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41. 发明授权

EP2588465B1 SGC STIMULATORS 有权转让
标题翻译： SGC兴奋剂
公开(公告)号：EP2588465B1
公开(公告)日：2017-01-25
申请号：EP11734221.2
申请日：2011-06-30
申请人： Ironwood Pharmaceuticals, Inc.
发明人： KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara , FRETZEN, Angelika
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/4155
CPC分类号： C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00

42. 发明公开

EP3112363A1 2-[1-[(2-FLUOROPHENYL)METHYL]-5-(3-ISOXAZOLYL)-1H-PYRAZOL-3-YL]-PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS AS SOLUBLE GUANYLATE CYCLASE (SGC) STIMULATORS FOR THE TREATMENT OF PULMONARY HYPERTENSION 审中-公开
标题翻译： 2- [1 - [（2-氟苯基）甲基] -5-（3-异恶唑基）-1H-吡唑-3-基] -PYRIMIDINDERIVATE及相关化合物如可溶性鸟苷酸环化酶（LGC）的刺激剂用于治疗肺动脉高血压
公开(公告)号：EP3112363A1
公开(公告)日：2017-01-04
申请号：EP16178941.7
申请日：2012-12-26
申请人： Ironwood Pharmaceuticals, Inc.
发明人： KIM, Charles , NAKAI, Takashi , MOORE, Joel , PERL, Nicholas, Robert , IM, G-yoon, Jame , BARDEN, Timothy, Claude , IYENGAR, Rajesh, R , ZIMMER, Daniel, P. , FRETZEN, Angelika , RENHOWE, Paul, Allan
IPC分类号： C07D413/14 , C07D403/04 , C07D417/14 , A61K31/4155 , A61P43/00
CPC分类号： A61K31/52 , A61K31/4439 , A61K31/506 , A61K31/513 , A61K31/519 , A61K45/06 , C07D403/04 , C07D413/14 , C07D417/14 , C07D473/00 , C07D487/04 , C07D513/22
摘要： 2-[1-[(2-Fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-pyrimidine derivatives and related compounds as soluble guanylate cyclase (sGC) stimulators, particularly NO-independent, heme-dependent stimulators, for treating pulmonary hypertension and other diseases.
摘要翻译： 2- [1 - [（2-氟苯基）甲基] -5-（3-异恶唑基）-1H-吡唑-3-基] -pyrimidines衍生物和相关化合物作为可溶性鸟苷酸环化酶（sGC的）刺激剂，特别是NO-独立，血红素依赖性刺激剂，用于治疗肺高血压等疾病。

43. 发明授权

EP2655356B1 FAAH INHIBITORS 有权
标题翻译： FAAH抑制剂
公开(公告)号：EP2655356B1
公开(公告)日：2016-08-03
申请号：EP11811264.8
申请日：2011-12-22
申请人： Ironwood Pharmaceuticals, Inc.
发明人： HUDSON, Colleen , BARDEN, Timothy, C. , JIA, James , MERMERIAN, Ara , PENG, Bo , YANG, Jane , YU, Xiang, Y. , SPROTT, Kevin , FRETZEN, Angelika
IPC分类号： C07D401/14 , C07D471/04 , A61K31/444 , A61K31/437 , A61P25/04
CPC分类号： C07D471/04 , A61K31/4045 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D209/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14

44. 发明公开

EP2655356A1 FAAH INHIBITORS 有权
标题翻译：详细缝边
公开(公告)号：EP2655356A1
公开(公告)日：2013-10-30
申请号：EP11811264.8
申请日：2011-12-22
申请人： Ironwood Pharmaceuticals, Inc.
发明人： HUDSON, Colleen , BARDEN, Timothy, C. , JIA, James , MERMERIAN, Ara , PENG, Bo , YANG, Jane , YU, Xiang, Y. , SPROTT, Kevin , FRETZEN, Angelika
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04 , A61K31/404 , A61P25/04
CPC分类号： C07D471/04 , A61K31/4045 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D209/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.

