专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US4341698A Enkaphalin derivatives 失效
标题翻译：恩考芬素衍生物
公开(公告)号：US4341698A
公开(公告)日：1982-07-27
申请号：US130431
申请日：1980-03-14
申请人： Albert A. Carr , Robert A. Farr , John M. Kane
发明人： Albert A. Carr , Robert A. Farr , John M. Kane
IPC分类号： A61K38/00 , C07D241/08 , C07K5/078 , C07K5/117 , C07C103/52
CPC分类号： C07K5/06139 , C07D241/08 , C07K5/1024 , A61K38/00
摘要： Novel analgesic and antipsychotic agents having the formula ##STR1## wherein Q is ##STR2## in which R.sub.1 is hydrogen, hydroxy or halogen and R.sub.4 is hydrogen or, R.sub.1 and R.sub.4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sulfinyl or sulfonyl, or Z and X, taken together, are methylidenyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R.sub.5 is hydrogen or halogen, and R.sub.2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group ##STR3## or the group ##STR4## wherein R.sub.3 is hydroxy, amino, alkylamino or dialkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantiomers and pharmaceutically acceptable salts thereof.
摘要翻译：其中Q为的新型止痛剂和抗精神病药，其中R1为氢，羟基或卤素，R4为氢或R1和R4均为羟基; Z是氢或具有1至4个碳原子的直链低级烷基，X是亚甲基，羰基，羟基亚甲基，硫代，亚磺酰基或磺酰基，或Z和X一起是亚甲基，条件是当X是磺酰基或亚磺酰基，Z不是氢; R 5是氢或卤素，R 2是H，具有1至4个碳原子的直链或支链低级烷基，基团“IMAGE”或基团“IMAGE”，其中R 3是羟基，氨基，烷基氨基或二烷基氨基，其中烷基部分是直链或支链的并且具有1至4个碳原子，非对映异构体，对映异构体和药学上可接受的盐。

42. 发明授权

US06297259B1 Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl) benzamides useful for the treatment of allergic diseases 失效
标题翻译：用于治疗过敏性疾病的N-取代的N-甲基-N-（4-（哌啶-1-基）-2-（芳基）丁基）苯甲酰胺
公开(公告)号：US06297259B1
公开(公告)日：2001-10-02
申请号：US09328964
申请日：1999-06-09
申请人： George P. Maynard , John M. Kane , Larry D. Bratton , Elizabeth M. Kudlacz
发明人： George P. Maynard , John M. Kane , Larry D. Bratton , Elizabeth M. Kudlacz
IPC分类号： A61K31445
CPC分类号： C07D401/04 , C07D211/22 , C07D211/70 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/06
摘要： The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
摘要翻译：本发明涉及可用作组胺受体拮抗剂的新型取代的N-甲基-N-（4-（哌啶-1-基）-2-（芳基）丁基）苯甲酰胺衍生物及其药学上可接受的盐和速激肽受体拮抗剂。这种拮抗剂可用于治疗过敏性鼻炎，包括季节性鼻炎和鼻窦炎; 炎性肠病，包括克罗恩病和溃疡性结肠炎; 哮喘; 支气管炎; 和呕吐。

43. 发明授权

US5874445A (+) -.alpha.- (2,3-dimethoxyphenyl)-1-(2-(4-fluorephenyl) ethyl)-4-piepridinemethanol 失效
标题翻译：（+） - α-（2,3-二甲氧基苯基）-1-（2-（4-氟苯基）乙基）-β-（4-哌啶甲醇）Ü
公开(公告)号：US5874445A
公开(公告)日：1999-02-23
申请号：US942629
申请日：1997-10-02
申请人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
发明人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
IPC分类号： A61K31/445 , A61K31/451 , A61P1/14 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/20 , A61P43/00 , C07D211/22
CPC分类号： C07D211/22
摘要： The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-�2-(4-fluorophenyl)ethyl!-4-piperidinemethanol, and its use in the treatment of a number of disease states.
摘要翻译：本发明涉及一种新的5HT2拮抗剂（+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇，其用于治疗疾病数量。

