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41. 发明授权

US06284266B1 Methods and apparatus for improved administration of fentanyl and sufentanil 失效
标题翻译：改善氟芬太尼和舒芬太尼治疗的方法和装置
公开(公告)号：US06284266B1
公开(公告)日：2001-09-04
申请号：US09162587
申请日：1998-09-29
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61K970
CPC分类号： A61F7/02 , A61B2017/00765 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Methods and apparatus for improving administration of analgesics through the use of heat. The present invention relates to the use of heat in conjunction with specially designed transdermal analgesic delivery systems and conventional commercial transdermal analgesic delivery systems to alter, mainly increase, the analgesic release rate from the transdermal analgesic delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热量来改善镇痛药的施用方法和装置。本发明涉及加热与特别设计的透皮止痛递送系统和常规商业经皮止痛递送系统的用途，以改变，主要增加经皮止痛剂递送系统或贮库部位的镇痛释放速率以适应某些临床需要。

42. 发明授权

US06264981B1 Oral transmucosal drug dosage using solid solution 有权
标题翻译：口服透粘膜用药剂量使用固体溶液
公开(公告)号：US06264981B1
公开(公告)日：2001-07-24
申请号：US09428071
申请日：1999-10-27
申请人： Hao Zhang , Jed Croft
发明人： Hao Zhang , Jed Croft
IPC分类号： A61K948
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/1694 , A61K9/2009 , A61K9/2013
摘要： The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical. The invention provides a drug formulation comprising a solid pharmaceutical agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral cavity, delivering the pharmaceutical agent by absorption through a patient's oral mucosal tissue. The formulation and method provide for improved oral mucosal delivery of the pharmaceutical agent.
摘要翻译：本发明涉及口服经粘膜递送药物的制剂和方法。本发明提供一种药物制剂，其包含固体溶剂中的固体药剂与溶解剂。该制剂被施用到患者的口腔中，通过患者的口腔粘膜组织吸收来递送药剂。制剂和方法提供改进的药物的口腔粘膜递送。

43. 发明授权

US06193821B1 Fine grain tantalum sputtering target and fabrication process 有权
标题翻译：细粒钽溅射靶和制造工艺
公开(公告)号：US06193821B1
公开(公告)日：2001-02-27
申请号：US09353700
申请日：1999-07-14
申请人： Hao Zhang
发明人： Hao Zhang
IPC分类号： C22F118
CPC分类号： C23C14/3414 , C22F1/18 , Y10S148/158
摘要： A process for treating substantially pure tantalum includes plastically deformed a billet, such as by side-forging or side-rolling, to reduce a first dimension of the billet transverse to the centerline, preferably by about 70% to about 85%. The billet is then upset, such as by upset forging or upset rolling, to reduce a second dimension of the billet transverse to the first dimension (for example, a second dimension lying parallel to the centerline), preferably by about 90% to about 99%. In accordance with an especially preferred process, the upsetting of the billet is followed by rolling along a plane normal to the second dimension. It has been found that billets prepared in accordance with the invention have grain sizes no greater than about 25 &mgr;m and predominantly textures relative to their rolling planes, so that targets machined from such billets in such a way that their sputtering surfaces correspond with these rolling planes will have the same predominant textures.
摘要翻译：用于处理基本上纯的钽的方法包括例如通过侧锻或侧面轧制来塑性变形坯料，以减少横向于中心线的坯料的第一尺寸，优选地减小约70％至约85％。然后，坯料例如通过镦锻或镦粗轧制而变形，以减小横向于第一尺寸（例如，平行于中心线的第二尺寸）的坯料的第二尺寸，优选地为约90％至约99 ％。根据特别优选的方法，坯料的镦锻随后沿着垂直于第二尺寸的平面滚动。已经发现，根据本发明制备的坯料相对于其轧制平面具有不大于约25μm的颗粒尺寸和主要<222>的纹理，使得从这些坯料加工的靶材使得它们的溅射表面对应于这些滚动平面将具有相同的主要<222>纹理。

44. 发明授权

US11418716B2 Spherical image based registration and self-localization for onsite and offsite viewing 有权
公开(公告)号：US11418716B2
公开(公告)日：2022-08-16
申请号：US16889578
申请日：2020-06-01
申请人： Nathaniel Boyless , Jiayi Liu , Sriram Siva , Hao Zhang
发明人： Nathaniel Boyless , Jiayi Liu , Sriram Siva , Hao Zhang
IPC分类号： H04N5/232 , G06F17/16 , G06T19/00
摘要： Systems and methods for image registration and self-localization for onsite and offsite viewing are provided. In one aspect, systems and methods for spherical image based registration and self-localization for onsite and offsite viewing, such as augmented reality viewing and virtual reality viewing, are provided. In one embodiment, a system includes a portable electric device fitted with a device camera, an external omnidirectional spherical camera, and a remote server. In one embodiment, a method of use employs a set of fiducial markers inserted in images collected by a spherical camera to perform image registration of spherical camera images and device camera images.

