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41. 发明申请

US20100114175A1 Facet Fusion Implants and Methods of Use 有权
标题翻译：方面融合植入物和使用方法
公开(公告)号：US20100114175A1
公开(公告)日：2010-05-06
申请号：US12686747
申请日：2010-01-13
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61B17/88
CPC分类号： A61B17/7064
摘要： An implant is insertable onto a vertebral facet joint includes a body with an inner surface that mates with one or both articular processes of the facet joint. The inner surface may define an interior cavity that accepts at least a portion of an inferior articular process and a superior articular process forming the facet joint. The body may be constructed of a bone growth material that fuses with the articular processes. The implant may help retain bone growth promoting substance that is inserted between or on articulating surfaces of the facet joint. A receiving portion of an exterior surface of one or both articular process may be prepared to stimulate bone growth. The implant may be placed onto the receiving portion to cover an exterior junction between or on the articulating surfaces of the facet joint. The implant may be secured to one or both of the articular processes.
摘要翻译：植入物可插入到椎骨小关节中，包括具有与小关节的一个或两个关节过程相配合的内表面的主体。内表面可以限定内腔，其接受下关节进程的至少一部分和形成小关节的上关节进程。身体可以由与关节进程融合的骨生长材料构成。植入物可以帮助保留插入在小关节的关节表面之间或之上的骨生长促进物质。可以制备一个或两个关节过程的外表面的接收部分以刺激骨生长。植入物可以放置在接收部分上以覆盖小面关节的关节表面之间或之上的外部连接。植入物可以固定在一个或两个关节突的过程中。

42. 发明申请

US20100056989A1 INSTRUMENTATION FOR INJECTION OF THERAPEUTIC FLUID INTO JOINTS 有权
标题翻译：将治疗性流体注射接头的仪器
公开(公告)号：US20100056989A1
公开(公告)日：2010-03-04
申请号：US12605780
申请日：2009-10-26
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61M5/31
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/00261 , A61B2018/00392 , A61M5/32 , A61M5/3298 , A61M2025/0085
摘要： Described are novel medical delivery devices that can be used to effectively distribute a medical agent to multiple sites within a tissue volume without requiring the device to be repositioned, including for example to distribute the medical agent within the nucleus pulposus tissue of a spinal disc. Also described are medical delivery devices configured to simultaneously remove fluid from the tissue volume into which a medical agent is being delivered, thus avoiding or otherwise decreasing any pressure build-up and facilitating an effective, uniform delivery of the therapeutic agent.
摘要翻译：描述了可用于有效地将药剂分配到组织体积内的多个部位而不需要重新定位装置的新型医疗输送装置，包括例如将药剂分配在脊髓盘的髓核组织内。还描述了被配置为同时从组织体积中去除流体的医疗输送装置，医药剂被递送到其中，从而避免或以其他方式减少任何压力积聚并促进治疗剂的有效且均匀的输送。

43. 发明申请

US20090263444A1 Fluocinolone Formulations in a Biodegradable Polymer Carrier 有权
标题翻译：在可生物降解聚合物载体中的氟轻松制剂
公开(公告)号：US20090263444A1
公开(公告)日：2009-10-22
申请号：US12413197
申请日：2009-03-27
申请人： William F. McKay , Christopher M. Hobot , Danielle Biggs , Katara Shaw , John Myers Zanella , Vanja M. King , Stephen Mark Cox , Kathy L. Remsen
发明人： William F. McKay , Christopher M. Hobot , Danielle Biggs , Katara Shaw , John Myers Zanella , Vanja M. King , Stephen Mark Cox , Kathy L. Remsen
IPC分类号： A61K9/00 , A61K31/58 , A61P29/00 , A61P37/06
CPC分类号： A61K31/58 , A61K9/0024 , A61K9/1647 , A61K31/585 , A61K47/34
摘要： Effective treatments of pain and inflammation are provided. Through the administration of an effective amount of fluocinolone at or near a target site, one can reduce, prevent or treat inflammation and pain and autoimmune disorders. In various embodiments, fluocinolone formulations may be provided within biodegradable polymers to reduce, prevent or treat sciatic pain and/or inflammation. In various embodiments, prevent transplant rejection for at least twenty-five days. In some embodiments, the pain relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译：提供有效的疼痛和炎症治疗。通过在靶位点附近施用有效量的氟轻松，可以减少，预防或治疗炎症和疼痛以及自身免疫性疾病。在各种实施方案中，可以在可生物降解的聚合物内提供氟轻松制剂以减少，预防或治疗坐骨神经痛和/或炎症。在各种实施方案中，防止移植排斥至少二十五天。在一些实施方案中，疼痛缓解可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

