专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明专利

CA2507501A1 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS 未知
公开(公告)号：CA2507501A1
公开(公告)日：2004-06-17
申请号：CA2507501
申请日：2003-11-26
申请人： INCYTE CORP
发明人： CAO GANFENG , ROBINSON DARIUS J , XUE CHU-BIAO , HAN AMY QI , FENG HAO , ZHENG CHANGSHENG , METCALF BRIAN , HUANG TAISHING
IPC分类号： C07D207/14 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D405/04 , C07D405/08 , C07D405/10 , C07D405/14 , C07D409/08 , C07D413/10 , C07D413/14 , C07D417/08 , C07D417/10 , C07D417/14 , C07D495/10
摘要： The present invention relates to 3-aminopyrrolidine derivatives of the formu la I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein ) which are useful as modulators of chemokine receptor activity. In particular , these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoi d arthritis.

42. 发明专利

NO336486B1 Nye 3-cykloalkylaminopyrrolidinderivater, sammensetninger som inneholder slike derivater, og slike derivater for behandling av diverse sykdommer 未知
公开(公告)号：NO336486B1
公开(公告)日：2015-09-07
申请号：NO20063255
申请日：2006-07-13
申请人： INCYTE CORP
发明人： XUE CHU-BIAO , METCALF BRIAN , ROBINSON DARIUS J , HAN AMY QI , ZHENG CHANGSHENG , WANG ANLAI , ZHANG YINGXIN
IPC分类号： C07D401/12 , A61K31/40 , A61K31/4025 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/506 , C07D207/14 , C07D401/14 , C07D413/14 , C07D417/02
摘要： Foreliggende oppfinnelse angår 3-cykloalkylaminopyrrolidinderivater med formel I (hvori R1, R2, R3, R4, R5 , R6, R7 , X, Y og Z er som definert heri) som er anvendelige som modulatorer av kjemokinreseptoraktivitet. Særlig er disse forbindelsene anvendelige som modulatorer av kjemokinreseptorer og mer spesifikt som modulatorer av CCR2 og/eller CCR5 reseptor. Forbindelsene og sammensetningene ifølge oppfinnelsen kan binde til kjemokinreseptorer, f eks CCR2 og/eller CCR5 kjemokinreseptorer, og er anvendelige for behandling av sykdommer assosiert med kjemokin, f eks CCR2 og/eller CCR5 aktivitet, slik som aterosklerose, restenose, lupus, organtransplantatrejeksjon og reumatoid artritt.

44. 发明专利

DK1696919T3 3-CYCLOALKYLAMINOPYRROLIDIN-DERIVATER SOM MODULATORER AF CHEMOKINRECEPTORER 未知
公开(公告)号：DK1696919T3
公开(公告)日：2013-12-09
申请号：DK04814497
申请日：2004-12-16
申请人： INCYTE CORP
发明人： XUE CHU-BIAO , METCALF BRIAN , HAN AMY QI , ROBINSON DARIUS J , ZHENG CHANGSHENG , WANG ANLAI , ZHANG YINGXIN
IPC分类号： C07D207/14 , A61K31/4025 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/02 , C07D417/12 , C07D417/14

45. 发明专利

CR20120152A DERIVADOS DE 3-AMINOPIRROLIDINA COMO MODULADORES DE RECEPTORES DE QUIMOCINA 未知
公开(公告)号：CR20120152A
公开(公告)日：2012-05-18
申请号：CR20120152
申请日：2012-03-27
申请人： INCYTE CORP
发明人： XUE CHU-BIAO , METCALF BRIAN , FENG HAO , CAO GANFENG , HUANG TAISHING , ZHENG CHANGSHENG , ROBINSON DARIUS J , HAN AMY QI
IPC分类号： C07D207/14 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D405/04 , C07D405/08 , C07D405/10 , C07D405/14 , C07D409/08 , C07D413/10 , C07D413/14 , C07D417/08 , C07D417/10 , C07D417/14 , C07D495/10
摘要： La presente invención se refiere a derivados de 3-aminopirrolidina de la fórmula I, (en donde R1, R2, R3, r4, R5, R6, R7, R8, X, Y y Z son como se definen en este documento), los cuales son empleados como moduladores de la actividad del receptor de quimocina. En particular, estos compuestos son empleados como moduladores de los receptores de quimocina y más específicamente, como moduladores del receptor CCR2 y/o CCR5.

46. 发明专利

CA2507501C 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS 未知
公开(公告)号：CA2507501C
公开(公告)日：2011-10-04
申请号：CA2507501
申请日：2003-11-26
申请人： INCYTE CORP
发明人： XUE CHU-BIAO , METCALF BRIAN , FENG HAO , CAO GANFENG , HUANG TAISHING , ZHENG CHANGSHENG , ROBINSON DARIUS J , HAN AMY QI
IPC分类号： C07D401/08 , C07D207/14 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D405/04 , C07D405/08 , C07D405/10 , C07D405/14 , C07D409/08 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/08 , C07D417/10 , C07D417/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (see formula I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

