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41. 发明申请

WO2012030443A3 BIOFUEL PRODUCTION THROUGH CATALYTIC DEOXYGENATION 审中-公开
标题翻译：催化脱氧生物柴油生产
公开(公告)号：WO2012030443A3
公开(公告)日：2012-05-18
申请号：PCT/US2011044722
申请日：2011-07-20
申请人： CHEVRON USA INC , ZHOU ZHEN , HUSAIN SHABBIR , LI LIN
发明人： ZHOU ZHEN , HUSAIN SHABBIR , LI LIN
IPC分类号： C10G31/00 , B01J21/06 , C07C7/00 , C10G3/00 , C10L1/02
CPC分类号： C10G3/48 , B01J21/063 , B01J23/002 , B01J23/06 , C10B53/02 , C10G3/45 , C10G3/49 , C10G2300/1014 , C10G2300/1018 , C10G2300/202 , C10G2300/4018 , Y02P30/20
摘要： A process useful for treating biologically derived oils in the production of biofuels is described. A biologically derived oil feed is deoxygenated by contacting the feed with a metal titanate catalyst. The process does not require the addition of hydrogen.
摘要翻译：描述了用于在生物燃料生产中处理生物衍生油的方法。通过使进料与金属钛酸盐催化剂接触使生物衍生的油进料脱氧。该过程不需要添加氢气。

42. 发明申请

WO2008042762A2 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASE 审中-公开
标题翻译：单核细胞多态性与心血管疾病相关
公开(公告)号：WO2008042762A2
公开(公告)日：2008-04-10
申请号：PCT/US2007079862
申请日：2007-09-28
申请人： CLEVELAND CLINIC FOUNDATION , WANG QINY , TOPOL ERIC J , SHEN GONG-QING , LI LIN , RAO SHAOQI
发明人： WANG QINY , TOPOL ERIC J , SHEN GONG-QING , LI LIN , RAO SHAOQI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： A method is provided for identifying a subject who has an increased risk for developing a cardiovascular disease. The method can include detecting an alteration in a portion of a LRP8 gene. The alternation can be located in at least one of exon 9, exon 17, exon 19, or intron 6 of the LRP8 gene. The presence of the alteration can be correlated with an increased risk for developing the cardiovascular disease.
摘要翻译：提供了一种用于鉴定患有心血管疾病发展风险增加的受试者的方法。该方法可以包括检测LRP8基因的一部分的改变。交替可以位于LRP8基因的外显子9，外显子17，外显子19或内含子6中的至少一个。改变的存在可以与发展心血管疾病的风险增加相关。

43. 发明申请

WO9921845A2 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES 审中-公开
标题翻译： 4-氨基噻唑衍生物，它们的制备及其作为依赖于细胞周期蛋白依赖性激酶的抑制剂的用途
公开(公告)号：WO9921845A2
公开(公告)日：1999-05-06
申请号：PCT/US9822809
申请日：1998-10-27
申请人： AGOURON PHARMA , CHONG WESLEY K M , CHU SHAO SONG , DUVADIE ROHIT R , LI LIN , XIAO WEI , YANG YI
发明人： CHONG WESLEY K M , CHU SHAO SONG , DUVADIE ROHIT R , LI LIN , XIAO WEI , YANG YI
IPC分类号： C07D277/20 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/551 , A61P35/00 , A61P43/00 , C07D213/00 , C07D235/00 , C07D277/42 , C07D277/56 , C07D333/00 , C07D417/06 , C07D417/12 , C07D417/14 , C07D521/00 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/06 , C07D417/12 , C07D417/14
摘要： This invention is directed to aminothiazole compounds of formula (I) wherein R is a substituted or unsubstituted group selected from: C1-6-alkyl; C1-6-alkenyl; C1-6-alkynyl; C1-6-alkoxyl; C1-6-alcohol; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; carbonyl; ether; (C1-6-alkyl)-carbonyl; (C1-6-alkyl)-aryl; (C1-6-alkyl)-cycloalkyl; (C1-6-alkyl)-(C1-6-alkoxyl); aryl-(C1-6-alkoxyl); thioether; thiol; and sulfonyl; wherein when R is substituted, each substituent independently is a halogen; haloalkyl; C1-6-alkyl; C1-6-alkenyl; C1-6-alkynyl; hydroxyl; C1-6-alkoxyl; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; and R is a carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, ring structure having a substituent at the position adjacent to the point of attachment, which ring structure is optionally further substituted, where each substituent of R independently is a halogen; haloalkyl; C1-6-alkyl; C1-6-alkenyl; C1-6-alkynyl; hydroxyl; C1-6-alkoxyl; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; or a pharmaceutically acceptable salt of a compound of formula (I), or a prodrug or pharmaceutically active metabolite of a compound of formula (I) or pharmaceutically acceptable salt thereof, for inhibiting cyclin-dependent kinases (CDKs), such as CDK1, CDK2, CDK4, and CDK6. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.
摘要翻译：本发明涉及式（I）的氨基噻唑化合物，其中R 1是取代或未取代的选自以下的基团：C 1-6 - 烷基; C 1-6 - 链烯基; C 1-6 - 炔基; C 1-6 - 烷氧基取代; C 1-6 - 醇; 碳环或杂环，单环或稠合或非稠合多环，环烷基; 碳环或杂环，单环或稠合或非稠合多环，芳基; 羰; 醚; （C 1-6 - 烷基）羰基; （C 1-6 - 烷基） - 芳基; （C 1-6 - 烷基） - 环烷基; （C 1-6 - 烷基） - （C 1-6 - 烷氧基）; 芳基 - （C 1-6 - 烷氧基）; 硫醚; 巯基; 和磺酰基; 其中当R 1被取代时，每个取代基独立地为卤素; 卤代; C 1-6 - 烷基; C 1-6 - 链烯基; C 1-6 - 炔基; 羟; C 1-6 - 烷氧基取代; 氨基; 硝基; 巯基; 硫醚; 亚胺; 氰基; 酰胺基; 膦酸; 膦; 羧基; 硫代羰基; 磺酰基; 磺胺; 酮; 醛; 酯; 氧; 碳环或杂环，单环或稠合或非稠合多环，环烷基; 或碳环或杂环，单环或稠合或非稠合的多环芳基; 并且R 2是碳环或杂环的单环或稠合或非稠合的多环环结构，其在与连接点相邻的位置上具有取代基，该环结构任选进一步被取代，其中R 2的每个取代基 >独立地为卤素; 卤代; C 1-6 - 烷基; C 1-6 - 链烯基; C 1-6 - 炔基; 羟; C 1-6 - 烷氧基取代; 氨基; 硝基; 巯基; 硫醚; 亚胺; 氰基; 酰胺基; 膦酸; 膦; 羧基; 硫代羰基; 磺酰基; 磺胺; 酮; 醛; 酯; 氧; 碳环或杂环，单环或稠合或非稠合多环，环烷基; 或碳环或杂环，单环或稠合或非稠合的多环芳基; 或式（I）化合物的药学上可接受的盐，或式（I）化合物或其药学上可接受的盐的前药或药学活性代谢物用于抑制细胞周期蛋白依赖性激酶（CDK）如CDK1，CDK2 ，CDK4和CDK6。本发明还涉及含有这些化合物的药物组合物的治疗或预防用途以及通过施用有效量的这些化合物治疗恶性肿瘤和其他病症的方法。

