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41. 发明授权

US07879893B2 Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer 有权
标题翻译：用于R-state胰岛素六聚体的HisB10 Zn2 +位点的配体
公开(公告)号：US07879893B2
公开(公告)日：2011-02-01
申请号：US10332541
申请日：2002-09-13
申请人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
发明人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
IPC分类号： A61K31/41 , A61K31/40 , C07D257/00 , C07D209/82
CPC分类号： C07D257/04 , A61K31/4192 , A61K31/426 , C07D249/18 , C07D277/20 , C07D403/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NH2 or a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.
摘要翻译：本发明涉及具有式A-B-C-D-X（III）的R状态胰岛素六聚体的HisB10 Zn 2+位点的新配体，其中：A是可逆结合胰岛素六聚体的HisB10 Zn 2+位点的化学基团; B是一个连接子; C是由0至5个中性氨基酸组成的片段; D是包含1至20个独立地选自氨基或胍基的带正电基团的片段; X为-OH，-NH 2或二氨基。本发明还涉及包含这种配体的R状态胰岛素六聚体和包含这种R状态胰岛素六聚体的含水胰岛素制剂。

42. 发明申请

US20100216690A1 Pegylated Single-Chain Insulin 审中-公开
标题翻译：聚乙二醇化单链胰岛素
公开(公告)号：US20100216690A1
公开(公告)日：2010-08-26
申请号：US11908646
申请日：2006-03-17
申请人： Peter Madsen , Thomas Borglum Kjeldsen
发明人： Peter Madsen , Thomas Borglum Kjeldsen
IPC分类号： A61K38/28 , C07K14/62 , A61P3/10
CPC分类号： C07K14/62 , A61K38/00 , A61K47/60
摘要： The present invention is related to a single-chain insulin comprising the B- and the A-chain of human insulin or analogues thereof connected by a connecting peptide having from 3-35 amino acid residues, wherein the single-chain insulin comprises at least one PEG group attached to at least one lysine residue in the single-chain insulin molecule and/or to the B1 N terminal amino acid residue. The PEGylated single-chain insulins may comprise up to 4 PEG groups which may be the same or different.
摘要翻译：本发明涉及包含通过具有3-35个氨基酸残基的连接肽连接的人胰岛素的B链和A链的单链胰岛素或其类似物，其中所述单链胰岛素包含至少一个 PEG基团连接至单链胰岛素分子中至少一个赖氨酸残基和/或连接至B1N末端氨基酸残基。 PEG化的单链胰岛素可以包含最多4个可以相同或不同的PEG基团。

43. 发明申请

US20100009899A1 Novel Insulin Derivatives 有权
标题翻译：新型胰岛素衍生物
公开(公告)号：US20100009899A1
公开(公告)日：2010-01-14
申请号：US12560833
申请日：2009-09-16
申请人： Ib Jonassen , Thomas Hoeg-Jensen , Svend Havelund , Ulla Ribel-Madsen , Tina Møller Tagmose , Peter Madsen
发明人： Ib Jonassen , Thomas Hoeg-Jensen , Svend Havelund , Ulla Ribel-Madsen , Tina Møller Tagmose , Peter Madsen
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： C07K14/62 , A61K38/28 , A61K47/542
摘要： The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula: —W—X—Y—Z wherein W, X, Y and Z are as defined in the disclosure.
摘要翻译：本发明涉及胰岛素衍生物，其是天然存在的胰岛素或其类似物，其具有连接于B链的N末端氨基酸残基的α-氨基或Lys链的ε-氨基的侧链存在于母体胰岛素的B链中的残基，侧链具有以下通式：-WXYZ，其中W，X，Y和Z如本公开中所定义。

