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41. 发明授权

US08058412B2 Dehydroxyfluorination agent 有权
标题翻译：脱羟基氟化剂
公开(公告)号：US08058412B2
公开(公告)日：2011-11-15
申请号：US12306826
申请日：2007-06-25
申请人： Akihiro Ishii , Takashi Ootsuka , Manabu Yasumoto , Hideyuki Tsuruta , Kenjin Inomiya , Koji Ueda , Kaori Mogi
发明人： Akihiro Ishii , Takashi Ootsuka , Manabu Yasumoto , Hideyuki Tsuruta , Kenjin Inomiya , Koji Ueda , Kaori Mogi
IPC分类号： C07D478/00 , C09K3/00 , C07C17/00 , C07C19/08 , C07C21/18
CPC分类号： C07B39/00 , C07B55/00 , C07B2200/07 , C07C17/16 , C07C67/307 , C07D207/16 , C07D209/48 , C07D405/04 , C07H19/09 , C07C19/08 , C07C69/63
摘要： There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2′-deoxy-2′-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.
摘要翻译：提供了含有硫酰氟（SO 2 F 2）和分子中不含游离羟基的有机碱的新型有用的脱羟基氟化剂。根据现有的脱羟基氟化剂，不需要使用全氟烷基磺酰氟，其在大规模使用中是不优选的，并且可以有利地制备作为药物，农药和光学的重要中间体的光学活性氟衍生物材料，例如4-氟脯氨酸衍生物，2'-脱氧-2'-氟尿苷衍生物，光学活性α-氟代羧酸酯衍生物和单氟甲基衍生物，甚至大规模。

42. 发明申请

US20100267940A1 Method for Producing 4-Deoxy-4-Fluoro-D-Glucose Derivative 审中-公开
标题翻译：生产4-脱氧-4-氟-D-葡萄糖衍生物的方法
公开(公告)号：US20100267940A1
公开(公告)日：2010-10-21
申请号：US12747071
申请日：2008-11-26
申请人： Akihiro Ishii , Manabu Yasumoto , Takashi Ootsuka , Yasuko Nigorikawa
发明人： Akihiro Ishii , Manabu Yasumoto , Takashi Ootsuka , Yasuko Nigorikawa
IPC分类号： C07H15/207 , C07H1/00
CPC分类号： C07H1/00 , C07H5/02 , C07H15/04
摘要： There is disclosed a method for producing a 4-deoxy-4-fluoro-D-glucose derivative by reacting a D-galactose derivative with either sulfuryl fluoride (SO2F2), trifluoromethanesulfonyl fluoride (CF3SO2F) or perfluorobutanesulfonyl fluoride (C4F9SO2F) in the presence of an organic base or in the presence of an organic base and a salt or complex of an organic base and hydrogen fluoride.
摘要翻译：公开了通过使D-半乳糖衍生物与硫酰氟（SO 2 F 2），三氟甲磺酰氟（CF 3 SO 2 F）或全氟丁磺酰氟（C 4 F 9 SO 2 F）在存在下反应生成4-脱氧-4-氟-D-葡萄糖衍生物的方法有机碱或有机碱和有机碱和氟化氢的盐或络合物存在下进行。

43. 发明申请

US20080103327A1 Process For Production Of Optically Active Alpha-Fluoro-Carboxylic Ester Derivatives 失效
标题翻译：光活性α-氟羧酸酯衍生物的制备方法
公开(公告)号：US20080103327A1
公开(公告)日：2008-05-01
申请号：US11597105
申请日：2005-08-05
申请人： Akihiro Ishii , Hideyuki Tsuruta , Takashi Ootsuka , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Koji Ueda
发明人： Akihiro Ishii , Hideyuki Tsuruta , Takashi Ootsuka , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Koji Ueda
IPC分类号： C07C69/63 , C07C31/38 , C07C69/635
CPC分类号： C07C67/307 , C07B2200/07 , C07C29/147 , C07C69/65 , C07C69/63 , C07C31/38
摘要： The present invention relates to a process for producing an optically active α-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active α-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CF3SO2F) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; R1 represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and R1 may form a covalent bond; and * represents an asymmetric carbon.
摘要翻译：本发明涉及通过使光学活性α-羟基羧酸酯衍生物与三氟甲磺酰氟（CF 3 SO 3）反应制备由式[2]表示的光学活性α-氟代羧酸酯衍生物的方法， 2 F）在有机碱存在下，在式[2]中，R表示碳数为1至12的直链或支链烷基; 碳数为1至6的芳族烃基，不饱和烃基，直链或支链烷氧基，芳氧基，卤素原子（氟，氯，溴和碘）的任意组合中的一个或两个，被保护的羧基被保护的氨基或被保护的羟基可以在烷基的任何碳原子上被取代; R 1表示碳数为1至8的直链或支链烷基; R和R 1的烷基的任何碳原子可以形成共价键; 和*表示不对称碳。