44. 发明申请

US20120081039A1 METHOD AND APPARATUS FOR A LED DRIVER WITH HIGH POWER FACTOR 有权
标题翻译：用于具有高功率因数的LED驱动器的方法和装置
公开(公告)号：US20120081039A1
公开(公告)日：2012-04-05
申请号：US13073095
申请日：2011-03-28
申请人： TA-YUNG YANG , LI LIN , CHIH-HSIEN HSIEH , CHUH-CHING LI , CHI-YIN LO , KUO-HSIEM HUANG
发明人： TA-YUNG YANG , LI LIN , CHIH-HSIEN HSIEH , CHUH-CHING LI , CHI-YIN LO , KUO-HSIEM HUANG
IPC分类号： H05B37/02
CPC分类号： H05B33/0815
摘要： A control circuit of a LED driver according to the present invention comprises an output circuit, an input circuit and an input-voltage detection circuit. The output circuit generates a switching signal to produce an output current for driving at least one LED in response to a feedback signal. The switching signal is coupled to switch a transformer. The input circuit samples an input signal for generating the feedback signal. The input signal is correlated to the output current of the LED driver. The input-voltage detection circuit generates an input-voltage signal in response to an input voltage of the LED driver. The input circuit will not sample the input signal when the input-voltage signal is lower than a threshold. The control circuit can eliminate the need of the input capacitor for improving the reliability of the LED driver.
摘要翻译：根据本发明的LED驱动器的控制电路包括输出电路，输入电路和输入电压检测电路。输出电路产生开关信号以产生用于响应于反馈信号驱动至少一个LED的输出电流。开关信号被耦合以切换变压器。输入电路对输入信号进行采样以产生反馈信号。输入信号与LED驱动器的输出电流相关。输入电压检测电路根据LED驱动器的输入电压产生输入电压信号。当输入电压信号低于阈值时，输入电路不会对输入信号进行采样。控制电路可以消除输入电容器的需要，提高LED驱动器的可靠性。

