专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US4438109A Tylosin derivatives 失效
标题翻译：泰乐菌素衍生物
公开(公告)号：US4438109A
公开(公告)日：1984-03-20
申请号：US285747
申请日：1981-07-22
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Akihiro Tanaka
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Akihiro Tanaka
IPC分类号： C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： Tylosin derivatives shown by the general formula ##STR1## wherein R represents a hydrogen atom or a hydroxyl group; R.sub.1 represents a halogen atom, a hydroxyl group, a tetrahydrofuranyloxy group, a tetrahydropyranyloxy group, a tetrahydrothiofuranyloxy group, a tetrahydrothiopyranyloxy group, an alkanoyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, a lower alkylthiomethyloxy group, a heterocyclic thio group which may have a substituent, a mono- or di- lower alkylamino lower alkylthio group or a group of ##STR2## (wherein R.sub.4 represents a hydroxyl group or an alkanoyloxy group); R.sub.2 represents a hydrogen atom, a hydroxyl group, or an alkanoyloxy group; R.sub.3 represents a hydroxyl group or an alkanoyloxy group; and represents a single bond or a double bond, but represents a double bond when R.sub.2 is a hydrogen atom.These compounds are useful as antibiotics.
摘要翻译：由通式表示的泰乐菌素衍生物，其中R表示氢原子或羟基; R 1表示卤素原子，羟基，四氢呋喃氧基，四氢吡喃氧基，四氢噻喃氧基，四氢噻喃氧基，烷酰氧基，芳基羰基氧基，芳烷基羰基氧基，低级烷基硫代甲氧基，可具有的杂环硫基取代基，单 - 或二 - 低级烷基氨基低级烷硫基或一组（其中R 4表示羟基或烷酰氧基）。 R2表示氢原子，羟基或烷酰氧基; R3表示羟基或烷酰氧基; 并且表示单键或双键，但当R 2为氢原子时，表示双键。这些化合物可用作抗生素。

42. 发明授权

US4424342A Anthracycline antibiotic compounds 失效
标题翻译：蒽环类抗生素化合物
公开(公告)号：US4424342A
公开(公告)日：1984-01-03
申请号：US361175
申请日：1982-03-24
申请人： Toshikazu Oki , Akihiro Yoshimoto , Yasue Matsuzawa , Tomoyuki Ishikura , Hamao Umezawa , Tomio Takeuchi
发明人： Toshikazu Oki , Akihiro Yoshimoto , Yasue Matsuzawa , Tomoyuki Ishikura , Hamao Umezawa , Tomio Takeuchi
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465 , C07H15/24 , A61K31/71
CPC分类号： C07H15/252 , C12P19/56 , C12R1/465
摘要： Disclosed are an antitumor compound having the chemical structure ##STR1## or its acid addition salts; and its preparation method which consists of treating a compound represented by the chemical structure ##STR2## wherein R is a COCH.sub.3 or CH(OH)CH.sub.3 group, by a streptomycetes strain or its mutants.
摘要翻译：公开了具有化学结构（I）或其酸加成盐的抗肿瘤化合物; 及其制备方法，该方法由化学结构（IMAGE）（II）表示的化合物

43. 发明授权

US4420473A Antibiotic, MF266 substance and production thereof 失效
标题翻译：抗生素，MF266物质及其生产
公开(公告)号：US4420473A
公开(公告)日：1983-12-13
申请号：US296923
申请日：1981-08-27
申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Kiyoto Ishii
发明人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Kiyoto Ishii
IPC分类号： C07H17/04 , A61K35/74 , A61P31/04 , A61P35/00 , C07G11/00 , C12P1/06 , C12P19/00 , C12P19/60 , C12R1/465 , A61K35/00
CPC分类号： C12R1/465 , C12P1/06
摘要： New antibiotic designated MF266 substance is now obtained from fermentaton of a new microorganism Streptomyces MF266-g4 (desposited under FERM-P 5401 or ATCC 31910). This new substance is useful as antibacterial agent and/or an antitumor agent for the inhibition of experimental animal tumors.
摘要翻译：现在从新发微生物链霉菌MF266-g4的发酵得到新的指定为MF266物质的抗生素（在FERM-P 5401或ATCC 31910下进行）。这种新物质可用作抑制实验动物肿瘤的抗菌剂和/或抗肿瘤剂。

