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41. 发明申请

US20060068356A1 Dental handpiece with a root canal length measurement function 失效
公开(公告)号：US20060068356A1
公开(公告)日：2006-03-30
申请号：US11239956
申请日：2005-09-29
申请人： Johann Eibl , Andreas Brandstaetter
发明人： Johann Eibl , Andreas Brandstaetter
IPC分类号： A61C1/00 , A61C19/04
CPC分类号： A61C1/084 , A61C19/041
摘要： A handpiece for measuring root canal length comprises an outer sleeve that is substantially non-insulating, a connecting device, an instrument carrier, at least one transmission element within the outer sleeve, a length measuring circuit portion, a contact portion and an insulating portion. The instrument carrier is configured to receive a dental instrument. The transmission element transmits force to move the instrument carrier so that a dental instrument received in the instrument carrier executes a rotating, reciprocating and/or vibrating working movement. The length measuring circuit portion is disposed inside the handpiece and operable to transmit measuring signals for measuring length. The contact portion is operable to establish a conductive path between the dental instrument serving as an electrode and the length measuring circuit portion. The insulating portion insulates the length measurement circuit portion and the contact device, through which a voltage is applied during measurement, from the outer sleeve.

42. 发明授权

US06924151B2 Stable factor VIII/vWF-complex 失效
标题翻译：稳定因子VIII / vWF-复合物
公开(公告)号：US06924151B2
公开(公告)日：2005-08-02
申请号：US09849484
申请日：2001-05-07
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
IPC分类号： A61K38/43 , A61K31/00 , A61K38/37 , A61P7/00 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/745 , C07K14/755 , G01N1/18
CPC分类号： C07K14/755 , Y10S514/834 , Y10T436/25375
摘要： There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as a method of producing this complex.
摘要翻译：公开了稳定的因子VIII / vWF-复合物，特别是包含不含低分子vWF分子和蛋白水解vWF降解产物的高分子vWF多聚体，以及生产该复合物的方法。

43. 发明授权

US06831159B1 Method for purifying factor VIII/vWF company by cation-exchange chromatography 有权
标题翻译：通过阳离子交换色谱法纯化因子VIII / VWF-复合物的方法
公开(公告)号：US06831159B1
公开(公告)日：2004-12-14
申请号：US09367459
申请日：2000-05-08
申请人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
发明人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
IPC分类号： A23J100
CPC分类号： A61K38/37 , C07K14/755
摘要： Methods for recovering factor VIII/vWF-complex that involve binding factor VIII/vWF-complex from a protein solution to a cation exchanger and recovering factor VIII/vWF-complex by step-wise elution are disclosed. The recovered complex contains high-molecular vWF multimers. Compositions containing factor VIII/vWF-complex as purified by cation exchange chromatography are also provided.
摘要翻译：公开了将蛋白质溶液与阳离子交换剂结合的因子VIII / vWF-复合物的因子VIII / vWF-复合物的回收方法，通过逐步洗脱回收因子VIII / vWF-复合物。回收的复合物含有高分子vWF多聚体。还提供了通过阳离子交换层析纯化的含有因子VIII / vWF-络合物的组合物。

44. 发明授权

US06573071B1 Factor X analogues with a modified protease cleavage site 有权
标题翻译：具有修饰的蛋白酶切割位点的因子X类似物
公开(公告)号：US06573071B1
公开(公告)日：2003-06-03
申请号：US09367791
申请日：1999-11-12
申请人： Michele Himmelspach , Uwe Schlokat , Friedrich Dorner , Andreas Fisch , Johann Eibl
发明人： Michele Himmelspach , Uwe Schlokat , Friedrich Dorner , Andreas Fisch , Johann Eibl
IPC分类号： C12P2100
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： Factor X analogues having a modification in the region of the natural Factor Xa activation cleavage site, said modification representing a processing site of a protease not naturally cleaving in this region of the Factor X sequence, preparations containing the Factor X analogues according to the invention, and processes for the preparation thereof are described.
摘要翻译：因子X类似物在天然因子Xa活化切割位点的区域具有修饰，所述修饰代表在因子X序列的该区域中不自然切割的蛋白酶的加工位点，所述制剂含有本发明的因子X类似物，并描述其制备方法。

45. 发明授权

US06465624B1 Purification of von-Willebrand factor by cation exchanger chromatography 有权
标题翻译：通过阳离子交换层析纯化冯维勒布兰德因子
公开(公告)号：US06465624B1
公开(公告)日：2002-10-15
申请号：US09367460
申请日：1999-10-21
申请人： Bernhard Fischer , Öyvind L. Schönberger , Artur Mitterer , Christian Fiedler , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Öyvind L. Schönberger , Artur Mitterer , Christian Fiedler , Friedrich Dorner , Johann Eibl
IPC分类号： A23J100
CPC分类号： C07K14/755 , A61K38/00
摘要： Disclosed are a method of recovering vWF in which vWF at a low salt concentration is bound to a cation exchanger and vWF having a high specific activity is recovered by fractionated elution, as well as a preparation having purified vWF obtainable by this method.
摘要翻译：公开了一种回收vWF的方法，其中低盐浓度的vWF与阳离子交换剂结合，并且通过分级洗脱回收具有高比活性的vWF，以及通过该方法可获得纯化的vWF的制剂。