44. 发明授权

US5739150A Piperidinyl thiacyclic derivatives 失效
标题翻译：哌啶基硫辛酸衍生物
公开(公告)号：US5739150A
公开(公告)日：1998-04-14
申请号：US457199
申请日：1995-06-01
申请人： Albert A. Carr , John M. Kane , George D. Maynard , Hsien C. Cheng , Mark W. Dudley
发明人： Albert A. Carr , John M. Kane , George D. Maynard , Hsien C. Cheng , Mark W. Dudley
IPC分类号： A61K31/4433 , A61K31/445 , A61K31/454 , A61P37/08 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D409/02 , C07D417/02
CPC分类号： C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14
摘要： Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
摘要翻译：可用于治疗过敏性疾病和对5HT2受体拮抗作用的疾病的哌啶基硫辛酸衍生物，药物组合物和使用这些化合物的治疗方法。

45. 发明授权

US5596003A Piperidinyl thiacyclic derivatives 失效
公开(公告)号：US5596003A
公开(公告)日：1997-01-21
申请号：US457901
申请日：1995-06-01
申请人： Albert A. Carr , John M. Kane , George D. Maynard , Hsien C. Cheng , Mark W. Dudley
发明人： Albert A. Carr , John M. Kane , George D. Maynard , Hsien C. Cheng , Mark W. Dudley
IPC分类号： A61K31/4433 , A61K31/445 , A61K31/454 , A61P37/08 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D417/02
CPC分类号： C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14
摘要： Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.

46. 发明授权

US5541200A Piperidinyl thiacyclic derivatives 失效
标题翻译：哌啶基硫辛酸衍生物
公开(公告)号：US5541200A
公开(公告)日：1996-07-30
申请号：US448799
申请日：1995-05-24
申请人： Albert A. Carr , John M. Kane , George D. Maynard , Hsien C. Cheng , Mark W. Dudley
发明人： Albert A. Carr , John M. Kane , George D. Maynard , Hsien C. Cheng , Mark W. Dudley
IPC分类号： A61K31/4433 , A61K31/445 , A61K31/454 , A61P37/08 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14
CPC分类号： C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14
摘要： Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
摘要翻译：哌啶基硫辛酸衍生物其中X，Y，R 1，R 2，R 3和R 4在本说明书中定义。可用于治疗对5HT2受体的拮抗作用的过敏性疾病和疾病，药物组合物和使用这些化合物的治疗方法。

47. 发明授权

US5198433A Lactamimides as calcium antagonists 失效
标题翻译：内酰胺酰胺作为钙拮抗剂
公开(公告)号：US5198433A
公开(公告)日：1993-03-30
申请号：US918350
申请日：1992-07-21
申请人： Michael G. Palfreyman , Norbert L. Wiech , Hsien C. Cheng , John M. Kane
发明人： Michael G. Palfreyman , Norbert L. Wiech , Hsien C. Cheng , John M. Kane
IPC分类号： A61K31/395 , A61K31/40 , A61K31/445 , A61K31/55
CPC分类号： A61K31/55 , A61K31/395 , A61K31/40 , A61K31/445
摘要： Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.
摘要翻译：申请人已经发现，某些先前已知的酰胺酰亚胺衍生物具有有价值的钙通道阻断活性。由于这种钙拮抗活性，化合物是抗高血压药，并且将具有与钙拮抗剂相关的其它活性。

48. 发明授权

US5128337A Lactamimides as calcium antagonists 失效
标题翻译：内酰胺酰胺作为钙拮抗剂
公开(公告)号：US5128337A
公开(公告)日：1992-07-07
申请号：US763799
申请日：1991-09-23
申请人： Michael G. Palfreyman , Norbert L. Wiech , Hsien C. Cheng , John M. Kane
发明人： Michael G. Palfreyman , Norbert L. Wiech , Hsien C. Cheng , John M. Kane
IPC分类号： A61K31/395 , A61K31/40 , A61K31/445 , A61K31/55
CPC分类号： A61K31/55 , A61K31/395 , A61K31/40 , A61K31/445
摘要： Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.
摘要翻译：申请人已经发现，某些先前已知的酰胺酰亚胺衍生物具有有价值的钙通道阻断活性。由于这种钙拮抗活性，化合物是抗高血压药，并且将具有与钙拮抗剂相关的其它活性。

