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41. 发明授权

US07427650B2 Absorbing structure having improved blocking properties 有权
标题翻译：具有改进的阻挡性能的吸收结构
公开(公告)号：US07427650B2
公开(公告)日：2008-09-23
申请号：US11766399
申请日：2007-06-21
申请人： Scott Smith , Bernfried Messner , Markus Frank
发明人： Scott Smith , Bernfried Messner , Markus Frank
IPC分类号： C08F8/30
CPC分类号： C08J3/12 , C08J3/128 , C08J3/245 , C08J2300/14 , C08J2333/00 , H01B7/288 , Y02A30/14 , Y10T428/31931
摘要： A process for producing an absorbing polymer structure (Pa) including the steps of obtaining a treated absorbing polymer structure (Pb) by increasing the absorption under load at a load of 0.3 or 0.9 psi (AUL) compared to an untreated absorbing polymer structure (Pu) by a first treatment of an outer region of the untreated absorbing polymer structure (Pu) and reducing the AUL compared to the treated polymer structure (Pb) by a second treatment of an outer region of the treated absorbing polymer structure (Pb). Such absorbing polymer structure (Pa) may be used in a composite and may be used in foams, moulded articles, fibers, sheets, films, cables, sealing materials, liquid-absorbing hygiene articles, carriers for plant growth-regulating and fungal growth-regulating agents, packaging materials and soil additives or building materials.
摘要翻译：一种制备吸收聚合物结构（Pa）的方法，包括以下步骤：与未处理的吸收聚合物结构（Pu）相比，在负载为0.3或0.9psi（AUL）的负载下增加吸收聚合物结构（Pb））通过第一处理未处理的吸收性聚合物结构（Pu）的外部区域，并且通过对经处理的吸收性聚合物结构（Pb）的外部区域进行第二次处理，将AUL与经处理的聚合物结构（Pb）相比降低。这种吸收聚合物结构（Pa）可以用于复合材料中，并且可以用于泡沫，模制品，纤维，片材，薄膜，电缆，密封材料，液体吸收卫生制品，用于植物生长调节的载体和真菌生长 - 调节剂，包装材料和土壤添加剂或建筑材料。

42. 发明授权

US07241820B2 Absorbing structure having improved blocking properties 有权
标题翻译：具有改进的阻挡性能的吸收结构
公开(公告)号：US07241820B2
公开(公告)日：2007-07-10
申请号：US10427054
申请日：2003-04-30
申请人： Scott Smith , Bernfried Messner , Markus Frank
发明人： Scott Smith , Bernfried Messner , Markus Frank
IPC分类号： C08F8/30
CPC分类号： C08J3/12 , C08J3/128 , C08J3/245 , C08J2300/14 , C08J2333/00 , H01B7/288 , Y02A30/14 , Y10T428/31931
摘要： A process for producing an absorbing polymer structure (Pa) including the steps of obtaining a treated absorbing polymer structure (Pb) by increasing the absorption under load at a load of 0.3 or 0.9 psi (AUL) compared to an untreated absorbing polymer structure (Pu) by a first treatment of an outer region of the untreated absorbing polymer structure (Pu) and reducing the AUL compared to the treated polymer structure (Pb) by a second treatment of an outer region of the treated absorbing polymer structure (Pb). Such absorbing polymer structure (Pa) may be used in a composite and may be used in foams, moulded articles, fibers, sheets, films, cables, sealing materials, liquid-absorbing hygiene articles, carriers for plant growth-regulating and fungal growth-regulating agents, packaging materials and soil additives or building materials.
摘要翻译：一种制备吸收聚合物结构（Pa）的方法，包括以下步骤：与未处理的吸收聚合物结构（Pu）相比，在负载为0.3或0.9psi（AUL）的负载下增加吸收聚合物结构（Pb））通过第一处理未处理的吸收性聚合物结构（Pu）的外部区域，并且通过对经处理的吸收性聚合物结构（Pb）的外部区域进行第二次处理，将AUL与经处理的聚合物结构（Pb）相比减少。这种吸收聚合物结构（Pa）可以用于复合材料中，并且可以用于泡沫，模制品，纤维，片材，薄膜，电缆，密封材料，液体吸收卫生制品，用于植物生长调节的载体和真菌生长 - 调节剂，包装材料和土壤添加剂或建筑材料。

