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    • 48. 发明授权
    • Method for producing triazolinethione derivatives
    • 三唑啉酮衍生物的制备方法
    • US06271389B1
    • 2001-08-07
    • US09509889
    • 2000-04-03
    • Reinhard LantzschManfred JautelatAchim HuppertsDavid Erdman
    • Reinhard LantzschManfred JautelatAchim HuppertsDavid Erdman
    • C07D24912
    • C07D249/12
    • According to a novel process, it is possible to prepare triazolinethione derivatives of the formula in which R1 and R2 are each as defined in the description by a) reacting hydrazine derivatives of the formula  with carbonyl compounds of the formula  in which R3 and R4 are each as defined in the description  with potassium thiocyanate, sodium thiocyanate or ammonium thiocyanate,  if appropriate in the presence of a diluent and if appropriate in the presence of an acid, and b) reacting the resulting triazolidinethione derivatives of the formula  with formic acid, if appropriate in the presence of a catalyst and if appropriate in the presence of a diluent. The triazolidinethione derivatives of the formula (V) are novel.
    • 根据一个新方法,可以制备式(Ⅲ)的三唑啉酮衍生物,其中R1和R2各自如说明书中所定义.a)使下式的肼衍生物与下式的羰基化合物反应:其中R 3和R 4各自如 如果在稀释剂存在下和适当的情况下在酸存在下,硫氰酸钠,硫氰酸钠或硫氰酸铵的描述,以及b)如果合适的话,在酸的存在下,将所得到的式I的三唑烷硫酮衍生物与甲酸反应, 催化剂,如果合适,则在稀释剂存在下。式(Ⅴ)的三唑烷酮二酮衍生物是新颖的。