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41. 发明专利

AP605A Glucan elicitor receptor and DNA molecule coding therefor. 未知
公开(公告)号：AP605A
公开(公告)日：1997-08-19
申请号：AP9600789
申请日：1995-06-16
申请人： KIRIN BREWERY
发明人： KAKITANI MAKOTO , UMEMOTO NAOYUKI , ISHIDA ISAO , IWAMATSU AKIHIRO
IPC分类号： C12N15/29 , C07K14/415 , C07K14/705 , C12N15/12 , C12N15/82 , C07C211/53
摘要： A glucan elecitor receptor

42. 发明专利

BR9506270A 未知
公开(公告)号：BR9506270A
公开(公告)日：1997-08-12
申请号：BR9506270
申请日：1995-06-16
申请人： KIRIN BREWERY
发明人： KAKITANI MAKOTO , UMEMOTO NAOYUKI , ISHIDA ISAO , IWAMATSU AKIHIRO , YOSHIKAWA KUNIKO
IPC分类号： C12N15/29 , C07K14/415 , C07K14/705 , C12N15/12 , C12N15/82 , C12N5/10

43. 发明专利

AU1111097A Mold-resistant plant and process for producing the same 未知
公开(公告)号：AU1111097A
公开(公告)日：1997-07-14
申请号：AU1111097
申请日：1996-12-13
申请人： KIRIN BREWERY
发明人： KAKITANI MAKOTO , UMEMOTO NAOYUKI , ISHIDA ISAO , YAMAOKA NAOTO
IPC分类号： C12N15/29 , C12N15/82 , A01H5/00

44. 发明专利

AU3905893A Plant resistant to two or more viruses and preparation thereof 未知
公开(公告)号：AU3905893A
公开(公告)日：1993-11-18
申请号：AU3905893
申请日：1993-04-16
申请人： KIRIN BREWERY
发明人： ISHIDA ISAO , OKADA YOSHIMI
IPC分类号： A01H5/00 , C12N5/10 , C12N9/22 , C12N15/09 , C12N15/55 , C12N15/82
摘要： A process for preparing a plant which is resistant to two or more RNA viruses by integrating into a plant chromosome a DNA sequence coding for a protein having an enzymatic activity of specifically decomposing a double-stranded RNA and expressing the same; and a plant resistant to RNA viruses which is prepared thereby.

45. 发明专利

CA2111565A1 PLANTS RESISTANT AGAINST PLURAL VIRUSES AND METHOD FOR PRODUCING THEM 未知
公开(公告)号：CA2111565A1
公开(公告)日：1993-10-28
申请号：CA2111565
申请日：1993-04-16
申请人： KIRIN BREWERY
发明人： ISHIDA ISAO , OKADA YOSHIMI
IPC分类号： A01H5/00 , C12N5/10 , C12N9/22 , C12N15/09 , C12N15/55 , C12N15/82 , C12N15/84
摘要： This invention relates to a method for producing a plant having resistance against RNA viruses by integrating a DNA sequence, which encodes a protein having an enzyme activity specifically breaking down a double-strand RNA, into a chromosome of a plant and making the DNA sequence express in the plant cells; and a plant having resistance against RNA viruses obtained according to the above method. A plant according to the present invention has resistance against plural RNA viruses.

46. 发明专利

CA2430013C TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES 未知
公开(公告)号：CA2430013C
公开(公告)日：2011-11-22
申请号：CA2430013
申请日：2001-11-30
申请人： MEDAREX INC , KIRIN BREWERY
发明人： TOMIZUKA KAZUMA , ISHIDA ISAO , LONBERG NILS , HALK ED
IPC分类号： A01K67/027 , A61K39/00 , A61K39/395 , C07K14/735 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/28 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/85 , C12P21/08
摘要： The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.

47. 发明专利

ES2295228T3 ROEDORES TRANSCROMOSOMICOS TRANSGENICOS PARA LA PREPARACION DE ANTICUERPOS HUMANOS. 未知
公开(公告)号：ES2295228T3
公开(公告)日：2008-04-16
申请号：ES01987182
申请日：2001-11-30
申请人： MEDAREX INC , KIRIN BREWERY
发明人： TOMIZUKA KAZUMA , ISHIDA ISAO , LONBERG NILS , HALK ED
IPC分类号： A01K67/027 , C12N15/00 , A61K39/00 , A61K39/395 , C07K14/735 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/28 , C12N5/06 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/85 , C12P21/08
摘要： Ratón transgénico que comprende dos loci humanos de inmunoglobulina, en el que un locus humano de inmunoglobulina es un locus humano de cadena pesada situado en un transcromosoma, y el otro locus humano de inmunoglobulina es una parte de un transgén de locus humano de cadena ligera integrado de manera estable en el genoma de ratón y que codifica una cadena ligera humana.

48. 发明专利

AU2002309063A1 ARTIFICIAL HUMAN CHROMOSOME CONTAINING HUMAN ANTIBODY LAMBDA LIGHT CHAIN GENE 未知
公开(公告)号：AU2002309063A1
公开(公告)日：2002-11-25
申请号：AU2002309063
申请日：2002-05-10
申请人： KIRIN BREWERY , MEDAREX INC
发明人： ISHIDA ISAO , YOSHIDA HITOSHI , TOMIZUKA KAZUMA , KUROIWA YOSHIMI
IPC分类号： A01K67/027 , A61K48/00 , C07K16/00 , C07K16/24 , C12N5/12 , C12N15/02 , C12N15/09 , C12N15/13 , C12N15/85 , C12N15/87 , C12N15/90 , C12P21/00 , C12P21/08
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody » light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the non-human animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.

49. 发明专利

ES2169040T3 未知
公开(公告)号：ES2169040T3
公开(公告)日：2002-07-01
申请号：ES93908104
申请日：1993-04-16
申请人： KIRIN BREWERY
发明人： ISHIDA ISAO , OKADA YOSHIMI
IPC分类号： A01H5/00 , C12N5/10 , C12N9/22 , C12N15/09 , C12N15/55 , C12N15/82 , A01N63/02
摘要： A process for preparing a plant which is resistant to two or more RNA viruses by integrating into a plant chromosome a DNA sequence coding for a protein having an enzymatic activity of specifically decomposing a double-stranded RNA and expressing the same; and a plant resistant to RNA viruses which is prepared thereby.

50. 发明专利

AU5304299A Method for modifying chromosomes 未知
公开(公告)号：AU5304299A
公开(公告)日：2000-03-14
申请号：AU5304299
申请日：1999-08-23
申请人： KIRIN BREWERY
发明人： TOMIZUKA KAZUMA , YOSHIDA HITOSHI , HANAOKA KAZUNORI , OSHIMURA MITSUO , ISHIDA ISAO , KUROIWA YOSHIMI
IPC分类号： A01K67/027 , C12N15/85 , C12N15/873 , C12N15/90
摘要： The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency thorugh its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof. The invention also relates to a method for producing a chimeric non-human animal or a non-human animal, which comprises a modified foreign chromosome(s) or a fragment(s) thereof; the chimeric non-human or non-human animal; a recombinant chromosome(s) or a fragment(s) thereof, which is obtained by deletion and/or translocation of a chromosome(s) or a fragment(s) thereof; a method for modifying a foreign chromosome(s) or a fragment(s) thereof in a cell; an artificial chromosome vector, which comprises a centromere sequence derived from human chromosome #14 and a recognition sequence for a site-directed recombination enzyme; and a recombinant chromosome(s) or a fragment(s) thereof obtained by deletion and/or translocation of a chromosome(s) or fragment(S) thereof.

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