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41. 发明申请

US20130011390A1 METHODS OF TREATING CENTRAL NERVOUS SYSTEM ISCHEMIC OR HEMORRHAGIC INJURY USING ANTI ALPHA4 INTEGRIN ANTAGONISTS 审中-公开
标题翻译：使用抗ALPHA4 INTEGRIN ANTAGONISTS治疗中枢神经系统异常或HEMORRHAGIC损伤的方法
公开(公告)号：US20130011390A1
公开(公告)日：2013-01-10
申请号：US13490092
申请日：2012-06-06
申请人： Jane Relton , Roy R. Lobb , Eric Whalley , Steven P. Adams
发明人： Jane Relton , Roy R. Lobb , Eric Whalley , Steven P. Adams
IPC分类号： A61K39/395 , A61P9/10 , A61P29/00 , A61P25/00 , A61P7/02
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2842 , C07K2317/76
摘要： Methods of, and compositions for, treating central nervous system injury with an antagonist of an alpha4 subunit containing integrin are described.
摘要翻译：描述了用含有整联蛋白的α4亚基拮抗剂治疗中枢神经系统损伤的方法和组合物。

42. 发明授权

US07001921B1 Cell adhesion inhibitors 失效
公开(公告)号：US07001921B1
公开(公告)日：2006-02-21
申请号：US10625626
申请日：2003-07-24
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
IPC分类号： A61K31/195 , C07C233/00
CPC分类号： A61K31/195
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.

43. 发明授权

US06710237B2 Drum pedal for enhanced mating of a drummer's foot 失效
标题翻译：鼓脚踏板，用于增强鼓手脚的交配
公开(公告)号：US06710237B2
公开(公告)日：2004-03-23
申请号：US10078126
申请日：2002-02-19
申请人： Steven P. Adams
发明人： Steven P. Adams
IPC分类号： G10D1302
CPC分类号： G10D13/006
摘要： A drum pedal for enhanced mating of a drummer's foot is disclosed. In a preferred embodiment, a foot pad is employed for attachment to a pedal of a drum having an upwardly extending protrusion that enables improved sensory perception to properly locate a drummer's foot and to enable learning and consistently applying a force to a sweet spot during drumming. The foot pad also includes shock absorption to reduce the negative effects of repeated impact to the user's foot during drumming. A variety of embodiments include traction treads, a plurality of protrusions or built up portions in different respective locations of the footpad, and an additional stiffening layer to effectively widen the foot pedal. A method of use includes locating the foot pad on a the foot pedal, and in particular locating a protrusion on the foot pedal to enable consistent drumming by improved sensory perception and positioning of a drummer's foot during drumming.
摘要翻译：公开了一种用于增强与鼓手相配的鼓踏板。在优选实施例中，脚垫用于连接到具有向上延伸突出部的鼓的踏板，其能够改善感官感知以适当地定位鼓手的脚并且使得能够在打击期间学习并一致地向最佳点施加力。脚垫还包括减震，以减少在打击期间对用户脚的反复冲击的负面影响。各种实施例包括牵引踏板，在脚垫的不同相应位置的多个突起或建立部分，以及附加的加强层，以有效地加宽脚踏板。一种使用方法包括将脚垫定位在脚踏板上，并且特别地将脚踏板上的突起定位在脚踏板上，以便通过改善在鼓鼓期间的鼓手脚的感觉知觉和定位来实现一致的打击。

44. 发明授权

US06596687B1 Cell adhesion inhibitors 失效
公开(公告)号：US06596687B1
公开(公告)日：2003-07-22
申请号：US09482296
申请日：2000-01-13
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3803
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1024 , C07K14/78 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.

45. 发明授权

US5614539A Urea compounds which are useful as platelet aggregation inhibitors 失效
标题翻译：可用作血小板聚集抑制剂的尿素化合物
公开(公告)号：US5614539A
公开(公告)日：1997-03-25
申请号：US446812
申请日：1995-06-01
申请人： Steven P. Adams , Foe S. Tjoeng , Mark E. Zupec
发明人： Steven P. Adams , Foe S. Tjoeng , Mark E. Zupec
IPC分类号： A61K38/00 , C07C279/12 , C07D213/55 , C07K5/072 , A61K31/44
CPC分类号： C07K5/06113 , C07C279/12 , C07D213/55 , A61K38/00
摘要： Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
摘要翻译： PCT No.PCT / US94 / 02157 Sec。 371日期：1995年6月1日 102（e）1995年6月1日PCT 1994年3月9日PCT公布。公开号WO94 / 21602 日期1994年9月29日提供抑制血小板聚集的新型尿素衍生物。本发明还涉及使用这些衍生物的药物组合物和方法。

46. 发明授权

US5409939A Phenyl amidine thio derivatives useful as platelet aggregation inhibitors 失效
标题翻译：可用作血小板聚集抑制剂的苯基脒硫代衍生物
公开(公告)号：US5409939A
公开(公告)日：1995-04-25
申请号：US17203
申请日：1993-02-12
申请人： Steven P. Adams , Richard J. Lindmark , Masateru Miyano , Joseph G. Rico
发明人： Steven P. Adams , Richard J. Lindmark , Masateru Miyano , Joseph G. Rico
IPC分类号： C07C317/28 , C07C317/50 , C07C323/59 , C07D213/71 , A61K31/44
CPC分类号： C07C323/59 , C07C317/28 , C07C317/50 , C07D213/71
摘要： This invention relates to compounds having the following formula ##STR1## which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine thio derivatives.
摘要翻译：本发明涉及具有以下结构式的化合物，其可用于抑制血小板聚集。本发明还涉及这种苯基脒硫代衍生物的药物组合物。