47. 发明专利

CU23667B7 DERIVADOS DE 3-CICLOALQUILAMINOPIRROLIDINA COMO MODULADORES DE RECEPTORES DE QUIMIOCINA 未知
公开(公告)号：CU23667B7
公开(公告)日：2011-05-27
申请号：CU20060116
申请日：2006-06-07
申请人： INCYTE CORP
发明人： ZHENG CHAGSHENG , ZHANG YINGXIN , XUE CHU-BIAO , WANG ANLAI , ROBINSON DARIUS J , METCALF BRIAN , HAN AMY QI
IPC分类号： A61K31/395 , C07D401/14
摘要： La presente invención se relaciona con derivados de 3-cicloalquilaminopirrolidona de la fórmula I: (donde R1, R2, R3, R4, R5, R6, R7, X, Y y Z son como se define aquí) los cuales son usados como moduladores de la actividad del receptor de quimiocina. En particular estos compuestos son útiles como moduladores de receptores de quimiocina y más específicamente como moduladores de receptor CCR2 y/o CCR5: Los compuestos y las composiciones de la invención pueden unirse a los receptores de quimiocina, ej. los receptores de quimiocina CCR2 y/o CCR5, y son usados para tratar enfermedades asociadas con quimiocina, ej. CCR2 y/o CCR5 actividad, tales como ateroesclerosis, restinosis, lupus, rechazo de transplante de órganos y artritis reumatoidea. ESPACIO PARA FÓRMULA

48. 发明专利

CA2550596C 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS 未知
公开(公告)号：CA2550596C
公开(公告)日：2011-03-15
申请号：CA2550596
申请日：2004-12-16
申请人： INCYTE CORP
发明人： XUE CHU-BIAO , METCALF BRIAN , HAN AMY QI , ROBINSON DARIUS J , ZHENG CHANGSHENG , WANG ANLAI , ZHANG YINGXIN
IPC分类号： C07D401/14 , A61K31/40 , A61K31/4025 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/495 , A61K31/506 , C07D207/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/02 , C07D417/12
摘要： The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula 1: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

49. 发明专利

HU0500848A2 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS 未知
公开(公告)号：HU0500848A2
公开(公告)日：2007-08-28
申请号：HU0500848
申请日：2003-11-26
申请人： INCYTE CORP
发明人： XUE CHU-BIAO , METCALF BRIAN , FENG HAO , CAO GANFENG , HUANG TAISHING , ZHENG CHANGSHENG , ROBINSON DARIUS J , HAN AMY QI
IPC分类号： C07D207/14 , A61K31/40 , A61P11/06 , A61P25/00 , A61P29/00 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D405/04 , C07D405/08 , C07D405/10 , C07D405/14 , C07D409/08 , C07D413/10 , C07D413/14 , C07D417/08 , C07D417/10 , C07D417/14 , C07D495/10
摘要： The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

50. 发明专利

CO5690550A2 DERIVADOS DE 3-AMINOPIRROLIDINA COMO MODULADORES DE RECEPTO- RES DE QUIMOCINA 未知
公开(公告)号：CO5690550A2
公开(公告)日：2006-10-31
申请号：CO05053243
申请日：2005-06-01
申请人： INCYTE CORP
发明人： XUE CHU-BIAO , METCALF BRIAN , ZHENG CHANGSHENG , ROBINSON DARIUS J , HAN AMY QI
IPC分类号： C07D207/14 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D405/04 , C07D405/08 , C07D405/10 , C07D405/14 , C07D409/08 , C07D413/10 , C07D413/14 , C07D417/08 , C07D417/10 , C07D417/14 , C07D495/10
摘要： 1.- Compuesto de la fórmula I:sus enantiómeros, diastereómeros, mezclas enantioméricas enriquecidas, mezclas racémicas de los mismos, profármacos, formas cristalinas, formas no cristalinas, formas amorfas de los mismos, solvatos de los mismos, metabolitos de los mismos y sales farmacéuticamente aceptables, caracterizado porque:X se selecciona del grupo que consiste de arilo, arilo mono o poli sustituido, heteroarilo heterociclo, heteroarilo mono o poli sustituido, carbociclo, carbociclo mono o poli sustituido (CR9R10)n en donde n = 0-5;Y es un enlace, o se selecciona del grupo que consiste de oxígeno, azufre, nitrógeno, enlace amida, enlace tioamida, sulfonamida, cetona, -CHOH-, CHO-alquilo-, oxima o una urea;Z se selecciona del grupo que consiste de carbociclo, un arilo, heterociclo o un heteroarilo con sustituyentes R11 de 0-3, en donde R11 se selecciona independientemente del grupo que consiste de: halógeno, alquilo, alquenilo, alquinilo, alcoxi, alcoxialquilo, alquiltioalquilo, tioalquilo, mono-, di- o trihaloalquilo, mono-, di- o trihaloalcoxi, nitro, amino, amino mono- o di-sustituido, aminoalquilo mono- o di-sustituido, carboxilo, carboxilo esterificado, carboxamido, carboxamido mono- o di-sustituido, carbamato, carbamato mono- o di-sustituido, sulfonamida, sulfonamida mono- o di-sustituida, alquilcarbonilo, alquilsulfonilo cíclico, arilsulfonilo, heteroarilsulfonilo, alquilcarbonilo, alquilcarbonilo cíclico, arilcarbonilo, heteroarilcarbonilo, tiocarboxamido, ciano y arilo R11a o heteroarilo R11a en donde R11a es H, halógeno, OH, amino, amino mono- o di-sustituido, mono-, di- o tri-haloalquilo, alcoxi, mono-, di- o trihaloalcoxi, carboxamida, sulfonamida, carbamato, urea o ciano; R1 se selecciona independientemente del grupo que consiste de: un carbociclo, heterociclo, arilo, heteroarilo, arilalquilo, heteroarilalquilo, arilalquenilo, heteroarilalquenilo, arilalquinilo, hetero-arilalquinilo, arilaminocarbonilo, heteroarilaminocarbonilo, arilcarboxamido, heteroarilcarboxamido, arilureido, heteroarilureido, ariloxi, heteroariloxi, arilalcoxi, heteroarilalcoxi, arilamino o heteroarilamino y en donde dicho grupos carbociclo, heterociclo, arilo, arilalquilo, ...

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式