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41. 发明申请

WO2013163246A3 POLYMERIZATION REACTIONS WITHIN MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置中的聚合反应
公开(公告)号：WO2013163246A3
公开(公告)日：2014-01-03
申请号：PCT/US2013037895
申请日：2013-04-24
申请人： HARVARD COLLEGE , BASF SE
发明人： ZIERINGER MAXIMILIAN , HOLTZE CHRISTIAN , WEITZ DAVID A , SIEBERT JOERG MAX GEORG ERICH
IPC分类号： C08F293/00 , B01F13/00 , B01J14/00 , B01J19/00 , B82Y40/00 , C08F2/01 , C08F2/12
CPC分类号： C08F2/22 , B01F3/0807 , B01F13/0062 , B01F13/0093 , B01F2005/0031 , B01J19/0093 , B01J2219/00792 , B01J2219/00833 , B01J2219/0084 , B01J2219/00891 , B01J2219/00903 , B01J2219/00936 , B01J2219/00961 , B01J2219/00963 , B01J2219/00966 , B01J2219/0097 , C08F2/01 , C08F293/005
摘要： The present invention generally relates to polymerization reactions within microfluidic devices. In certain cases, the invention allows for precise control of the polymerization of different types of monomers to form a copolymer by controlling the steps of polymerization and/or controlling the addition of monomers at various time scales within a microfluidic droplet and/or a microfluidic environment, often to a degree that is unattainable by other block polymerization techniques. For example, in one aspect, the present invention is directed to systems and methods for producing polymers such as block copolymers, gradient polymers, random copolymers, etc. For instance, in one set of embodiments, a first monomer contained within a channel, such as a microfluidic channel, is allowed to polymerize to form a first block of a block copolymer. Additional blocks may be added, for example, by flowing the first block and other monomers through a second channel (which may be an extension of the first channel), by polymerizing additional blocks of the copolymer in other channels, by creating droplets containing one or more blocks and allowing the blocks to polymerize, or the like. In some embodiments, a droplet, such as a multiple emulsion droplet, may be creating containing two or more monomers, which are allowed to polymerize together. Still other embodiments of the invention are generally directed to methods of creating such devices, methods of using such devices, kits involving such devices, or the like.
摘要翻译：本发明一般涉及微流体装置内的聚合反应。在某些情况下，本发明允许通过控制聚合和/或控制在微流体液滴和/或微流体环境内的各种时间尺度添加单体的步骤来精确控制不同类型的单体的聚合以形成共聚物，通常达到其它嵌段聚合技术无法达到的程度。例如，在一个方面，本发明涉及用于生产聚合物如嵌段共聚物，梯度聚合物，无规共聚物等的体系和方法。例如，在一组实施方案中，包含在通道内的第一单体，例如作为微流体通道，被允许聚合以形成嵌段共聚物的第一嵌段。可以通过例如通过使第一块和其它单体流过第二通道（其可以是第一通道的延伸），通过在其它通道中聚合共聚物的附加嵌段，通过产生含有一个或多个更多的块和允许块聚合等。在一些实施方案中，液滴，例如多重乳液液滴可能产生含有两种或更多种单体，这些单体可一起聚合。本发明的其它实施例通常涉及创建这种设备的方法，使用这种设备的方法，涉及这种设备的套件等。

42. 发明申请

WO2014047236A3 SYSTEMS AND METHODS FOR SPRAY DRYING IN MICROFLUIDIC AND OTHER SYSTEMS 审中-公开
标题翻译：微流体和其他系统中喷雾干燥的系统和方法
公开(公告)号：WO2014047236A3
公开(公告)日：2015-05-28
申请号：PCT/US2013060522
申请日：2013-09-19
申请人： HARVARD COLLEGE , BASF SE
发明人： AMSTAD ESTHER , HOLTZE CHRISTIAN , WEITZ DAVID A
IPC分类号： B01J2/02 , B01F5/04 , B01F13/00 , B01J2/04 , B01L3/02 , H01J49/04
CPC分类号： B01D1/20 , B01J2/02 , B01J2/04 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. By at least partially drying fluids within a microfluidic channel, instead of or in addition to conventional spray drying techniques, better control of the drying process can be achieved in certain aspects of the invention. In addition, various embodiments of the invention are generally directed to systems and methods for drying fluids contained within a channel such as a microfluidic channel. For example, a fluid may be partially or completely dried within a microfluidic channel, prior to being sprayed into a collection region. In some embodiments, gases such as air may be directed into a channel containing a fluid, which may facilitate drying of the fluid. In some cases, the fluid may be accelerated due to the introduction of gases into the channel, and in certain embodiments, droplets of fluid may be disrupted to form smaller droplets as a result. In certain cases, the fluids may also be dried to form supersaturated droplets.
摘要翻译：本发明一般涉及微流体，以及喷雾干燥和其它干燥技术。通过至少部分地干燥微流体通道内的流体，代替常规喷雾干燥技术或除常规喷雾干燥技术之外，可以在本发明的某些方面实现干燥过程的更好控制。此外，本发明的各种实施方案通常涉及用于干燥包含在通道（例如微流体通道）内的流体的系统和方法。例如，在喷射到收集区域之前，流体可以在微流体通道内部分或完全干燥。在一些实施例中，诸如空气的气体可以被引导到包含流体的通道中，这可以促进流体的干燥。在某些情况下，流体可能由于气体进入通道而被加速，并且在某些实施方案中，结果液体液滴可能被破坏以形成较小的液滴。在某些情况下，流体也可以被干燥以形成过饱和的液滴。

