号： H01M4/96 , H01M4/8867 , H01M4/8882 , H01M4/90 , H01M4/9083 , H01M8/1004 , Y02P70/56
摘要： An oxygen-reducing catalyst layer, and a method of making the oxygen-reducing catalyst layer, where the oxygen-reducing catalyst layer includes a catalytic material film disposed on a substrate with the use of physical vapor deposition and thermal treatment. The catalytic material film includes a transition metal that is substantially free of platinum. At least one of the physical vapor deposition and the thermal treatment is performed in a processing environment comprising a nitrogen-containing gas.
摘要翻译：一种氧还原催化剂层以及一种制造氧还原催化剂层的方法，其中氧还原催化剂层包括使用物理气相沉积和热处理设置在基板上的催化材料膜。催化材料膜包括基本上不含铂的过渡金属。在包含含氮气体的处理环境中进行物理气相沉积和热处理中的至少一种。

49. 发明申请

US20070014069A1 Method and apparatus to protect an ethernet network by suppression of transient voltage pulses using a plasma limiter 审中-公开
标题翻译：通过使用等离子体限制器抑制瞬态电压脉冲来保护以太网网络的方法和装置
公开(公告)号：US20070014069A1
公开(公告)日：2007-01-18
申请号：US11474241
申请日：2006-06-23
申请人： Peter Krueger , Louie Elliott , Clifton Murphy , Thomas Wood , Robert Pap
发明人： Peter Krueger , Louie Elliott , Clifton Murphy , Thomas Wood , Robert Pap
IPC分类号： H02H9/06
CPC分类号： H01T19/04 , H01J17/40
摘要： The invention described here is a circuit protection device based on the principle of a plasma limiter. A plasma limiter uses an electrode such as a very sharp tungsten needle in an easily ionized gas to perform field enhancement using the interference voltage to initiate avalanche breakdown of the plasma. The gas becomes conductive, causing the interference voltage to short-circuit to ground thereby protecting the transceiver Integrated Circuit (IC). This device protects IC's that can be damaged by voltages greater than about 15 volts when damaging voltages have occurred on the wire(s) for a brief time. The damaging voltage creates an electromagnetic field that is enhanced by the sharp electrode thereby causing the easily ionized gas to become plasma and conduct between the wire and grounded electrode. This conduction prevents the damaging voltage on the wire from becoming so great that IC's become damaged. A protection module consists of devices to protect one or many signals in a single module. An implementation of the protection module is a free-standing module that is placed inline with a cable. Also, an implementation of the protection module is a device to be mounted on the printed circuit board or mounted to a panel of the circuit to be protected.
摘要翻译：这里描述的发明是基于等离子体限制器的原理的电路保护装置。等离子体限制器在容易电离的气体中使用诸如非常锋利的钨针之类的电极，使用干涉电压进行场增强，以引发等离子体的雪崩击穿。气体导通，导致干扰电压短路到地，从而保护收发器集成电路（IC）。该器件保护IC在短时间内损坏电线时可能会受到大于15伏的电压的损坏。损坏的电压产生电磁场，该电磁场被尖锐的电极增强，从而使容易离子化的气体变成等离子体并在导线和接地的电极之间导电。这种传导可防止线路上的损坏电压变得如此之大，以至于IC损坏。保护模块由保护单个模块中的一个或多个信号的设备组成。保护模块的实现是一个独立的模块，与电缆放在一起。此外，保护模块的实现是要安装在印刷电路板上或者安装到待保护电路的面板上的装置。

50. 发明申请

US20060283605A1 Coiled tubing transport system and method 有权
公开(公告)号：US20060283605A1
公开(公告)日：2006-12-21
申请号：US11155056
申请日：2005-06-17
申请人： Thomas Wood , Randolph Charron
发明人： Thomas Wood , Randolph Charron
IPC分类号： E21B19/22 , B65H67/02
CPC分类号： E21B19/22 , B65H49/38 , E21B7/02
摘要： A coiled tubing transfer system comprising a carrier having a bed, the bed having a width and the length, the length of the bed being longer than the width of the bed, a reel removably supported on the bed, the reel comprising a spool rotatably journaled in first and second supports, the spool having a core with a diameter and long axis extending between the supports, the long axis having a length greater than the width of the bed, the reel being positionable on the bed in a first position with the long axis of the core extending lengthwise of the bed, the longest dimension of the reel transverse to the long axis of the core being less than the width of the bed and a length of coiled tubing useable in earth borehole operations being wound around the core, the coiled tubing having an outside diameter of from 1″ to 9″, the ratio of the diameter of the coiled tubing to the diameter of the core being from 1:20 to 1:70.

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