49. 发明授权

US5106845A Calcium antagonists 失效
标题翻译：钙拮抗剂
公开(公告)号：US5106845A
公开(公告)日：1992-04-21
申请号：US457997
申请日：1990-01-10
申请人： Albert A. Carr , Hsien C. Cheng , John M. Kane
发明人： Albert A. Carr , Hsien C. Cheng , John M. Kane
IPC分类号： C07D233/48 , C07D235/30 , C07D239/14 , C07D243/04 , C07D245/02 , C07D401/04
CPC分类号： C07D401/04 , C07D233/48 , C07D235/30 , C07D239/14 , C07D243/04 , C07D245/02
摘要： The present invention is directed to a new class of cyclic guanidines of the formula: ##STR1## in which Q is represented by a substituent selected from the group consisting of (CH.sub.2).sub.n in which n is an integer from 2-10, ##STR2## A is a substituent selected from the group consisting of --NH--(CH.sub.2).sub.m in which m is an integer from 0-5, a piperidino substituent, or a piperazino substituent; both Ar and Ar.sub.1 are each independently represented by a phenyl ring, each of which may be optionally substituted with up to 3 substituents, each selected from the group consisting of halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, and trifluoromethyl; and R is represented by either hydrogen or a C.sub.1-4 alkyl; R.sub.1 is represented by hydrogen or a C.sub.1-4 alkyl; the optional isomers and tautomers thereof; and the pharmaceutically acceptable acid addition salts thereof, and their use as calcium antagonists.
摘要翻译：本发明涉及一类新的具有下式的环状胍，其中Q由选自（CH 2）n的取代基表示，其中n是2-10的整数，IMA图 > A是选自-NH-（CH 2）m的取代基，其中m是0-5的整数，哌啶子基取代基或哌嗪基取代基; Ar和Ar 1各自独立地表示为苯环，每个苯基环可任选被至多3个选自卤素，C 1-4烷基，C 1-4烷氧基和三氟甲基的取代基取代; 并且R由氢或C 1-4烷基表示; R1由氢或C1-4烷基表示; 其可选的异构体和互变异构体; 及其药学上可接受的酸加成盐及其作为钙拮抗剂的用途。

50. 发明授权

US4435571A 5-(Substituted benzyl)-6-oxo-2-piperazine carboxylic acids and esters 失效
标题翻译： 5-（取代的苄基）-6-氧代-2-哌嗪羧酸和酯
公开(公告)号：US4435571A
公开(公告)日：1984-03-06
申请号：US399553
申请日：1982-07-19
申请人： Albert A. Carr , Robert A. Farr , John M. Kane
发明人： Albert A. Carr , Robert A. Farr , John M. Kane
IPC分类号： A61K38/00 , C07D241/08 , A61K31/495
CPC分类号： C07D241/08 , A61K38/00
摘要： The present invention relates to compounds of the formula ##STR1## wherein R' is hydrogen, straight or branched chain lower alkyl having from 1 to 4 carbon atoms or benzyl, Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms, Y is hydrogen or a nitrogen blocking group selected from the group consisting of tertiary alkoxycarbonyl, benzyloxycarbonyl, cycloalkoxycarbonyl and vinyloxycarbonyl, R.sub.c is hydrogen, halogen or benzyloxy and R.sub.d is hydrogen, or R.sub.c and R.sub.d are benzyloxy; or an individual diastereomer thereof. Said compounds having use as intermediates in the production of enkephalin derivatives which in turn are used as analgesic and antipsychotic agents.
摘要翻译：本发明涉及下式化合物，其中R'是氢，具有1至4个碳原子的直链或支链低级烷基或苄基，Z是氢或具有1至4个碳原子的直链低级烷基， Y是氢或选自叔烷氧基羰基，苄氧基羰基，环烷氧基羰基和乙烯氧基羰基的氮阻断基，Rc是氢，卤素或苄氧基，Rd是氢，或Rc和Rd是苄氧基; 或其单独的非对映异构体。所述化合物在生产脑啡肽衍生物中被用作中间体，其又被用作镇痛药和抗精神病药。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式