43. 发明申请

US20060064775A1 Method for increasing resistance against stress factors in plants 审中-公开
标题翻译：增加植物对胁迫因子抗性的方法
公开(公告)号：US20060064775A1
公开(公告)日：2006-03-23
申请号：US10548748
申请日：2004-03-10
申请人： Markus Frank , Karl-Heinz Kogel , Ralph Huckelhoven
发明人： Markus Frank , Karl-Heinz Kogel , Ralph Huckelhoven
IPC分类号： A01H1/00 , C12N15/87
CPC分类号： C07K14/415 , C12N15/8271 , C12N15/8279
摘要： The invention relates to methods for generating or increasing the resistance, in plants, to at least one biotic or abiotic stress factor, preferably to plant pathogens, by increasing the expression of at least one Bax inhibitor 1 (BI1) protein in at least one plant tissue, with the proviso that the expression in the leaf epidermis remains essentially unchanged. The invention furthermore relates to recombinant expression cassettes and vectors which comprise a nucleic acid sequence coding for a BI protein under the control of a tissue-specific promoter, the promoter having essentially no activity in the leaf epidermis. The invention furthermore relates to recombinant plants transformed with said expression cassettes or vectors, to cultures, parts or recombinant propagation material derived from these plants, and to the use of same for the production of foodstuffs, feeding stuffs, seed, pharmaceuticals or fine chemicals.
摘要翻译：本发明涉及通过增加至少一种植物中至少一种Bax抑制剂1（BI1）蛋白的表达，在植物中产生或增加至少一种生物或非生物胁迫因子（优选植物病原体）的方法组织，条件是叶表皮中的表达基本保持不变。本发明还涉及包含在组织特异性启动子控制下编码BI蛋白的核酸序列的重组表达盒和载体，所述启动子在叶表皮中基本上没有活性。本发明还涉及用所述表达盒或载体转化的重组植物，衍生自这些植物的培养物，部分或重组繁殖材料，以及用于生产食品，饲料，种子，药物或精细化学品的重组植物。

44. 发明申请

US20050049185A1 Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-2 and uses thereof 有权
标题翻译：编码染色体7p15-2上的多药耐药性人P-糖蛋白同源物的基因及其用途
公开(公告)号：US20050049185A1
公开(公告)日：2005-03-03
申请号：US10952328
申请日：2004-09-29
申请人： Markus Frank , Mohamed Sayegh
发明人： Markus Frank , Mohamed Sayegh
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C07K16/28 , C12N15/83 , A61K38/17
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C07K16/28 , C07K2317/34
摘要： The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
摘要翻译：本发明涉及位于人染色体7p15-21上的MDR家族P-糖蛋白，编码该P-糖蛋白的多核苷酸序列及其片段。该基因用于评估针对多药耐药的治疗的癌细胞易感性的方法，以及用于设计与癌症多药耐药有关的诊断和治疗方法。本发明还涉及用于确定测试化合物是否可能抑制多药耐药性的方法。

45. 发明授权

US09051289B2 Process and intermediates for preparing GPR40 agonists 有权
标题翻译：制备GPR40激动剂的方法和中间体
公开(公告)号：US09051289B2
公开(公告)日：2015-06-09
申请号：US14494631
申请日：2014-09-24
申请人： Georg Dahmann , Holger Wagner , Matthias Eckhardt , Markus Frank , Marco Santagostino , Juergen Schnaubelt , Uwe Stertz , Thorsten Pachur
发明人： Georg Dahmann , Holger Wagner , Matthias Eckhardt , Markus Frank , Marco Santagostino , Juergen Schnaubelt , Uwe Stertz , Thorsten Pachur
IPC分类号： C07D307/80 , C07D407/12 , C07D405/12 , C07D513/04
CPC分类号： C07D307/80 , C07D405/12 , C07D407/12 , C07D513/04
摘要： The present invention relates to compounds of formula I wherein RS denotes F or CF3, Ra denotes H or C1-4-alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.
摘要翻译：本发明涉及式I化合物，其中RS表示F或CF 3，R a表示H或C 1-4 - 烷基，Z表示离去基团或任选取代或保护的羟基，适合于合成二氢氧化二氢苯并呋喃基乙酸的中间体，其是GPR40激动剂，涉及制备这些中间体的方法和制备在过渡金属催化剂和手性助剂存在下使用不对称催化氢化反应的GPR40激动剂的方法。