43. 发明申请

WO2014047236A2 SYSTEMS AND METHODS FOR SPRAY DRYING IN MICROFLUIDIC AND OTHER SYSTEMS 审中-公开
标题翻译：用于微流体和其他系统中的喷雾干燥的系统和方法
公开(公告)号：WO2014047236A2
公开(公告)日：2014-03-27
申请号：PCT/US2013060522
申请日：2013-09-19
申请人： HARVARD COLLEGE , BASF SE
发明人： AMSTAD ESTHER , HOLTZE CHRISTIAN , WEITZ DAVID A
IPC分类号： B01J2/02
CPC分类号： B01D1/20 , B01J2/02 , B01J2/04 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. By at least partially drying fluids within a microfluidic channel, instead of or in addition to conventional spray drying techniques, better control of the drying process can be achieved in certain aspects of the invention. In addition, various embodiments of the invention are generally directed to systems and methods for drying fluids contained within a channel such as a microfluidic channel. For example, a fluid may be partially or completely dried within a microfluidic channel, prior to being sprayed into a collection region. In some embodiments, gases such as air may be directed into a channel containing a fluid, which may facilitate drying of the fluid. In some cases, the fluid may be accelerated due to the introduction of gases into the channel, and in certain embodiments, droplets of fluid may be disrupted to form smaller droplets as a result. In certain cases, the fluids may also be dried to form supersaturated droplets.
摘要翻译：本发明一般涉及微流体，并涉及喷雾干燥和其他干燥技术。通过至少部分干燥微流体通道内的流体，代替常规喷雾干燥技术或除常规喷雾干燥技术之外，可以在本发明的某些方面实现对干燥过程的更好控制。另外，本发明的各种实施例通常涉及用于干燥包含在诸如微流体通道的通道内的流体的系统和方法。例如，流体可以在被喷射到收集区域之前在微流体通道内部分地或完全地被干燥。在一些实施例中，诸如空气的气体可以被引导到包含流体的通道中，这可以有利于流体的干燥。在一些情况下，由于向通道中引入气体，流体可能被加速，并且在某些实施例中，流体的液滴可能被破坏以形成更小的液滴。在某些情况下，流体也可以被干燥以形成过饱和液滴。

44. 发明公开

EP2473262A4 MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
标题翻译：几种化合物生产的乳液
公开(公告)号：EP2473262A4
公开(公告)日：2015-12-02
申请号：EP10814398
申请日：2010-09-01
申请人： HARVARD COLLEGE , BASF SE
发明人： WEITZ DAVID A , ROMANOWSKY MARK , HOLTZE CHRISTIAN
IPC分类号： B01F5/00 , B01F3/08 , B01F15/04
CPC分类号： B01F13/0084 , B01F3/0807 , B01F2003/0838 , Y10T137/0318 , Y10T137/87571

45. 发明申请

WO2016004068A8 HYDROGEL COMPOSITIONS COMPRISING ENCAPSULATED CELLS AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含封装细胞的水凝胶组合物及其使用方法
公开(公告)号：WO2016004068A8
公开(公告)日：2016-03-24
申请号：PCT/US2015038601
申请日：2015-06-30
申请人： SHIN JAE-WON , MAO ANGELO S , UTECH STEFANIE , WEITZ DAVID A , MOONEY DAVID J , UZUN OKTAY
发明人： SHIN JAE-WON , MAO ANGELO S , UTECH STEFANIE , WEITZ DAVID A , MOONEY DAVID J , UZUN OKTAY
IPC分类号： A61K35/12 , C12N11/10 , C12N11/12
CPC分类号： A61K9/4816 , A61K9/0019 , A61K9/5036 , A61K9/5052 , A61K35/12 , A61K35/28 , A61K2035/124 , C12N11/04 , C12N11/10
摘要： The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositons. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
摘要翻译：本发明提供了包含在水凝胶胶囊中的细胞的可注射组合物和制备这些组合物的方法。本发明还提供了使用这些组合物促进造血作用并治疗或预防受试者的心血管和免疫学障碍的方法。

