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41. 发明专利

YU89901A DERIVATI ERITROPOETINA 未知
公开(公告)号：YU89901A
公开(公告)日：2004-05-12
申请号：YUP89901
申请日：2000-06-28
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , HILGER BERND , JOSEL HANS-PETER
IPC分类号： A61K38/00 , A61K38/22 , A61K47/48 , A61P7/06 , A61P13/12 , A61P31/18 , A61P35/00 , C07K14/505
摘要： Opisani su konjugati glikoproteina eritropoetina, naznačeni time što se konjugati sastoje od glikoproteina eritropoetina, koji sadrži najmanje jednu slobodnu amino grupu i koji poseduje in vivo biološku aktivnost koja uzrokuje da ćelije koštane srži povećaju produkciju retikulocita i crvenih krvnih ćelija, pri čemu je glikoprotein izabran iz grupe koja se sastoji od humanog eritropoetina i njegovih analoga, koji poseduju primarnu strukturu humanog eritropoetina, modifikovanu adicijom 1 do 6 mesta glikolizacije ili rearanžmanom najmanje jednog mesta glikolizacije; naznačeni glikoprotein je kovalentno vezan tako da formira jednu do tri niži alkoksi-poli(etilen glikol) grupe, pri čemu je svaka poli(etilen glikol) grupa kovalentno vezana za glikoprotein, preko linkera sa formulom -C(O)-X-S-Y, gde C(O) iz linker grupe formira amidnu vezu sa jednom od pomenutih amino grupa, i gde X i Y imaju značenje definisano u opisu pronalaska i u zahtevima, prosečna molekulska težina svakog poli(etilen glikol) ostatka je od oko 20 kilodaltona do oko 40 kilodaltona, a prosečna molekulska težina konjugata je od oko 51 kilodaltona do oko 175 kilodaltona.

42. 发明专利

BR0116381A 未知
公开(公告)号：BR0116381A
公开(公告)日：2004-02-25
申请号：BR0116381
申请日：2001-12-08
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , ENGEL ALFRED , SCHURIG HARTMUT ERNST , FRANZE REINHARD , TISCHER WILHELM , HILGER BERND , WOZNY MANFRED
IPC分类号： C12P21/02 , A61K47/48 , A61P7/06 , A61P13/12 , A61P31/18 , A61P35/00 , C07K1/113 , C07K14/505
摘要： The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal alpha-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have the sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to one poly(ethylene glycol) group of the formula -CO-(CH 2 ) x -(OCH 2 CH 2 ) m -OR wherein the -CO of the poly(ethylene glycol) group forms an amide bond with said N-terminal alpha-amino group; and wherein R is lower alkyl; x is 2 or 3; and m is from about 450 to about 1350.

43. 发明专利

CA2431964A1 CONJUGATES OF ERYTHROPOIETIN (PEP) WITH POLYETHYLENE GLYCOL (PEG) 未知
公开(公告)号：CA2431964A1
公开(公告)日：2002-06-27
申请号：CA2431964
申请日：2001-12-08
申请人： HOFFMANN LA ROCHE
发明人： SCHURIG HARTMUT ERNST , ENGEL ALFRED , WOZNY MANFRED , HILGER BERND , TISCHER WILHELM , FRANZE REINHARD , BURG JOSEF
IPC分类号： C12P21/02 , A61K47/48 , A61P7/06 , A61P13/12 , A61P31/18 , A61P35/00 , C07K1/113 , C07K14/505 , A61K38/18
摘要： The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N- terminal .alpha.-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin a nd analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least o ne glycosylation site; said glycoprotein being covalently linked to one poly(ethylene glycol) group of the formula -CO-(CH2)x-(OCH2CH2)m-OR with the - CO of the poly(ethylene glycol) group forming an amide bond with said N- terminal .alpha.-amino group; wherein R is lower alkyl; x is 2 or 3; and m i s from about 450 to about 1350.

44. 发明专利

CA2378533A1 ERYTHROPOIETIN CONJUGATES WITH POLYETHYLENGLYCOL 未知
公开(公告)号：CA2378533A1
公开(公告)日：2001-01-11
申请号：CA2378533
申请日：2000-06-28
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , HILGER BERND , JOSEL HANS-PETER
IPC分类号： A61K38/00 , A61K38/22 , A61K47/48 , A61P7/06 , A61P13/12 , A61P31/18 , A61P35/00 , C07K14/505 , A61K38/18
摘要： Erythropoietin glycoprotein conjugates are disclosed, said conjugates compri se an erythropoietin glycoprotein having at least one free amino group and havi ng the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have the primar y structure of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or by the rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to form one to three lower- alkoxy poly(ethylene glycol) groups, each poly(ethylene glycol) group being covalently linked to the glycoprotein via a linker of the formula -C(O)-X-S- Y- with the C(O) of the linker forming an amide bond with one of said amino groups, wherein X and Y are as defined in the description and claims, the average molecular weight of each poly(ethylene glycol) moiety is from about 20 kilodaltons to about 40 kilodaltons, and the molecular weight of the conjuga te is from about 51 kilodaltons to about 175 kilodaltons.