45. 发明申请

US20130063986A1 CONTROL CIRCUIT FOR CONTROLLING THE MAXIMUM OUTPUT CURRENT OF POWER CONVERTER AND METHOD THEREOF 有权
标题翻译：用于控制功率转换器的最大输出电流的控制电路及其方法
公开(公告)号：US20130063986A1
公开(公告)日：2013-03-14
申请号：US13611091
申请日：2012-09-12
申请人： TA-YUNG YANG , LI LIN , YUE-HONG TANG , JUNG-SHENG CHEN
发明人： TA-YUNG YANG , LI LIN , YUE-HONG TANG , JUNG-SHENG CHEN
IPC分类号： H02M3/335
CPC分类号： H02M3/33507 , H02M2001/0003
摘要： A control circuit of the power converter according to the present invention comprises a feedback circuit, an output circuit and an adaptive clamping circuit. The feedback circuit generates a feedback signal in accordance with an output of the power converter. The output circuit generates a switching signal in accordance with the feedback signal for regulating the output of the power converter. The adaptive clamping circuit limits the level of the feedback signal under a first level for a first load condition. The feedback circuit determines a slew rate of the feedback signal for increasing the level of the feedback signal from the first level to a second level. The adaptive clamping circuit is disabled and the level of the feedback signal can be increased to the second level for a second load condition.
摘要翻译：根据本发明的功率转换器的控制电路包括反馈电路，输出电路和自适应钳位电路。反馈电路根据功率转换器的输出产生反馈信号。输出电路根据用于调节功率转换器的输出的反馈信号产生开关信号。自适应钳位电路在第一负载条件下将反馈信号的电平限制在第一电平。反馈电路确定用于将反馈信号的电平从第一电平增加到第二电平的反馈信号的转换速率。自适应钳位电路被禁用，并且反馈信号的电平可以在第二负载条件下增加到第二电平。

46. 发明申请

US20110254537A1 Method and Apparatus for Detecting CCM Operation of a Magnetic Device 审中-公开
标题翻译：用于检测磁性装置的CCM操作的方法和装置
公开(公告)号：US20110254537A1
公开(公告)日：2011-10-20
申请号：US13069523
申请日：2011-03-23
申请人： TA-YUNG YANG , JUNG-SHENG CHEN , LI LIN , PEI-SHENG TSU , YI-MIN HSU , CHUH-CHING LI
发明人： TA-YUNG YANG , JUNG-SHENG CHEN , LI LIN , PEI-SHENG TSU , YI-MIN HSU , CHUH-CHING LI
IPC分类号： G01R19/00
CPC分类号： G01R31/40
摘要： A method and an apparatus for detecting a CCM operation of a magnetic device are developed. The method generates a current signal in accordance with a switching current of the magnetic device and generates a first current signal and a second current signal by sampling the current signal. A mode signal is further generated according to the first current signal and the second current signal. The mode signal indicates the magnetic device is operated in CCM or DCM. The apparatus comprises a first sample circuit, a second sample circuit, and an arbiter. The first sample circuit samples the current signal to generate the first current signal. The second sample circuit samples the current signal to generate the second current signal. The arbiter generates the mode signal according to the first current signal and the second current signal for indicating the magnetic device is operated in CCM or DCM.
摘要翻译：开发了用于检测磁性装置的CCM操作的方法和装置。该方法根据磁性装置的开关电流产生电流信号，并通过对当前信号进行采样产生第一电流信号和第二电流信号。根据第一电流信号和第二电流信号进一步产生模式信号。模式信号表示磁性设备在CCM或DCM中运行。该装置包括第一采样电路，第二采样电路和仲裁器。第一采样电路对当前信号进行采样以产生第一电流信号。第二采样电路对当前信号进行采样以产生第二电流信号。仲裁器根据第一电流信号产生模式信号，并且用于指示磁性装置的第二电流信号在CCM或DCM中操作。

47. 发明申请

US20120057375A1 METHOD AND APPARATUS FOR A FLYBACK POWER CONVERTER PROVIDING OUTPUT VOLTAGE AND CURRENT REGULATION WITHOUT INPUT CAPACITOR 有权
标题翻译：提供无输入电容输出电压和电流调节功能的逆变电源转换器的方法和装置
公开(公告)号：US20120057375A1
公开(公告)日：2012-03-08
申请号：US13013100
申请日：2011-01-25
申请人： TA-YUNG YANG , LI LIN
发明人： TA-YUNG YANG , LI LIN
IPC分类号： H02M3/335
CPC分类号： H02M3/33523
摘要： A control circuit of a power converter according to the present invention comprises an output circuit, at least one input circuit and an input-voltage detection circuit. The output circuit generates a switching signal for regulating an output of the power converter in response to at least one feedback signal. The switching signal is coupled to switch a transformer of the power converter. The input circuit samples at least one input signal for generating the feedback signal. The input signal is correlated to the output of the power converter. The input-voltage detection circuit generates an input-voltage signal in response to the level of the an input voltage of the power converter. The input circuit will not sample the input signal when the input-voltage signal is lower than a threshold. The control circuit can eliminate the need of the input capacitor for improving the reliability of the power converter.
摘要翻译：根据本发明的功率转换器的控制电路包括输出电路，至少一个输入电路和输入电压检测电路。输出电路响应于至少一个反馈信号产生用于调节功率转换器的输出的开关信号。开关信号被耦合以切换功率转换器的变压器。输入电路对至少一个用于产生反馈信号的输入信号进行采样。输入信号与功率转换器的输出相关。输入电压检测电路响应于功率转换器的输入电压的电平产生输入电压信号。当输入电压信号低于阈值时，输入电路不会对输入信号进行采样。控制电路可以消除输入电容器的需要，提高功率转换器的可靠性。

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