46. 发明申请

WO2008058297A3 NON-SPHERICAL PARTICLES 审中-公开
标题翻译：非球形颗粒
公开(公告)号：WO2008058297A3
公开(公告)日：2008-06-26
申请号：PCT/US2007084561
申请日：2007-11-13
申请人： UNIV HARVARD , KIM JIN WOONG , LARSEN RYAN J , WEITZ DAVID A
发明人： KIM JIN WOONG , LARSEN RYAN J , WEITZ DAVID A
IPC分类号： C08J3/00
CPC分类号： C08J3/246
摘要： Under one aspect, a collection of particles includes at least about 60% non-spherical particles, each of the non-spherical particles including a first spheroid having a first polymer composition; a second spheroid having a second polymer composition; and a third spheroid having a third polymer composition. The first and second polymer compositions at least partially interpenetrate, thus joining the first and second spheroids together, and the third polymer composition at least partially interpenetrates at least one of the first and second polymer compositions at a juncture of the third spheroid with at least one of the first and second spheroids.
摘要翻译：在一个方面，颗粒的集合包括至少约60％的非球形颗粒，每个非球形颗粒包括具有第一聚合物组合物的第一球体; 具有第二聚合物组合物的第二球体; 和具有第三聚合物组合物的第三球体。第一和第二聚合物组合物至少部分地相互渗透，从而将第一和第二球体接合在一起，并且第三聚合物组合物在第三球体的至少一个接合部处至少部分地互穿第一和第二聚合物组合物中的至少一种的第一和第二球体。

47. 发明专利

HK1253013A1 用於條形碼化核酸的系統和方法未知
公开(公告)号：HK1253013A1
公开(公告)日：2019-06-06
申请号：HK18112379
申请日：2018-09-27
申请人： HARVARD COLLEGE , UNIV VILNIUS
发明人： WEITZ DAVID A , KLEIN ALLON MOSHE , AKARTUNA ILKE , MAZUTIS LINAS , KIRSCHNER MARC W
IPC分类号： C12P20060101 , C12Q20060101

48. 发明专利

CA2778816C DROPLET CREATION TECHNIQUES 未知
公开(公告)号：CA2778816C
公开(公告)日：2018-07-31
申请号：CA2778816
申请日：2010-10-26
申请人： HARVARD COLLEGE
发明人： WEITZ DAVID A , ABATE ADAM R
IPC分类号： B01L3/00 , B01F13/00
摘要： The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes.

49. 发明专利

CA3021735A1 IMMOBILIZATION-BASED SYSTEMS AND METHODS FOR GENETIC ANALYSIS AND OTHER APPLICATIONS 未知
公开(公告)号：CA3021735A1
公开(公告)日：2017-10-26
申请号：CA3021735
申请日：2017-04-19
申请人： HARVARD COLLEGE
发明人： WEITZ DAVID A , ZHANG HUIDAN , HEYMAN JOHN
IPC分类号： C12Q1/68 , B01F3/08 , B01J13/02 , G01N33/50
摘要： The present invention generally relates to microfluidics and labeled nucleic acids. Certain aspects are generally directed to containing cells in gels, such as agarose gels, and determining nucleic acids within the cells, e.g., while contained within the gels. The nucleic acids may be, for example, genomic DNA, mRNA, transcriptomes, or the like. In some embodiments, for instance, both genomic DNA and RNA (e.g., as in a transcriptome) from a cell may be determined. In some cases, the nucleic acids may be attached to beads for sequencing or other purposes. Such systems may be useful, for example, for high-throughput sequencing or other applications.

50. 发明专利

BRPI1008965A2 aumento de escala de dispositivos microfluídicos 未知
公开(公告)号：BRPI1008965A2
公开(公告)日：2016-03-15
申请号：BRPI1008965
申请日：2010-03-12
申请人： HARVARD COLLEGE
发明人： ABATE ADAM R , WEITZ DAVID A , ROMANOWSKY MARK
IPC分类号： B01F25/46 , B01J19/00

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