46. 发明授权

US6165711A Process for disintegrating nucleic acids and preparing biological products of guaranteed quality 失效
标题翻译：分解核酸并制备质量保证的生物制品的方法
公开(公告)号：US6165711A
公开(公告)日：2000-12-26
申请号：US155758
申请日：1998-11-18
申请人： Friedrich Dorner , Noel Barrett , Johann Eibl
发明人： Friedrich Dorner , Noel Barrett , Johann Eibl
IPC分类号： A61K39/12 , A61L2/00 , C12N7/04 , C12N15/10 , C12Q1/70 , C12Q1/68 , C12N5/00 , A01N63/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61L2/0011 , A61L2/08 , C12N7/00 , C12N15/10 , C12N2740/16034 , C12N2770/24034 , C12N2770/24061 , C12N2770/24134
摘要： The invention relates to a method for the disintegration of any biologically active nucleic acid in a biological material, wherein a biologically active material is exposed or multiply exposed to laser beam to disintegrate essentially all biologically active nucleic acid in said biological material, while the biological integrity and activity of said biological material is maintained.
摘要翻译： PCT No.PCT / AT97 / 00068 Sec。 371日期：1998年11月18日 102（e）1998年11月18日PCT PCT 1997年4月8日提交PCT公布。出版物WO97 / 37686 日期1997年10月16日本发明涉及一种生物材料中任何生物活性核酸分解的方法，其中将生物活性材料暴露于或多次暴露于激光束以分解所述生物材料中的所有生物活性核酸同时保持所述生物材料的生物完整性和活性。

47. 发明授权

US6086871A Prothrombin derivatives 失效
标题翻译：凝血酶原衍生物
公开(公告)号：US6086871A
公开(公告)日：2000-07-11
申请号：US952967
申请日：1998-01-26
申请人： Bernhard Fischer , Uwe Schlokat , Artur Mitterer , Falko-Gunter Falkner , Johann Eibl
发明人： Bernhard Fischer , Uwe Schlokat , Artur Mitterer , Falko-Gunter Falkner , Johann Eibl
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K38/55 , A61P7/02 , C12N9/64 , C12N9/74 , C12N15/57 , C12P21/04 , C12Q1/56 , G01N33/53 , G01N33/86 , A61K38/48 , C12N1/20 , C12N15/00
CPC分类号： C12N9/6424 , C12N9/6429 , C12Y304/21005 , G01N33/86 , A61K38/00 , G01N2333/974
摘要： The invention relates to new prothrombin mutants or derivatives thereof which comprise one or more changes in their protein sequence as compared to natural protein, are either inactive or have an activity of approximately 10% at the most, preferably approximately 0.25% at the most, of the natural protein and which have a binding capacity relative to natural ligands (natural or synthetic anticoagulants) substantially corresponding to that of the natural protein. Furthermore, the use of mutated prothrombin mutants or derivatives, respectively, as pharmaceutical preparations is described.
摘要翻译： PCT No.PCT / AT96 / 00105 Sec。 371日期1998年1月26日 102（e）1998年1月26日PCT PCT 1996年6月12日PCT公布。出版物WO96 / 41868 日期1996年12月27日本发明涉及与天然蛋白相比包含其蛋白质序列的一个或多个变化的新的凝血酶原突变体或其衍生物，其为无活性的或具有最多约10％的活性，优选约0.25％最多的天然蛋白质，并且相对于天然配体（天然或合成抗凝剂）具有与天然蛋白质天然配体相当的结合能力。此外，描述了分别使用突变的凝血酶原突变体或衍生物作为药物制剂。

48. 发明授权

US6034222A Method for the separation of recombinant pro-factor IX from recombinant factor IX 失效
标题翻译：重组原因子IX与重组因子IX分离的方法
公开(公告)号：US6034222A
公开(公告)日：2000-03-07
申请号：US538893
申请日：1995-10-04
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61P7/04 , B01D15/08 , C12N9/64 , C12P21/02 , C12R1/91 , A61K35/14 , A23J1/00
CPC分类号： C12N9/644 , C12Y304/21022 , A61K38/00
摘要： A method for separation of recombinant pro-Factor IX from recombinant Factor IX by a chromatographic method is described. According to a preferred embodiment, the mixture of both proteins is bound to an ion exchanger and pro-Factor IX and Factor IX are eluted separately from each other by buffer solutions with different salt concentrations and/or pH values.According to the method of the invention, pro-Factor IX and Factor IX are obtainable in highly pure form and free from the other factor respectively.
摘要翻译：描述了通过色谱法从重组因子IX分离重组原因子IX的方法。根据优选的实施方案，两种蛋白质的混合物结合到离子交换剂，并且通过具有不同盐浓度和/或pH值的缓冲溶液将原因子IX和因子IX彼此分开洗脱。根据本发明的方法，原因子IX和因子IX可以分别以高纯度的形式获得并且不受其他因素的影响。