44. 发明申请

US20090123563A1 Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand 审中-公开
标题翻译：包含胰岛素，锌离子和锌结合配体的药物制剂
公开(公告)号：US20090123563A1
公开(公告)日：2009-05-14
申请号：US11814123
申请日：2006-02-06
申请人： Niels Christian Kaarsholm , Helle Birk Olsen , Peter Madsen , Soeren Ostegaard , Palle Jakobsen , Tina Moeller Tagmose
发明人： Niels Christian Kaarsholm , Helle Birk Olsen , Peter Madsen , Soeren Ostegaard , Palle Jakobsen , Tina Moeller Tagmose
IPC分类号： A61K33/30 , A61P3/10
CPC分类号： A61K38/28
摘要： Novel preparations comprising branched ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The preparations have a prolonged action designed for flexible injection regimes.
摘要翻译：包含R状态胰岛素六聚体的HisB10 Zn2 +位点的支链配体的新型制剂。制剂的灵活注射方案设计时间长。

45. 发明申请

US20060183668A1 Novel insulin derivatives 有权
标题翻译：新型胰岛素衍生物
公开(公告)号：US20060183668A1
公开(公告)日：2006-08-17
申请号：US11343005
申请日：2006-01-30
申请人： Ib Jonassen , Thomas Hoeg-Jensen , Svend Havelund , Ulla Ribel-Madsen , Tina Tagmose , Peter Madsen
发明人： Ib Jonassen , Thomas Hoeg-Jensen , Svend Havelund , Ulla Ribel-Madsen , Tina Tagmose , Peter Madsen
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： C07K14/62 , A61K38/28 , A61K47/542
摘要： The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula: -W-X-Y-Z wherein W, X, Y and Z are as defined in the disclosure.
摘要翻译：本发明涉及胰岛素衍生物，其是天然存在的胰岛素或其类似物，其具有连接于B链的N末端氨基酸残基的α-氨基或Lys链的ε-氨基的侧链残基存在于母体胰岛素的B链中，侧链具有以下通式：<？in-line-formula description =“In-line Formulas”end =“lead”？> - WXYZ < 公式描述=“在线公式”end =“tail”？>其中W，X，Y和Z如本公开中所定义。

46. 发明申请

US20050162051A1 Modular furniture system 审中-公开
标题翻译：模块化家具系统
公开(公告)号：US20050162051A1
公开(公告)日：2005-07-28
申请号：US10512786
申请日：2003-05-01
申请人： Peter Madsen , William Pokletar
发明人： Peter Madsen , William Pokletar
IPC分类号： A47B47/04 , A47B81/00 , A47B83/00 , A47B87/00 , A47B87/02
CPC分类号： A47B83/001 , A47B47/047 , A47B87/007 , A47B87/0284
摘要： A modular furniture system based on a fundamental building block is provided. The building block, or cell, includes first and second end plates and at least one horizontal support beam. A plurality of stacked and/or side-by-side cells provide a framework that can be arranged in an almost limitless number of ways. The cells serve as both storage space and division between neighboring work spaces, thus conserving raw materials and recovering floor space. The cells further provide raceways for concealing electrical wires and data cables, and are adapted for supporting work surfaces and connecting to vertical panels. The cells are adapted to receive various storage components, such as drawers, which may be inserted from both a front side and a back side of each cell. The cells are also adapted to receive tiles, which may cover open sides of each cell and/or cover the end plates of each cell. The tiles may provide any of a multitude of different aesthetic and functional surfaces. A single cell or stack of cells may include a foundation for increased rigidity and sturdiness.
摘要翻译：提供了基于基本构件的模块化家具系统。构建块或电池包括第一和第二端板以及至少一个水平支撑梁。多个堆叠和/或并排单元提供可以以几乎无限数量的方式布置的框架。这些电池既用作相邻工作空间之间的存储空间，也可以分开，从而节省原材料并回收占地面积。电池还提供用于隐藏电线和数据电缆的滚道，并且适于支撑工作表面并连接到垂直面板。电池适于接收可从每个电池单元的前侧和后侧插入的各种存储部件，例如抽屉。电池还适于接收瓷砖，其可以覆盖每个电池的开放侧面和/或覆盖每个电池的端板。瓷砖可以提供任何多种不同的美学和功能表面。单个电池或电池堆可能包括增加刚性和坚固性的基础。

