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41. 发明专利

AU2011276158A1 Cancer therapy using CLDN6 target-directed antibodies in vivo 未知
公开(公告)号：AU2011276158A1
公开(公告)日：2013-01-10
申请号：AU2011276158
申请日：2011-07-04
申请人： UNIV MAINZ JOHANNES GUTENBERG , GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TURECI OZLEM , KOSLOWSKI MICHAEL , WALTER KORDEN , KREUZBERG MARIA , LUXEN SYLVIA
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.

42. 发明专利

AU2012233044A1 Genetic products differentially expressed in tumors and the use thereof 未知
公开(公告)号：AU2012233044A1
公开(公告)日：2012-10-25
申请号：AU2012233044
申请日：2012-09-26
申请人： GANYMED PHARMACEUTICALS AG
发明人： KOSLOWSKI MICHAEL , TURECI OZLEM , SAHIN UGUR
IPC分类号： C07K14/47 , A61K38/17 , A61K39/00 , C07H21/00 , C07K16/30
摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for said products. Said invention also relate' to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic coding acids for said polypeptides, peptides and proteins. .

43. 发明专利

AU2012202225A1 Monoclonal antibodies against claudin-18 for treatment of cancer 未知
公开(公告)号：AU2012202225A1
公开(公告)日：2012-05-10
申请号：AU2012202225
申请日：2012-04-17
申请人： JOHANNES GUTENBERG UNI MAINZ VERTRETEN DURCH DEN PRASIDENTEN , GANYMED PHARMACEUTICALS AG
发明人： SCHRODER ANJA KRISTINA , UHEREK CRISTOPH , USENER DIRK , BRANDENBURG GUNDA , SAHIN UGUR , TURECI OZLEM , THIEL PHILIPPE , FRITZ STEFAN , GEPPERT HARALD-GERHARD
IPC分类号： C07K16/30 , A61K39/395 , A61K47/48 , A61P35/00 , C12N5/12
摘要： Abstract The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDI 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

44. 发明专利

ZA200907675B MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER 未知
公开(公告)号：ZA200907675B
公开(公告)日：2011-04-28
申请号：ZA200907675
申请日：2009-11-02
申请人： JOHANNES GUTENBERG-UNIVERSITAT MAINZ , GANYMED PHARMACEUTICALS AG
发明人： USENER DIRK , BRANDENBERG GUNDA , TURECI OZLEM , SAHIN UGUR
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.

45. 发明专利

NZ578130A Genetic products differentially expressed in tumors and the use thereof 未知
公开(公告)号：NZ578130A
公开(公告)日：2011-02-25
申请号：NZ57813003
申请日：2003-11-21
申请人： GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TURECI OZLEM , KOSLOWSKI MICHAEL
IPC分类号： C12N5/10 , A61K39/00 , A61K39/395 , A61K48/00 , C07K14/47 , C07K16/30 , C07K16/32 , C12N15/11
摘要： Disclosed is a pharmaceutical composition, comprising one or more components selected from the group consisting of: (i) a tumour-associated antigen or a functional fragment thereof; (ii) a nucleic acid which codes for a tumour-associated antigen or a functional fragment thereof; (iii) an antibody which binds to a tumour-associated antigen or a functional fragment thereof; (iv) an antisense nucleic acid which hybridizes specifically with a nucleic acid coding for a tumour associated antigen; (v) an isolated host cell which expresses a tumour associated antigen or a functional fragment thereof; and (vi) isolated complexes between a tumour-associated antigen or a functional fragment thereof and an HLA molecule. The tumour-associated antigen disclosed in (i)-(vi) has a sequence encoded by a nucleic acid which is selected from the group consisting of: a) a nucleic acid which comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 84, as defined in the specification, a fragment thereof, wherein said fragment thereof encodes a functional fragment of the tumour-associated antigen encoded by the nucleic acid sequence, b) a nucleic acid which hybridizes with the nucleic acid of a) under stringent conditions, c) a nucleic acid which is degenerate with respect to the nucleic acid of a) or b), and d) a nucleic acid which is complementary to the nucleic acid of a), b) or c).