45. 发明授权

US11249697B2 Printing system and printing method 有权
公开(公告)号：US11249697B2
公开(公告)日：2022-02-15
申请号：US17201017
申请日：2021-03-15
申请人： Chenglan Li , Takeshi Shikama , Hao Zhang , Zhenwei Shi
发明人： Chenglan Li , Takeshi Shikama , Hao Zhang , Zhenwei Shi
IPC分类号： G06F15/00 , G06F3/12 , G06K1/00 , G06K15/10 , G06K15/02
摘要： A printing system and a printing method are provided. The user terminal includes a print content processing unit and a sliding print content conversion unit, and the handheld printer includes an inkjet printing unit that performs inkjet printing at a predetermined inkjet width in a sliding direction when performing sliding print. The print content processing unit determines the number of sliding print motions and sequentially generates bitmaps corresponding to the respective sliding print motions based on the respective print content mode and the inkjet width, and generates bitmap format instructions corresponding to the respective bitmaps. The sliding print content conversion unit converts pixels in the bitmaps into binary data to form sliding print content. The handheld printer sequentially prints the respective sliding print content based on the respective bitmap format instructions and the print content mode.

46. 发明申请

US20180333395A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS 审中-公开
公开(公告)号：US20180333395A1
公开(公告)日：2018-11-22
申请号：US16038739
申请日：2018-07-18
申请人： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
发明人： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC分类号： A61K31/4192 , C07D249/06 , C07D401/14 , C07D401/04 , A61K31/27 , A61K31/454
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

47. 发明授权

US09714939B1 Concentated liquid single component TMB substrate for detection assay of horseradish peroxidase 有权
公开(公告)号：US09714939B1
公开(公告)日：2017-07-25
申请号：US15409274
申请日：2017-01-18
申请人： Hao Zhang
发明人： Hao Zhang
IPC分类号： G01N33/58 , G01N33/535 , C12Q1/28 , A61K47/08 , A61K47/10 , A61K47/40
CPC分类号： G01N33/535 , A61K47/08 , A61K47/10 , A61K47/40 , C12Q1/28 , G01N33/52 , G01N33/581 , G01N2333/908
摘要： Through special formulations, stable twenty-fold concentrate of single component TMB substrate is produced to minimize the volume and reduce the transportation cost. Reconstitution of the concentrate upon delivery to the distal site can be made with deionized water to yield single component TMB substrate solution for routine immunodiagnostic applications.

48. 发明授权

US09456798B2 Methods and apparatus for individually optimizing uniform contrast enhancements in computed tomography imaging 有权
标题翻译：用于单独优化计算机断层摄影成像中均匀对比度增强的方法和装置
公开(公告)号：US09456798B2
公开(公告)日：2016-10-04
申请号：US14710052
申请日：2015-05-12
申请人： Ming Xue , Wei Lu , Seth Kligerman , Hao Zhang , Warren D'Souza , Wookjin Choi
发明人： Ming Xue , Wei Lu , Seth Kligerman , Hao Zhang , Warren D'Souza , Wookjin Choi
IPC分类号： G06K9/00 , A61B6/00 , G06T7/00 , G06T11/00 , A61B6/03
CPC分类号： A61B6/545 , A61B6/032 , A61B6/481 , A61B6/486 , A61B6/504 , G06T7/0012 , G06T11/006 , G06T2207/10081 , G06T2207/20104 , G06T2207/30101 , G06T2211/404
摘要： A method is provided for optimizing a contrast injection function for CT imaging. The method includes injecting, with an injector pump, a test bolus of a contrast agent into a subject. The method also includes computing, on a processor, an impulse enhancement function. The method also includes determining, on a processor, a target enhancement function for a region of interest. The method also includes determining, with a processor, a plurality of parameters for a functional form for a contrast injection function in a time domain. The method also includes determining for the contrast injection function a constraint. The method also includes determining, with a processor, particular values for the plurality of parameters, which satisfy the constraint and minimize a difference between a value of an enhancement function and the target enhancement function computed in the time domain at discrete time periods without use of a Fourier transform.
摘要翻译：提供了一种用于优化CT成像的造影剂注射功能的方法。该方法包括用注射器泵将造影剂的测试团注入受试者。该方法还包括在处理器上计算脉冲增强功能。该方法还包括在处理器上确定感兴趣区域的目标增强功能。该方法还包括使用处理器确定用于时域中的对比度注入功能的功能形式的多个参数。该方法还包括确定对比度注入功能的约束。该方法还包括使用处理器确定满足约束的多个参数的特定值，并且使离散时间段内在增强函数的值和在时域中计算的目标增强函数之间的差最小化，而不使用傅立叶变换。

