专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明专利

CA2352503A1 IL-5 INHIBITING 6-AZAURACIL DERIVATIVES 未知
公开(公告)号：CA2352503A1
公开(公告)日：2000-06-02
申请号：CA2352503
申请日：1999-11-22
申请人： JANSSEN PHARMACEUTICA NV
发明人： LACRAMPE JEAN FERNAND ARMAND , LIGNY YANNICK , FREYNE EDDY JEAN EDGARD , DEROOSE FREDERIK DIRK
IPC分类号： C07D253/06 , A61K31/53 , A61P11/06 , A61P27/14 , A61P29/00 , A61P37/08 , A61P43/00 , C07D253/075 , C07D403/10 , C07D405/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present invention is concerned with the compounds of formula (I) the N- oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 4; - A- B- represents -(CH2)r-, -(CH2)t-O-, -(CH2)t-S(=O)u- or -(CH2)t-NR3-; r is 2 to 4; t is 1 to 3; u is 0 to 2; X1 is O, S, NR3 or a direct bond; R1 and R4 are C1-6alkyl, halo, polyhaloC1-6alkyl, hydroxy, mercapto, C1-6alkyloxy, C1- 6alkylthio, C1-6alkylcarbonyloxy, aryl, cyano, nitro, Het3, R6, NR7R8 or substituted C1-4alkyl; R2 is aryl, Het1, C3-7cycloalkyl, cyano, optionally substituted C1-6alkyl, -C(=Q)-X2-R15; R3 is hydrogen or C1-4alkyl; R15 is hydrogen, optionally substituted C1-6alkyl, C3-7cycloalkyl, aryl; where X2 i s a direct bond, R15 may also be halo or Het1; where X2 is NR5, R15 may also b e hydroxy; where X2 is C(=O)-NH-NH or NH-NH-C(=O), R15 may be replaced by R11; Q is O, S or NR3; X2 is O, S, NR5, C(=O)-NH-NH, NH-NH-C(=O) or a direct bond; R5 is hydrogen, C1-6alkyl, C1-6alkyloxy or arylC1-6alkyl; R6 is a sulfonyl or sulfinyl derivative; R7 and R8 are independently hydrogen, optionally substituted C1-4alkyl, aryl, a carbonyl containing moiety, C3-7cycloalkyl, - Y- C1-4alkanediyl-C(=O)-O-R14, Het3 and R6; R11 is hydroxy, mercapto, cyano, nitro, halo, trihalomethyl, C1-4alkyloxy, formyl, trihaloC1-4alkylsulfonylox y, R6, NR7R8, C(=O)NR7R8, C1-4alkanediyl-C(=O)-O-R14, -C(=O)-O-R14, -Y-C1- 4alkanediyl-C(=O)-O-R14, aryl, aryloxy, arylcarbonyl, C3-7cycloalkyl, C3- 7cycloalkyloxy, phthalimide-2-yl, Het3, Het4 and C(=O)Het3; aryl is optional ly substituted phenyl; Het1, Het2, Het3 and Het4 are optionally substituted heterocycles; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.

