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41. 发明授权

US4182682A Preparation for shrinkproofing wool and process for the production of the preparation 失效
标题翻译：羊毛防缩制备及制备方法
公开(公告)号：US4182682A
公开(公告)日：1980-01-08
申请号：US968766
申请日：1978-12-12
申请人： Gotz Koerner , Gunter Schmidt , Friedhelm Nickel
发明人： Gotz Koerner , Gunter Schmidt , Friedhelm Nickel
IPC分类号： D06M11/00 , D06M13/02 , D06M13/51 , D06M13/513 , D06M15/643 , D06M101/00 , D06M101/02 , D06M101/10 , D06M101/12 , D06M13/10
CPC分类号： D06M15/643
摘要： A composition for shrinkproofing wool which is composed of 1 to 50 weight percent of organopolysiloxanes containing mercaptoalkyl and mercaptoaryl groups and having between 10 to 1000 silicon atoms per mercaptoalkyl or mercaptoaryl group, and 50 to 99 weight percent water, emulsifiers and organic solvents. The use of the composition provides durable shrinkproofing properties in wool and does not adversely affect the handle of the fabric.
摘要翻译：一种用于羊毛收缩的组合物，其由1至50重量％的含有巯基烷基和巯基芳族基团并且每个巯基烷基或巯基芳基具有10至1000个硅原子和50至99重量％的水，乳化剂和有机溶剂的有机聚硅氧烷组成。使用该组合物可在羊毛中提供耐久的防缩性能，并且不会对织物的手柄产生不利影响。

42. 发明授权

US3999275A Tool for driving balance weights onto spoked wheels 失效
标题翻译：用于在平衡轮上平衡重的工具
公开(公告)号：US3999275A
公开(公告)日：1976-12-28
申请号：US662255
申请日：1976-02-27
申请人： Gunter Schmidt
发明人： Gunter Schmidt
IPC分类号： B25B27/00 , G01M1/32 , B25B27/02
CPC分类号： B25B27/0078 , G01M1/326 , Y10T29/5393
摘要： A tool for driving balance weights of the type having the shape of a slotted bushing which is attached to a spoke nipple by a press fit, the tool having a handle at one end and a weight receiving opening at the other. A lateral slot communicates with the opening for receiving a spoke and a crowned anvil is provided between the ends for hammering the weight in place against the rim without deforming the weight.
摘要翻译：一种用于驱动具有通过压配合附接到轮辐接头的开槽衬套的形状的类型的平衡重的工具，该工具在一端具有手柄和在另一端具有重量接收开口。横向槽与开口连通以接收轮辐，并且在端部之间设置加冠的砧座，用于将重物锤撞在边缘上而不会使重物变形。

43. 发明申请

US20090241060A1 Method for navigating between sections in a display space 有权
公开(公告)号：US20090241060A1
公开(公告)日：2009-09-24
申请号：US12386709
申请日：2009-04-21
申请人： Gunter Schmidt , Michael R. Alvers
发明人： Gunter Schmidt , Michael R. Alvers
IPC分类号： G06F3/048
CPC分类号： G06F3/0481
摘要： A computer-implemented method for navigating between sections in a display space is furnished. The sections in the display space are each assigned to a particular location of the display space, and representatives are provided which are each assigned to a particular section in the display space using an unambiguous relation. The method for navigating includes the following steps: selecting at least one representative that is assigned to a particular section in the display space with the aid of the unambiguous relation; and navigating to the particular section in the display space with the aid of the unambiguous relation with the particular section in the display space.

44. 发明申请

US20080167197A1 MASS LABELS 有权
标题翻译：质量标签
公开(公告)号：US20080167197A1
公开(公告)日：2008-07-10
申请号：US11841707
申请日：2007-08-20
申请人： Gunter Schmidt , Andrew Hugin Thompson , Robert Alexander Walker Johnstone
发明人： Gunter Schmidt , Andrew Hugin Thompson , Robert Alexander Walker Johnstone
IPC分类号： C40B20/08 , C40B50/06 , C40B40/06 , C40B40/10
CPC分类号： C07H21/00 , C07K1/1077 , C12Q1/6872 , C40B40/00 , G01N33/6803 , G01N2458/15 , Y10T436/13
摘要： Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterized as having a mass different from that of all other mass marker moieties in the set as determined by mass spectrometry. Further, each mass normalisation moiety ensures that each mass label in the set has substantially the same mass as determined by mass spectrometry.
摘要翻译：本文提供了一组质量标签。一组中的每个质量标签包括：1）质量标记部分; 2）质量归一化部分; 和3）将质量标记部分连接到质量标准化部分的可切割的连接体。每个质量标记物部分的特征在于质量不同于通过质谱法测定的组中所有其它质量标记物部分的质量。此外，每个质量归一化部分确保组中的每个质量标签具有与通过质谱法测定的质量基本相同的质量。