44. 发明申请

US20090240255A1 Osteogenic packing device and method 有权
公开(公告)号：US20090240255A1
公开(公告)日：2009-09-24
申请号：US12454223
申请日：2009-05-14
申请人： William F. McKay , Bradley T. Estes
发明人： William F. McKay , Bradley T. Estes
IPC分类号： A61B17/58
CPC分类号： A61F2/4611 , A61B2090/062 , A61F2/442 , A61F2/446 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/30225 , A61F2002/30329 , A61F2002/30405 , A61F2002/30616 , A61F2002/30785 , A61F2002/30797 , A61F2002/3082 , A61F2002/3085 , A61F2002/4602 , A61F2002/4623 , A61F2002/4627 , A61F2002/4662 , A61F2220/0025 , A61F2230/0069 , A61F2250/0064
摘要： An osteogenic material packing device is used to pack osteogenic material onto a spinal fusion device. The packing device has a cavity defined therein, which is adapted to receive the spinal fusion device. The packing device further includes an access port, which intersects the cavity to receive the osteogenic material. A cannula is coupled to the packing device and an inserter is coupled to the fusion device in order to insert the fusion device into the packing device. Osteogenic material is packed through the access port around the fusion device. The fusion device then is slid through the cannula and inserted in the intervertebral space between adjacent vertebrae.

45. 发明授权

US07563455B2 Highly-mineralized osteogenic sponge compositions, and uses thereof 有权
公开(公告)号：US07563455B2
公开(公告)日：2009-07-21
申请号：US09923116
申请日：2001-08-06
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/28 , A61F2/00 , A61F2/44
CPC分类号： A61L27/56 , A61K38/1875 , A61L27/227 , A61L27/46 , A61L2430/02 , C08L89/06
摘要： Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogenetic protein. The compositions enable increased osteoinductive activity while retaining a reliable scaffold for the formation of new bone at an implant site. Methods for therapeutic use of the compositions are also described.

46. 发明申请

US20090157193A1 Tendon and Ligament Repair Sheet and Methods of Use 审中-公开
标题翻译：肌腱和韧带修复单和使用方法
公开(公告)号：US20090157193A1
公开(公告)日：2009-06-18
申请号：US11958482
申请日：2007-12-18
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/02 , A61B19/00
CPC分类号： A61F2/08 , A61B17/1146 , A61B2017/00893
摘要： Methods and device for treating or healing an injured tendon or ligament is disclosed. The device, a tendon and ligament repair sheet, has a porous layer and a denser layer, and optionally a therapeutic agent in the porous layer, the denser layer or both. The repair sheet is made from a resorbable or non-resorbable polymer. The repair sheet is securely attached to the injured tendon, ligament, muscle, or bone and has a suture pull out strength of at least 3N. If the injury involve severing of a ligament or tendon, one should place the severed ends in close proximity to each other and securely attach the repair sheet to both sides of the severed tendon or ligament at a distance from the injury so that the repair sheet remains securely attached to the tendon, ligament, muscle, or bone while the tissue is healing.
摘要翻译：公开了治疗或愈合损伤的肌腱或韧带的方法和装置。该装置，腱和韧带修复片具有多孔层和更致密的层，并且任选地在多孔层中的治疗剂，更致密的层或两者都是。修复片由可再吸收或不可吸收的聚合物制成。修复片牢固地附着在受伤的肌腱，韧带，肌肉或骨骼上，并具有至少3N的缝合线拔出强度。如果损伤涉及切断韧带或肌腱，则应将切断的末端彼此靠近，并将修复片牢固地附接到断裂的肌腱或韧带的两侧，距伤口一定距离处，使修复片保留当组织愈合时，牢固地附着于腱，韧带，肌肉或骨骼。

47. 发明申请

US20090105117A1 STEM CELLS AND LIM MINERALIZATION PROTEINS 有权
标题翻译：干细胞和LIM矿物质蛋白
公开(公告)号：US20090105117A1
公开(公告)日：2009-04-23
申请号：US11875267
申请日：2007-10-19
申请人： Jeffrey C. Marx , William F. McKay , Susan J. Drapeau
发明人： Jeffrey C. Marx , William F. McKay , Susan J. Drapeau
IPC分类号： A61K38/00 , C12N5/00 , A61F2/02 , A61F2/08 , A61F2/28 , A61F2/06 , A61F2/04 , A61F2/44
CPC分类号： A61L27/54 , A61F2002/2817 , A61F2002/4445 , A61F2002/445 , A61K9/0024 , A61K38/1875 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C12N5/0602 , C12N2501/105 , C12N2501/155 , C12N2501/165 , C12N2501/60 , C12N2501/998 , C12N2510/00 , A61K2300/00
摘要： Methods of changing a phenotype of a cell are provided. The methods comprise increasing an amount of an amino acid sequence which is at least 70% identical to an amino acid sequence encoding an LMP protein or a fragment thereof in a cell. The cells may be contacted by either a composition comprising a nucleic acid sequence encoding the amino acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or by a composition comprising acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or any combination thereof. The cells may be contacted either in vivo or ex-vivo.
摘要翻译：提供改变细胞表型的方法。所述方法包括增加与细胞中编码LMP蛋白或其片段的氨基酸序列至少70％相同的氨基酸序列的量。细胞可以由包含编码与编码LMP或其片段的氨基酸序列至少70％相同的氨基酸序列的核酸序列或包含至少70％的酸序列的组合物的组合物接触，与编码LMP或其片段的氨基酸序列或其任何组合相同。细胞可以在体内或体外接触。

