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41. 发明申请

US20070119598A1 SYSTEM AND METHOD FOR DOWNHOLE OPERATION USING PRESSURE ACTIVATED AND SLEEVE VALVE ASSEMBLY 有权
标题翻译：使用压力和活塞阀组件的井下操作系统和方法
公开(公告)号：US20070119598A1
公开(公告)日：2007-05-31
申请号：US11614927
申请日：2006-12-21
申请人： Dewayne Turner , Marvin Traweek , Richard Ross
发明人： Dewayne Turner , Marvin Traweek , Richard Ross
IPC分类号： E21B34/14 , E21B43/08
CPC分类号： E21B43/08 , E21B34/102 , E21B43/088 , E21B43/12 , E21B43/14
摘要： An isolation system for producing oil and gas from one or more formation zones and methods of use are provided comprising one or more pressure activated and tool shiftable valve assemblies. The tool shiftable valve may be actuated before or after actuation of the pressure activated valve.
摘要翻译：提供一种用于从一个或多个地层区域生产油和气体的隔离系统和使用方法，其包括一个或多个压力启动和可移动工具的阀组件。可以在致动压力启动阀之前或之后致动工具可移动阀。

42. 发明申请

US20070119594A1 HYDRAULIC SLEEVE VALVE WITH POSITION INDICATION, ALIGNMENT, AND BYPASS 有权
标题翻译：具有位置指示，对准和旁路的液压套筒阀
公开(公告)号：US20070119594A1
公开(公告)日：2007-05-31
申请号：US11558812
申请日：2006-11-10
申请人： Dewayne Turner , Richard Ross , Kenneth Rozek , Todd Chretien
发明人： Dewayne Turner , Richard Ross , Kenneth Rozek , Todd Chretien
IPC分类号： E21B34/00
CPC分类号： E21B34/14 , E21B34/10
摘要： A hydraulic sleeve valve is disclosed that comprises a bypass relief system that provides an indication that the valve has reached a predetermined position, such as, for example, the fully opened or fully closed condition. The bypass relief may also provide a valve control fluid circulation function to filter or otherwise manipulate the control fluid. Also disclosed are flow port alignment systems that maintain the valve flow ports in predetermined relationships.
摘要翻译：公开了一种液压套筒阀，其包括旁路释放系统，其提供阀已经到达预定位置，例如完全打开或完全关闭状态的指示。旁路释放装置还可以提供阀控制流体循环功能以过滤或以其他方式操纵控制流体。还公开了以预定关系维持阀流动端口的流动端口对准系统。

43. 发明申请

US20070054364A1 Polypeptide variants 审中-公开
标题翻译：多肽变体
公开(公告)号：US20070054364A1
公开(公告)日：2007-03-08
申请号：US11595991
申请日：2006-11-13
申请人： Richard Ross , Peter Artymiuk , Jon Sayers
发明人： Richard Ross , Peter Artymiuk , Jon Sayers
IPC分类号： A61K38/17 , A61K48/00 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/61 , A61K38/00 , C07K14/5759 , C07K2319/00
摘要： The invention relates to the provision of oligomeric polypeptides (dimers, trimers etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptide linker molecules. The linker molecules optionally comprise protease sensitive sites to modulate the release of biologically active cytokines when administered to a human or animal subject.
摘要翻译：本发明涉及提供包含通过柔性多肽接头分子连接的细胞因子的配体结合结构域的寡聚多肽（二聚体，三聚体等）。连接分子任选地包含蛋白酶敏感位点，以在施用于人或动物受试者时调节生物活性细胞因子的释放。

44. 发明申请

US20050143541A1 Water- and oil-repellent fluoroacrylates 有权
标题翻译：拒水拒油氟代丙烯酸酯
公开(公告)号：US20050143541A1
公开(公告)日：2005-06-30
申请号：US11027604
申请日：2004-12-28
申请人： Gregg Caldwell , John Clark , David Kinning , Alan Kirk , Thomas Klun , Ramesh Kumar , Roger Mader , George Moore , Zai-Ming Qiu , Richard Ross
发明人： Gregg Caldwell , John Clark , David Kinning , Alan Kirk , Thomas Klun , Ramesh Kumar , Roger Mader , George Moore , Zai-Ming Qiu , Richard Ross
IPC分类号： C07C69/653 , C07C233/18 , C07C271/08 , C07C271/20 , C07C271/28 , C07C311/04 , C07C311/09 , C08F20/24 , C08F220/38 , C08F114/18
CPC分类号： C08F220/38 , C07C271/20 , C07C271/28 , C07C311/09 , Y10T442/2287
摘要： Fluoroacrylates comprise the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: CnF2n+1—X—OH wherein: R=hydrogen or an alkyl group of 1 to 4 carbon atoms, m=2 to 8, Rf═CnF2n+1, y=0 to 6, and q=1 to 8; (b) at least one unbranched symmetric diisocyanate; and (c) at least one hydroxy-terminated alkyl (meth)acrylate or 2-fluoro acrylate monomer having 2 to about 30 carbon atoms in its alkylene portion.
摘要翻译：氟代丙烯酸酯包括以下反应产物：（a）至少一种由下式表示的含氟醇：<？in-line-formula description =“In-line Formulas”end =“lead”？> C