47. 发明授权

US6110913A N-substituted azaheterocyclic carboxylic acids and esters thereof 失效
标题翻译： N-取代的氮杂环状羧酸及其酯
公开(公告)号：US6110913A
公开(公告)日：2000-08-29
申请号：US55633
申请日：1998-04-06
申请人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Sindelar Karel , Silhankova Alexandra
发明人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Sindelar Karel , Silhankova Alexandra
IPC分类号： A01N43/46 , A61K31/40 , A61K31/44 , A61K31/451 , A61K31/54 , A61P19/02 , C07D207/08 , C07D207/10 , C07D207/12 , C07D211/20 , C07D211/26 , C07D211/70 , C07D223/18 , C07D265/38
CPC分类号： C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译：本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。

48. 发明授权

US6017915A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US6017915A
公开(公告)日：2000-01-25
申请号：US79599
申请日：1998-05-15
申请人： Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Uffe Bang Olsen , Peter Madsen , Zdenek Polivka , Otylie Konigova , Frantisek Miksik , Martina Kovandova , Alexandra Silhankova , Karel Sindelar
发明人： Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Uffe Bang Olsen , Peter Madsen , Zdenek Polivka , Otylie Konigova , Frantisek Miksik , Martina Kovandova , Alexandra Silhankova , Karel Sindelar
IPC分类号： C07D321/12 , A61K31/335 , A61K31/357 , A61K31/4406 , A61K31/55 , A61P3/08 , A61P25/00 , A61P29/00 , C07D273/00 , C07D273/01 , C07D405/06 , C07D405/12 , C07D413/06 , A61K31/535 , C07D413/12
CPC分类号： C07D405/06 , C07D405/12 , C07D413/06
摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译：本发明涉及新型N-取代氨基醇，氨基酸及其酸衍生物，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用途用于临床治疗C型纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用的疼痛，痛觉过敏和/或炎性疾病。

49. 发明授权

US5958957A Modulators of molecules with phosphotyrosine recognition units 失效
公开(公告)号：US5958957A
公开(公告)日：1999-09-28
申请号：US842801
申请日：1997-04-16
申请人： Henrik Sune Andersen , Niels Peter Hundahl Moller , Peter Madsen
发明人： Henrik Sune Andersen , Niels Peter Hundahl Moller , Peter Madsen
IPC分类号： C07D231/20 , C07D249/14 , C07D257/04 , C07D271/10 , C07D271/113 , C07D277/34 , C07D285/08 , C07D285/12 , C07D285/125 , C07D285/135 , C07D417/06 , C07F9/38 , A61K31/14 , C07D271/07
CPC分类号： C07D271/113 , C07D231/20 , C07D249/14 , C07D257/04 , C07D277/34 , C07D285/08 , C07D285/125 , C07D285/135 , C07D417/06 , C07F9/3834 , C07F9/3882
摘要： The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention relates to modulation of the activity of molecules with phospho-tyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganisms, eukaryotic cells, whole animals and human beings. The novel organic compounds are compounds of formula (I)(L).sub.n --Ar.sub.1 --R.sub.1 --A (I)wherein(L).sub.n, n, Ar.sub.1, R.sub.1 and A are as defined in the application.

50. 发明授权

US5874428A N-substituted aza-heterocyclic carboxylic acids and esters thereof 失效
标题翻译： N-取代的氮杂杂环羧酸及其酯
公开(公告)号：US5874428A
公开(公告)日：1999-02-23
申请号：US623289
申请日：1996-03-28
申请人： Florenzio Zaragossa D.o slashed.rwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
发明人： Florenzio Zaragossa D.o slashed.rwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
IPC分类号： C07D223/28 , A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/535 , A61K31/538 , A61K31/55 , A61P3/08 , A61P3/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02 , A01N43/46 , C07D223/18
CPC分类号： C07D401/06 , C07D207/16 , C07D211/60 , C07D211/62 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译：本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。

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