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41. 发明专利

CA2331315A1 IDENTIFICATION OF MOLECULAR INTERACTION SITES IN RNA FOR NOVEL DRUG DISCOVERY 未知
公开(公告)号：CA2331315A1
公开(公告)日：1999-11-18
申请号：CA2331315
申请日：1999-05-12
申请人： ISIS PHARMACEUTICALS INC
发明人： GRIFFEY RICHARD , MCNEIL JOHN , ECKER DAVID J , SAMPATH RANGA
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P31/04 , C07H21/02 , C07H21/04 , C12N15/11 , C12Q1/68
摘要： Methods of identifying molecular interactions sites in eukaryotic and prokaryotic nucleic acids, especially RNA, are described. Secondary structural elements are identified from highly conserved sequences. Methods of preparing databases relating to such molecular interaction sites are also provided herein as are databases themselves. Therapeutic, agricultural, industrial, and other applicability results from interaction of such molecular interaction sites with "small" and other molecules.

42. 发明专利

AU3965099A Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation 未知
公开(公告)号：AU3965099A
公开(公告)日：1999-11-01
申请号：AU3965099
申请日：1999-04-13
申请人： ISIS PHARMACEUTICALS INC
发明人： COWSERT LEX M , BAKER BRENDA F , MCNEIL JOHN , FREIER SUSAN M , SASMOR HENRI M , BROOKS DOUGLAS G , OHASI CARA , WYATT JACQUELINE R , BORCHERS ALEXANDER H , VICKERS TIMOTHY A
IPC分类号： C12N15/09 , C07B61/00 , C12N15/10 , C12Q1/68 , C40B30/02 , C40B40/02 , C40B50/02 , C40B50/06 , G06F17/30 , G06F17/50 , G06F19/18 , G06F19/22
摘要： Iterative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A "virtual" oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.

43. 发明专利

ZA200306810B Method for rapid detection and identification of bioagents. 未知
公开(公告)号：ZA200306810B
公开(公告)日：2004-09-06
申请号：ZA200306810
申请日：2003-09-01
申请人： ISIS PHARMACEUTICALS INC
发明人： ECKER DAVID J , GRIFFEY RICHARD H , HOFSTADLER STEVEN , MCNEIL JOHN , SAMPATH RANGARAJAN
IPC分类号： G01N27/62 , C12N15/09 , C12Q1/68 , C12N

44. 发明专利

CA2508726A1 METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND ANIMALS 未知
公开(公告)号：CA2508726A1
公开(公告)日：2004-07-22
申请号：CA2508726
申请日：2003-12-05
申请人： ISIS PHARMACEUTICALS INC
发明人： MCNEIL JOHN , ECKER DAVID J , SAMPATH RANGARAJAN , GRIFFEY RICHARD H , BLYN LAWRENCE B , HALL THOMAS A , CROOKE STANLEY T , RANKEN RAYMOND , HOFSTADLER STEVEN A
IPC分类号： A61K20060101 , A61K9/00 , C07H21/00 , C12Q1/68 , C12Q1/70 , G06F19/00
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.

45. 发明专利

AU2003298030A1 METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND ANIMALS 未知
公开(公告)号：AU2003298030A1
公开(公告)日：2004-06-30
申请号：AU2003298030
申请日：2003-12-05
申请人： ISIS PHARMACEUTICALS INC
发明人： ECKER DAVID J , GRIFFEY RICHARD H , HOFSTADLER STEVEN A , SAMPATH RANGARAJAN , MCNEIL JOHN , CROOKE STANLEY T
IPC分类号： A61B20060101 , C07H21/02 , C12P19/34 , C12Q1/68 , G01N33/48

46. 发明专利

AU2002318423A1 A secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 未知
公开(公告)号：AU2002318423A1
公开(公告)日：2003-03-03
申请号：AU2002318423
申请日：2002-06-26
申请人： ISIS PHARMACEUTICALS INC
发明人： GRIFFEY RICHARD H , ECKER DAVID J , HOFSTADLER STEVEN A , CROOKE STANLEY T , MCNEIL JOHN , SAMPATH RANGARAJAN
IPC分类号： A61B20060101 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N31/00 , G01N33/48 , G01N33/50 , G06F19/00 , G06F19/18
摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.

