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41. 发明授权

US08989848B2 Apparatus and method for non-invasively detecting diseases that affect structural properties in biological tissues 有权
标题翻译：非侵入性检测影响生物组织结构特性的疾病的装置和方法
公开(公告)号：US08989848B2
公开(公告)日：2015-03-24
申请号：US13291072
申请日：2011-11-07
申请人： Dale A. Rorabaugh , Neil M. Davis , Vincent F. Brancaccio , Paul Williams
发明人： Dale A. Rorabaugh , Neil M. Davis , Vincent F. Brancaccio , Paul Williams
IPC分类号： A61B5/00 , A61B3/117 , A61B5/145 , A61B5/1455 , G01N21/64 , G01N21/65
CPC分类号： A61B3/1173 , A61B5/0068 , A61B5/0071 , A61B5/14546 , A61B5/1455 , A61B5/4842 , G01N21/6486 , G01N21/65 , G01N2800/042
摘要： Apparatus and methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual.
摘要翻译：用于生物组织的光谱分析的装置和方法，以将个体分类为糖尿病或非糖尿病，或确定个体中疾病或医学状况的概率，进展或水平。

42. 发明申请

US20140314826A1 NOVEL POLYMERS WHICH RESIST BACTERIAL ATTACHMENT 有权
标题翻译：新型聚合物，可抵抗细菌附着
公开(公告)号：US20140314826A1
公开(公告)日：2014-10-23
申请号：US14115451
申请日：2012-05-04
申请人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
发明人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
IPC分类号： A61L29/08 , A61L29/16
CPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F220/18 , C08F220/22 , C08F220/24 , C08F220/56 , C08F222/1006 , C08L33/08 , C08L33/10 , C08L33/26 , A01N25/10 , A01N25/34
摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR (I) [H2C═CR′—C(═O)—NH—]nR (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
摘要翻译：本发明提供了抑制细菌附着于表面的方法，该方法包括由聚合物形成表面，或将聚合物施用于表面，其中聚合物是由（甲基）丙烯酸酯或（甲基）丙烯酰胺单体形成的均聚物或由一种或多种（甲基）丙烯酸酯或（甲基）丙烯酰胺单体形成的共聚物，其中（甲基）丙烯酸酯或（甲基）丙烯酰胺单体为式（I）或（II）：[H 2C≡CR'-C 其中n为1,2或3，R'独立地为H或CH 3，R为（C 1 -C 6）总共具有2至24个碳原子的有机基团，其中有机基团包括脂族或芳族烃部分，并且其中有机基团不包括任何羟基。

43. 再颁专利

USRE45124E1 Methods of atomic layer deposition using titanium-based precursors 有权
标题翻译：使用钛基前体的原子层沉积方法
公开(公告)号：USRE45124E1
公开(公告)日：2014-09-09
申请号：US13842164
申请日：2013-03-15
申请人： Peter Nicholas Heys , Andrew Kingsley , Fuquan Song , Paul Williams , Thomas Leese , Hywel Owen Davies , Rajesh Odedra
发明人： Peter Nicholas Heys , Andrew Kingsley , Fuquan Song , Paul Williams , Thomas Leese , Hywel Owen Davies , Rajesh Odedra
IPC分类号： H05H1/24 , C23C16/00 , C23C8/00
CPC分类号： C23C16/45553
摘要： Methods of forming titanium-containing films by atomic layer deposition are provided. The methods comprise delivering at least one precursor to a substrate, wherein the at least one precursor corresponds in structure to Formula I: wherein: R is C1-C6-alkyl; n is zero, 1, 2, 3, 4 or 5; L is C1-C6-alkoxy or amino, wherein the amino is optionally independently substituted 1 or 2 times with C1-C6-alkyl.
摘要翻译：提供了通过原子层沉积形成含钛膜的方法。所述方法包括将至少一种前体递送至底物，其中所述至少一种前体在结构上相应于式I：其中：R是C 1 -C 6 - 烷基; n为零，1，2，3，4或5; L是C1-C6-烷氧基或氨基，其中氨基任选独立地被C 1 -C 6 - 烷基取代1或2次。

44. 发明申请

US20120046110A1 MULTI-PROCESS COMMUNICATION REGARDING GAMING INFORMATION 有权
标题翻译：关于游戏信息的多进程通信
公开(公告)号：US20120046110A1
公开(公告)日：2012-02-23
申请号：US13070893
申请日：2011-03-24
申请人： Lee AMAITIS , Paul Williams , Sunny Tara
发明人： Lee AMAITIS , Paul Williams , Sunny Tara
IPC分类号： A63F9/24
CPC分类号： A63F13/87 , A63F13/73 , G07F17/3237
摘要： Various embodiments that may generally relate to mobile gaming, location determination, mobile devices, authentication, and so on are described. Various methods are described. Various apparatus are described. Further embodiments are described.
摘要翻译：描述了通常涉及移动游戏，位置确定，移动设备，认证等的各种实施例。描述各种方法。描述各种装置。进一步描述实施例。