45. 发明专利

ES2704013T3 Procedimiento para la regeneración de una columna de cromatografía 未知
公开(公告)号：ES2704013T3
公开(公告)日：2019-03-13
申请号：ES08784776
申请日：2008-07-15
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , REICHERT KLAUS , SCHROTH AXEL , SCHURIG HARTMUT , WESSNER AXEL
IPC分类号： B01D15/36 , B01D15/20 , B01J49/00 , C07K1/18
摘要： Procedimiento para la regeneración de una columna de cromatografía de intercambio catiónico fuerte después de la elución de compuestos de interés que comprende las siguientes etapas en este orden: - eluir polipéptidos adsorbidos de la columna con una solución tamponada acuosa que comprende cloruro de sodio a una concentración de al menos 500 mM, - limpiar la columna con agua purificada, - aplicar una solución de hidróxido de sodio 0,5 M a la columna, - limpiar la columna con agua purificada, - aplicar una solución que comprende dihidrogenofosfato de sodio 0,5 M y ácido fosfórico 1 M a la columna, - limpiar la columna con agua purificada, - aplicar una solución de hidróxido de sodio 0,5 M a la columna durante al menos 4 horas, y - regenerar la columna de cromatografía de intercambio catiónico limpiando la columna con agua purificada.

46. 发明专利

SI2173450T1 Postopek regeneracije kromatografske kolone 未知
公开(公告)号：SI2173450T1
公开(公告)日：2019-02-28
申请号：SI200832026
申请日：2008-07-15
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , REICHERT KLAUS , SCHROTH AXEL , SCHURIG HARTMUT , WESSNER AXEL
IPC分类号： B01D15/00 , B01J49/00 , C07K1/00

47. 发明专利

BRPI1010119A2 "método de produção de composição de anticorpo e uso de cromatografia de troca de íons analítica" 未知
公开(公告)号：BRPI1010119A2
公开(公告)日：2016-03-15
申请号：BRPI1010119
申请日：2010-07-22
申请人： HOFFMANN LA ROCHE
发明人： HILGER BERNHARD , WALLERIUS CLAUS , ZETTL FRANK , BURG JOSEF , STIENS LARS , KAISER THORSTEN , KUHNE WOLFGANG
IPC分类号： C07K1/14 , C07K16/00 , C07K16/32

48. 发明专利

CA2692612C PURIFICATION OF PEGYLATED POLYPEPTIDES 未知
公开(公告)号：CA2692612C
公开(公告)日：2015-02-10
申请号：CA2692612
申请日：2008-07-15
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , REICHERT KLAUS , SCHROTH AXEL , SCHURIG HARTMUT , WESSNER AXEL
IPC分类号： C07K14/505 , A61K38/18 , A61K47/48 , C07K1/18
摘要： The current invention comprises a method for the purification of mono-PEGylated erythropoietin comprising two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chro-matography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

49. 发明专利

AU2008277887B2 Purification of PEGylated peptides 未知
公开(公告)号：AU2008277887B2
公开(公告)日：2012-12-13
申请号：AU2008277887
申请日：2008-07-15
申请人： HOFFMANN LA ROCHE
发明人： SCHROTH AXEL , WESSNER AXEL , BURG JOSEF , SCHURIG HARTMUT , REICHERT KLAUS
IPC分类号： C07K1/18 , A61K38/18 , A61K47/48
摘要： The current invention comprises a method for the purification of mono-PEGylated erythropoietin comprising two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

50. 发明专利

CZ301833B6 Konjugát erytropoetinu s polyethylenglykolem, zpusob jeho prípravy a lécivo pro lécení anemie s jeho obsahem 未知
公开(公告)号：CZ301833B6
公开(公告)日：2010-07-07
申请号：CZ20014682
申请日：2000-06-28
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , HILGER BERND , JOSEL HANS-PETER
IPC分类号： A61K47/48 , A61K38/00 , A61K38/22 , A61P7/06 , A61P13/12 , A61P31/18 , A61P35/00 , C07K14/505
摘要： Konjugát obsahující erytropoetinový (EPO) glykoprotein mající alespon jednu volnou aminoskupinu a zvyšující produkci retikulocytu a erytrocytu bunkami kostní drene, kde EPO glykoprotein je vybrán z lidského EPO a jeho analogu, které mají primární strukturu lidského EPO modifikovanou adicí 1 až 6 glykosylacních míst nebo prestavbou alespon jednoho glykosylacního místa; jež spocívá v deleci kteréhokoliv z míst s N-pripojeným sacharidem v lidském EPO a adici místa s N-pripojeným sacharidem v pozici 88 aminokyselinové sekvence lidského EPO; kde uvedený glykoprotein je kovalentne navázán na jednu až tri (C.sub.1.n.-C.sub.6.n.)alkoxy poly(ethylenglykolové) skupiny, z nichž každá je kovalentne pripojena ke glykoproteinu pres spojovník -C(O)-X-S-Y-, kde C(O) spojovníku tvorí amidovou vazbu s jednou z uvedených aminoskupin, X je -(CH.sub.2.n.).sub.k.n.- nebo -CH.sub.2.n.(O-CH.sub.2.n.-CH.sub.2.n.).sub.k.n.-, k je císlo od 1 do 10, Y je skupina vzorce i, ii, iii nebo iv, prumerná molekulová hmotnost každé poly(ethylenglykolové) skupiny je 20 až 40 kDa, a molekulová hmotnost konjugátu je 51 až 175 kDa. Zpusob jeho prípravy a lécivo pro lécení anemie s jeho obsahem.

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