44. 发明授权

US4395402A Analgesic agent 失效
标题翻译：止痛药
公开(公告)号：US4395402A
公开(公告)日：1983-07-26
申请号：US303938
申请日：1981-09-21
申请人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Mitsugu Hachisu , Kenji Kawamura , Shunzo Fukatsu , Yasuharu Sekizawa
发明人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Mitsugu Hachisu , Kenji Kawamura , Shunzo Fukatsu , Yasuharu Sekizawa
IPC分类号： A61K31/135 , A61K31/165 , A61K31/195 , A61K31/215 , A61K38/00 , A61P25/04 , C07C229/36 , C07C237/20 , C07C279/14 , C07C323/60 , C07K5/06 , A61K37/00
CPC分类号： A61K31/195 , C07K5/06043 , A61K38/00
摘要： A new analgesic agent is now provided, which comprises as the active ingredient 3-amino-2-hydroxy-4-phenylbutanoic acid and some related compounds thereof. These compounds have now found to be effective as inhibitor against enkephalinase and as an agent for enhancing analgesic activity of morphine.
摘要翻译：现在提供一种新的止痛剂，其包含作为活性成分的3-氨基-2-羟基-4-苯基丁酸及其一些相关化合物。现在发现这些化合物作为抑制脑啡肽酶和作为增强吗啡镇痛作用的药剂是有效的。

45. 发明授权

US4394446A Process for the preparation of the antibiotic oxanosine 失效
标题翻译：制备抗生素牛油苷的方法
公开(公告)号：US4394446A
公开(公告)日：1983-07-19
申请号：US323650
申请日：1981-11-20
申请人： Hamao Umezawa , Nobuyoshi Shimada , Hiroshi Naganawa , Tomohisa Takita , Masa Hamada , Tomio Takeuchi
发明人： Hamao Umezawa , Nobuyoshi Shimada , Hiroshi Naganawa , Tomohisa Takita , Masa Hamada , Tomio Takeuchi
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61P31/04 , A61P31/12 , A61P35/00 , C07H19/24 , C12P19/28 , C12P19/40 , C12R1/465 , C12N1/20
CPC分类号： C12R1/465 , C07H19/24 , C12P19/28 , Y10S435/886 , Y10S514/908
摘要： The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral and carcinostatic activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.
摘要翻译：具有结构的新型抗生素，恶嗪酸抑制革兰氏阴性菌的生长，具有抗病毒和抗癌活性。它是通过培养链霉菌属的产生恶土氨的微生物，优选链霉菌属（Streptomyces capreolus）MG265-CF3，ATCC号31963产生的。

46. 发明授权

US4358602A Ebelactones and production thereof 失效
标题翻译：内酯及其生产
公开(公告)号：US4358602A
公开(公告)日：1982-11-09
申请号：US240457
申请日：1981-03-04
申请人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka
发明人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka
IPC分类号： A61K31/335 , A61K31/337 , A61K31/365 , A61P37/04 , C07D305/12 , C12N9/99 , C12P17/02 , C12R1/465
CPC分类号： C12R1/465 , C07D305/12 , C12P17/02
摘要： New physiologically active substances, ebelactone A and ebelactone B which are generally termed ebelactone are produced from a new microorganism, Streptomyces MG7-G1 strain identified FERM-P 5363 or ATCC No. 31860 and ATCC No. 31880. Ebelactone is useful as a host defense stimulator having an activity to enhance cell-mediated immunity, and also as an anti-inflammatory agent.
摘要翻译：通常称为内酯的新的生理活性物质Ebelactone A和ebelactone B由新的微生物，鉴定为FERM-P 5363的链霉菌MG7-G1菌株或ATCC No.31860和ATCC No.31880产生.Ebelactone可用作宿主防御刺激剂具有增强细胞介导的免疫力的活性，并且还作为抗炎剂。