47. 发明授权

US5359053A Modified deazapyrimidines 失效
标题翻译：改性去氮杂嘧啶
公开(公告)号：US5359053A
公开(公告)日：1994-10-25
申请号：US879648
申请日：1992-05-06
申请人： Thomas E. Rogers , Steven H. Gray , Balekudru Devadas , Steven P. Adams
发明人： Thomas E. Rogers , Steven H. Gray , Balekudru Devadas , Steven P. Adams
IPC分类号： C07H19/048 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68 , C12Q1/70 , C07H15/12 , C07H17/00 , C07H19/06
CPC分类号： C07H21/00 , C12Q1/6813 , C12Q1/6827 , C12Q1/6832 , C12Q1/6876 , C12Q1/689 , C12Q1/6895 , C12Q1/701 , C12Q2600/156 , Y10S435/805
摘要： The probes of the invention are able to withstand higher temperatures, thereby allowing unmatched probes and mismatched probes to be washed off at higher hybridization stringency, thereby eliminating background readings and improving ease and accuracy of probe use.
摘要翻译：本发明的探针能够承受更高的温度，从而使得不匹配的探针和错配的探针在更高的杂交严格性下被洗掉，从而消除背景读数并提高探针使用的简便性和准确性。

48. 发明授权

US5338858A Triazolyl, tetrazolyl and azido-substituted fatty acid analog enzyme substrates 失效
标题翻译：三唑基，四唑基和叠氮基取代的脂肪酸类似物酶底物
公开(公告)号：US5338858A
公开(公告)日：1994-08-16
申请号：US963620
申请日：1992-10-20
申请人： Balekudru Devadas , Jeffrey I. Gordon , Steven P. Adams
发明人： Balekudru Devadas , Jeffrey I. Gordon , Steven P. Adams
IPC分类号： A61K31/41 , A61K31/655 , A61P31/12 , C07C247/12 , C07C323/52 , C07D249/02 , C07D249/04 , C07D257/04 , C07D521/00 , C07K1/107 , C07K1/113 , C07K14/00 , C12N9/10 , C12P21/02 , C07D255/02 , C07C117/08
CPC分类号： C07D257/04 , C07C247/12 , C07C323/52 , C07D231/12 , C07D233/56 , C07D249/04 , C07D249/08 , C07K1/1077 , C12N9/1029
摘要： Azido-substituted fatty acid analogs which are useful in the fatty acid acylation of peptides and proteins and as antiviral agents are disclosed having the following chemical structure:Z--(CH.sub.2).sub.x COORwhereinZ=azido, tetrazolyl or triazolylR=H or C.sub.1 -C.sub.8 alkyl, andx=8-12.
摘要翻译：公开了可用于肽和蛋白质和抗病毒剂的脂肪酸酰化的叠氮取代的脂肪酸类似物，其具有以下化学结构：Z-（CH 2）x COOR其中Z =叠氮基，四唑基或三唑基R = H或C1- C8烷基，x = 8-12。

49. 发明授权

US5225531A Hexapeptide Lys Gly Ala Gly Asp Val 失效
标题翻译：六肽Lys Gly Ala Gly Asp Val
公开(公告)号：US5225531A
公开(公告)日：1993-07-06
申请号：US866678
申请日：1992-04-09
申请人： Hattie D. Gresham , Steven P. Adams , Eric J. Brown
发明人： Hattie D. Gresham , Steven P. Adams , Eric J. Brown
IPC分类号： A61K38/00 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/75
CPC分类号： C07K14/75
摘要： A novel hexapeptide is disclosed which has ligand binding specificity of the leukocyte response integrin expressed by human neutrophils and that has the following amino acid sequence ##STR1##

50. 发明授权

US5091396A Pyridyl peptide mimetic compounds which are useful platelet-aggregation inhibitors 失效
标题翻译：吡啶基肽模拟化合物是有用的血小板聚集抑制剂
公开(公告)号：US5091396A
公开(公告)日：1992-02-25
申请号：US637728
申请日：1991-01-07
申请人： Foe S. Tjoeng , Steven P. Adams , Robert B. Garland , Masateru Miyano
发明人： Foe S. Tjoeng , Steven P. Adams , Robert B. Garland , Masateru Miyano
IPC分类号： C07C279/14 , C07K5/02 , C07K5/072
CPC分类号： C07K5/06113 , C07C279/14 , C07K5/021
摘要： Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8,y=0 to 4,W=CH.sub.2 --CH.sub.2 or C.dbd.CH,Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,R=C.sub.1-6 alkyl,Ar=a nitrogen-containing heterocyclic group, andAsp=aspartic acid residue.
摘要翻译：提供了具有作为血小板聚集抑制剂的有用活性的新型肽模拟化合物。这些化合物具有化学结构，其中x = 4至8，y = 0至4，W = CH 2 -CH 2或C = CH，Z = H，COOH，CONH 2，CH 2 OH，CO 2 R，CH 2 OR或C 1-6烷基，R = C 1-6烷基，Ar =含氮杂环基，Asp =天冬氨酸残基。

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