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41. 发明授权

US06369028B1 Octacyclodepsipeptides having an endoparasiticidal action 失效
标题翻译：具有内寄生性杀伤作用的Octacyclodepsipeptide
公开(公告)号：US06369028B1
公开(公告)日：2002-04-09
申请号：US08246029
申请日：1994-05-19
申请人： Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
发明人： Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
IPC分类号： A61K3800
CPC分类号： C07D273/00 , C07C235/12 , C07C235/34
摘要： The present invention relates to compounds of the general formula (I) in which R1, R2, R11 and R12 represent the same or different radicals selected from the group of C1-8-alkyl, C1-8-halogenoalkyl, C3-6-cycloalkyl, aralkyl or aryl, R3, R5, R7, R9, represent the same or different radicals selected from the group of hydrogen or straight-chain C1-5-alkyl or branched C4-7-alkyl which may optionally be substituted by hydroxyl, C1-4-alkoxy, carboxyl carboxamide, imidazolyl, indolyl, guanidino, —SH or C1-4-alkylthio, and furthermore represents aryl, aralkyl or heteroarylmethyl which may be substituted by halogen, hydroxyl, C1-4-alkyl, C1-4-alkoxy, nitro or a —NR13R14 group in which R13 and R14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom forms a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally C1-4-alkyl substituted, R4, R6, R8, R10 represent the same or different radicals selected from the group of hydrogen, straight-chain C1-5-alkyl and represents isopropyl, sec.-butyl, t-butyl, C2-6-alkenyl, C3-7-cycloalkyl, which may optionally be substituted by hydroxyl, C1-4-alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, SH or C1-4-alkylthio and represent aryl, aralkyl or heteroarylmethyl which may be substituted by halogen, hydroxyl, C1-4-alkyl, C1-4-alkoxy, and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1，R 2，R 11和R 12表示相同或不同的选自C 1-8 - 烷基，C 1-8 - 卤代烷基，C 3-6 - 环烷基，芳烷基或芳基，R 3，R 5，R 7，R 9表示相同或不同的选自氢或直链C 1-5烷基或支链C 4-7 - 烷基的基团，其可任选被羟基，C 1-4 烷氧基，羧基羧酰胺，咪唑基，吲哚基，胍基，-SH或C 1-4 - 烷硫基，此外表示可被卤素，羟基，C 1-4 - 烷基，C 1-4 - 烷氧基，硝基取代的芳基，芳烷基或杂芳基甲基或-NR 13 R 14基团，其中R 13和R 14彼此独立地表示氢或烷基或与相邻的氮原子一起形成可选地被O，S或N中断的5,6或7-元环，并且其任选地为C1 R 4，R 6，R 8，R 10表示选自该基团的相同或不同的基团的氢，直链C1-5 - 烷基，代表异丙基，仲丁基，叔丁基，C 2-6 - 烯基，C 3-7 - 环烷基，其可任选被羟基，C 1-4 - 烷氧基，羧基，羧酰胺，咪唑基，吲哚基，胍基，SH或C 1-4 - 烷硫基，代表可被卤素，羟基，C 1-4 - 烷基，C 1-4 - 烷氧基及其立体异构体取代的芳基，芳烷基或杂芳基甲基，其制备方法及其作为内寄生物杀虫剂的用途。

42. 发明授权

US07132295B2 Isotopically coded affinity markers 3 失效
标题翻译：同位素标记的亲和标记3
公开(公告)号：US07132295B2
公开(公告)日：2006-11-07
申请号：US10494999
申请日：2002-10-30
申请人： Hans-Georg Lerchen , Hans-Ulrich Siegmund , Dorian Immler , Andreas Schumacher , Daniel Auriel
发明人： Hans-Georg Lerchen , Hans-Ulrich Siegmund , Dorian Immler , Andreas Schumacher , Daniel Auriel
IPC分类号： G01N24/00 , G01N33/532 , C07C335/16 , C07D291/06 , A61K51/04
CPC分类号： C07D207/452 , C07D495/04 , C07K1/13 , C07K5/06026 , C07K5/06052 , C07K5/06113 , C07K5/06147 , C07K5/06165 , G01N33/58 , G01N2458/15 , Y10T436/24
摘要： This application relates to isotopically labeled affinity markers of the formula (II) for mass spectrometric analysis of proteins. In formula (II), the groups A, PRG, S, Z, L', Z', R, R', k, l, m, and n are as defined in the claims. The application also provides a process for preparing these materials, a method for analyzing proteins using such materials, and a kit containing one or more of these materials.
摘要翻译：本申请涉及用于蛋白质质谱分析的式（II）的同位素标记的亲和标记物。在式（II）中，基团A，PRG，S，Z，L'，Z'，R，R'，k，l，m和n如权利要求中所定义。该应用还提供了制备这些材料的方法，使用这种材料分析蛋白质的方法，以及包含这些材料中的一种或多种的试剂盒。