42. 发明专利

AU6082599A Interleukin-5 inhibiting 6-azauracil derivatives 未知
公开(公告)号：AU6082599A
公开(公告)日：2000-04-10
申请号：AU6082599
申请日：1999-09-14
申请人： JANSSEN PHARMACEUTICA NV
发明人： FREYNE EDDY JEAN EDGARD , LACRAMPE JEAN FERNAND ARMAND , DEROOSE FREDERIK DIRK , VENET MARC GASTON
IPC分类号： C07D253/06 , A61K31/53 , A61K31/7028 , A61K31/706 , A61K51/00 , A61P17/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P37/00 , C07D253/075 , C07D401/10 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07H15/26
摘要： The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X is O, S, NR or a direct bond; Y is O, S, NR or S(O)2; R independently is C1-6alkyl, halo, polyhaloC1-6alkyl, hydroxy, mercapto, C1-6alkyloxy, C1-6alkylthio, C1-6alkylcarbonyloxy, aryl, cyano, nitro, Het , R , NR R or substituted C1-4alkyl; R is Het , C3-7cycloalkyl or optionally substituted C1-6alkyl and if X is O, S or NR , then R may also represent aminocarbonyl, aminothiocarbonyl, C1-4alkylcarbonyl, C1-4alkylthiocarbonyl, arylcarbonyl, arylthiocarbonyl, Het carbonyl or Het thiocarbonyl; R and R independently are hydrogen, C1-6alkyl or C3-7cycloalkyl; R and R form a C2-6alkanediyl; R is hydrogen or C1-4alkyl; R a sulfonyl or sulfinyl derivative; R and R are independently hydrogen, optionally substituted C1-4alkyl, aryl, a carbonyl containing moiety, C3-7cycloalkyl, -Y-C1-4alkanediyl-C(=O)-O-R , Het and R ; R is hydroxy, mercapto, cyano, nitro, halo, trihalomethyl, C1-4alkyloxy, formyl, trihaloC1-4alkylsulfonyloxy, R , NR R , C(=O)NR R , C1-4alkanediyl-C(=O)-O-R , - C(=O)-O-R , -Y-C1-4alkanediyl-C(=O)-O-R , aryl, aryloxy, arylcarbonyl, C3-7cycloalkyl, C3-7cycloalkyloxy, phthalimide-2-yl, Het , Het and C(=O)Het ; R is hydrogen, C1-4alkyl, C3-7cycloalkyl, aminocarbonylmethylene or mono-or di(C1-4alkyl)aminocarbonylmethylene; aryl is optionally substituted phenyl; Het , Het , Het and Het are optionally substituted heterocycles; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.

45. 发明专利

AU676703B2 Antiallergic triazolo(pyrrolo, thieno or furano)azepine derivatives 未知
公开(公告)号：AU676703B2
公开(公告)日：1997-03-20
申请号：AU5628094
申请日：1993-11-25
申请人： JANSSEN PHARMACEUTICA NV
发明人： JANSSENS FRANS EDUARD , LACRAMPE JEAN FERNAND ARMAND , PILATTE ISABELLE NOELLE CONSTA
IPC分类号： A61K31/55 , A61K31/554 , A61P37/08 , C07D487/14 , C07D491/12 , C07D491/14 , C07D491/147 , C07D495/14 , C07D519/00
摘要： PCT No. PCT/EP93/03322 Sec. 371 Date May 8, 1995 Sec. 102(e) Date May 8, 1995 PCT Filed Nov. 25, 1993 PCT Pub. No. WO94/13681 PCT Pub. Date Jun. 23, 1994Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I) the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G- is a bivalent radical of formula -X-C(R1)=CH- (a-1); or -CH=C(R2)-X- (a-2); X represents O, S or NR3; R3 represents hydrogen, C1-6alkyl or C1-4alkylcarbonyl; -B=D- is a bivalent radical of formula -C(R4)=N- (b-1); or -N=C(R5)- (b-2); L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2) or -Alk-Het3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.

46. 发明专利

PL309255A1 ANTIALLERGIC DERIVATIVES OF TRIAZOLO(PYROLO, THIENO OR FURANO)AZEPINE 未知
公开(公告)号：PL309255A1
公开(公告)日：1995-10-02
申请号：PL30925593
申请日：1993-11-25
申请人： JANSSEN PHARMACEUTICA NV
发明人： JANSSENS FRANS EDUARD , LACRAMPE JEAN FERNAND ARMAND , PILATTE ISABELLE NOELLE CONSTA
IPC分类号： A61K31/55 , A61K31/554 , A61P37/08 , C07D487/14 , C07D491/12 , C07D491/14 , C07D491/147 , C07D495/14 , C07D519/00 , C07D495/04 , A61K31/33
摘要： PCT No. PCT/EP93/03322 Sec. 371 Date May 8, 1995 Sec. 102(e) Date May 8, 1995 PCT Filed Nov. 25, 1993 PCT Pub. No. WO94/13681 PCT Pub. Date Jun. 23, 1994Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I) the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G- is a bivalent radical of formula -X-C(R1)=CH- (a-1); or -CH=C(R2)-X- (a-2); X represents O, S or NR3; R3 represents hydrogen, C1-6alkyl or C1-4alkylcarbonyl; -B=D- is a bivalent radical of formula -C(R4)=N- (b-1); or -N=C(R5)- (b-2); L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2) or -Alk-Het3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.

