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41. 发明公开

EP2971140A1 DNA SEQUENCES TO ASSESS CONTAMINATION IN DNA SEQUENCING 审中-公开
标题翻译： DNA序列，用于污染的DNA测序评估
公开(公告)号：EP2971140A1
公开(公告)日：2016-01-20
申请号：EP14767628.2
申请日：2014-03-12
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W. , MOTLEY, Stanley
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34 , A61K35/12 , A61K35/66
CPC分类号： C12Q1/689 , C12Q1/6848 , C12Q1/6869 , C12Q2535/122 , C12Q2545/101 , C12Q2547/101
摘要： The present invention relates to systems and methods for detecting contamination in nucleic acid analyses. In particular, the present invention relates to systems and methods for detecting contamination in DNA sequencing assays.

42. 发明公开

EP2844775A1 DNA SEQUENCING 有权
标题翻译： DNA测序
公开(公告)号：EP2844775A1
公开(公告)日：2015-03-11
申请号：EP13785146.5
申请日：2013-05-02
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2525/101 , C12Q2525/185 , C12Q2527/137 , C12Q2563/107 , C12Q2537/165
摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, and systems for sequencing a nucleic acid using one or more labels and signal amplitude to distinguish bases.

43. 发明公开

EP2844772A1 DNA SEQUENCING 有权
标题翻译： DNA测序
公开(公告)号：EP2844772A1
公开(公告)日：2015-03-11
申请号：EP13784766.1
申请日：2013-05-02
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2525/101 , C12Q2525/185 , C12Q2563/107
摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, systems, and kits for sequencing a nucleic acid using a degenerate two-base code. Particular embodiments provide: 1) that the two-base degenerate code relates a first element to a base comprising adenine (A) or guanine (G) and a second element to a base comprising cytosine (C) or thymine (T); 2) that the two-base degenerate code relates a first element to a base comprising A or C and a second element to a base comprising G or T; and 3) that the two-base degenerate code relates a first element to a base comprising G or C and a second element to a base comprising A or T.
摘要翻译：本文提供了关于核酸测序的技术，并且具体但不排他地涉及使用简并双碱基密码对核酸进行测序的方法，组合物，系统和试剂盒。具体的实施方案提供：1）双碱基简并密码将第一元件与包含腺嘌呤（A）或鸟嘌呤（G）的碱基相连，第二元件与包含胞嘧啶（C）或胸腺嘧啶（T）的碱基相关; 2）所述双碱基退化密码将第一元件与包含A或C的碱基相关，将第二元件与包含G或T的碱基相关联; 和3）双碱基退化密码将第一个元件与包含G或C的碱基相关，第二个元件与包含A或T的碱基相关。

44. 发明公开

EP2753629A1 SAMPLE PREPARATION METHODS 有权
标题翻译：检测方法的莱姆病的
公开(公告)号：EP2753629A1
公开(公告)日：2014-07-16
申请号：EP12829439.4
申请日：2012-09-06
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W. , CROWDER, Christopher
IPC分类号： C07H1/08 , C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/1013 , C12Q1/6844 , Y02A50/57 , C12Q2565/627
摘要： The present invention provides whole blood nucleic acid extraction methods, compositions, and kits, as well as nested isothermal amplification methods, compositions, and kits. In certain embodiments, these methods are applied to detecting Lyme disease, including in patients without classic erythema migrans skin lesions.

45. 发明公开

EP3789502A1 DNA SEQUENCING 审中-公开
公开(公告)号：EP3789502A1
公开(公告)日：2021-03-10
申请号：EP20204156.2
申请日：2013-05-02
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W.
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34 , C12Q1/6869 , G16B30/00
摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, and systems for sequencing a nucleic acid using two or more labels and signal ratios to distinguish bases.

46. 发明授权

EP2844775B1 DNA SEQUENCING 有权
公开(公告)号：EP2844775B1
公开(公告)日：2018-07-18
申请号：EP13785146.5
申请日：2013-05-02
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2525/101 , C12Q2525/185 , C12Q2527/137 , C12Q2563/107 , C12Q2537/165
摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, and systems for sequencing a nucleic acid using one or more labels and signal amplitude to distinguish bases.

