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41. 发明申请

US20110263582A1 CYCLIC UREA INHIBITORS OF 11 B-HYDROXYSTEROID DEHYDROGENASE 1 失效
标题翻译： 11 B羟基脱氢酶脱氢酶的循环尿素抑制剂1
公开(公告)号：US20110263582A1
公开(公告)日：2011-10-27
申请号：US12747391
申请日：2008-12-10
申请人： David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
发明人： David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
IPC分类号： A61K31/535 , C07D239/10 , C07D413/12 , A61K31/513 , A61P3/10 , A61P3/04 , A61P3/00 , A61P5/48 , A61P9/12 , A61P3/06 , A61P9/00 , A61P9/10 , A61P19/10 , A61P27/06 , A61P5/00 , A61P25/24 , A61P25/22 , A61P25/28 , A61P15/00 , A61P15/08 , A61P1/16 , A61P31/06 , A61P31/08 , A61P17/06 , C07D265/10
CPC分类号： C07D239/10 , C07D239/42 , C07D265/10 , C07D401/12 , C07D413/12
摘要： This invention relates to novel compounds of the Formula (I), (Ia) and (Ib), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, j which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell Or the inhibition of the conversion of cortisone to Cortisol in a cell.
摘要翻译：本发明涉及式（I），（Ia）和（Ib）的新化合物，其药学上可接受的盐及其药物组合物，j可用于治疗与调节或抑制11β的疾病。 -HSD1在哺乳动物。本发明进一步涉及新化合物的药物组合物及其用于还原或控制细胞中皮质醇生产的方法或抑制细胞中可的松转化为皮质醇。

42. 发明申请

US20110191319A1 SEARCH QUERY PROCESSING 有权
标题翻译：搜索查询处理
公开(公告)号：US20110191319A1
公开(公告)日：2011-08-04
申请号：US13014409
申请日：2011-01-26
申请人： Xuping Nie , He Xiao , Wei He , Jinghui Zhong
发明人： Xuping Nie , He Xiao , Wei He , Jinghui Zhong
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30672
摘要： Providing search results includes: receiving a search query; determining a plurality of preprocessing functions to be performed on the search query, based at least in part on a search label corresponding to the search query; performing the plurality of preprocessing functions on the search query to obtain a plurality preprocessed search queries; generating, based at least in part on precision levels associated with the plurality of preprocessed search queries, a search plan comprising a selected preprocessed search query; and inputting the search plan to the search engine to obtain the search results.
摘要翻译：提供搜索结果包括：接收搜索查询; 至少部分地基于与搜索查询对应的搜索标签来确定要对搜索查询执行的多个预处理功能; 在搜索查询上执行多个预处理功能以获得多个预处理搜索查询; 至少部分地基于与所述多个预处理搜索查询相关联的精度级别生成包括所选择的预处理搜索查询的搜索计划; 并将搜索计划输入到搜索引擎以获得搜索结果。