46. 发明授权

US08962636B2 Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions 有权
标题翻译：取代喹唑啉，其制备方法及其在药物组合物中的用途
公开(公告)号：US08962636B2
公开(公告)日：2015-02-24
申请号：US14232418
申请日：2012-07-13
申请人： Waldemar Pfrengle , Markus Frank , Thomas Klein
发明人： Waldemar Pfrengle , Markus Frank , Thomas Klein
IPC分类号： A61K31/522 , A61K45/06 , C07D473/06 , A61K31/155 , A61K31/4439 , C07D473/04
CPC分类号： C07D473/06 , A61K31/155 , A61K31/4439 , A61K31/522 , A61K45/06 , C07D473/04
摘要： The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV(DPP-IV).
摘要翻译：本发明涉及式（I）的取代喹唑啉，其中X和Y如权利要求1所定义，其互变异构体，立体异构体，混合物和盐具有有价值的药理学性质，特别是对酶二肽基肽酶的活性的抑制作用 -IV（DPP-IV）。

47. 发明授权

US08645895B2 Checking an ESD behavior of integrated circuits on the circuit level 有权
标题翻译：检查电路级集成电路的ESD特性
公开(公告)号：US08645895B2
公开(公告)日：2014-02-04
申请号：US12742956
申请日：2008-12-04
申请人： Lars Bergmann , Angela Konrad , Markus Frank
发明人： Lars Bergmann , Angela Konrad , Markus Frank
IPC分类号： G06F17/50
CPC分类号： G06F17/5036 , H01L27/0251
摘要： A system and a method for testing the ESD behavior, wherein a circuit (7) is automatically tested at circuit diagram level in that technology-specific ESD data is provided in database (2) for each circuit component present in the circuit, without requiring complex circuit simulations, for example based on front end or back end data, by taking into account the layout.
摘要翻译：一种用于测试ESD行为的系统和方法，其中电路（7）以电路图级自动测试，因为技术专用ESD数据在数据库（2）中为电路中存在的每个电路组件提供，而不需要复杂电路模拟，例如基于前端或后端数据，通过考虑布局。

48. 发明授权

US08592652B2 Use of subtilisin-like RNR9 polynucleotide for achieving pathogen resistance in plants 失效
标题翻译：使用枯草杆菌蛋白酶样RNR9多核苷酸来实现植物中的病原体抗性
公开(公告)号：US08592652B2
公开(公告)日：2013-11-26
申请号：US12523101
申请日：2008-01-15
申请人： Markus Frank , Patrick Schweizer , Dimitar Douchkov
发明人： Markus Frank , Patrick Schweizer , Dimitar Douchkov
IPC分类号： C12N15/82 , C12N5/04 , C12N15/90
CPC分类号： C12N15/8282 , C12N9/50
摘要： The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one subtilisin polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare subtilisin (HvRNR9) and Triticum aestivum subtilisin (TaRNR9) polynucleotide and describes homologous sequences (RNR9) thereof, and to their use in methods for obtaining a pathogen resistance in plants, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.
摘要翻译：本发明涉及通过减少至少一种枯草杆菌蛋白酶多肽或其功能等同物的表达来产生或增加植物中病原体抗性的方法。本发明涉及编码大麦草枯草杆菌蛋白酶（HvRNR9）和小麦枯草杆菌蛋白酶（TaRNR9）多核苷酸的新型核酸序列，并描述其同源序列（RNR9）及其在获得植物病原体抗性的方法中的用途，以及核酸构建体，表达盒和载体，其包含这些序列并且适于介导植物中的真菌抗性。本发明还涉及用这些表达盒或载体转化的转基因生物，特别是植物，以及由其衍生的培养物，部分或转基因繁殖材料。