49. 发明授权

US09442095B2 Optical coherence photoacoustic microscopy 有权
标题翻译：光学相干光声显微镜
公开(公告)号：US09442095B2
公开(公告)日：2016-09-13
申请号：US13524813
申请日：2012-06-15
申请人： Shuliang Jiao , Hao Zhang
发明人： Shuliang Jiao , Hao Zhang
IPC分类号： G01B9/02 , G01B17/00 , G01N29/06
CPC分类号： G01B9/0203 , G01B9/02091 , G01N29/0681 , G01N29/2418
摘要： A system and method for providing an optical coherence photoacoustic (OC-PAM) microscopy. An OC-PAM microscope includes a light source that outputs light, a scanner, a detector, a transducer, and an image processing module. The scanner receives the light and scans the light across a sample. The detector receives reflected light from the sample in response to the scanned light. The transducer detects photoacoustic waves induced in the sample by the scanned light. The image processing module receives output from the detector and the transducer and generates a photoacoustic microscopy (PAM) image and an optical coherence tomography (OCT) image based on the received output from the detector and the transducer. The PAM and OCT image data may be fused to form a single, OC-PAM image. Additionally, a series of PAM images and OCT images, respectively, may be combined to generate three-dimensional PAM and OCT images, respectively.
摘要翻译：一种用于提供光学相干光声（OC-PAM）显微镜的系统和方法。 OC-PAM显微镜包括输出光的光源，扫描仪，检测器，换能器和图像处理模块。扫描仪接收光并扫描样品上的光。检测器响应于扫描光接收来自样品的反射光。传感器通过扫描光检测样品中感应的光声。图像处理模块接收来自检测器和换能器的输出，并且基于从检测器和换能器接收的输出产生光声显微镜（PAM）图像和光学相干断层摄影（OCT）图像。 PAM和OCT图像数据可以被融合以形成单个OC-PAM图像。另外，可分别组合一系列PAM图像和OCT图像以分别产生三维PAM和OCT图像。

50. 发明授权

US09179585B2 Positioning device for inserting pin into printed circuit broad 有权
标题翻译：用于将引脚插入印刷电路的定位装置
公开(公告)号：US09179585B2
公开(公告)日：2015-11-03
申请号：US13283960
申请日：2011-10-28
申请人： Youru Guo , Hao Zhang
发明人： Youru Guo , Hao Zhang
IPC分类号： B23P19/00 , H05K13/00
CPC分类号： H05K13/0015 , H05K13/0069 , Y10T29/4913
摘要： A positioning device is provided for inserting a pin into a PCB. The positioning device includes an X-Y platform and a reference platform. The X-Y platform includes a positioning point and supports a PCB having a first receiving passageway for receiving a pin. The reference platform supports a reference template having a reference point that corresponds with the first receiving passageway. An x-axis guide rail and a y-axis guide rail is disposed on the X-Y platform, such that the positioning point on the X-Y platform is moveable relative to the reference template in an x-axis direction and/or a y-axis direction to align the first receiving passageway on the PCB with a fixed insertion point of a pin insertion machine.
摘要翻译：提供了一种用于将销插入PCB中的定位装置。定位装置包括X-Y平台和参考平台。 X-Y平台包括定位点并支撑具有用于接收销的第一接收通道的PCB。参考平台支持具有与第一接收通道相对应的参考点的参考模板。 x轴导轨和y轴导轨设置在XY平台上，使得XY平台上的定位点可相对于基准模板在x轴方向和/或y轴方向上移动以将PCB上的第一接收通道与插针机的固定插入点对准。

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