46. 发明专利

AU2010202440A1 Genetic products differentially expressed in tumors and the use thereof 未知
公开(公告)号：AU2010202440A1
公开(公告)日：2010-07-01
申请号：AU2010202440
申请日：2010-06-10
申请人： GANYMED PHARMACEUTICALS AG
发明人： KOSLOWSKI MICHAEL , TURECI OZLEM , SAHIN UGUR
IPC分类号： C07K14/47 , A61K39/00 , C07K16/30

47. 发明专利

NZ539649A Claudin-18 gene and protein and related compositions and uses thereof 未知
公开(公告)号：NZ539649A
公开(公告)日：2009-09-25
申请号：NZ53964903
申请日：2003-11-21
申请人： GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TURECI OZLEM , KOSLOWSKI MICHAEL
IPC分类号： C12N15/11 , A61K39/00 , A61K39/395 , A61K48/00 , C07K14/47 , C07K16/30 , C07K16/32 , C12N5/10
摘要： Disclosed is a pharmaceutical composition, comprising one or more components selected from the group consisting of: (i) a tumor-associated antigen or a functional fragment thereof, (ii) a nucleic acid which codes for a tumor-associated antigen or a functional fragment thereof, (iii) an antibody which binds to a tumor-associated antigen or a functional fragment thereof, (iv) an antisense nucleic acid which hybridizes specifically with a nucleic acid coding for a tumor-associated antigen, (v) an isolated host cell which expresses a tumor-associated antigen or a functional fragment thereof, and (vi) isolated complexes between a tumor-associated antigen or a functional fragment thereof and an HLA molecule, said tumor-associated antigen having a sequence encoded by a nucleic acid which is selected from the group consisting of: (a) a nucleic acid which comprises a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 7 and 8, a fragment or derivative thereof, wherein said fragment or derivative thereof encodes a functional fragment or functional derivative of the tumor-associated antigen encoded by the nucleic acid sequence, (b) a nucleic acid which hybridizes with the nucleic acid of (a) under stringent conditions, (c) a nucleic acid which is degenerate with respect to the nucleic acid of (a) or (b), and (d) a nucleic acid which is complementary to the nucleic acid of (a), (b) or (c).

48. 发明专利

CA2703259A1 IDENTIFICATION OF TUMOR-ASSOCIATED MARKERS FOR DIAGNOSIS AND THERAPY 未知
公开(公告)号：CA2703259A1
公开(公告)日：2009-04-30
申请号：CA2703259
申请日：2008-10-22
申请人： GANYMED PHARMACEUTICALS AG , UNIV MAINZ JOHANNES GUTENBERG
发明人： SAHIN UGUR , TURECI OZLEM , KOSLOWSKI MICHAEL
IPC分类号： C07K14/47
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.

49. 发明专利

AU2008256489A1 Monoclonal antibodies against claudin-18 for treatment of cancer 未知
公开(公告)号：AU2008256489A1
公开(公告)日：2008-12-04
申请号：AU2008256489
申请日：2008-05-27
申请人： GANYMED PHARMACEUTICALS AG , UNIV MAINZ JOHANNES GUTENBERG
发明人： SAHIN UGUR , TURECI OZLEM , BRANDENBURG GUNDA , USENER DIRK
IPC分类号： A61K39/395 , A61K47/48 , A61P35/00 , C07K16/30 , C12N5/12
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.

50. 发明专利

NZ535146A Genetic products differentially expressed in tumors and use thereof 未知
公开(公告)号：NZ535146A
公开(公告)日：2006-06-30
申请号：NZ53514603
申请日：2003-03-12
申请人： GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TURECI OZLEM , KOSLOWSKI MICHAEL
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/28 , C07K16/30 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/02 , C12N15/63 , C12Q1/68 , G01N33/53 , C12N9/04
摘要： A pharmaceutical composition comprises an agent that inhibits expression or activity of a tumor-associated antigen which has a nucleic acid encoded sequence selected from the group consisting of: (a) a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 19-21 and 54-57, a functional fragment or derivative thereof; (b) a nucleic acid that hybridizes with the nucleic acid of (a) under stringent conditions; (c) a nucleic acid which is degenerate with respect to the nucleic acid of (a) or (b), and (d) a nucleic acid which is complementary to the nucleic acid of (a), (b) or (c); in which the agent is an antisense nucleic acid coding for the tumor-associated antigen, and/or an antibody which binds selectively to the tumor-associated antigen. The pharmaceutical composition can be used in the manufacture of a medicament for treating, diagnosing or monitoring a disease characterised by expression of the tumor-associated antigen. Also described are use of host cells, cytolytic or cytokine releasing T cells, antibodies, methods of detection or diagnosing a disease characterised by expression of a tumor-associated antigen.

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