47. 发明专利

NO952198A 未知
公开(公告)号：NO952198A
公开(公告)日：1995-08-03
申请号：NO952198
申请日：1995-06-02
申请人： JANSSEN PHARMACEUTICA NV
发明人： JANSSENS FRANS EDUARD , LACRAMPE JEAN FERNAND ARMAND , PILATTE ISABELLE NOELLE CONSTA
IPC分类号： A61K31/55 , A61P37/08 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04

48. 发明专利

FI952724A0 未知
公开(公告)号：FI952724A0
公开(公告)日：1995-06-02
申请号：FI952724
申请日：1995-06-02
申请人： JANSSEN PHARMACEUTICA NV
发明人： JANSSENS FRANS EDUARD , LACRAMPE JEAN FERNAND ARMAND , PILATTE ISABELLE NOELLE CONSTA
IPC分类号： A61K31/55 , A61K31/554 , A61P37/08 , C07D487/14 , C07D491/12 , C07D491/14 , C07D491/147 , C07D495/14 , C07D519/00 , C07D
摘要： PCT No. PCT/EP93/03322 Sec. 371 Date May 8, 1995 Sec. 102(e) Date May 8, 1995 PCT Filed Nov. 25, 1993 PCT Pub. No. WO94/13681 PCT Pub. Date Jun. 23, 1994Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I) the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G- is a bivalent radical of formula -X-C(R1)=CH- (a-1); or -CH=C(R2)-X- (a-2); X represents O, S or NR3; R3 represents hydrogen, C1-6alkyl or C1-4alkylcarbonyl; -B=D- is a bivalent radical of formula -C(R4)=N- (b-1); or -N=C(R5)- (b-2); L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2) or -Alk-Het3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.

49. 发明专利

CA2150804A1 ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES 未知
公开(公告)号：CA2150804A1
公开(公告)日：1994-06-23
申请号：CA2150804
申请日：1993-11-25
申请人： JANSSEN PHARMACEUTICA NV
发明人： JANSSENS FRANS EDUARD , LACRAMPE JEAN FERNAND ARMAND , PILATTE ISABELLE NOELLE CONSTA
IPC分类号： A61K31/55 , A61K31/554 , A61P37/08 , C07D487/14 , C07D491/12 , C07D491/14 , C07D491/147 , C07D495/14 , C07D519/00
摘要： Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G-is a bivalent radical of formula -X-C(R1) CH (a-1); or -CH C(R2)-X- (a-2); X represents O, S or NR3; R3 represents hydrogen, C1-6alkyl or C1-4alkylcarbonyl, -B D- is a bivalent radical of formula -C(R4) N- (b-1); or -N C(R5)- (b-2); L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2) or -Alk-Het3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.

50. 发明专利

ES2431564T3 Inhibidores de la interacción entre MDM2 y p53 未知
公开(公告)号：ES2431564T3
公开(公告)日：2013-11-27
申请号：ES07727057
申请日：2007-03-19
申请人： JANSSEN PHARMACEUTICA NV
发明人： LACRAMPE JEAN FERNAND ARMAND , MEYER CHRISTOPHE , SCHOENTJES BRUNO , LARDEAU DELPHINE YVONNE RAYMONDE , PONCELET ALAIN PHILIPPE , VAN HIJFTE LUC
IPC分类号： C07D401/12 , A61K31/4409 , A61P35/00 , C07D405/12 , C07D471/04
摘要： Compuesto de fórmula (I),**Fórmula** una forma de N-óxido, una sal de adición o una forma estereoquímicamente isomérica del mismo, en la quem es 0 y entonces se pretende que sea un enlace directo; n es 0 ó 2 y cuando n es 0 entonces se pretende que sea un enlace directo; p es 1 s es 0 y entonces se pretende que sea un enlace directo; t es 0 y entonces se pretende que sea un enlace directo; R1 y R2 son cada uno independientemente hidrógeno, A es un radical seleccionado de **Fórmula** en las que R4 y R5 se seleccionan cada uno independientemente de hidrógeno o alquiloxilo C1-6,Z es un radical seleccionado de **Fórmula** en la que R6 o R7 se seleccionan cada uno independientemente de hidrógeno.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式