43. 发明授权

US07960697B2 Electron beam apparatus 有权
标题翻译：电子束装置
公开(公告)号：US07960697B2
公开(公告)日：2011-06-14
申请号：US12257304
申请日：2008-10-23
申请人： Zhongwei Chen , Weiming Ren , Joe Wang , Xuedong Liu , Juying Dou , Fumin He , Feng Cao , Yan Ren , Xiaoli Guo , Wei He , Qingpo Xi
发明人： Zhongwei Chen , Weiming Ren , Joe Wang , Xuedong Liu , Juying Dou , Fumin He , Feng Cao , Yan Ren , Xiaoli Guo , Wei He , Qingpo Xi
IPC分类号： H01J49/44
CPC分类号： H01J37/073 , H01J37/244 , H01J37/28 , H01J2237/06341 , H01J2237/24592
摘要： The present invention relates to a charged particle beam apparatus which employs a scanning electron microscope for sample inspection and defect review.The present invent provides solution of improving imaging resolution by utilizing a field emission cathode tip with a large tip radius, applying a large accelerating voltage across ground potential between the cathode and anode, positioning the beam limit aperture before condenser lens, utilizing condenser lens excitation current to optimize image resolution, applying a high tube bias to shorten electron travel time, adopting and modifying SORIL objective lens to ameliorate aberration at large field of view and under electric drifting and reduce the urgency of water cooling objective lens while operating material analysis.The present invent provides solution of improving throughput by utilizing fast scanning ability of SORIL and providing a large voltage difference between sample and detectors.
摘要翻译：本发明涉及采用扫描电子显微镜进行样品检查和缺陷检查的带电粒子束装置。本发明提供了通过利用具有大的尖端半径的场致发射阴极尖端来提高成像分辨率的解决方案，在阴极和阳极之间的地电位上施加大的加速电压，将光束极限孔定位在聚光透镜之前，利用聚光透镜激发电流优化图像分辨率，应用高管偏压缩短电子行进时间，采用和修正SORIL物镜，以改善大视野和电漂移下的像差，并减少水冷物镜在操作材料分析时的紧迫性。本发明提供了通过利用SORIL的快速扫描能力并在样品和检测器之间提供大的电压差来提高产量的解决方案。

44. 发明申请

US20110112176A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF KIF10 GENES 审中-公开
标题翻译：用于抑制KIF10基因表达的组合物和方法
公开(公告)号：US20110112176A1
公开(公告)日：2011-05-12
申请号：US12940083
申请日：2010-11-05
申请人： John Frederick Boylan , Birgit Bramlage , Wei He , Markus Hossbach , Ingo Roehl
发明人： John Frederick Boylan , Birgit Bramlage , Wei He , Markus Hossbach , Ingo Roehl
IPC分类号： A61K31/713 , C07H21/02 , C12N15/63 , C12N5/10 , A61P35/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/3515
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a KIF10 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a KIF10 gene using said pharmaceutical composition; and methods for inhibiting the expression of KIF10 in a cell.
摘要翻译：本发明涉及用于抑制KIF10基因表达的双链核糖核酸（dsRNA）。本发明还涉及包含dsRNA或核酸分子的药物组合物或其编码与其药学上可接受的载体的载体; 用于使用所述药物组合物治疗由KIF10基因表达引起的疾病的方法; 以及抑制细胞中KIF10表达的方法。

45. 外观设计

USD634976S1 Curved flatware set 有权
标题翻译：弯曲的餐具组
公开(公告)号：USD634976S1
公开(公告)日：2011-03-29
申请号：US29377128
申请日：2010-10-18
申请人： Wei He , Xin Quan Ho
设计人： Wei He , Xin Quan Ho

46. 发明授权

US07902358B2 Prokineticin 1 receptor antagonists 有权
标题翻译：原肌动蛋白1受体拮抗剂
公开(公告)号：US07902358B2
公开(公告)日：2011-03-08
申请号：US11647091
申请日：2006-12-28
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , A61K31/506 , A61P1/00 , A61P1/06
CPC分类号： C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译：本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。

47. 发明申请

US20110015157A1 CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 失效
标题翻译： 11BETA - 羟基脱氢酶脱氢酶的循环抑制剂1
公开(公告)号：US20110015157A1
公开(公告)日：2011-01-20
申请号：US12670205
申请日：2008-07-25
申请人： David A. Claremon , Wei He , Gerard McGeehan , Suresh B. Singh , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Wei Zhao , Linghang Zhuang , Salvacion Cacatian , Katerina Leftheris
发明人： David A. Claremon , Wei He , Gerard McGeehan , Suresh B. Singh , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Wei Zhao , Linghang Zhuang , Salvacion Cacatian , Katerina Leftheris
IPC分类号： A61K31/675 , C07D265/10 , A61K31/535 , A61P17/02 , A61P37/00 , A61P19/02 , A61P9/12 , A61P27/06 , A61P3/10 , C07D413/04 , C07D413/10 , A61K31/5377 , C07D417/10 , A61K31/541 , A61K31/5355
CPC分类号： C07D413/04 , C07D265/10 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14
摘要： This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih); (Ii); (Ij), (Ik), (II) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
摘要翻译：本发明涉及式（I），（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih）（Ii）; （Ij），（Ik），（II）其药学上可接受的盐及其药物组合物，其可用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病的治疗。本发明进一步涉及新化合物的药物组合物及其用于减少或控制细胞中皮质醇产生或抑制细胞中可的松转化为皮质醇的方法。