49. 发明授权

US08329988B2 Method for increasing pathogen resistance in transgenic plants 失效
标题翻译：在转基因植物中增加病原体抗性的方法
公开(公告)号：US08329988B2
公开(公告)日：2012-12-11
申请号：US12444927
申请日：2007-10-12
申请人： Markus Frank , Patrick Schweizer , Dimitar Douchkov
发明人： Markus Frank , Patrick Schweizer , Dimitar Douchkov
IPC分类号： A01H5/00 , A01H5/10 , C12N15/09 , C12N15/82
CPC分类号： C12N15/8282 , C07K14/415
摘要： The invention relates to a method of increasing the resistance to one or more penetrating pathogen(s) in a monocotyledonous or dicotyledonous plant or a part of a plant, for example in an organ, tissue, a cell or a part of a plant cell, for example in an organell, wherein a DNA sequence which codes for an armadillo repeat ARM1 protein and which mediates an increased pathogen resistance, preferably an increased resistance to fungal pathogens, is increased into, and expressed in, the plant or plant cell; or wherein an endogenous DNA sequence which codes for an armadillo repeat ARM1 protein and which mediates an increased pathogen resistance, preferably an increased resistance to fungal pathogens, is increased in the plant or plant cell in comparison with the original, or wild-type, plant, or wherein the endogenous gene sequence or preferably the 5′-untranslated region (5′UTR) is modified in comparison with the original sequence. The invention also relates to plants, to parts of a plant, for example an organ, tissue, a cell or a part of a plant cell, for example an organelle, which are obtained by the above methods, and to corresponding propagation material.
摘要翻译：本发明涉及增加对单子叶植物或双子叶植物或植物的一部分，例如在器官，组织，细胞或植物细胞的一部分中的一种或多种穿透性病原体的抗性的方法，例如在细胞器中，其中编码犰狳重复ARM1蛋白并且介导增加的病原体抗性，优选增加的对真菌病原体的抗性的DNA序列增加到植物或植物细胞中并在其中表达; 或者其中与原始或野生型植物相比，在植物或植物细胞中增加编码犰狳重复ARM1蛋白并且介导增加的病原体抗性，优选增加的对真菌病原体的抗性的内源DNA序列，或其中内源性基因序列或优选5'-非翻译区（5'UTR）与原始序列相比被修饰。本发明还涉及植物，例如通过上述方法获得的植物部分，例如器官，组织，细胞或植物细胞的一部分，例如细胞器，以及相应的繁殖材料。

50. 发明申请

US20120094834A1 method for increasing the vigor and/or crop yield of agricultural plants under essentially non-existent pathogen pressure 审中-公开
标题翻译：在基本上不存在的病原体压力下增加农作物的活力和/或作物产量的方法
公开(公告)号：US20120094834A1
公开(公告)日：2012-04-19
申请号：US13318613
申请日：2010-05-03
申请人： Markus Frank , David Ernest Silva
发明人： Markus Frank , David Ernest Silva
IPC分类号： A01N63/00 , A01N63/04 , A01P1/00 , A01P21/00 , A01P13/02 , A01P7/04 , A01N63/02 , A01P3/00
CPC分类号： A01N63/00 , A01N43/653 , A01N47/30 , A01N55/02 , A01N59/20 , A01N63/04 , Y02A50/356 , A01N37/46 , A01N47/24 , A01N2300/00
摘要： A method for increasing the vigor and/or crop yield of agricultural plants under essentially non-existent pathogen pressure, wherein the plants, the plant propagules, the seed of the plants and/or the locus where the plants are growing or are intended to grow are treated with an effective amount of a composition comprising a) the Bacillus subtilis strain with NRRL Accession No. B-21661 or a cell-free extract thereof, and/or a mutant of this strain or extract having all the identifying characteristics of the respective strain or extract as component (I), and b) optionally at least one chemical compound as component (II), selected from the active compound groups A) to J): A) strobilurins; B) carboxamides; C) azoles; D) heterocyclic compounds; E) carbamates; F) other active substances; G) growth regulators; H) herbicides; J) insecticides.
摘要翻译：在基本上不存在的病原体压力下增加农作物的活力和/或作物产量的方法，其中植物，植物繁殖体，植物的种子和/或植物正在生长或旨在生长的场所用有效量的组合物处理，所述组合物包含a）具有NRRL登录号B-21661的枯草芽孢杆菌菌株或其无细胞提取物，和/或具有各自的所有鉴定特征的该菌株或提取物的突变体应变或提取物作为组分（I），和b）任选的至少一种化合物作为组分（II），选自活性化合物组A）至J）：A）嗜球果伞素; B）甲酰胺; C）唑类; D）杂环化合物; E）氨基甲酸酯; F）其他活性物质; G）生长调节剂; H）除草剂; J）杀虫剂。

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