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41. 发明申请

US20100098633A1 SELECTIVE SEPRASE INHIBITORS 审中-公开
标题翻译：选择性SEPRASE抑制剂
公开(公告)号：US20100098633A1
公开(公告)日：2010-04-22
申请号：US12566324
申请日：2009-09-24
申请人： Craig ZIMMERMAN , John W. Babich , John Joyal , John Marquis , Jian-cheng Wang
发明人： Craig ZIMMERMAN , John W. Babich , John Joyal , John Marquis , Jian-cheng Wang
IPC分类号： A61K51/04 , A61K31/69 , A61K31/555 , A61K31/40 , C07F13/00 , A61P35/00
CPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , C07D403/14 , C07F13/005
摘要： Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by overexpression of seprase include complexes that contains a proline moiety and a radionuclide adapted for radioimaging and/or radiotherapy:
摘要翻译：可用于以seprase过表达为特征的疾病的诊断成像和治疗性治疗中的新型放射性药物包括含有脯氨酸部分和适于放射成像和/或放射治疗的放射性核素的复合物：

42. 发明申请

US20090175794A1 INHIBITORS OF CARBONIC ANHYDRASE IX 有权
标题翻译：碳氢化合物抑制剂IX
公开(公告)号：US20090175794A1
公开(公告)日：2009-07-09
申请号：US12350894
申请日：2009-01-08
申请人： Craig Zimmerman , John W. Babich , John Joyal , Genliang Lu , Kevin P. Maresca , Chris Barone
发明人： Craig Zimmerman , John W. Babich , John Joyal , Genliang Lu , Kevin P. Maresca , Chris Barone
IPC分类号： A61K49/00 , C07F15/00 , A61K31/555 , A61P35/00
CPC分类号： A61K51/0406 , A61K31/18 , A61K31/4192 , A61K31/444 , A61K31/555 , A61K51/0446 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0474 , C07C311/37 , C07C335/16 , C07C335/20 , C07D213/36 , C07D249/04 , C07D285/135 , C07D401/12 , C07D403/12 , C07D417/12
摘要： Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by over expression of CA-IX comprise a complex that contains a sulfonamide moiety which is capable of binding the active catalytic site of CA-IX, and a radionuclide adapted for radioimaging and/or radiotherapy:
摘要翻译：可用于CA-IX过表达特征的疾病的诊断成像和治疗性治疗的新型放射性药物包含含有能够结合CA-IX的活性催化位点的磺酰胺部分和适于放射成像的放射性核素的复合物， /或放疗：

43. 发明申请

US20090148382A1 Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof 审中-公开
标题翻译：锝和铼 - 双（杂芳基）络合物及其使用方法
公开(公告)号：US20090148382A1
公开(公告)日：2009-06-11
申请号：US10589206
申请日：2005-02-14
申请人： John W. Babich , William C. Eckelman , Kevin P. Maresca , John W. Valliant , Jon Zubieta
发明人： John W. Babich , William C. Eckelman , Kevin P. Maresca , John W. Valliant , Jon Zubieta
IPC分类号： A61K51/08 , C07D401/12 , C07F19/00 , C07K1/107 , C07K5/08 , A61K51/04
CPC分类号： C07D233/64 , A61K51/04 , C07D213/38 , C07D217/14 , C07D235/14 , C07D235/20 , C07D277/28 , C07F13/005
摘要： One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.
摘要翻译：本发明的一个方面涉及锝（Tc）和铼（Re）与各种杂芳族配体的复合物，例如喹啉基和异喹啉基配体，以及它们在荧光和放射成像中用于各种临床诊断应用的用途，以及放射性药物治疗应用。本发明的另一方面涉及形成上述配合物的一部分的喹啉基和异喹啉基配体。还描述了制备锝和铼络合物的方法。本发明的另一方面涉及基于通过固相合成方法与小肽缀合的衍生化赖氨酸，丙氨酸和双氨基酸的喹啉基和异喹啉基配体。另外，本发明涉及使用本发明复合物成像哺乳动物区域的方法。

44. 发明申请

US20090023787A1 TECHNETIUM-DIPYRIDINE COMPLEXES, AND METHODS OF USE THEREOF 有权
标题翻译：技术 - 二吡啶配合物及其使用方法
公开(公告)号：US20090023787A1
公开(公告)日：2009-01-22
申请号：US12124736
申请日：2008-05-21
申请人： John W. Babich , Kevin P. Maresca
发明人： John W. Babich , Kevin P. Maresca
IPC分类号： A61K31/44 , C07D213/38 , C07D213/55 , C07K2/00 , C07F13/00
CPC分类号： C07D213/38 , C07F13/005
摘要： One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to novel pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium complexes are also described. Another aspect of the invention relates to novel pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.
摘要翻译：本发明的一个方面涉及锝（Tc）与各种杂芳族配体如吡啶基和咪唑基配体的新型复合物，以及它们在放射性药物中用于各种临床诊断和治疗应用的用途。本发明的另一方面涉及形成上述配合物的一部分的新型吡啶基配体。还描述了制备锝络合物的方法。本发明的另一方面涉及基于通过固相合成方法与小肽缀合的衍生化赖氨酸，丙氨酸和双氨基酸的新型吡啶基配体。另外，本发明涉及使用本发明复合物成像哺乳动物区域的方法。

45. 发明授权

US07179444B2 Pendant fatty acid imaging agents 失效
公开(公告)号：US07179444B2
公开(公告)日：2007-02-20
申请号：US10405094
申请日：2003-04-01
申请人： John W. Babich
发明人： John W. Babich
IPC分类号： A61K51/00 , A61K36/14
CPC分类号： A61K51/0478 , A61K51/0402 , A61K51/0487 , C07F13/005
摘要： The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for the myocardium.

46. 发明授权

US06491893B1 Compounds for targeting and imaging infection and inflammation 失效
标题翻译：用于靶向和成像感染和炎症的新型化合物
公开(公告)号：US06491893B1
公开(公告)日：2002-12-10
申请号：US09553006
申请日：2000-04-20
申请人： John W. Babich
发明人： John W. Babich
IPC分类号： A61K5100
CPC分类号： A61K51/088 , A61K47/642 , A61K51/08
摘要： The present invention provides novel agents for specifically targeting and detecting or treating focal sites of infection or inflammation in a subject.
摘要翻译：本发明提供用于特异性靶向和检测或治疗受试者感染或炎症的焦点部位的新型药剂。

47. 发明授权

US06187286B1 Tumor imaging agents, methods and kits 失效
标题翻译：肿瘤成像剂，方法和试剂盒
公开(公告)号：US06187286B1
公开(公告)日：2001-02-13
申请号：US08846999
申请日：1997-05-01
申请人： David R. Elmaleh , John W. Babich
发明人： David R. Elmaleh , John W. Babich
IPC分类号： A61K5100
CPC分类号： A61K51/0491 , A61K51/0497
摘要： The invention provides tumor imaging agents comprising a radionuclide in association with a nucleotide polyphosphate targeting molecule. Methods for using the tumor imaging agents and kits containing the tumor imaging agents or components suitable for production of the tumor imaging agents are also provided.
摘要翻译：本发明提供包含与核苷酸聚磷酸酯靶向分子相关联的放射性核素的肿瘤成像剂。还提供了使用肿瘤显像剂和含有肿瘤成像剂或适合于产生肿瘤成像剂的组分的试剂盒的方法。

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