45. 发明申请

US20110183867A1 Polymer arrays for biofilm adhesion testing 审中-公开
标题翻译：用于生物膜粘附测试的聚合物阵列
公开(公告)号：US20110183867A1
公开(公告)日：2011-07-28
申请号：US12672528
申请日：2008-08-07
申请人： Martyn Christopher Davies , Morgan Alexander , Paul Williams , Robert Langer , Daniel Anderson , Andrew Urquhart
发明人： Martyn Christopher Davies , Morgan Alexander , Paul Williams , Robert Langer , Daniel Anderson , Andrew Urquhart
IPC分类号： C40B30/00 , C40B30/06
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00691 , B01J2219/00711 , B01J2219/00716 , B01J2219/00736 , B01J2219/00743 , B82Y30/00 , C12Q1/04
摘要： This invention relates to a method of screening arrays of polymers having pre-determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation.
摘要翻译：本发明涉及一种筛选具有预定表面能的聚合物阵列的方法。本发明的聚合物阵列可用于筛选微生物附着。更具体地，阵列可用于筛选特定细菌或真菌对阵列中特定聚合物的粘附。此外，本发明涉及将原位聚合物合成与所得聚合物阵列的物理化学表征和随后的细菌或真菌粘附的生物测定相结合的方法。这允许对细菌或真菌粘附不敏感的候选聚合物进行高通量筛选和表征，或者可以在需要这些聚合物的情况下用于支持细菌或真菌附着。阵列也可用于筛选抑制或促进生物膜形成。

46. 发明申请

US20090074983A1 METHODS OF ATOMIC LAYER DEPOSITION USING TITANIUM-BASED PRECURSORS 有权
标题翻译：使用基于钛的前驱体的原子层沉积的方法
公开(公告)号：US20090074983A1
公开(公告)日：2009-03-19
申请号：US12207973
申请日：2008-09-10
申请人： Peter Nicholas Heys , Andrew Kingsley , Fuquan Song , Paul Williams , Thomas Leese , Hywel Owen Davies , Rajesh Odedra
发明人： Peter Nicholas Heys , Andrew Kingsley , Fuquan Song , Paul Williams , Thomas Leese , Hywel Owen Davies , Rajesh Odedra
IPC分类号： C23C16/513 , C23C16/44 , C23C16/48
CPC分类号： C23C16/45553
摘要： Methods of forming titanium-containing films by atomic layer deposition are provided. The methods comprise delivering at least one precursor to a substrate, wherein the at least one precursor corresponds in structure to Formula I: wherein: R is C1-C6-alkyl; n is zero, 1, 2, 3, 4 or 5; L is C1-C6-alkoxy or amino, wherein the amino is optionally independently substituted 1 or 2 times with C1-C6-alkyl.
摘要翻译：提供了通过原子层沉积形成含钛膜的方法。所述方法包括将至少一种前体递送至底物，其中所述至少一种前体在结构上相应于式I：其中：R是C 1 -C 6 - 烷基; n为零，1，2，3，4或5; L是C1-C6-烷氧基或氨基，其中氨基任选独立地被C 1 -C 6 - 烷基取代1或2次。

47. 发明申请

US20080282970A1 Cyclopentadienyl Type Hafnium and Zirconium Precursors and Use Thereof in Atomic Layer Deposition 有权
标题翻译：环戊二烯基铪和锆前体及其在原子层沉积中的应用
公开(公告)号：US20080282970A1
公开(公告)日：2008-11-20
申请号：US12093846
申请日：2006-06-08
申请人： Peter Nicholas Heys , Paul Williams , Fuquan Song
发明人： Peter Nicholas Heys , Paul Williams , Fuquan Song
IPC分类号： C23C16/18 , C07F17/00 , C30B23/02
CPC分类号： C23C16/45525 , C23C16/405 , C23C16/45553
摘要： Precursors suitable for chemical vapour deposition, especially ALD, of hafnium oxide or zirconium oxide, have the general formula: (R1Cp)2MR2 wherein Cp represents a cyclopentadienyl ligand, R1 is H or a substituting alkyl group, alkoxy group or amido group of the Cp ligand, R2 is an alkyl group, an alkoxy group or an amido group and M is hafnium or zirconium.
摘要翻译：适用于化学气相沉积的前体，特别是氧化铪或氧化锆的ALD具有以下通式：<？in-line-formula description =“In-line formula”end =“lead”？>（R 1 ＆lt; / SUP＆gt; Cp）＆lt; 2＆gt;＆lt;？in-line-formula description =“In-line Formulas”end =“tail”？>其中Cp表示环戊二烯基配体，R 1是H或Cp配体的取代烷基，烷氧基或酰氨基，R 2是烷基，烷氧基或酰氨基 M是铪或锆。