47. 发明专利

AU756906B2 Identification of molecular interaction sites in RNA for novel drug discovery 未知
公开(公告)号：AU756906B2
公开(公告)日：2003-01-23
申请号：AU3982399
申请日：1999-05-12
申请人： ISIS PHARMACEUTICALS INC
发明人： ECKER DAVID J , SAMPATH RANGA , GRIFFEY RICHARD , MCNEIL JOHN
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P31/04 , C07H21/02 , C07H21/04 , C12N15/11 , C12Q1/68

48. 发明专利

CA2424786A1 SELF-DISPENSING STORAGE DEVICE 未知
公开(公告)号：CA2424786A1
公开(公告)日：2002-04-11
申请号：CA2424786
申请日：2001-09-27
申请人： ISIS PHARMACEUTICALS INC
发明人： MCNEIL JOHN
IPC分类号： G01F15/12 , B01J4/00 , B01L3/02 , B25J5/02 , B67D7/02 , B81B1/00 , C12M1/00 , G01F13/00 , G01N35/02 , G01N35/10 , G01N1/10
摘要： A system and method for dispensing a sample using a self-dispensing system ( 1) including a sample storage device (2), a dispensing mechanism (3), and a driving mechanism (4) for driving the dispensing mechanism. The dispensing mechanism is formed as part of and is in dispensing communication with the sample storage device. Preferably the dispensing mechanism is a positive displacement mechanism and includes an inlet valve, an actuator, and an outl et valve. The driving mechanism may be positioned internal or external to the dispensing mechanism and drives the dispensing mechanism thereby inducing a flow of a measured quantity of sample (6) into or out of the storage device. Preferably, the dispensing mechanism is relatively inexpensive and is disposable. The system and method alternatively, may include a plurality of storage devices each having a corresponding dispensing mechanism arranged in , for example, a plate (21). The system and method provide for precision and reproducible dispensing of a sample with improved efficiency.

49. 发明专利

AU7622800A System and method for sample positioning in a robotic system 未知
公开(公告)号：AU7622800A
公开(公告)日：2001-05-10
申请号：AU7622800
申请日：2000-09-29
申请人： ISIS PHARMACEUTICALS INC
发明人： MCNEIL JOHN
IPC分类号： G01N35/00 , G01N35/04 , G01N35/02
摘要： A system and method for positioning a sample, or cargo, with respect to a device in a robotic system is provided. The system includes a macro positioning system for "gross" movement of the sample between stations and a micro positioning system for precisely locating the sample in a predetermined location at a station with respect to a device that will interact with the sample. The macro positioning system provides a positioning mechanism for the general movement of a sample along a pathway between various destinations or stations wherein the sample is "grossly" positioned with respect to the station. Once at the station, the micro positioning subsystem disposed between a sample carrier and the station provides a positioning mechanism for "precisely" positioning the sample in a predetermined location at the station with respect to a device that will interact with, or perform some function on, the sample. The system and method provide for multiple sample carrying robots having autonomous navigation thereby providing flexibility and stacker-like queuing for near 100% device utilization.

50. 发明专利

AU3982399A Identification of molecular interaction sites in rna for novel drug discovery 未知
公开(公告)号：AU3982399A
公开(公告)日：1999-11-29
申请号：AU3982399
申请日：1999-05-12
申请人： ISIS PHARMACEUTICALS INC
发明人： ECKER DAVID J , SAMPATH RANGA , GRIFFEY RICHARD , MCNEIL JOHN
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P31/04 , C07H21/02 , C07H21/04 , C12N15/11 , C12Q1/68

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