43. 发明申请

US20050049406A1 Isotopically coded affinity markers 3 失效
标题翻译：同位素标记的亲和标记3
公开(公告)号：US20050049406A1
公开(公告)日：2005-03-03
申请号：US10494999
申请日：2002-10-30
申请人： Hans-Georg Lerchen , Hans-Ulrich Siegmund , Dorian Immler , Andreas Schumacher , Daniel Auriel
发明人： Hans-Georg Lerchen , Hans-Ulrich Siegmund , Dorian Immler , Andreas Schumacher , Daniel Auriel
IPC分类号： C07D207/44 , C07D207/452 , C07D495/04 , C07K1/13 , C07K5/06 , C07K5/072 , C07K5/078 , G01N33/58 , C08G63/48 , C07K14/00
CPC分类号： C07D207/452 , C07D495/04 , C07K1/13 , C07K5/06026 , C07K5/06052 , C07K5/06113 , C07K5/06147 , C07K5/06165 , G01N33/58 , G01N2458/15 , Y10T436/24
摘要： The invention concerns isotopically coded affinity markers (ICAT) for mass spectrometric analysis of proteins, and the preparation and use if said markers.
摘要翻译：本发明涉及用于蛋白质质谱分析的同位素标记的亲和标记（ICAT），以及如果所述标记物的制备和使用。

44. 发明授权

US06468966B1 Octacyclodepsipeptides having an endoparasiticidal action 失效
标题翻译：具有内寄生性杀伤作用的Octacyclodepsipeptide
公开(公告)号：US06468966B1
公开(公告)日：2002-10-22
申请号：US08246022
申请日：1994-05-19
申请人： Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
发明人： Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
IPC分类号： A61K3800
CPC分类号： C07D273/00 , A61K38/00 , C07K11/02
摘要： The present invention relates to compounds of the general formula (I) in which R1 and R12 represent the same or different radicals selected from the group of C2-9-alkyl, C1-8-halogen-alkyl, C3-6-cycloalkyl, aralkyl or aryl, R3 to R10 represent the same or different radicals selected from the group of hydrogen, C1-5-alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a —NR13R14 group in which R13 or R14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C1-4-alkyl, R2 and R11 represent the same of different radicals selected from the group of C1-4-alkyl, and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1和R 12表示相同或不同的选自C 2-9 - 烷基，C 1-8 - 卤素 - 烷基，C 3-6 - 环烷基，芳烷基或芳基，R 3至R 10表示选自氢，可任选被羟基，烷氧基，羧基，羧酰胺，咪唑基，吲哚基，胍基，硫代或硫代烷基取代的C 1-5 - 烷基的相同或不同的基团，并且表示芳基，烷基芳基或杂芳基甲基，其任选被卤素，羟基，烷基，烷氧基，硝基或-NR 13 R 14基团取代，其中R 13或R 14彼此独立地表示氢或烷基或与相邻的氮原子一起形成5,6或任选地被O，S或N中断并且任选被C 1-4 - 烷基取代的R 7和R 11代表与选自C 1-4 - 烷基及其立体异构体的不同基团相同的7-元环，进行准备a 并将其用作内寄生物杀虫剂。

45. 发明授权

US5717063A Octacyclodepsipeptides having an endoparasiticidal action 失效
标题翻译：具有内寄生性杀伤作用的Octacyclodepsipeptide
公开(公告)号：US5717063A
公开(公告)日：1998-02-10
申请号：US456148
申请日：1995-05-31
申请人： Jurgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
发明人： Jurgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
IPC分类号： A01N43/72 , A61K31/395 , A61K38/00 , A61P33/00 , A61P33/10 , C07D273/00 , C07K1/113 , C07K11/02 , A61K38/15 , C07K11/00
CPC分类号： C07D273/00 , C07K11/02 , A61K38/00
摘要： The present invention relates to compounds of the general formula (I) ##STR1## in which R.sup.1 and R.sup.12 represent the same or different radicals selected from the group of C.sub.2-9 -alkyl, C.sub.1-8 -halogeno-alkyl, C.sub.3-6 -cycloalkyl, aralkyl or aryl, R.sup.3 to R.sup.10 represent the same or different radicals selected from the group of hydrogen, C.sub.1-5 -alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a --NR.sup.13 R.sup.14 group in which R.sup.13 or R.sup.14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C.sub.1-4 -alkyl, R.sup.2 and R.sup.11 represent the same of different radicals selected from the group of C.sub.1-4 -alkyl, and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1和R 12表示相同或不同的选自C 2-9 - 烷基，C 1-8 - 卤代烷基，C 3 - -6-环烷基，芳烷基或芳基，R 3至R 10表示相同或不同的选自氢，可任选被羟基，烷氧基，羧基，羧酰胺，咪唑基，吲哚基，胍基，硫代或硫代烷基，并且表示任选被卤素，羟基，烷基，烷氧基，硝基或-NR 13 R 14基团取代的芳基，烷基芳基或杂芳基甲基，其中R 13或R 14彼此独立地表示氢或烷基或与相邻的氮原子形成5,6或7-元环，其任选地被O，S或N中断，并且其任选被C 1-4 - 烷基取代，R 2和R 11表示与选自C 1-4的不同基团相同的基团 - 烷基和它们的立体异构体继承人的准备和用作内寄生虫病药物。

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