45. 发明授权

US07094531B1 Nucleic acid sequencing 失效
标题翻译：核酸测序
公开(公告)号：US07094531B1
公开(公告)日：2006-08-22
申请号：US09341641
申请日：1998-01-15
申请人： Gunter Schmidt , Andrew Hugin Thompson
发明人： Gunter Schmidt , Andrew Hugin Thompson
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/63 , C12N1/20 , C07H21/04
CPC分类号： C12Q1/6874 , C12Q1/6872
摘要： Provided is a method for sequencing DNA, which comprises: (a) obtaining a target DNA population comprising one or more single-stranded DNAs to be sequenced, each of which is present in a unique amount and bears a primer to provide a double-stranded portion of the DNA for ligation thereto; (b) contacting the DNA population with an array of hybridisation probes, each probe comprising a label cleavably attached to a known base sequence of predetermined length, the array containing all possible base sequences of that predetermined length; (c) removing all unligated probes; followed by the steps of: (d) cleaving the ligated probes to release each label; (e) recording the quantity of each label; and (f) activating the extended double-stranded portion to enable ligation thereto; wherein (g) steps (b) to (f) are repeated in a cycle for a sufficient number of times to determine the sequence of the or each single-stranded DNA by determining the sequence of release of each label.
摘要翻译：提供了一种用于测序DNA的方法，其包括：（a）获得包含待测序的一个或多个单链DNA的靶DNA群体，其中每一个以独特的量存在并承载引物以提供双链 DNA连接部分; （b）使DNA群体与杂交探针阵列接触，每个探针包含与预定长度的已知碱基序列可切割地连接的标记，该阵列包含该预定长度的所有可能的碱基序列; （c）清除所有未连接的探针; 其次是以下步骤：（d）切割连接的探针以释放每个标签; （e）记录每个标签的数量; 和（f）活化延伸的双链部分以使其能够连接; 其中（g）步骤（b）至（f）在循环中重复足够多次，以通过确定每个标记的释放顺序来确定该单链DNA或每个单链DNA的序列。

46. 发明申请

US20050096320A1 Triazolotriazinones and the use thereof 审中-公开
标题翻译：三唑并三嗪酮及其用途
公开(公告)号：US20050096320A1
公开(公告)日：2005-05-05
申请号：US10728180
申请日：2003-12-04
申请人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsby , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsby , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： A61K31/53 , A61K31/55 , A61K31/551 , A61P7/04 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/08 , A61P15/00 , A61P15/10 , A61P25/28 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel triazolotriazinones of the general formula and to a method for their production and pharmaceutical use thereof.
摘要翻译：本发明涉及通式的新型三唑并三氮嗪酮及其制备方法和药物用途。

47. 发明申请

US20050049250A1 7-Aikyl and cycloalkyl-substituted imidazotriazinones 失效
标题翻译： 7-芳基和环烷基取代的咪唑并三嗪酮
公开(公告)号：US20050049250A1
公开(公告)日：2005-03-03
申请号：US10850510
申请日：2004-05-20
申请人： Ulrich Niewohner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
发明人： Ulrich Niewohner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/539 , A61K31/55 , A61K31/5513 , A61K31/675 , A61P7/12 , A61P9/00 , A61P9/08 , A61P9/10 , A61P15/00 , A61P15/10 , A61P21/02 , A61P43/00 , C07D487/04 , C07D519/00 , C07F9/6561
CPC分类号： C07D487/04 , C07F9/6561
摘要： The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
摘要翻译：本发明涉及7-烷基 - 和环烷基取代的咪唑并三嗪酮，其制备方法和用作药物，特别是作为cGMP代谢磷酸二酯酶的抑制剂。