47. 发明授权

US4355026A 4-Demethoxy,11-deoxy anthracycline derivatives 失效
标题翻译： 4-脱甲氧基，11-脱氧蒽环类衍生物
公开(公告)号：US4355026A
公开(公告)日：1982-10-19
申请号：US300874
申请日：1981-09-11
申请人： Hamao Umezawa , Tomio Takeuchi , Hiroshi Naganawa , Kuniaki Tatsuta
发明人： Hamao Umezawa , Tomio Takeuchi , Hiroshi Naganawa , Kuniaki Tatsuta
IPC分类号： C07C50/24 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07C43/215 , C07C45/00 , C07C45/26 , C07C67/00 , C07D307/32 , C07D309/30 , C07H13/08 , C07H15/252 , A61K31/71 , A61K31/65 , C07H15/24
CPC分类号： C07D307/32 , C07C43/215 , C07C45/26 , C07D309/30 , C07H13/08 , C07H15/252 , Y02P20/55 , Y10S514/908
摘要： New 4-demethoxy-11-deoxydaunomycin and 4-demethoxy-11-deoxyadriamycin anthracycline derivatives have been prepared and found to be useful antimicrobial and antitumor agents.
摘要翻译：已经制备了新的4-脱甲氧基-11-脱氧果阿霉素和4-脱甲氧基-11-脱氧阿霉素蒽环类衍生物，发现它们是有用的抗微生物剂和抗肿瘤剂。

48. 发明授权

US4337336A Derivative of kanamycin A and a process for the preparation thereof 失效
标题翻译：卡那霉素A的衍生物及其制备方法
公开(公告)号：US4337336A
公开(公告)日：1982-06-29
申请号：US235576
申请日：1981-02-18
申请人： Hamao Umezawa , Sumio Umezawa , Shunzo Fukatsu , Toshio Yoneta , Tadashi Wakazawa
发明人： Hamao Umezawa , Sumio Umezawa , Shunzo Fukatsu , Toshio Yoneta , Tadashi Wakazawa
IPC分类号： C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234
摘要： There are provided new compounds, 3',4'-anhydro-4'-epi derivatives of kanamycin A of the formula: ##STR1## wherein R represents an alkyl, aralkyl or aryl group and Y represents an alkylidene, aralkylidene, cycloalkylidene or tetrahydropyranylidene group which are useful as an intermediate for the synthesis of 3',4'-dideoxykanamycin A and 4'-deoxykanamycin A from kanamycin A. The compounds of formula (I) can be prepared by treating the corresponding 4'-O-sulfonyl derivative with an alkali metal alcoholate in a lower alkanol under an alkaline condition.
摘要翻译：提供了下式的卡那霉素A的新化合物3'，4'-脱水-4'-表面衍生物：其中R表示烷基，芳烷基或芳基，Y表示亚烷基，亚烷基，可用作合成来自卡那霉素A的3'，4'-二脱氧卡那霉素A和4'-脱氧卡那霉素A的中间体的环亚烷基或四氢吡喃亚基。式（I）化合物可以通过将相应的4'- 磺酰基衍生物与碱金属醇化物在低级烷醇中在碱性条件下反应。

