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41. 发明授权

US06258942B1 TADG7: a novel gene expressed in ovarian tumor and uses thereof 失效
标题翻译： TADG7：一种在卵巢肿瘤中表达的新基因及其用途
公开(公告)号：US06258942B1
公开(公告)日：2001-07-10
申请号：US08926808
申请日：1997-09-09
申请人： Timothy J. O'Brien , Sung Moon
发明人： Timothy J. O'Brien , Sung Moon
IPC分类号： C07H2104
CPC分类号： C07K14/47
摘要： The invention is a protein having the amino acid sequence of Seq. I.D. No. 1 or an allelic variation retaining the biological activity of the protein having the amino acid sequence of Seq. I.D. No. 1, a DNA segment coding for a protein according to claim 1, preferably DNA segment according to claim 2 having the sequence of Seq. I.D. No. 2, or a substitution analog or allelic variation of Seq. I.D. No. 2, a chimeric cell comprising the DNA segment coding for a protein of Seq. I.D. No. 1, preferably a chimeric cell comprising the DNA segment of Seq. I.D. No. 2, a vector comprising a DNA segment coding for a protein having Seq. I.D. No. 1 operably linked to a promoter. The invention provides a preferred vector comprising the following components operably linked from 5′ to 3′: (a) a promoter; (b) a signal sequence; (c) 5′ portion of a highly expressed gene endogenous to a selected host cell; (d) a linker sequence; all preceding the nucleotide sequence coding for TADG7 protein. The invention provides a protein production method which comprises expressing a DNA segment coding for a protein with the amino acid sequence of Seq. I.D. No. 1 in a chimeric host cell, preferably one which comprises expressing the DNA segment having the sequence of Seq. I.D. No. 2 or a substitution analog. The protein may play a role in signal transduction. The invention provides a means for early detection of ovarian cancer.
摘要翻译：本发明是具有Seq的氨基酸序列的蛋白质。 ID。 1或保留具有Seq的氨基酸序列的蛋白质的生物活性的等位基因变异。 ID。权利要求1所述的编码蛋白质的DNA片段，优选具有Seq序列的权利要求2所述的DNA片段。 ID。第2号，或Seq的取代类似物或等位基因变异。 ID。 No.2，包含编码Seq蛋白的DNA区段的嵌合细胞。 ID。 No.1，优选包含Seq的DNA片段的嵌合细胞。 ID。 No.2，包含编码具有Seq的蛋白质的DNA区段的载体。 ID。与启动子可操作地连接。本发明提供了一种优选的载体，其包含与5'至3'可操作地连接的以下组分：（a）启动子; （b）信号序列; （c）所选宿主细胞内源的高表达基因的5'部分; （d）接头序列; 在编码TADG7蛋白的核苷酸序列之前。本发明提供一种蛋白质生产方法，其包括用Seq的氨基酸序列表达编码蛋白质的DNA区段。 ID。 1，在嵌合宿主细胞中，优选包括表达具有Seq序列的DNA区段。 ID。 2或替代类似物。蛋白质可能在信号转导中起作用。本发明提供了早期检测卵巢癌的手段。

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