48. 发明申请

US20050043303A1 Novel imidazo[1,3,5]triazinones and their use 失效
标题翻译：新型咪唑并[1,3,5]三嗪酮及其用途
公开(公告)号：US20050043303A1
公开(公告)日：2005-02-24
申请号：US10892984
申请日：2004-07-15
申请人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/539 , A61K31/55 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/08 , A61P15/10 , A61P25/00 , A61P25/20 , A61P25/28 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to imidazo[1,3,5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
摘要翻译：本发明涉及咪唑并[1,3,5]三嗪酮，其制备方法和使用方法，特别是作为环状GMP代谢磷酸二酯酶的抑制剂。

49. 发明授权

US06582916B1 Metal ion-binding mass markers for nucleic acids 失效
标题翻译：用于核酸的金属离子结合质量标记物
公开(公告)号：US06582916B1
公开(公告)日：2003-06-24
申请号：US09743748
申请日：2001-03-16
申请人： Gunter Schmidt , Andrew Hugin Thompson , Robert Alexander W. Johnstone
发明人： Gunter Schmidt , Andrew Hugin Thompson , Robert Alexander W. Johnstone
IPC分类号： C12Q168
CPC分类号： C12Q1/6872 , C07H21/00 , Y10T436/143333 , Y10T436/24
摘要： Provided is a method for characterising an analyte, which method comprises: a) providing a compound in which the analyte is attached by at cleavable linker to a mass marker relatable to the analyte; b) cleaving the mass marker from the analyte; and c) identifying the mass marker, thereby characterising the analyte, wherein the mass marker comprises a metal ion-binding moiety.
摘要翻译：提供了一种用于表征分析物的方法，该方法包括：a）提供其中分析物通过可切割接头连接到与分析物相关的质量标记的化合物; b）从分析物中切割质量标记物; 和c）鉴定所述质量标记，从而表征所述分析物，其中所述质量标记包含金属离子结合部分。

50. 发明授权

US06355418B1 Chimeric oligonucleotides and uses thereof in the identification of antisense binding sites 失效
标题翻译：嵌合寡核苷酸及其在鉴定反义结合位点中的用途
公开(公告)号：US06355418B1
公开(公告)日：2002-03-12
申请号：US09043149
申请日：1998-03-13
申请人： Gunter Schmidt
发明人： Gunter Schmidt
IPC分类号： C12Q168
CPC分类号： C07H21/00
摘要： A chimaeric oligonucleotide library for use in identifying an antisense binding site in a target mRNA, comprising a plurality of distinct chimaeric oligonucleotides capable of hybridizing to mRNA to form a duplex, the nucleotide sequences of which each have a common length of 7 to 20 bases and are generated randomly or generated from information characterizing the sequence of the target mRNA, wherein substantially all the nucleotide sequences of said common length which are present as sub-sequences in the target mRNA are present in the library, and wherein each nucleotide sequence comprises: a) a recognition region comprising a sequence of nucleotides which is recognizable by a duplex-cutting RNAase when hybridized to the mRNA, and b) a flanking region comprising a sequence of chemically-modified nucleotides which binds to the mRNA sufficiently tightly to stabilize the duplex for cutting of the mRNA in the duplex by the duplex-cutting RNAase, wherein the nucleotides constituting the flanking region are different from those constituting the recognition region, and wherein each oligonucleotide is protected against exonuclease attack.
摘要翻译：用于鉴定靶mRNA中的反义结合位点的嵌合寡核苷酸文库，其包含能够与mRNA杂交以形成双链体的多个不同的嵌合寡核苷酸，其核苷酸序列的长度为7至20个碱基，由表达靶mRNA序列的信息产生，其中基本上所有作为目标mRNA中的亚序列存在的所述共同长度的所有核苷酸序列存在于文库中，并且其中每个核苷酸序列包含：）识别区域，其包含当与mRNA杂交时由双链切割RNA酶识别的核苷酸序列，和b）包含化学修饰的核苷酸序列的侧翼区域，所述化学修饰的核苷酸序列足够紧密地结合到mRNA上以稳定双链体通过双链切割RNA酶切割双链体中的mRNA，其中构成fl 贴附区域与构成识别区域的区域不同，并且其中每个寡核苷酸被保护免受外切核酸酶攻击。

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