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41. 发明公开

EP2493313A4 KINASE INHIBITORS 有权转让
标题翻译：激酶INHIBITOREN
公开(公告)号：EP2493313A4
公开(公告)日：2013-05-15
申请号：EP10827573
申请日：2010-10-29
申请人： GENOSCO , OSCOTEC INC
发明人： KIM HONG WOO , KOH JONG SUNG , LEE JAEKYOO , SONG HO-JUHN , KIM YOUNGSAM , LEE HEE KYU , CHOI JANG-SIK , LIM SUN-HEE , CHANG SUNHWA
IPC分类号： A61K31/519 , A61P25/28 , A61P29/00 , A61P35/00 , C07D471/04
CPC分类号： A61K31/519 , C07D471/04
摘要： The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.
摘要翻译：本发明提供了一组新的蛋白激酶抑制剂，吡啶并[4,3，-d]嘧啶-5-酮衍生物及其药学上可接受的盐，其可用于促进细胞增殖性疾病和病症如癌症，自身免疫性疾病，感染，心血管疾病和神经变性疾病和障碍。本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。本发明还提供了包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂的药物制剂。本发明还提供了在吡啶并[4,3， - d]嘧啶-5-酮衍生物的合成过程中产生的有用的中间体。

42. 发明专利

ES2890552T3 Compuestos de pirimidina sustituidos y su uso como inhibidores de SYK 未知
公开(公告)号：ES2890552T3
公开(公告)日：2022-01-20
申请号：ES14856054
申请日：2014-10-21
申请人： GENOSCO , OSCOTEC INC
发明人： LEE JAEKYOO , CHOI JANG-SIK , HWANG HAE-JUN , SONG HO-JUHN , KIM JUNG-HO , KIM SE-WON , KOH JONG SUNG , LEE JAESANG , LEE TAE-IM , CHOI YUNG-GEUN , PARK SUNG-HO , LEE IN YONG , SUH BYUNG-CHUL , SALGAONKAR PARESH DEVIDAS , JUNG DONG-SIK
IPC分类号： C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00 , C07D413/04
摘要： Un compuesto de Fórmula (I): **(Ver fórmula)** en la cual: R1, R2, R3, R4, R5, R6a, R6b, X e Y son como se describen en el presente documento: X es CH o N; Y es C o N; cuando Y es N, R2 está ausente; R1 se selecciona de H, alquilo de C1-C6, cicloalquilo de C3-C7, C(O)OR7 o S(O)2R7, en el que el alquilo de C1-C6 está opcionalmente sustituido con uno o más halógenos, hidroxilo u OR7; R2 se selecciona de H, halógeno o alquilo de C1-C4, en donde el alquilo de C1-C4 está opcionalmente sustituido con uno o más halógenos; R3 se selecciona de H, halógeno, C(O)R7 o S(O2)R7; R4 se selecciona de H, halógeno, alquilo de C1-C6 o cicloalquilo de C3-C7, en el que alquilo de C1-C6 o cicloalquilo de C3-C7 está opcionalmente sustituido con uno o más halógenos, amino, hidroxilo, alcoxi o haloalquilo; R5 se selecciona de H, halógeno, alquilo de C1-C6 y cicloalquilo de C3-C7, en el que alquilo de C1-C6 o cicloalquilo de C3-C7 está opcional e independientemente sustituido con uno o más halógenos, alcoxi o haloalquilo; R6a se selecciona de H, halógeno, hidroxilo, CN, CH2OH, NH2, alquilo de C1-C6, cicloalquilo de C3-C7, OR7, NR7R7, NHR7 o NHC(O)R7; R6b se selecciona de H, CH2OH, CH2NH2 y alquilo de C1-C6; R7 se selecciona independientemente de alquilo de C1-C6, cicloalquilo de C3-C7, fenilo o haloalquilo, en el que el alquilo de C1-C6, cicloalquilo de C3-C7, fenilo o haloalquilo está opcional e independientemente sustituido con uno o más sustituyentes seleccionados entre fenilo, cicloalquilo, alquilo, halógeno, amino e hidroxilo, o una sal farmacéuticamente aceptable de los mismos.