47. 发明授权

EP2844774B1 DNA SEQUENCING 有权转让
公开(公告)号：EP2844774B1
公开(公告)日：2018-07-18
申请号：EP13785056.6
申请日：2013-05-02
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W.
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2537/165 , C12Q2563/107
摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, and systems for sequencing a nucleic acid using two or more labels and signal ratios to distinguish bases.

48. 发明公开

EP3211100A1 AMPLIFICATION PRIMERS AND METHODS 审中-公开
标题翻译：扩增引物和方法
公开(公告)号：EP3211100A1
公开(公告)日：2017-08-30
申请号：EP17165748.9
申请日：2012-12-21
申请人： Ibis Biosciences, Inc.
发明人： GRAY, Phillip N. , ESHOO, Mark W.
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/1096 , C12P19/34 , C12Q1/6853 , C12Q1/6855 , C12Q2525/131 , C12Q2525/151 , C12Q2525/161 , C12Q2525/179
摘要： The present invention provides methods, compositions, and kits for performing amplification (e.g., whole genome amplification) employing primers that have a 5' restriction site, a 3' random sequence (e.g., a random hexamer), and an identifiable barcode sequence. In certain embodiments, the amplification generates individual amplified sequences that are ligated together to form concatamers containing at least two amplified sequences (e.g., not contiguous on the original target sequence) that are separated by the barcode sequences. In particular embodiments, a plurality of the concatamers are sequenced and aligned with an alignment algorithm that uses the barcode sequences to identify artificial junctions between amplified sequences.
摘要翻译：本发明提供了使用具有5'限制位点，3'随机序列（例如，随机六聚体）和可识别的条形码序列的引物进行扩增（例如全基因组扩增）的方法，组合物和试剂盒。在某些实施方案中，扩增产生连接在一起形成连接体的单个扩增序列，所述连接体含有至少两个被条形码序列分开的扩增序列（例如，不与原始靶序列邻接）。在特定的实施方案中，多个连接子被测序并与使用条形码序列鉴定扩增序列之间的人工连接的比对算法对齐。

49. 发明授权

EP2753629B1 METHODS FOR DETECTING LYME DISEASE 有权
标题翻译：检测方法的莱姆病的
公开(公告)号：EP2753629B1
公开(公告)日：2016-10-19
申请号：EP12829439.4
申请日：2012-09-06
申请人： Ibis Biosciences, Inc.
发明人： ESHOO, Mark W. , CROWDER, Christopher
IPC分类号： C07H1/08 , C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6806 , C12N15/1013 , C12Q1/6844 , Y02A50/57 , C12Q2565/627
摘要： The present invention provides whole blood nucleic acid extraction methods, compositions, and kits, as well as nested isothermal amplification methods, compositions, and kits. In certain embodiments, these methods are applied to detecting Lyme disease, including in patients without classic erythema migrans skin lesions.

50. 发明公开

EP2970366A1 NUCLEOTIDE ANALOGS FOR SEQUENCING 失效
标题翻译：用于测序的核苷酸类似物
公开(公告)号：EP2970366A1
公开(公告)日：2016-01-20
申请号：EP14769128.1
申请日：2014-03-12
申请人： Ibis Biosciences, Inc.
发明人： HAYDEN, Mark A. , HUFF, Jeffrey , ESHOO, Mark W. , PICURI, John
IPC分类号： C07H21/04 , C07H19/00 , C12Q1/68
CPC分类号： C12Q1/6869 , C07H19/10 , C07H21/04 , C12Q2523/319 , C12Q2525/117 , C12Q2563/107 , C12Q2563/113 , C12Q2563/116 , C12Q2563/137
摘要： Provided herein is technology relating to sequencing nucleic acids, but not exclusively, to compositions, methods, systems, and kits related to nucleotides comprising an electrochemically detectable moiety and one or more photolabile synthesis-inhibiting moieties.
摘要翻译：本文提供了与核酸测序相关的技术，但不排他地涉及与包含电化学可检测部分和一个或多个光不稳定合成抑制部分的核苷酸相关的组合物，方法，系统和试剂盒。

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