49. 发明授权

US4298727A 3',4'-Dideoxykanamycin A and 1-N-(S)-.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives thereof 失效
标题翻译： 3'，4'-双脱氧卡那霉素A和1-N-（S）-α-羟基-ω-氨基烷酰基）衍生物
公开(公告)号：US4298727A
公开(公告)日：1981-11-03
申请号：US114779
申请日：1980-01-23
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomo Jikahara , Toshiaki Miyake
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomo Jikahara , Toshiaki Miyake
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： 3',4'-Dideoxy derivative and 1-N-((S)-.alpha.-hydroxy-.omega.-aminoalkanoyl)-3',4'-dideoxy derivative of kanamycin A are now synthetized from kanamycin A and show a wider and/or higher antibacterial activity than the parent kanamycin A so that they are useful in therapeutic treatment of infections by gram-negative and gram-positive bacteria, including drug-resistant strains thereof. The production of these new derivatives may be made by preparing a protected kanamycin A derivative having its 3'- and 4'-hydroxyl groups unprotected and having its all or substantially all other functional groups protected from the initial material, kanamycin A, sulfonylating the 3'- and 4'-hydroxyl groups, removing the 3'- and 4'-sulfonyloxy groups from the resulting 3',4'-di-sulfonic acid ester product to give a 3'-eno-kanamycin A derivative, hydrogenating the 3'-eno-kanamycin A derivative to saturate the 3',4'-unsaturated bond and to yield a protected 3',4'-dideoxykanamycin A product, followed by removal of the remainiing protective groups, and optionally further followed by 1-N-acylation of the 1-amino group of the resulting 3',4'-dideoxykanamycin A with an (S)-.alpha.-hydroxy-.omega.-aminoalkanoic acid or its reactive equivalent.
摘要翻译：卡那霉素A的3'，4'-二脱氧衍生物和1-N - （（S）-α-羟基-ω-氨基烷酰基）-3'，4'-二脱氧衍生物现在从卡那霉素A合成并显示出更宽和/ 或更高的抗菌活性，使得它们可用于革兰氏阴性和革兰氏阳性细菌（包括其耐药菌株）的感染的治疗性治疗。这些新衍生物的生产可以通过制备其未被保护的3'和4'-羟基的保护的卡那霉素A衍生物和其全部或基本上所有其它保护起始材料的卡那霉素A的其他官能团来制备，磺酰化3 '和4'-羟基，从所得的3'，4'-二磺酸酯产物中除去3'-和4'-磺酰氧基，得到3'-烯 - 卡那霉素A衍生物，将3 ' - 卡那霉素A衍生物使3'，4'-不饱和键饱和并产生受保护的3'，4'-二脱氧卡那霉素A产物，然后除去剩余的保护基，并且任选地进一步加入1-N 所得的3'，4'-二脱氧卡那霉素A的1-氨基酸与（S）-α-羟基-ω-氨基链烷酸或其反应性等同物的酰基化。

50. 发明授权

US4259319A Antibiotic auromomycin, and process for production thereof 失效
标题翻译：抗生素自由基霉素及其生产方法
公开(公告)号：US4259319A
公开(公告)日：1981-03-31
申请号：US936835
申请日：1978-08-25
申请人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka , Kiyoshi Watanabe , Toshiaki Yamashita , Noriyuki Naoi , Takayoshi Hidaka
发明人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka , Kiyoshi Watanabe , Toshiaki Yamashita , Noriyuki Naoi , Takayoshi Hidaka
IPC分类号： C12P21/00 , A61K38/00 , A61P35/00 , C07G11/00 , C12P1/06
CPC分类号： C12P1/06
摘要： A new antibiotic designated as auromomycin is prepared from the culture broth of Streptomyces macromomyceticus, a macromomycin-producing strain, as yellow crystals. Auromomycin is recovered in pure form from the culture broth by using hydrophobic chromatography with Octyl Sephalose CL-4B or Phenyl Sepharose CL-4B.
摘要翻译：从黄曲霉大麻霉菌（Streptomyces macromomyceticus）的培养液中制备一种新的抗生素，称为黄霉素，为黄色晶体。通过使用具有辛基海藻糖CL-4B或苯基琼脂糖CL-4B的疏水层析从培养液中回收Auromomycin。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式