43. 发明专利

MY173494A KINASE INHIBITORS 未知
公开(公告)号：MY173494A
公开(公告)日：2020-01-29
申请号：MYPI2012001886
申请日：2010-10-29
申请人： GENOSCO , OSCOTEC INC
发明人： KIM HONG WOO , KOH JONG SUNG , LEE JAEKYOO , SONG HO-JUHN , KIM YOUNGSAM , LEE HEE KYU , CHOI JANG-SIK , LIM SUN-HEE , CHANG SUNHWA
IPC分类号： C07D471/04 , A61K31/519 , A61P25/28 , A61P29/00 , A61P35/00
摘要： The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3-d]pyrimidin-5-one derivatives.

44. 发明专利

ZA201406038B SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS 未知
公开(公告)号：ZA201406038B
公开(公告)日：2015-12-23
申请号：ZA201406038
申请日：2014-08-18
申请人： GENOSCO , OSCOTEC INC
发明人： LEE JAESANG , JUNG DONG SIK , LEE IN YONG , HAN IK-HWAN , CHOI YUNG-GEUN , LEE TAE-IM , KOH JONG SUNG , KIM JUNG-HO , KIM SE WON , SONG HO-JUHN , LEE JAEKYOO , LEE EUNHO , HWANG HAE-JUN , CHOI JANG-SIK

45. 发明专利

ZA201407588B SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS 未知
公开(公告)号：ZA201407588B
公开(公告)日：2015-11-25
申请号：ZA201407588
申请日：2014-10-20
申请人： GENOSCO , OSCOTEC INC
发明人： LEE IN YONG , LEE JAEKYOO , SONG HO-JUHN , KIM HONG WOO , KIM SE WON , KIM JUNG-HO , KOH JONG SUNG , LEE HEE KYU
摘要： Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

47. 发明专利

SG11201405942RA SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS 未知
公开(公告)号：SG11201405942RA
公开(公告)日：2014-10-30
申请号：SG11201405942R
申请日：2013-03-15
申请人： GENOSCO , OSCOTEC INC
发明人： KIM HONG WOO , LEE HEE KYU , SONG HO-JUHN , LEE JAEKYOO , KOH JONG SUNG , KIM YOUNGSAM , KIM JUNG-HO , KIM SE WON , LEE IN YONG
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
摘要： Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

48. 发明专利

HK1179477A1 KINASE INHIBITORS 未知
公开(公告)号：HK1179477A1
公开(公告)日：2013-10-04
申请号：HK13106673
申请日：2013-06-05
申请人： GENOSCO , OSCOTEC INC
发明人： LEE JAEKYOO , SONG HO-JUHN , KOH JONG SUNG , LEE HEE KYU , KIM YOUNGSAM , KIM HONG WOO , CHANG SUNHWA , LIM SUN-HEE , CHOI JANG-SIK , KIM JUNG-HO , KIM SE-WON
IPC分类号： C07D20060101
摘要： The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

49. 发明专利

ZA201204246B KINASE INHIBITORS 未知
公开(公告)号：ZA201204246B
公开(公告)日：2013-09-25
申请号：ZA201204246
申请日：2012-06-11
申请人： GENOSCO , OSCOTEC INC
发明人： KIM HONG WOO , KOH JONG SUNG , LEE JAEKYOO , SONG HO-JUHN , KIM YOUNGSAM , LEE HEE KYU , CHOI JANG-SIK , LIM SUN-HEE , CHANG SUNHWA , KIM JUNG-HO , KIM SE-WON
IPC分类号： A01N20060101 , A61K20060101
摘要： The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

50. 发明专利

CA2863517A1 SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS 未知
公开(公告)号：CA2863517A1
公开(公告)日：2013-07-25
申请号：CA2863517
申请日：2013-01-18
申请人： GENOSCO , OSCOTEC INC
发明人： CHOI JANG-SIK , HWANG HAE-JUN , LEE EUNHO , LEE JAEKYOO , SONG HO-JUHN , KIM SE WON , KIM JUNG-HO , KOH JONG SUNG , CHANG SUNHWA , LEE TAE-IM , CHOI YUNG-GEUN , HAN IK-HWAN , LEE JAESANG
IPC分类号： C07D403/14 , A61K31/506 , A61P11/00 , A61P29/00 , C07D405/14
摘要： Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

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