45. 发明授权

US5846011A Bottle with built-in telescoping applicator head and spout for applying fluid to a body 失效
标题翻译：具有内置伸缩式涂抹头和喷嘴的瓶子，用于将液体施加到身体
公开(公告)号：US5846011A
公开(公告)日：1998-12-08
申请号：US796602
申请日：1997-02-07
申请人： Melvin Bernstein , Richard Ross
发明人： Melvin Bernstein , Richard Ross
IPC分类号： A45D34/04 , A61F13/40 , B65D47/06 , B65D47/26 , B65D47/30 , B65D47/42 , A45D34/00
CPC分类号： A45D34/04 , A45D34/042 , A61M35/006 , B65D47/061 , B65D47/265 , B65D47/305 , B65D47/42 , A45D2200/1018 , A45D2200/1081
摘要： A bottle (1) for storing a fluid and for applying the fluid to a human body comprises a container (2) having an opening; and an elongated rod member (11) having a longitudinal axis, the rod member (11) being located in the opening, and the rod member being slidable along its longitudinal axis relative to the container (2) and being sealed against the container (2) so that an inner end of the rod member (11) is located within the container (2) and an outer end of the rod member (11) is located outside the container (2). The rod member (11) has at least one duct (15) extending at least partially in the direction of the longitudinal axis of the rod member (11), the at least one duct (15) forming a fluid connection between an outlet at the outer end of the rod member (11) and an orifice that is situated within the container. An applicator (9) is mounted at the outer end of the rod member (11) and has an applicator member or pad (10) that is permeable for the fluid and which is in fluid communication with the outlet of the duct (15). An auxiliary spout (14) is provided. The user may selectively use the applicator member with the applicator pad or the auxiliary spout.
摘要翻译：用于存储流体并将流体施加到人体的瓶子（1）包括具有开口的容器（2）以及具有纵向轴线的细长杆构件（11），所述杆构件（11）位于所述开口中，并且所述杆构件可相对于所述容器（2）沿其纵向轴线滑动并且被密封抵靠所述容器（2）），使得杆构件（11）的内端位于容器（2）内，并且杆构件（11）的外端位于容器（2）的外部。杆构件（11）具有至少部分地沿着杆构件（11）的纵向轴线的方向延伸的至少一个管道（15），所述至少一个管道（15）在出口处形成流体连接杆构件（11）的外端和位于容器内的孔口。施用器（9）安装在杆构件（11）的外端，并且具有用于流体可渗透并且与管道（15）的出口流体连通的施加器构件或垫（10）。提供辅助喷口（14）。用户可以选择性地使用施用器构件与施加器垫或辅助喷口。

46. 发明授权

US08273552B2 Modified growth hormone polypeptides 有权
标题翻译：改良生长激素多肽
公开(公告)号：US08273552B2
公开(公告)日：2012-09-25
申请号：US12678282
申请日：2008-09-10
申请人： Peter Artymiuk , Richard Ross , Jon Sayers
发明人： Peter Artymiuk , Richard Ross , Jon Sayers
IPC分类号： A61K38/27 , C07K14/61 , C12N15/16 , C12N15/63 , C12N5/10
CPC分类号： C07K14/61
摘要： We describe modified growth hormone fusion proteins and dimers comprising said fusion proteins; nucleic acid molecules encoding said proteins and methods of treatment that use said proteins in the treatment of conditions that result from growth hormone excess.
摘要翻译：我们描述修饰的生长激素融合蛋白和包含所述融合蛋白的二聚体; 编码所述蛋白质的核酸分子和使用所述蛋白质治疗由生长激素过量引起的病症的治疗方法。