45. 发明公开

EP3701962A1 STABLE SOLID FORMULATION OF A GC-C RECEPTOR AGONIST POLYPEPTIDE SUITABLE FOR ORAL ADMINISTRATION 审中-实审
公开(公告)号：EP3701962A1
公开(公告)日：2020-09-02
申请号：EP20152529.2
申请日：2009-08-14
申请人： Ironwood Pharmaceuticals, Inc.
发明人： FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong , DEDHIYA, Mahendra , MO, Yun
IPC分类号： A61K38/00 , A61K9/50 , A61K9/16 , A61K9/20 , A61K9/48 , A61K38/10 , A61K38/12 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P43/00
摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr ("linaclotide") or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

46. 发明授权

EP2499154B1 TREATMENTS FOR GASTROINTESTINAL DISORDERS 有权
标题翻译：治疗胃肠疾病
公开(公告)号：EP2499154B1
公开(公告)日：2016-12-21
申请号：EP10782095.3
申请日：2010-11-09
申请人： Ironwood Pharmaceuticals, Inc.
发明人： CURRIE, Mark, G. , FRETZEN, Angelika , KESSLER, Marco , ZIMMER, Daniel, P.
IPC分类号： C07K7/08 , C07K14/47
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , C07K7/08 , C07K14/4702

47. 发明授权

EP2797915B1 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure 有权转让
标题翻译： 2-苄基-3-（恶唑/噻唑）-5-（嘧啶-2-基）-1（H） - 吡唑衍生物作为高血压和心脏衰竭的治疗中可溶性鸟苷酸环化酶（SGC）的刺激剂
公开(公告)号：EP2797915B1
公开(公告)日：2016-07-13
申请号：EP12812498.9
申请日：2012-12-26
申请人： Ironwood Pharmaceuticals, Inc.
发明人： KIM, Charles , NAKAI, Takashi , MOORE, Joel , PERL, Nicholas, Robert , IM, G-yoon, Jamie , BARDEN, Timothy, Claude , IYENGAR, Rajesh, R. , ZIMMER, Daniel, P. , FRETZEN, Angelika , RENHOWE, Paul, Allan
IPC分类号： C07D413/14 , C07D403/04 , C07D417/14 , A61K31/4155 , A61P43/00
CPC分类号： A61K31/52 , A61K31/4439 , A61K31/506 , A61K31/513 , A61K31/519 , A61K45/06 , C07D403/04 , C07D413/14 , C07D417/14 , C07D473/00 , C07D487/04 , C07D513/22

48. 发明授权

EP2509992B1 TREATMENTS FOR GASTROINTESTINAL DISORDERS 有权
标题翻译：治疗为胃肠道疾病
公开(公告)号：EP2509992B1
公开(公告)日：2015-10-14
申请号：EP10795838.1
申请日：2010-12-07
申请人： Ironwood Pharmaceuticals, Inc.
发明人： CURRIE, Mark, G. , ZIMMER, Daniel, P. , FRETZEN, Angelika , KESSLER, Marco , CALI, Brian, M.
IPC分类号： C07K7/08 , A61K38/10 , A61K38/00 , A61K9/00 , A61K45/06
CPC分类号： C07K7/08 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K45/06

49. 发明公开

EP2588465A1 SGC STIMULATORS 有权转让
标题翻译： SGC-STIMULATOREN
公开(公告)号：EP2588465A1
公开(公告)日：2013-05-08
申请号：EP11734221.2
申请日：2011-06-30
申请人： Ironwood Pharmaceuticals, Inc.
发明人： KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara , FRETZEN, Angelika
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/4155
CPC分类号： C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
摘要： Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述式I化合物。它们作为sGC的刺激剂是有用的，特别是NO独立的血红素依赖性刺激物。这些化合物可用于治疗，预防或治疗本文公开的各种疾病。

50. 发明公开

EP2536742A2 TREATMENTS FOR GASTROINTESTINAL DISORDERS 有权
标题翻译： BEHANDLUNGENFÜRMAGEN-DARM-ERKRANKUNGEN
公开(公告)号：EP2536742A2
公开(公告)日：2012-12-26
申请号：EP11706694.4
申请日：2011-02-17
申请人： Ironwood Pharmaceuticals, Inc.
发明人： FRETZEN, Angelika , ZHAO, Hong , KESSLER, Marco
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/08 , A61K38/10 , A61K45/06 , C07K7/06
摘要： The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明涉及用于治疗胃肠道疾病和病症的肽，组合物和相关方法，包括但不限于肠易激综合征（IBS），胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩氏病疾病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良，内脏痛，胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻），与便秘相关的病症和病症，以及其它病症和病症。使用激活鸟苷酸环化酶C（GC-C）受体的肽和其它试剂。

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