48. 发明申请

US20070262277A1 Single Use Diaphragm Valve Body 审中-公开
标题翻译：单用隔膜阀体
公开(公告)号：US20070262277A1
公开(公告)日：2007-11-15
申请号：US10578815
申请日：2004-10-27
申请人： Paul Williams , Kenneth Bibbo
发明人： Paul Williams , Kenneth Bibbo
IPC分类号： F16K7/04
CPC分类号： F16K7/123 , F16K7/126
摘要： A diaphragm valve (1) comprising a valve body (2); a diaphragm (12) which is sealed to the valve body (2) to define a flow passage (9) which extends between an inlet port (7) and an outlet port (8), both defined by the valve body (2); and an operating mechanism secured to the valve body (2) for moving the diaphragm (12) into sealing engagement with a seat (11) provided on the valve body (2) in order to close the flow passage (9) to fluid flow. The valve body (2) and diaphragm (12) are formed as a disposable assembly having a relatively less flexible region which forms a valve seat (11) and a relatively more flexible region (12) which forms the diaphragm which may be forced into engagement with the valve seat (11) to close the flow passage (9) to fluid flow, and a housing (3) is provided for mechanically supporting the region of the valve body in which the seat area is defined.
摘要翻译：一种包括阀体（2）的隔膜阀（1）; 隔膜（12），其被密封到阀体（2）以限定在由阀体（2）限定的入口（7）和出口（8）之间延伸的流动通道（9）; 以及固定到所述阀体（2）的操作机构，用于使所述隔膜（12）与设置在所述阀体（2）上的阀座（11）密封接合，以便将所述流路（9）关闭成流体流动。阀体（2）和隔膜（12）形成为具有相对较小柔性区域的一次性组件，其形成阀座（11）和形成隔膜的相对更柔性的区域（12），该区域可能被迫接合其中阀座（11）将流动通道（9）关闭以流体流动，并且提供壳体（3）用于机械地支撑限定了座椅区域的阀体的区域。

49. 发明申请

US20060006188A1 Removable cover assembly with pivoting covers and hoisting pins 失效
标题翻译：可旋转盖组件，带枢轴盖和提升销
公开(公告)号：US20060006188A1
公开(公告)日：2006-01-12
申请号：US10886441
申请日：2004-07-06
申请人： Paul Williams
发明人： Paul Williams
IPC分类号： B65D51/04
CPC分类号： B65F1/16 , Y10S220/908
摘要： A removable cover assembly for a refuse container has a frame with pivotable plastic covers and retractable hoisting pins, which can be utilized using the same hoisting apparatus as is used for the refuse container.
摘要翻译：用于垃圾容器的可拆卸盖组件具有带有可枢转的塑料盖和可收回的提升销的框架，其可以使用与用于垃圾容器的相同的提升装置来使用。

50. 发明申请

US20050175979A1 Methods for absolute cell counting 审中-公开
标题翻译：绝对细胞计数方法
公开(公告)号：US20050175979A1
公开(公告)日：2005-08-11
申请号：US10504036
申请日：2003-02-26
申请人： Paul Williams
发明人： Paul Williams
IPC分类号： C12Q1/00 , G01N15/14 , G01N33/50
CPC分类号： G01N15/1459 , G01N33/5005 , G01N33/5094 , G01N2015/1486 , G01N2015/149
摘要： The invention concerns a method for determining the absolute cell count of an identifiable cell sub-population contained in a sample by introducing into an aliquot of said biological sample a pre-determined amount of a fluid reagent comprising a known concentration of fixed and labelled cells; then using flow cytometry to determine an absolute cell count of said cell sub-population.
摘要翻译：本发明涉及一种用于通过将包含已知浓度的固定和标记细胞的预定量的流体试剂引入到所述生物样品的等分试样中来确定样品中包含的可鉴定细胞亚群的绝对细胞计数的方法; 然后使用流式细胞术来确定所述细胞亚群的绝对细胞计数。

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