48. 发明申请

US20080317805A1 LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS 审中-公开
标题翻译：局部管理低剂量的角质层
公开(公告)号：US20080317805A1
公开(公告)日：2008-12-25
申请号：US11765040
申请日：2007-06-19
申请人： William F. McKay , John Myers Zanella , Christopher M. Hobot
发明人： William F. McKay , John Myers Zanella , Christopher M. Hobot
IPC分类号： A61K31/566 , A61K31/56 , A61K9/00 , A61P25/04
CPC分类号： A61K31/58 , A61K9/0024 , A61K31/56 , A61K31/566 , A61K31/573
摘要： This invention provides for using a locally delivered low dose of a corticosteroid to treat pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back pain, facet pain, osteoarthritis, rheumatoid arthritis, osteolysis, tendonitis, carpal tunnel syndrome, or tarsal tunnel syndrome. More specifically, a locally delivered low dose of a corticosteroid can be released into the epidural space, perineural space, or the foramenal space at or near the site of a patient's pain by a drug pump or a biodegradable drug depot.
摘要翻译：本发明提供使用局部递送的低剂量皮质类固醇来治疗由任何炎性疾病引起的疼痛，包括坐骨神经痛，椎间盘突出症，狭窄症，脊髓病，腰背痛，小平面疼痛，骨关节炎，类风湿性关节炎，骨质溶解，腱炎，腕管综合征，或t疮综合征。更具体地，局部递送的低剂量的皮质类固醇可以通过药物泵或可生物降解的药物贮库释放到患者的疼痛部位处或附近的硬膜外腔，神经周围区域或其附近的孔内空间。

49. 发明申请

US20080221511A1 BONE VOID FILLER 有权
标题翻译：骨无孔填充
公开(公告)号：US20080221511A1
公开(公告)日：2008-09-11
申请号：US12043652
申请日：2008-03-06
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/28 , A61M5/31
CPC分类号： A61L27/24 , A61L27/12 , A61L27/46 , A61L27/505 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/602 , A61L2300/64
摘要： A novel composition and kit for a bone void filler are provided. The improved bone void filler includes a porous, collagen scaffolding admixed with calcium phosphate and at least one stabilizer agent. Optionally, the bone void filler further includes at least one bioactive agent.
摘要翻译：提供了一种用于骨空隙填充剂的新型组合物和试剂盒。改进的骨空隙填料包括与磷酸钙和至少一种稳定剂混合的多孔的胶原支架。任选地，骨空隙填料还包括至少一种生物活性剂。

50. 发明申请

US20080044449A1 Medical implant sheets useful for tissue regeneration 有权
标题翻译：用于组织再生的医用植入片
公开(公告)号：US20080044449A1
公开(公告)日：2008-02-21
申请号：US11506078
申请日：2006-08-17
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61K33/42 , A61F2/02
CPC分类号： A61B17/58 , A61B17/06066 , A61B17/06166 , A61B17/80 , A61C8/0006 , A61F2/2846 , A61F2/30907 , A61F2/30965 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/367 , A61F2/4081 , A61F2002/2825 , A61F2002/2835 , A61F2002/2871 , A61F2002/2892 , A61F2002/2896 , A61F2002/30064 , A61F2002/30153 , A61F2002/30289 , A61F2002/30327 , A61F2002/30428 , A61F2002/30785 , A61F2002/30957 , A61F2220/0025 , A61F2230/0019 , A61F2230/0091 , A61F2250/0039 , A61F2310/00796 , A61F2310/0097 , A61F2310/00976 , A61F2310/00982 , A61L27/446 , A61L27/58
摘要： Described is a medical device in the form of a thin sheet having granules of a calcium-containing, osteoconductive material interconnected by a thin web of polymeric material. The device includes a first face and a second face, wherein at least the first face is populated with proturbances presenting exposed regions of the calcium-containing, osteoconductive material provided by underlying granules. Methods of making and using such devices are also described, as are methods and devices involving the use of very thin polymeric sheets conformed to bone-ingrowth surfaces of load-bearing orthopedic implants.
摘要翻译：描述的是一种薄片形式的医疗装置，其具有通过聚合物材料薄网互连的含钙，骨传导材料的颗粒。所述装置包括第一面和第二面，其中至少所述第一面具有呈现由下面的颗粒提供的含钙，骨传导性材料的暴露区域的保湿性。还描述了制造和使用这些装置的方法，以及涉及使用符合承重整形外科植入物的骨向内生长表面的非常薄的聚合物片材的方法和装置。

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