48. 发明授权

US07834814B2 Antenna arrangement 有权
标题翻译：天线布置
公开(公告)号：US07834814B2
公开(公告)日：2010-11-16
申请号：US12215262
申请日：2008-06-25
申请人： Wanbo Xie , Wei He , Shu Liu , Rong Bang An
发明人： Wanbo Xie , Wei He , Shu Liu , Rong Bang An
IPC分类号： H01Q9/00
CPC分类号： H01Q1/243 , H01Q5/335 , H03H7/40 , H04B1/0053 , H04B1/0458 , H04B1/18
摘要： An antenna arrangement for radio communication in a first radio communication band and for communication in a second radio communication band including a multiple-resonance antenna element having a feed for connection to radio frequency circuitry; and a load connected to the feed and comprising a plurality of reactive components including a first reactive component that controls the impedance of the load for the first radio communication band and a second reactive component, separate from the first reactive component, that controls the impedance of the load for the second radio communication band wherein the plurality of reactive components of the load are configured to provide an impedance that changes between being inductive at a first frequency in the first radio communication band to being capacitive at a second frequency in the first radio communication band and that changes between being inductive at a third frequency in the second radio communication band to being capacitive at a fourth frequency in the second radio communication band.
摘要翻译：一种用于第一无线电通信频带中的无线电通信的天线装置，以及用于在第二无线电通信频带中通信的天线装置，所述第二无线电通信频带包括具有用于连接到射频电路的馈送的多谐振天线元件; 以及连接到所述馈电的负载，并且包括多个无功分量，所述无功分量包括控制所述第一无线电通信频带的负载的阻抗的第一无功分量和与所述第一无功分量分离的第二无功分量，所述第二无功分量控制所述第一无功分量的阻抗第二无线电通信频带的负载，其中负载的多个无功分量被配置为提供在第一无线电通信中在第一无线电通信频带中的第一频率处的电感到第二频率处的电容之间的阻抗并且在第二无线电通信频带中在第三频率处感应到第二无线电通信频带中的第四频率处的电容变化。

49. 发明授权

US07741356B2 Compounds as opioid receptor modulators 有权
标题翻译：化合物作为阿片受体调节剂
公开(公告)号：US07741356B2
公开(公告)日：2010-06-22
申请号：US11079647
申请日：2005-03-14
申请人： Henry J. Breslin , Chaozhong Cai , Wei He , Robert W. Kavash
发明人： Henry J. Breslin , Chaozhong Cai , Wei He , Robert W. Kavash
IPC分类号： A61K31/4174 , A61K31/4178 , C07D233/64
CPC分类号： A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要： The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
摘要翻译：本发明涉及式（I）的新型阿片受体调节剂。本发明还涉及制备这些化合物的方法，含有这些化合物的药物组合物，以及它们在治疗可通过调节阿片类受体而改善或治疗的病症中的用途。

50. 发明授权

US07659402B2 Piperidines as opioid receptor modulators 有权
标题翻译：哌啶类作为阿片受体调节剂
公开(公告)号：US07659402B2
公开(公告)日：2010-02-09
申请号：US11242763
申请日：2005-10-04
申请人： Henry J. Breslin , Wei He , Robert W. Kavash
发明人： Henry J. Breslin , Wei He , Robert W. Kavash
IPC分类号： C07D217/00
CPC分类号： C07D401/04 , C07D211/60 , C07D217/26 , C07D413/04
摘要： This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.
摘要翻译：本发明涉及作为阿片样物质受体调节剂，拮抗剂和激动剂的新化合物，其可用于治疗阿片类调节障碍如疼痛和胃肠道疾病。

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