44. 发明申请

US20070191639A1 Optically active 1-Aryl-2-fluoro-substituted ethylamine and method for producing same 有权
标题翻译：光活性1-芳基-2-氟取代的乙胺及其制备方法
公开(公告)号：US20070191639A1
公开(公告)日：2007-08-16
申请号：US10591669
申请日：2005-02-21
申请人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Katsuhide Suto , Koji Ueda
发明人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Katsuhide Suto , Koji Ueda
IPC分类号： C07C209/26
CPC分类号： C07C251/24 , C07C209/52 , C07C209/62 , C07C211/29 , C07C249/02
摘要： The present invention relates to a method of producing an optically active 1-aryl-2-fluoro-substituted ethylamine compound of the formula [2] or a salt thereof by hydrogenolysis of an optically active secondary amine compound of the formula [1] or a salt thereof in the presence of a transition metal catalyst of Group VIII [Chem. 59] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] [Chem. 60] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon].
摘要翻译：本发明涉及通过氢解式[1]的光学活性仲胺化合物或式[1]的光学活性的1-芳基-2-氟取代的乙胺化合物或其盐，其盐在第VIII族的过渡金属催化剂存在下[Chem。 59]其中Ar表示芳基; n表示1或2的整数; 和*表示不对称碳] 60] [其中Ar表示芳基; n表示1或2的整数，和*表示不对称碳]。

45. 发明授权

US07025101B2 Pneumatic radial tire with specified tread portion bending rigidity ratio 失效
标题翻译：具有规定胎面部分弯曲刚度比的气动子午线轮胎
公开(公告)号：US07025101B2
公开(公告)日：2006-04-11
申请号：US10515022
申请日：2003-05-20
申请人： Takashi Ootsuka
发明人： Takashi Ootsuka
IPC分类号： B60C3/04 , B60C9/00 , B60C9/02 , B60C9/18
CPC分类号： B60C9/18 , B60C9/04 , B60C9/08 , B60C2200/10 , Y10T152/10765 , Y10T152/10855
摘要： There is provided a pneumatic radial tire for a motorcycle capable of developing an excellent steering stability in a high-speed cornering subjected to a large camber angle, and having an aspect ratio of 0.50–0.85, in which a tensile strength at break of a carcass ply cord is not less than 980 MPa, and an absolute value of a carcass total rigidity obtained by adding carcass rigidities of carcass plies is not less than 30000, and a tensile strength at break of a belt layer cord is not less than 2350 MPa, and an absolute value of a belt total rigidity obtained by adding belt rigidities of belt layers is not less than 170000, and a bending rigidity ratio as a ratio of out-of-plane bending rigidity to in-plane bending rigidity is within a range of 4.20–9.10.
摘要翻译：提供了一种用于摩托车的充气子午线轮胎，其能够在经受大的外倾角的高速转弯中显示出优异的操纵稳定性，并且纵横比为0.50-0.85，其中胎体的断裂拉伸强度帘线帘线不小于980MPa，通过添加胎体帘布层的胎体刚性而获得的胎体总刚度的绝对值不小于30000，带束帘线的断裂拉伸强度不小于2350MPa，并且通过增加带束层的带刚性而获得的带总刚度的绝对值不小于170000，并且作为面外弯曲刚性与面内弯曲刚度之比的弯曲刚度比在 4.20-9.10。

46. 发明申请

US20050205188A1 Pneumatic radial tire for motorcycle 失效
标题翻译：气动子午线轮胎
公开(公告)号：US20050205188A1
公开(公告)日：2005-09-22
申请号：US10515022
申请日：2003-05-20
申请人： Takashi Ootsuka
发明人： Takashi Ootsuka
IPC分类号： B60C9/04 , B60C9/08 , B60C9/18 , B60C9/00
CPC分类号： B60C9/18 , B60C9/04 , B60C9/08 , B60C2200/10 , Y10T152/10765 , Y10T152/10855
摘要： There is provided a pneumatic radial tire for a motorcycle capable of developing an excellent steering stability in a high-speed cornering subjected to a large camber angle, and having an aspect ratio of 0.50-0.85, in which a tensile strength at break of a carcass ply cord is not less than 980 MPa, and an absolute value of a carcass total rigidity obtained by adding carcass rigidities of carcass plies is not less than 30000, and a tensile strength at break of a belt layer cord is not less than 2350 MPa, and an absolute value of a belt total rigidity obtained by adding belt rigidities of belt layers is not less than 170000, and an out-of-plane bending rigidity in widthwise direction of a tread portion is 0.40-0.70 kg/mm and an in-plane bending rigidity in peripheral direction thereof is 0.05-0.15 kg/mm and a bending rigidity ratio as a ratio of out-of-plane bending rigidity to in-plane bending rigidity is within a range of 4.20-9.10.
摘要翻译：提供了一种用于摩托车的充气子午线轮胎，其能够在经受大的外倾角的高速转弯中显示出优异的操纵稳定性，并且纵横比为0.50-0.85，其中胎体的断裂拉伸强度帘线帘线不小于980MPa，通过添加胎体帘布层的胎体刚性而获得的胎体总刚度的绝对值不小于30000，带束帘线的断裂拉伸强度不小于2350MPa，并且通过增加带束层的带刚性而获得的带总刚度的绝对值不小于170000，并且胎面部分的宽度方向上的面外弯曲刚度为0.40-0.70kg / mm，其周向的平面弯曲刚性为0.05〜0.15kg / mm，作为面外弯曲刚性与面内弯曲刚性的比的弯曲刚度比在4.20〜9.10的范围内。

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