47. 发明授权

US08173782B2 Fusion protein comprising growth hormone and growth hormone receptor 失效
标题翻译：包含生长激素和生长激素受体的融合蛋白
公开(公告)号：US08173782B2
公开(公告)日：2012-05-08
申请号：US12175582
申请日：2008-07-18
申请人： Richard Ross , Peter Artymiuk , Jon Sayers
发明人： Richard Ross , Peter Artymiuk , Jon Sayers
IPC分类号： C07K14/61 , C07K19/00 , C07K1/10 , C07H21/04 , C12N15/63 , C12N1/19 , C12N5/10 , C12N1/21 , A61K38/27 , C12P21/02
CPC分类号： C07K14/72 , A61K38/00 , C07K14/52 , C07K14/61 , C07K14/715 , C07K2319/00 , Y10S530/815
摘要： Agents which bind to cell surface receptors; methods to manufacture such agents; therapeutic compositions comprising such agents; and screening methods to identify novel agents.
摘要翻译：与细胞表面受体结合的药剂; 制造这种药剂的方法; 包含这些试剂的治疗组合物; 和筛选方法来鉴定新型药剂。

48. 发明申请

US20110245174A1 GLP-1 FUSION POLYPEPTIDES 审中-公开
标题翻译： GLP-1融合多肽
公开(公告)号：US20110245174A1
公开(公告)日：2011-10-06
申请号：US13060050
申请日：2009-08-18
申请人： Peter Artymiuk , Richard Ross , Jon Sayers
发明人： Peter Artymiuk , Richard Ross , Jon Sayers
IPC分类号： A61K38/26 , C07K19/00 , C07H21/04 , A61P3/10 , A61P9/00 , A61P3/00 , A61P3/06
CPC分类号： C07K14/605 , A61K38/00 , C07K14/72 , C12N9/50
摘要： We describe nucleic acid molecules that encode fusion polypeptides comprising GLP-1, or a receptor binding part thereof, linked directly or indirectly to a polypeptide that naturally binds GLP-1.
摘要翻译：我们描述了编码包含与天然结合GLP-1的多肽直接或间接连接的GLP-1或其受体结合部分的融合多肽的核酸分子。

49. 发明授权

US07901524B1 Actuation concepts for variable stiffness materials 有权
标题翻译：可变刚度材料的致动概念
公开(公告)号：US07901524B1
公开(公告)日：2011-03-08
申请号：US11347505
申请日：2006-02-03
申请人： Geoffrey McKnight , Bill Barvosa-Carter , Chris Henry , Andrew Keefe , Richard Ross , Guillermo Herrera
发明人： Geoffrey McKnight , Bill Barvosa-Carter , Chris Henry , Andrew Keefe , Richard Ross , Guillermo Herrera
IPC分类号： C22F1/00 , B64C5/10 , B29C61/00 , B21D39/08
CPC分类号： B64C3/48 , B29C53/02 , B29C61/00 , F03G7/065 , Y10S72/70
摘要： Apparatus and associated methods for actuating variable stiffness material (VSM) structures and achieving deformation of the structures. The apparatus and the associated methods use internal embedded actuation elements and/or externally attached elements to the VSM structures to achieve the desired deformation. In particular, the actuation can be changed due to the variable stiffness nature of the materials. That is, the invention provides the ability to control the deformation of structures using local stiffness control over subregions of the component in addition to or in substitution for actuation. Furthermore, the invention exploits the variable stiffness properties of the VSM structures to enable new functionalities impossible to realize with conventional constant stiffness materials.
摘要翻译：用于致动可变刚度材料（VSM）结构并实现结构变形的装置和相关方法。该装置和相关联的方法使用内部嵌入的致动元件和/或外部附接到VSM结构的元件来实现期望的变形。特别地，可以由于材料的可变刚度性质而改变启动。也就是说，本发明提供了除了或者代替致动之外，使用局部刚度控制来控制结构的变形的能力。此外，本发明利用VSM结构的可变刚度特性来实现用常规恒定刚度材料不可能实现的新功能。

50. 发明申请

US20100035804A1 POLYPEPTIDE ANTAGONIST 审中-公开
标题翻译：多肽拮抗剂
公开(公告)号：US20100035804A1
公开(公告)日：2010-02-11
申请号：US12296180
申请日：2007-04-05
申请人： Sarbendra Pradhananga , John Sayers , Richard Ross , Peter Artymiuk
发明人： Sarbendra Pradhananga , John Sayers , Richard Ross , Peter Artymiuk
IPC分类号： A61K38/17 , C12P21/06 , C12N1/21 , C12N15/63 , A61K31/7088 , C07K14/435 , C07H21/04
CPC分类号： C07K14/61
摘要： We describe a circularly permuted growth hormone polypeptide antagonist; compositions comprising said antagonist and methods to treat conditions that would benefit from administration of said antagonist.
摘要翻译：我们描述一种循环置换的生长激素多肽拮抗剂; 包含所述拮抗剂的组合物和治疗将受益于所述拮抗剂施用的病症的方法。

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