49. 发明授权

US5597800A Treatment with lys-plasminogen of reperfusion injury and brain edema caused by ischemia 失效
标题翻译：用裂解纤溶酶原的再灌注损伤治疗和脑缺血引起的脑水肿
公开(公告)号：US5597800A
公开(公告)日：1997-01-28
申请号：US345468
申请日：1994-11-21
申请人： Johann Eibl , Ludwig Pichler , Hans-Peter Schwarz
发明人： Johann Eibl , Ludwig Pichler , Hans-Peter Schwarz
IPC分类号： A61K38/00 , A61K38/43 , A61K38/46 , A61K38/48 , A61P9/00 , A61P9/10
CPC分类号： A61K38/484 , Y10S514/802
摘要： A treatment of ischemia and the attendant reperfusion injury entails the administration plasmin and plasmin-forming proteins, including lys-plasminogen and similar substances. Lys-plasminogen, which can be obtained from the proteolytic cleavage of glu-plasminogen, has been found to have a protective effect on tissue that has been injured by ischemic conditions. The administration of lys-plasminogen alone, in a dosage of about 10-1000 caseinolytic units/kg, can be used to treat subjects during the time of reperfusion and after reperfusion has already occurred. Lys-plasminogen also can be administered in conjunction with clot lysis therapies, such as those that employ tissue plasminogen activator and the like. Lys-plasminogen can also lessen cerebral edema which results from cerebral ischemia.
摘要翻译：缺血和伴随的再灌注损伤的治疗需要施用纤溶酶和纤溶酶形成蛋白，包括溶酶原纤溶酶原和类似物质。已经发现，可以从葡萄糖分解纤维蛋白溶酶原的蛋白水解切割中获得的Lys-plasminogen对缺血条件损伤的组织具有保护作用。在再灌注期间和再灌注已经发生后，以约10-1000个酪蛋白分解单位/ kg的剂量单独施用lys-plasminogen可用于治疗受试者。 Lys-纤溶酶原也可以与凝块溶解疗法结合使用，例如使用组织纤溶酶原激活剂等的那些。 Lys-纤溶酶原也可以减轻由脑缺血引起的脑水肿。

50. 发明授权

US5478093A Surgical handpiece 失效
标题翻译：外科手机
公开(公告)号：US5478093A
公开(公告)日：1995-12-26
申请号：US268008
申请日：1994-06-28
申请人： Johann Eibl , Gunter Teufelberger , Johann Fersterer
发明人： Johann Eibl , Gunter Teufelberger , Johann Fersterer
IPC分类号： A61B17/00 , A61B17/16 , A61C1/10 , A61C1/14 , A61M3/02 , B23B31/20
CPC分类号： A61B17/1679 , A61B17/00 , A61B17/162 , A61B17/1688 , A61C1/10 , A61C1/14 , A61B17/1644 , A61B2017/1651 , A61B2217/007 , A61M3/0279 , Y10T279/17521 , Y10T279/17529
摘要： A handpiece for use in small-scale surgery and microsurgery, for example, oral surgery or surgery in the ear, nose and throat area includes a handpiece sleeve and a collet chuck which is rotatable about an axis and is arranged in the handpiece sleeve. The collet chuck is spring-biased and can be released by an actuating member. The collet chuck serves to hold a tool and is composed of two tubular members which are movable relative to each other along the axis of rotation of the collet chuck. A chucking lever for releasing the collet chuck is pivotable about a lever axis which is directed essentially in normal direction relative to the collet chuck axis. The actuating member includes a drive member which is movable in axial direction together with the two tubular members of the collet chuck, but does not rotate together with the tubular members. The drive member projects with a portion thereof in direction of the collet chuck axis into an undercut portion of the chucking lever.
摘要翻译：用于小规模手术和显微手术的手机，例如在耳鼻喉区域的口腔手术或手术，包括可绕轴线旋转并布置在手持套筒中的手柄套筒和夹头卡盘。夹头卡盘是弹簧偏置的并且可以由致动构件释放。夹头卡盘用于保持工具，并且由两个管状构件组成，这两个管状构件可沿着夹头卡盘的旋转轴线相对于彼此移动。用于释放夹头卡盘的夹紧杆可围绕杠杆轴线枢转，杠杆轴线基本上相对于夹头卡盘轴线在法向方向上定向。致动构件包括驱动构件，该驱动构件可与夹头卡盘的两个管状构件一起在轴向方向上移动，但不与管状构件一起旋转。驱动部件将其一部分沿夹头卡盘轴线的方向突出成夹紧杆的底切部分。

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